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26th International Conference on Human-Computer Interaction, HCII 2024

作者： Tsao, Yu-Chung Pei, Yu-Cheng Liu, Kai-Fen Tseng, Kevin C. Department of Occupational Medicine Chang Gung Memorial Hospital Taoyuan Taiwan Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Taoyuan Taiwan Department of Industrial Design and Master Program of Innovation and Design National Taipei University of Technology Taipei Taiwan Product Design and Development Laboratory Taoyuan Taiwan

ISBN: (纸本)9783031768088

In Taiwan, there are 364,000 patients suffering from chronic kidney disease, with over 90% of them requiring haemodialysis to sustain their lives due to kidney function failure. However, the substantial demand for haemodialysis care has often resulted in nurses’ overwork. The nature of their work, which requires high concentration and puts them under constant high pressure for prolonged periods, significantly impacts the physical and psychological well-being of haemodialysis nurses. Despite this, only a limited number of studies have addressed the health problems caused by their work. Therefore, this study attempts to conduct a systematic literature review to investigate and summarise health problems and risk factors related to musculoskeletal disorders caused by the work of haemodialysis nurses. The study conducted a systematic literature search in PubMed and Web of Science databases, eventually including ten articles for discussion. The systematic review covers topics that may contribute to haemodialysis nurses’ health problems and musculoskeletal disorders. Furthermore, the study aims to analyse whether musculoskeletal symptoms among haemodialysis nurses are due to the specific nature of haemodialysis tasks, work intensity, stress, fatigue, and other factors. The research findings indicate that haemodialysis nurses experience significant work-related stress due to their unique responsibilities, labour-intensive and skill-intensive tasks, repetitive nature of their tasks, and improper posture. These factors may lead to musculoskeletal problems, with hand-related musculoskeletal discomfort twice as prevalent in haemodialysis nurses as in other specialities. Musculoskeletal disorders are one of the leading causes of absenteeism among haemodialysis nurses. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Ergonomics

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Plain language summary: does enzalutamide treatment with or without leuprolide improve outcomes and affect quality of life in patients with high-risk biochemical recurrence?

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Future Oncology 2025年第5期21卷 501-514页

作者： Freedland, Stephen J. Gleave, Martin De Giorgi, Ugo Rannikko, Antti Pieczonka, Christopher M. Tutrone Jr, Ronald F. Venugopal, Balaji Woo, Henry H. Ramirez-Backhaus, Miguel Tarazi, Jamal Tang, Yiyun Ganguli, Arijit Haas, Gabriel P. Shore, Neal D. Department of Urology Cedars-Sinai Medical Center Los Angeles CA United States Section of Urology Durham VA Medical Center Durham NC United States The Vancouver Prostate Centre University of British Columbia Vancouver BC Canada IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Meldola Italy Department of Urology and Research Program in Systems Oncology University of Helsinki Helsinki Finland Helsinki University Hospital Helsinki Finland US Urology Partners and Associated Medical Professionals of New York Syracuse NY United States Chesapeake Urology Research Associates Towson MD United States Beatson West of Scotland Cancer Centre University of Glasgow UK Glasgow United Kingdom College of Health and Medicine Australian National University Canberra ACT Australia SAN Prostate Centre of Excellence Sydney Adventist Hospital Sydney NSW Australia Servicio de Urología Fundación Instituto Valenciano de Oncología Valencia Spain Global Product Development Pfizer Collegeville PA United States Global Product Development San Francisco Pfizer CA United States Medical Affairs Astellas Pharma Northbrook IL United States Global Development Astellas Pharma Northbrook IL United States Carolina Urologic Research Center/AUC Urologists Myrtle Beach SC United States

Plain Language Summary: What is this summary about? This is a plain language summary of two research articles originally published in the New England Journal of Medicine and NEJM Evidence. The EMBARK study included patients with a type of advanced prostate cancer called non-metastatic castration-sensitive prostate cancer (nmCSPC) and high-risk biochemical recurrence (BCR). These patients experience a quick rise in prostate-specific antigen (PSA) levels after prostate cancer surgery or radiation treatment. Patients with a shorter PSA doubling time (PSADT) have quickly rising PSA levels. The patients from EMBARK had a short PSADT of 9 months or less, and their prostate cancer had not spread to other parts of the body. Prostate cancer treatments that lower testosterone levels, such as leuprolide, are widely used in patients with nmCSPC and high-risk BCR. In the EMBARK study, researchers wanted to know if enzalutamide treatment with or without leuprolide improved outcomes compared with leuprolide and placebo in patients with nmCSPC and high-risk BCR. Researchers also looked at the safety of these medicines and their effect on quality of life. What were the results? Researchers found that patients who received enzalutamide with or without leuprolide had a longer time until cancer spread to other parts of the body or death. It also took longer for their PSA levels to rise further and for them to start a new prostate cancer treatment. No new side effects were seen in the enzalutamide groups beyond those already known for enzalutamide. The most common side effects in all groups were hot flash, tiredness, and joint pain. The common side effects in the enzalutamide alone group were gynecomastia and breast tenderness. The median time that it took until patients had a confirmed drop in overall quality of life was similar between the enzalutamide combination, the enzalutamide alone, and the leuprolide plus placebo groups. What do the results of the study mean? Enzalutamide with

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Polydextrose and guar gum as a fat substitute in rice cookies and its physical, textural, and sensory properties

Food Chemistry Advances

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Food Chemistry Advances 2022年 1卷

作者： Samakradhamrongthai, Rajnibhas Sukeaw Maneechot, Sakornphop Wangpankhajorn, Prasert Jannu, Taruedee Renaldi, Gerry Food Science and Technology Program Faculty of Agro-Industry Prince of Songkla University Songkhla Hat Yai 90110 Thailand Agro-Industrial Product Development Research Unit Faculty of Agro-Industry Prince of Songkla University Songkhla Hat Yai 90110 Thailand Division of Product Development Technology Faculty of Agro-Industry Chiang Mai University Mai Chiang 50100 Thailand

This study was to investigate the combined effect of polydextrose and guar gum, as a fat replacer, on physical, chemical, textural, and sensory properties of developed Sungyod rice cookies (SYRC). The variation of polydextrose (5.00-9.50%), guar gum (0.50-1.00%), and butter (12.00-16.50%) were optimized using a d-optimal mixture design with 3 center points. The suitable formulation for SYRC with the optimized quantity of polydextrose (5.00%), guar gum (1.00%), and butter (16.00%) was obtained and can substitute the fat content in control SYRC up to 6%. The substitution of polydextrose and guar gum significantly affected the physical, chemical, textural, and sensory properties, especially fat content which could be reduced by 27.86% as compared with control SYRC formulation. The consumer acceptance of optimized SYRC was in the range of like slightly to like very much (6.7–7.4). The research outcomes indicated that polydextrose and guar gum can substitute fat content in SYRC and can be applied to create bakery products which can further recommend the exploitation of various ingredients to deliver reduced-fat products. © 2022

关键词： Cookie Fat substitutes Guar gum Polydextrose Sungyod rice

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Travel Time Estimation by means of Google API Data ⁎

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IFAC-PapersOnLine 2020年第2期53卷 15434-15439页

作者： Jan M.S. Wagner Manuel Eschbach Kari Vosseberg Marc Gennat Graduate Program in Product Development in Mechanical Engineering Hochschule Niederrhein University of Applied Sciences 47805 Krefeld Germany

Modern urban planning not only has to coordinate the needs of many different inhabitants and traffic participants, but also faces other challenges such as modal shift towards sustainable transportation. A comprehensive database of historical traffic, which would facilitate a decision based on data, is lacking in many cities. This became clear in consultation with our partners from the city of Krefeld. A novel method is the use of public available traffic information such as traffic colors or travel time data from navigation providers. In this contribution a method is applied to estimate the travel duration from the traffic colors on city level. Here we show for the first time how it can be applied cost-effectively and how the accuracy can be estimated in combination with a validation of the database by test drives for urban streets. It will also be investigated, whether speed variation has an influence on the estimation of driving time. We found out that this influence is negligible for the investigated example and the mean deviation of estimation accuracy from the measured values is less than six percent. Based on these promising results, it is possible to build up a database for improved urban and traffic planning at low cost. This can lead to better information for all traffic participants, thus, an improved traffic flow control could result in a reduction of car traffic emissions in the end.

关键词： Parameter Estimation Convex optimization Floating Cars Travel Time Google Maps

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Effect of Stevia, Okra Fruit Powder, and Thai White Chili on Physical, Chemical, and Sensory Properties of Confectionery Jam

SSRN

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SSRN 2023年

作者： Samakradhamrongthai, Rajnibhas Sukeaw Nortuy, Nutthamon Sangsee, Orapan Srichan, Phatthamon Sangpimpa, Wanalee Jannu, Taruedee Supawan, Thanyapohn Chanakun, Phruttinan Yimkaew, Yadaporn Renaldi, Gerry Division of Product Development Technology Faculty of Agro-Industry Chiang Mai University Chiang Mai50100 Thailand Food Science and Technology Program Faculty of Agro-Industry Prince of Songkla University Songkhla Hat Yai90110 Thailand INNOvation and Nouveau Interdisciplinary Research Unit Faculty of Agro-Industry Chiang Mai University Chiang Mai50100 Thailand

Jam is a product obtained by incorporating fruits and/or vegetables (whole or divided) into a mass of concentrated, unglazed syrup. This can be produced using vegetables and spices as ingredients providing functional and sensory properties, attractive for vegetarians and vegans. The study aimed to develop a white chili Chaiburi jam product using okra fruit powder as an ingredient to create an alternative low-methoxyl jam product. The white chili Chaiburi jam mixed with okra fruit powder (WCOJ) was varied stevia (23.5–25%), okra fruit powder (0.5–2.0%), and white chili Chaiburi (0.1–1.0%) using mixture design (d-optimal) with 3 centerpoints. The physicochemical, chemical, and sensory of WCOJ were analyzed and evaluated. The WCOJ contained stevia, okra fruit powder, and white chili Chaiburi at 24.0%, 1.6%, and 1%. The optimized WCOJ provided sufficient total phenolic compound and antioxidant activities (DPPH: 94.65 mg TE/100g DW;ABTS: 42.67 mg TE/100g DW) with low methoxyl content (0.34%). The sensory preference scores of WCOJ from consumer acceptance were slightly like (5.6–7.3) which indicated that the WCOJ can provide satisfaction in all evaluated attributes and can be concluded that okra fruit powder can be incorporated effectively in the development of a chili jam. © 2023, The Authors. All rights reserved.

关键词： Vegetables

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Enhanced angiotensin-converting enzyme inhibition and antioxidant activities through synergistic green tea and black rice extracts

Food Chemistry Advances

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Food Chemistry Advances 2025年 7.0卷

作者： Chaisan, Worrapob Salee, Nuttinee Pakakaew, Peeraporn Utama-ang, Niramon Division of Product Development Technology Faculty of Agro Industry Chiang Mai University Thailand Program of Food Production Engineering and Innovation College of Integrated of Science and Technology Rajamangala University of Technology Lanna Chiang Mai Thailand Division of Food Science and Technology Faculty of Agro Industry Chiang Mai University Thailand Cluster of High Value Products from Thai Rice and Plants for Health Chiang Mai University Thailand

The study investigated the synergistic effects of green tea extract (GTE) and black rice extract (BRE) on total phenolic content, flavonoid content, antioxidant activities and angiotensin-converting enzyme (ACE) inhibition. The influence of GTE concentrations (14.64–85.36 % w/w) and pH levels (3.59–6.41) was analyzed by regression and response surface methodology. Optimized conditions of synergistic effect (85.36 % w/w GTE and 14.64 % of BRE at pH 6.0) yielded the highest antioxidant activities (DPPH IC₅₀ = 0.112±0.015 mg/mL, ABTS = 89.14±1.58 mmol TE/100 g, FRAP = 373.66±3.42 mmol Fe²⁺/100 g), the highest total phenolic (120.98±1.60 mmol GAE/100 g), flavonoid contents (15.28±1.07 mmol QE/100 g) and ACE inhibitory activity (IC₅₀ = 6.125±0.106 μg/mL). Therefore, this condition was selected to produce the combined extract for determining the combination index (CI). The CI was 0.349±0.075 for DPPH and 0.505±0.019 for ACE inhibition, indicating confirmation of a synergistic effect. These findings suggest that the combined extract could serve as a valuable functional ingredient, enhancing access to bioactive-rich resources for nutritionally supportive and sustainable diets. With potential applications in food systems and healthcare, this agro-ingredient may contribute to improved access to resources for blood pressure management and non-communicable disease (NCDs) prevention, aligning with broader goals in nutrition and health equity. © 2025

关键词： ACE inhibitory activity Antioxidant activity Black rice Green tea Synergistic effect

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Bacillus tequilensis Isolated from Fermented Intestine of Holothuria Scabra Produces Fibrinolytic Protease with Thrombolysis Activity

Bacillus tequilensis Isolated from Fermented Intestine of Ho...

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2020 International Conference on Advances in Biological Science and Technology, ICABST 2020

作者： Hidayati, Nur Nurrahman, Nurrahman Fuad, Hayatun Munandar, Hendra Zilda, Dewi Seswita Ernanto, Aditya Rahman Samiasih, Amin Oedjijono, Oedjijono Ethica, Stalis Norma Magister Study Program of Medical Laboratory Science Universitas Muhammadiyah Semarang50273 Indonesia Food Technology Study Program Faculty of Nursing and Health Sciences Universitas Muhammadiyah Semarang50273 Indonesia Lombok Nusa Tenggara Barat83352 Indonesia Research and Development Center for Marine and Fishery Product Processing and Biotechnology Ministry of Maritime Affairs and Fisheries of Indonesia Jakarta10260 Indonesia Faculty of Nursing and Health Sciences Universitas Muhammadiyah Semarang50273 Indonesia Faculty of Biology Universitas Jenderal Soedirman Purwokerto53122 Indonesia

Among essential treatment of cardiovascular disorders are fibrinolytic proteases. Most thrombolysis agents are fibrinolytic enzymes from group of bacterial proteases. This work reports a potent bacterium isolated from fermented intestine of H. scabra, which could produce fibrinolytic protease with high thrombolysis activity. Bacterial selection was conducted based on proteolytic and fibrinolytic activities indicated as clear zone on skim milk and fibrin agar media, respectively. Crude proteases from the selected bacterial isolates were subjected to thrombolytic activity test based on gravimetric method, which results were confirmed after 7 repetitions. As result, 4 fibrinolytic protease-producing bacterial isolates HFSI-3, HFSI-4, HFSI-5 and HFSI-8 were obtained. Among them, HFSI-5 isolate identified as Bacillus tequilensis on the basis of the 16S rRNA gene sequencing and morphological properties produced crude protease with the highest thrombolytic activity. The thrombolytic activity of crude protease produced by B. tequilensis HFSI-5 is worthy of comparing to that of standard fibrinolytic enzyme Nattokinase showing its potential as thrombolysis agent. © Published under licence by IOP Publishing Ltd.

关键词： Bacteriology

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Protective effect of Hovenia dulcis Thunb. leaf extracts against ethanol-induced DNA damage in SH-SY5Y cells

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Journal of Ethnopharmacology 2023年第1期304卷 116042页

作者： de Godoi, Rafael Souza Garcia, Ana Letícia Hilario Borges, Malu Siqueira George, Hellen Kaiane Ferraz, Alexandre de Barros Falcão Corrêa, Dione Silva da Silva, Fernanda Rabaioli da Silva, Juliana Laboratory of Genetic Toxicology Postgraduate Program in Cellular and Molecular Biology Applied to Health (PPGBioSaúde) Lutheran University of Brazil (ULBRA) Laboratory of Genetic Toxicology Av. Farroupilha 8001 RS Canoas 92425-900 Brazil Laboratory of Genetic Toxicology Postgraduate Program in Health and Human Development (PPGSDH) La Salle University (UniLaSalle) Av. Victor Barreto 2288 RS Canoas 92010-000 Brazil Product and Development Research Center Lutheran University of Brazil (ULBRA) Av. Farroupilha 8001 RS Canoas 92425-900 Brazil Department of Chemistry Federal Institute of Piauí (IFPI) PI Teresina Brazil

Ethnopharmacological relevance: Hovenia dulcis Thunb. has been used as a medicinal herb for the treatment of hepatic diseases and alcohol intoxication. Aim of the study: The genotoxic effect and the antigenotoxic potential of ethanolic extract of H. dulcis leaves and its methanolic fraction were evaluated against ethanol-induced damages in SH-SY5Y cells. Materials and methods: The phytochemical analysis and antioxidant activity of H. dulcis extracts were also assessed. In addition, a systems biology analysis was performed to investigate the molecular pathway of action of the H. dulcis leaves compounds. Results: The ethanolic extract and its methanolic fraction presented genotoxicity through comet assay at 0.5 and 0.25 mg/mL. On the other hand, both extracts showed protective action against ethanol at all concentrations. Additionally, an NBT assay was performed and demonstrated an ability of the extracts to reduce superoxide anion formation when SH-SY5Y cells were challenged with ethanol. HPLC analysis indicated the presence of quercitrin, isoquercitrin, and rutin. Further, system biology assays indicated a molecular action pathway, where the compounds from the leaves of H. dulcis, in addition to performing free radical scavenging activity, activate PP2A, and may inhibit the apoptosis pathway activated by ethanol-induced oxidative stress. Conclusions: This work is important to indicate potential antigenotoxic and antioxidant properties of H. dulcis leaves, and its use can be investigated against DNA damage induced by ethanol. © 2022 Elsevier B.V.

关键词： Antigenotoxic Comet assay Flavonoids Rhamnaceae System biology

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Potency of Gedi (Abelmoschus manihot (L.) Medik) Fresh Leaves as a Natural Galactagogue in Comparison to Common Natural Galactagogues in Indonesia

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Current developments in Nutrition 2024年 8卷 103129-103129页

作者： Winata, Grace Marlina Hardinsyah, Hardinsyah Marliyati, Sri Anna Rimbawan, Rimbawan Andrianto, Dimas IPB University (Nutrition Science Program Graduate School) PT. Indofood CBP Sukses Makmur Tbk. (New Product Development Department Corp. R&D Division) Indonesia IPB University Indonesia

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Status report Swan sandwich nozzle program for Ariane 6 70

Status report Swan sandwich nozzle program for Ariane 6

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70th International Astronautical Congress, IAC 2019

作者： Brox, L. Wir, M. Almqvist, M. Hallberg, M. Pettersson, A.I. Lind, A. Technology Lead Space Future Programs Design Lead SWAN NE Product development Nozzles Manufacturing Engineer Nozzles SWAN Development Program SWAN Nozzle Extension

The SWAN sandwich nozzle for Vulcain 2.1 Engine in Ariane 6 launcher is under development and is in the final stages of qualification engine testing. The paper aims to show the experience learned in the SWAN (SandWich Advanced Nozzle) flight development program for Vulcain 2.1 engine in Ariane 6 application. Challenges in design and manufacturing for the new nozzle extension are shown with results gained up to autumn 2019. The Paper will report on the following activities: • Results of development and qualification test campaigns performed 2018-2019 • Challenges in design and manufacturing of the first SWAN NE's • Status report on SWAN maturation for flight on the Vulcain 2.1 engine GKN Aerospace has for almost two decades continuously improved and verified its patented manufacturing method for actively cooled nozzle extensions, i.e. the "Sandwich" laser welded channel wall technology. The GKN Aerospace Sandwich nozzle technology shows clear customer benefit in liquid rocket propulsion applications. Its technological maturity as well as cost saving potential has been demonstrated for gas generator and closed cycle engine applications in collaboration with several customers. Together with Ariane Group, the ETID - Expander Technology Integrated Demonstrator - Nozzle Extension demonstrator have also been tested in the recent year, with great success, see ref.[10]. Both the SWAN and the ETID significantly contribute to the verification and maturation of the GKN sandwich wall technology for both regeneratively cooled and dump cooled Nozzle designs. Copyright © 2019 by the International Astronautical Federation (IAF). All rights reserved.

关键词： Rockets

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