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26th International Conference on Human-Computer Interaction, HCII 2024

作者： Tsao, Yu-Chung Pei, Yu-Cheng Liu, Kai-Fen Tseng, Kevin C. Department of Occupational Medicine Chang Gung Memorial Hospital Taoyuan Taiwan Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Taoyuan Taiwan Department of Industrial Design and Master Program of Innovation and Design National Taipei University of Technology Taipei Taiwan Product Design and Development Laboratory Taoyuan Taiwan

ISBN: (纸本)9783031768088

In Taiwan, there are 364,000 patients suffering from chronic kidney disease, with over 90% of them requiring haemodialysis to sustain their lives due to kidney function failure. However, the substantial demand for haemodialysis care has often resulted in nurses’ overwork. The nature of their work, which requires high concentration and puts them under constant high pressure for prolonged periods, significantly impacts the physical and psychological well-being of haemodialysis nurses. Despite this, only a limited number of studies have addressed the health problems caused by their work. Therefore, this study attempts to conduct a systematic literature review to investigate and summarise health problems and risk factors related to musculoskeletal disorders caused by the work of haemodialysis nurses. The study conducted a systematic literature search in PubMed and Web of Science databases, eventually including ten articles for discussion. The systematic review covers topics that may contribute to haemodialysis nurses’ health problems and musculoskeletal disorders. Furthermore, the study aims to analyse whether musculoskeletal symptoms among haemodialysis nurses are due to the specific nature of haemodialysis tasks, work intensity, stress, fatigue, and other factors. The research findings indicate that haemodialysis nurses experience significant work-related stress due to their unique responsibilities, labour-intensive and skill-intensive tasks, repetitive nature of their tasks, and improper posture. These factors may lead to musculoskeletal problems, with hand-related musculoskeletal discomfort twice as prevalent in haemodialysis nurses as in other specialities. Musculoskeletal disorders are one of the leading causes of absenteeism among haemodialysis nurses. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Ergonomics

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Using hands-on design challenges in a product development master's degree program

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Journal of Engineering Education 2000年第4期89卷 487-493页

作者： Frey, Daniel D. Smith, Mark Bellinger, Scott Department of Aeronautics Massachusetts Inst. of Technology United States PD21 Program Rochester Institute of Technology United States Manufacturing Outreach Program Rochester Institute of Technology United States Manufacturing Technologies Ctr. for Intgd. Mfg. Studies Rochester Institute of Technology 111 Lomb Memorial Drive Rochester NY 14623 United States MIT 77 Massachusetts Avenue Cambridge MA 02139 United States Product Development Rochester Institute of Technology 111 Lomb Memorial Drive Rochester NY 14623 United States

A design challenge has been developed as the first experience in a new Master's degree program in product development, offered by a consortium of schools: the Massachusetts Institute of Technology, the Rochester Institute of Technology, and the University of Detroit Mercy. The program admits experienced technical specialists who have been identified by their employers as future leaders of product development. The program begins with a brief, intense design challenge that exposes the students to a multi-disciplinary problem and initiates reflection on systems architecture and organizational processes. The unique requirements of hands-on design challenges for graduate education in product development are discussed from a constructionist view-point. Implementation details of the design challenge are presented and the results from the first two years are analyzed. Students in the program rate the design challenge as a very good introduction to the program and agree that the exercise provides material for discussion of system architecture and organizational processes.

关键词： Engineering education

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AN APPLICATION ANALYZER

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IBM SYSTEMS JOURNAL 1984年第4期23卷 336-350页

作者： AMBROSETTI, R CIRIANI, TA PENNACCHI, R Program Product Development Center IBM Italy Rome Italy

An interactive tool aimed toward supporting the application user/analyst in specifying, analyzing, and documenting a business area is presented. Application Analyzer/Experimental (APAX) requires no assumptions of predefined procedural schemes. It is a flexible tool open to any preferred user approach. APAX is essentially a series of visual display screens, each one interactively offering facilities that support the user in analyzing the application, the component functions at any logical level, and the data. The conceptual starting point of APAX was general system theory and set theory rather than computer science. The aim of this approach was to generate a structure broad enough to be able to analyze and specify general systems and then to apply the framework to those special systems that represent business areas. A general flexible tool was obtained on which several improvements have been possible without major difficulties.

关键词： COMPUTER programMING

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Plain language summary: does enzalutamide treatment with or without leuprolide improve outcomes and affect quality of life in patients with high-risk biochemical recurrence?

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Future Oncology 2025年第5期21卷 501-514页

作者： Freedland, Stephen J. Gleave, Martin De Giorgi, Ugo Rannikko, Antti Pieczonka, Christopher M. Tutrone Jr, Ronald F. Venugopal, Balaji Woo, Henry H. Ramirez-Backhaus, Miguel Tarazi, Jamal Tang, Yiyun Ganguli, Arijit Haas, Gabriel P. Shore, Neal D. Department of Urology Cedars-Sinai Medical Center Los Angeles CA United States Section of Urology Durham VA Medical Center Durham NC United States The Vancouver Prostate Centre University of British Columbia Vancouver BC Canada IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Meldola Italy Department of Urology and Research Program in Systems Oncology University of Helsinki Helsinki Finland Helsinki University Hospital Helsinki Finland US Urology Partners and Associated Medical Professionals of New York Syracuse NY United States Chesapeake Urology Research Associates Towson MD United States Beatson West of Scotland Cancer Centre University of Glasgow UK Glasgow United Kingdom College of Health and Medicine Australian National University Canberra ACT Australia SAN Prostate Centre of Excellence Sydney Adventist Hospital Sydney NSW Australia Servicio de Urología Fundación Instituto Valenciano de Oncología Valencia Spain Global Product Development Pfizer Collegeville PA United States Global Product Development San Francisco Pfizer CA United States Medical Affairs Astellas Pharma Northbrook IL United States Global Development Astellas Pharma Northbrook IL United States Carolina Urologic Research Center/AUC Urologists Myrtle Beach SC United States

Plain Language Summary: What is this summary about? This is a plain language summary of two research articles originally published in the New England Journal of Medicine and NEJM Evidence. The EMBARK study included patients with a type of advanced prostate cancer called non-metastatic castration-sensitive prostate cancer (nmCSPC) and high-risk biochemical recurrence (BCR). These patients experience a quick rise in prostate-specific antigen (PSA) levels after prostate cancer surgery or radiation treatment. Patients with a shorter PSA doubling time (PSADT) have quickly rising PSA levels. The patients from EMBARK had a short PSADT of 9 months or less, and their prostate cancer had not spread to other parts of the body. Prostate cancer treatments that lower testosterone levels, such as leuprolide, are widely used in patients with nmCSPC and high-risk BCR. In the EMBARK study, researchers wanted to know if enzalutamide treatment with or without leuprolide improved outcomes compared with leuprolide and placebo in patients with nmCSPC and high-risk BCR. Researchers also looked at the safety of these medicines and their effect on quality of life. What were the results? Researchers found that patients who received enzalutamide with or without leuprolide had a longer time until cancer spread to other parts of the body or death. It also took longer for their PSA levels to rise further and for them to start a new prostate cancer treatment. No new side effects were seen in the enzalutamide groups beyond those already known for enzalutamide. The most common side effects in all groups were hot flash, tiredness, and joint pain. The common side effects in the enzalutamide alone group were gynecomastia and breast tenderness. The median time that it took until patients had a confirmed drop in overall quality of life was similar between the enzalutamide combination, the enzalutamide alone, and the leuprolide plus placebo groups. What do the results of the study mean? Enzalutamide with

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Enhanced angiotensin-converting enzyme inhibition and antioxidant activities through synergistic green tea and black rice extracts

Food Chemistry Advances

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Food Chemistry Advances 2025年 7.0卷

作者： Chaisan, Worrapob Salee, Nuttinee Pakakaew, Peeraporn Utama-ang, Niramon Division of Product Development Technology Faculty of Agro Industry Chiang Mai University Thailand Program of Food Production Engineering and Innovation College of Integrated of Science and Technology Rajamangala University of Technology Lanna Chiang Mai Thailand Division of Food Science and Technology Faculty of Agro Industry Chiang Mai University Thailand Cluster of High Value Products from Thai Rice and Plants for Health Chiang Mai University Thailand

The study investigated the synergistic effects of green tea extract (GTE) and black rice extract (BRE) on total phenolic content, flavonoid content, antioxidant activities and angiotensin-converting enzyme (ACE) inhibition. The influence of GTE concentrations (14.64–85.36 % w/w) and pH levels (3.59–6.41) was analyzed by regression and response surface methodology. Optimized conditions of synergistic effect (85.36 % w/w GTE and 14.64 % of BRE at pH 6.0) yielded the highest antioxidant activities (DPPH IC₅₀ = 0.112±0.015 mg/mL, ABTS = 89.14±1.58 mmol TE/100 g, FRAP = 373.66±3.42 mmol Fe²⁺/100 g), the highest total phenolic (120.98±1.60 mmol GAE/100 g), flavonoid contents (15.28±1.07 mmol QE/100 g) and ACE inhibitory activity (IC₅₀ = 6.125±0.106 μg/mL). Therefore, this condition was selected to produce the combined extract for determining the combination index (CI). The CI was 0.349±0.075 for DPPH and 0.505±0.019 for ACE inhibition, indicating confirmation of a synergistic effect. These findings suggest that the combined extract could serve as a valuable functional ingredient, enhancing access to bioactive-rich resources for nutritionally supportive and sustainable diets. With potential applications in food systems and healthcare, this agro-ingredient may contribute to improved access to resources for blood pressure management and non-communicable disease (NCDs) prevention, aligning with broader goals in nutrition and health equity. © 2025

关键词： ACE inhibitory activity Antioxidant activity Black rice Green tea Synergistic effect

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Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC.

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 421-428页

作者： Nut Koonrungsesomboon Kesara Na-Bangchang Juntra Karbwang Department of Clinical Product Development Institute of Tropical MedicineNagasaki University Graduate Program in Bioclinical Sciences Chulabhorn International College of MedicineThammasat University

The rhizome of Atractylodes Iancen(***)(Thunb.) DC.(AL)is extensively used in Chinese,Thai,and Japanese traditional medicines as crude extracts/decoctions or a component in various herbal *** pharmacological activities of *** its major constituents have been demonstrated in *** *** in animal *** from the toxicity studies in animal models suggest safety profile of AL,and its active *** extensive use with positive impression in many diseases,there has not been a clinical study that can conclusively support its efficacy and safely profile in *** review comprehensively summarizes current information on the pharmacological activities of AL and their active constituents including anticancer,anti-inflammatory,antimicrobial and antipyretic activities,as well as activities on central nervous,cardiovascular,and gastrointestinal systems.

关键词： Atractylodes lancea Pharmacological activities Traditional medicine Herb

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A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for the emergent vesicular stomatitis virus (VSV) viral vector vaccine for Lassa fever

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Vaccine 2025年 58卷 127137-127137页

作者： Spurgers, Kevin Wynn, Melissa Charles, Lovelyn Hamm, Stefan Matassov, Demetrius Gerardi, Cheryl Smith, Emily R. Gurwith, Marc Chen, Robert T. Emergent Product Development Gaithersburg Inc Gaithersburg MD United States Auro Vaccines LLC Pearl River NY United States Brighton Collaboration a program of the Task Force for Global Health Decatur GA United States

There are currently no prophylactic vaccines licensed to protect against Lassa fever caused by Lassa virus (LASV) infection. The Emergent BioSolutions (EBS) vaccine candidate, EBS-LASV, is being developed for the prevention of Lassa fever. EBS-LASV is a live-attenuated recombinant Vesicular Stomatitis Virus (rVSV)-vectored vaccine encoding the surface glycoprotein complex (GPC) from LASV and has two attenuating vector modifications: a gene shuffle of the VSV N gene and a deletion of the VSV G gene. Several preclinical safety studies demonstrate that EBS-LASV is safe when administered to animals. Likewise, in non-human primate immunogenicity and efficacy studies, administration of EBS-LASV produces a cellular and humoral immune response that fully protects NHPs from a lethal Lassa virus challenge. Together, these studies supported a first-in-human dose-escalation, safety, and immunogenicity clinical study. This paper uses a viral vector vaccine safety template developed by the Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) Working Group to review the features of the rVSV-vectored EBS-LASV vaccine candidate and provides a high-level summary of safety findings from preclinical studies and the Phase 1 clinical study. © 2025 The Authors

关键词： EBS-LASV Lassa fever Lassa virus Vaccine benefit/risk Vaccine efficacy Vaccine safety Vesicular stomatitis virus Viral vector vaccine

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Application of bioactive molecular networking to identify corneal-cytoprotective compounds from Dialium cochinchinense Pierre. leaves

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Current Plant Biology 2025年 42卷

作者： Nguyen, Thi Tuyet Nhung Lin, Yu-Chi Nguyen, Le-Anh-Tuan Chao, Chih-Hua Vo, Thanh-Hoa Hsu, Su-Jung Tsai, Keng-Chang Lee, Ching-Kuo Cheng, Jing-Jy Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan National Research Institute of Chinese Medicine Taipei 11221 Taiwan Faculty of Pharmacy Lac Hong University Dong Nai 810000 Viet Nam School of Pharmacy China Medical University Taichung 404328 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404327 Taiwan University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam Institute of Fisheries Science National Taiwan University Taipei 106 Taiwan Center for Discovery and Development of Healthcare Product Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Viet Nam

Dry eye disease (DED) requires innovative therapeutic strategies targeting inflammation and oxidative stress. In this study, we demonstrate for the first time that Dialium cochinchinense leaf extracts exhibited significant anti-inflammatory activities by inhibiting the nuclear transcription factor-κB (NF-κB) signaling pathway in macrophages. Additionally, these extracts showed notable antioxidant and cytoprotective capabilities, effectively mitigating oxidative stress-induced damage in corneal epithelial cells. We employed an advanced bioactive molecular networking strategy to prioritize and isolate key bioactive compounds, providing distinct advantages over traditional phytochemical screening methods. This approach led to the discovery of a new compound, 6S,9R-2′-O-sinapoyl-roseoside, and 11 known phenolic compounds. Notably, 10 of these compounds exhibited substantial corneal-cytoprotective effects in vitro. Network pharmacology analysis revealed 65 key shared targets between these compounds and DED, linked to PI3K/AKT and MAPK pathways critical for inflammation and cell survival. Subsequent molecular docking and molecular dynamics simulations confirmed stable and high-affinity binding interactions between the identified lead compounds and key protein targets implicated in DED. These findings demonstrate D. cochinchinense leaf extract and its bioactive constituents are promising natural candidates for DED, providing a scientific basis for further translational research and potential drug development. © 2025 The Authors

关键词： Bioactive molecular networking Cytoprotective effect Dialium cochinchinense Dry eye disease Molecular dynamics simulations Network pharmacology

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Land cover and water type classification using images captured by the Phlippines' first earth-observing microsatellite diwata-1 38

Land cover and water type classification using images captur...

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38th Asian Conference on Remote Sensing - Space Applications: Touching Human Lives, ACRS 2017

作者： Madalipay, Jasper Perez, Gay Jane Fulgencio, Louisse Anne Felix, Mark Jayson Macapagal, Marco Leonardo, Ellen Mae Felicio, Francisco Miguel Vergel, Kaye Namuco, Shielo Remote Sensing Product Development Project PHL-Microsat Program Institute of Environmental Science and Meteorology University of the Philippines Diliman Philippines

Diwata-1 is the Philippines' first earth-observing microsatellite with multispectral and high-resolution telescopes intended for a wide spectrum of applications including agriculture, forestry, urban, and coastal studies. In this study, land cover and water type classification was performed using Diwata-1 images captured across the country. Supervised classification using maximum likelihood method was utilized to categorize different land cover and water types. The accuracy of the generated land and water classification maps were evaluated using error matrices based on high-resolution images from Google Earth. Based on the results, shallow water pixels were successfully delineated from the deep waters. Vegetated areas were differentiated from non-vegetated ones;however, several bare and built-up pixels were misclassified mainly due to resemblances in spectral information. Nonetheless, average overall accuracy of 79.46% and average kappa coefficient of 0.6279 indicated good accuracy for the classified images. These preliminary results may pave the way for a more detailed classification such as identification of different vegetation types. Furthermore, land cover and water type classification maps can aid decision makers in assessment, planning and management of the Philippines' environmental resources. © 2017 ACRS. All rights reserved.

关键词： Pixels

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Status report Swan sandwich nozzle program for Ariane 6 70

Status report Swan sandwich nozzle program for Ariane 6

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70th International Astronautical Congress, IAC 2019

作者： Brox, L. Wir, M. Almqvist, M. Hallberg, M. Pettersson, A.I. Lind, A. Technology Lead Space Future Programs Design Lead SWAN NE Product development Nozzles Manufacturing Engineer Nozzles SWAN Development Program SWAN Nozzle Extension

The SWAN sandwich nozzle for Vulcain 2.1 Engine in Ariane 6 launcher is under development and is in the final stages of qualification engine testing. The paper aims to show the experience learned in the SWAN (SandWich Advanced Nozzle) flight development program for Vulcain 2.1 engine in Ariane 6 application. Challenges in design and manufacturing for the new nozzle extension are shown with results gained up to autumn 2019. The Paper will report on the following activities: • Results of development and qualification test campaigns performed 2018-2019 • Challenges in design and manufacturing of the first SWAN NE's • Status report on SWAN maturation for flight on the Vulcain 2.1 engine GKN Aerospace has for almost two decades continuously improved and verified its patented manufacturing method for actively cooled nozzle extensions, i.e. the "Sandwich" laser welded channel wall technology. The GKN Aerospace Sandwich nozzle technology shows clear customer benefit in liquid rocket propulsion applications. Its technological maturity as well as cost saving potential has been demonstrated for gas generator and closed cycle engine applications in collaboration with several customers. Together with Ariane Group, the ETID - Expander Technology Integrated Demonstrator - Nozzle Extension demonstrator have also been tested in the recent year, with great success, see ref.[10]. Both the SWAN and the ETID significantly contribute to the verification and maturation of the GKN sandwich wall technology for both regeneratively cooled and dump cooled Nozzle designs. Copyright © 2019 by the International Astronautical Federation (IAF). All rights reserved.

关键词： Rockets

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