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Mechanical behaviours and modelling of nanostructure anode in Lithium-Ion battery (LIB) – enabling low-cost 3D nanostructures in future LIB for sustainable energy storage

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AIP Conference Proceedings 2023年第1期2594卷

作者： C. Harito J. Wijaya R. Fajarna S. K. Tippabhotla O. Thomas F. E. Gunawan A. S. Budiman Industrial Engineering Department Faculty of Engineering Bina Nusantara University Jakarta Indonesia 11480 Industrial Engineering Department BINUS Graduate Program – Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia 11480 Xtreme Materials Lab Engineering Product Development Singapore University of Technology and Design (SUTD) Singapore Aix-Marseille Université CNRS IM2NP UMR 7334 Marseille France

Anode design is a crucial factor for the further development of lithium-ion battery (LIB) technology, especially in terms of achieving high charging rate performance, as typically needed in electric vehicles (EV). In the present work, a unique battery test cell was designed and fabricated to study in-situ the mechanical behavior of the silicon nanowire electrode during electrochemical lithiation using synchrotron X-ray microdiffraction. Modelling of the nanostructured anode was also performed to provide further understanding of the in-situ findings. The combined approach provides further in-depth understanding of the evolution of the mechanics in the silicon nanowires (1D nanostructure) during operation of the battery, and furthermore shows the path for potentially enhancing the performance of the device. 3D nanostructures have been identified as the key to dramatically enhanced kinetics performance of LIB. However, existing fabrication methodologies for 3D nanostructures are inherently expensive – using advanced lithography techniques or other nanopatterning methodologies, as well as using additive manufacturing approaches. Electrospinning (as an integrated additive manufacturing methodology) may be used to produce low-cost 3D-printed fiber structures. This will pave the way to achieve the order of magnitude increase in battery kinetics as needed to realize the vision of the sustainable transportation.

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Gedong Gincu cultivar mango (Mangifera indica L.) activity against hepatitis C virus in Huh7 cell line

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AIP Conference Proceedings 2024年第1期3065卷

作者： Dadan Ramadhan Apriyanto Ahmad Fariz Zamzam Zein Tutik Sri Wahyuni S. Suciati Maria Inge Lusida Department of Parasitology Immunology and Microbiology Faculty of Medicine Universitas Swadaya Gunung Jati Cirebon Indonesia Doctoral Program in Medical Sciences Faculty of Medicine Universitas Airlangga Surabaya Indonesia Department of Internal Medicine Faculty of Medicine Universitas Swadaya Gunung Jati Cirebon Indonesia Department of Pharmaceutical Sciences Faculty of Pharmacy Universitas Airlangga Mulyorejo Surabaya Indonesia Natural Product Medicine Research and Development Institute of Tropical Disease Universitas Airlangga Campus C Universitas Airlangga Mulyorejo Surabaya Indonesia

Chronic hepatitis C disease causes fibrosis, cirrhosis, and liver cancer, resulting in abnormal liver function cause mortality. The development of hepatitis C therapy in the last decade has resulted in severe side effects, resistance, and high cost, thus is needed as an alternative to medicinal plants. Gedong Gincu cultivar is a typical mango plant (Mangifera indica L.) from the Cirebon region which has characteristics such as aroma, taste, and skin color as well as its nutritional content and with high economic value compared to other mango cultivars. The aim of this study was to screen the Gedong Gincu cultivar mango plant leaves, fruit pulp, seeds and fruit skin against Hepatitis C Virus (HCV). In vitro study used the Huh7 cell line to examine the gedong gincu plant ethanol extract against HCV is used a focus on forming units for anti-HCV and MTT assay to examine the cytotoxicity against the Huh7 cell line. The results showed that four extracts, ethanol extracts from leaves (EL), fruit pulp (EFP), seeds (ES), and fruit skin (EFS) of the Gedong Gincu cultivar mango, with inhibition concentration 50% (IC50) of 58.8, 110.4, 8.2, and 27.4 µg/mL, respectively. Huh7it cells were incubated with the extracts for 48 h and it appears that EL, EFP, ES, and EFS is not toxic up to 800 µg/mL. These results suggested that ES of Mangifera indica gedong gincu cultivar is a potential source of anti-HCV and required to isolate the antiviral compound as anti-HCV.

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Peri-operative atezolizumab in early-stage triple-negative breast cancer: final results and ctDNA analyses from the randomized phase 3 IMpassion031 trial

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Nature Medicine 2025年 1-8页

作者： Elizabeth A. Mittendorf Zoe June Assaf Luciana Molinero Nadia Harbeck Hong Zhang Shigehira Saji Kyung Hae Jung Roberto Hegg Andreas Koehler Joohyuk Sohn Hiroji Iwata Melinda L. Telli Cristiano Ferrario Kevin Punie Aditi Qamra Yun Xu Max Dieterich Mario Liste-Hermoso Esther Shearer-Kang Stephen Y. Chui Carlos H. Barrios Department of Surgery Division of Breast Surgery Brigham and Women’s Hospital Boston MA USA Breast Oncology Program Dana-Farber/Brigham and Women’s Cancer Center Boston MA USA Oncology Biomarker Development Genentech South San Francisco CA USA Department of Gynecology and Obstetrics and Comprehensive Cancer Center Munich Breast Center Ludwig-Maximilians-University Hospital Munich Germany Memorial Sloan Kettering Cancer Center New York NY USA Fukushima Medical University Fukushima Japan Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea University of São Paulo São Paulo Brazil Gemeinschaftspraxis für Haematologie und Onkologie Langen Langen Germany Yonsei Cancer Center Yonsei University Health System Seoul Republic of Korea Aichi Cancer Center Hospital Nagoya Japan Department of Medicine Stanford University School of Medicine Stanford CA USA Jewish General Hospital–McGill University Montréal Quebec Canada Department of General Medical Oncology and Multidisciplinary Breast Centre Leuven Cancer Institute University Hospitals Leuven Leuven Belgium Data and Statistical Sciences—Oncology Hoffmann-La Roche Limited Mississauga Ontario Canada Product Development Oncology F. Hoffmann-La Roche Ltd Basel Switzerland Product Development Safety Genentech South San Francisco CA USA Product Development Oncology Genentech South San Francisco CA USA Latin American Cooperative Oncology Group (LACOG) Oncoclínicas Porto Alegre Brazil

Previously published results demonstrated that the randomized phase 3 IMpassion031 trial met its primary objective: adding atezolizumab to neoadjuvant chemotherapy significantly improved pathologic complete response (pCR) rate in patients with stage II/III triple-negative breast cancer (TNBC). Here we report the prespecified final analysis of the secondary endpoints with 3 years’ follow-up, together with exploratory analyses of circulating tumor (ct)DNA. Patients with previously untreated stage II/III TNBC enrolled in 75 academic and community sites in 13 countries were randomized 1:1 to receive neoadjuvant chemotherapy with either peri-operative atezolizumab (n= 165) or preoperative placebo (n= 168). Descriptive secondary endpoints included event-free, disease-free and overall survival. Long-term outcomes favored the atezolizumab group (event-free survival hazard ratio (HR), 0.76; 95% confidence interval (CI), 0.47–1.21; disease-free survival HR, 0.76; 95% CI, 0.44–1.30; overall survival HR, 0.56; 95% CI, 0.30–1.04). Among patients without pCR, 14 of 70 (20%) atezolizumab-treated and 33 of 99 (33%) placebo-treated patients received additional adjuvant therapy, frequently capecitabine. In exploratory biomarker analyses, patients with baseline ctDNA-negative status (6%) had excellent long-term outcomes. Most patients (87%) had cleared ctDNA at surgery. ctDNA-positive status at surgery identified a subset of non-pCR patients with poorest prognosis. Long-term safety was consistent with primary results. These data show that adding atezolizumab to chemotherapy for stage II/III TNBC is associated with favorable long-term outcomes, and ctDNA dynamics provide prognostic value beyond pCR. *** identifier:NCT03197935.

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Impact on the design phase of industrial housing when applying a product platform approach 26

Impact on the design phase of industrial housing when applyi...

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26th Annual Conference of the International Group for Lean Construction: Evolving Lean Construction Towards Mature production Management Across Cultures and Frontiers, IGLC 2018

作者： Thajudeen, Shamnath Lennartsson, Martin Elgh, Fredrik Prowood Graduate Program. Product development department School of Engineering Jönköping Sweden Department of building engineering and lighting science School of Engineering Jönköping Sweden Product development department School of Engineering Jönköping Sweden

ISBN: (纸本)9789380689296

With a glulam-based post-beam building system, a variety of building solutions is offered on the market for multi-story buildings. The building system must be adaptable to the demands of each project. However, short lead-time, efficient manufacturing and assembly must be ensured. The use of product platforms has been acknowledged as an enabler to manage external (customer) and internal (production) efficiency. The building system cannot be locked to a set of standard components as a high level of customisation is required. A set of methods and tools is needed to support the design work and to ensure that solutions stay inside the boundaries of the platform definition. The aim of this work is to map the state-of-practice in the design phase for a glulam building system from a platform theory perspective and outline a path forward for applying a sustainable platform development in companies where a component-based product platform does not suffice. Empirical data were gathered from an on-going product platform development including interviews and document analysis. The results show the lack of definition in platform-based product development from a theoretical perspective and need for development of support methods for design that align with different production strategies. © IGLC 2018 - Proceedings of the 26th Annual Conference of the International Group for Lean Construction: Evolving Lean Construction Towards Mature production Management Across Cultures and Frontiers. All rights reserved.

关键词： Housing

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Optimization of stingray (Trygon sephen) smoking to extend shelf life and consumer preferences using response surface methodology

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IOP Conference Series: Earth and Environmental Science 2021年第1期733卷

作者： H Suprapto S Kumalaningsih W Wignyanto I Santoso S Sucipto Doctoral Program in Agroindustrial Technology Faculty of Agricultural Technology Universitas Brawijaya Malang Department of Agricultural Product Technology Faculty of Agriculture Mulawarman University Samarinda Halal and Qualified Industry Development (Hal-Q-ID) Faculty of Agricultural Technology Brawijaya University Malang

Smoking is one of the preservation processes that are widely used in fishery products. To date, the fish smoking process has not been standardized so that the quality and shelf life of products are varied. Therefore, the optimization of fish smoking is essential. This study aims to determine the optimization of the smoking process of stingrays to obtain smoked stingrays which have a long shelf life and high sensory value that consumers like. This study used the Response Surface Method (RSM) using three independent variables, including the soaking time of stingrays in liquid smoke (2-4 hours), smoking temperature (60-80°C), and smoking time (3-5 hours). The storage time (days) and consumer preferences (value) were measured in this study. The results showed that stingrays soaked in liquid smoke for 3 hours, heated to 86.8°C for 3 hours, showed the best results with a shelf life of up to 9 days and most preferred by consumers. This result can be made as a recommendation for the standardization of stingray smoking.

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The Best of Both Worlds: Agile development Meets product Line Engineering at Lockheed Martin

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Insight 2019年第2期22卷 25-31页

作者： Gregg, Susan P. Scharadin, Rick Clements, Paul C. Principal project engineer for the Lockheed Martin Corporation. Over twenty years of senior program management experience related to complex large scale system development open architecture designs software product line development product integration and test and delivery for various Navy Aegis Baselines. Vice president of Customer Success at BigLever Software Inc.

Agile development has long been touted to optimize software development team efficiency and improve project success. product line engineering (PLE) brings large-scale improvements in cost, time to market, product quality, and more. Can these two paradigms work in concert with each other? This paper details the experience of Lockheed Martin as it introduced large-scale agile development practices on one of its largest and most successful product line engineering efforts. © 2016 by BigLever Software, Inc. Published and used by INCOSE with permission.

关键词： Cost engineering

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Modeling crystallographic anisotropy in interfacial sliding phenomenon in nanoindentation of nanoscale Cu/Nb accumulated rolling bonding (ARB) multilayered materials

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AIP Conference Proceedings 2023年第1期2594卷

作者： A. S. Budiman R. Sahay F. E. Gunawan C. Harito H. Gunawan I. Radchenko E. Navarro S. Escoubas T. Cornelius O. Thomas N. Raghavan Industrial Engineering Department BINUS Graduate Program – Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia Xtreme Materials Lab Engineering Product Development Singapore University of Technology and Design (SUTD) Singapore Industrial Engineering Department Faculty of Engineering Bina Nusantara University Jakarta Indonesia 11480 Center for Advancing Materials Performance from the Nanoscale (CAMP-nano) State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University (XJTU) Xi'an China Aix-Marseille Université CNRS IM2NP UMR 7334 Marseille France

Nanoindentation is widely used to investigate mechanical properties of materials at small scales. In this work, owing to the presence of contrasting interfaces along rolling (RD) and transverse direction (TD), a 16 nm accumulative roll bonding (ARB) Cu/Nb nanolaminate as a test material due to its crystallographic anisotropy was used. Nanoindentation was performed and then Scanning Probe Microscopy (SPM) data was conducted to measure the pile-up height along RD and TD in the nanoscale Cu/Nb multilayered materials. It was found that the 16 nm Cu/Nb ARB nanolayered material along RD showed higher surface pile-up than TD attributed the observation to the variation in the Cu/Nb interface plasticity along RD and TD. Further, a comparation and validation of experimental indentation data by performing 2D axisymmetric Finite Element Analysis (FEA) indicated that the simulation compares well with the experimentally generated load-displacement curves, while qualitative agreement was obtained with the pileup data. It is believed that the characterization of surface pile-up is very important for enabling the nanoscale Cu/Nb ARB nanolaminates as the novel stretchable/flexible metallic conductor materials (with emerging applications such as e-skins, human-computer interaction, and soft robotics) that may prove crucial for the global green and sustainability efforts (soft robots for collecting plastic trashes in ocean).

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Potential of fibrinolytic protease enzyme from tissue of sand sea cucumber (Holothuria scabra) as thrombolysis agent

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IOP Conference Series: Earth and Environmental Science 2021年第1期743卷

作者： N Hidayati H Fuad H Munandar DS Zilda AR Sulistyaningtyas N Nurrahman S Darmawati SN Ethica Magister Study Program of Clinical Laboratory Science Universitas Muhammadiyah Semarang Indonesia Balai Bio Industri Laut-LIPI (Lembaga Ilmu Penelitian Indonesia) Lombok Nusa Tenggara Barat Indonesia Research and Development Center for Marine and Fishery Product Processing and Biotechnology Technology Study Program Faculty of Nursing and Health Sciences Universitas Muhammadiyah Semarang Indonesia Medical Laboratory Technology Study Program Faculty of Nursing and Health Sciences Universitas Muhammadiyah Semarang Indonesia Food Technology Study Program Faculty of Nursing and Health Sciences Universitas Muhammadiyah Semarang Indonesia

Cardiovascular diseases (CVD) are still the main cause of death in modern society with thrombosis as their most common underlying pathology. The occurrence of thrombosis is characterized by thrombus formation in the circulatory system of the body causing blood clot blockage. Thrombus blocking blood vessels can be destroyed through fibrinolysis by plasmin. Commonly administered fibrinolytic drugs activate plasminogen and convert plasminogen to plasmin which degrades fibrin. However, these agents have limitations such as higher costs, shorter half-lives, allergic reactions and intravenous administration-caused bleeding. Hence, more effective and safer antithrombotic drugs are needed in anti-thrombosis therapy. This paper was intended to assess the ability of Holothuria scabra tissue fibrinolytic proteases as a thrombolytic agent based on literature studies. Summary of recent studies showed that various strong fibrinolytic enzymes could be produced from various animal tissues such as snake and earthworm, yet from sea organism' tissues are barely reported. In this literature review, the potential of protease enzymes from tissue of H. scabra as thrombolysis agent is summarized and discussed. Among the findings is that H. scabra has the highest protein content among other sea cucumbers in Indonesia, yet the isolation of protease enzymes from H. scabra tissue has not been reported. Hence, there is high possibility in finding novel proteases, which may include serine and metallo-protease known for their thrombolysis activities.

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Design and synthesis of hydroxychloroquine-sugar conjugates as promising antimalarial agents

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Bioorganic & Medicinal Chemistry Letters 2025年 125-126卷 130289页

作者： Emil Salim Hilkatul Ilmi Aty Widyawaruyanti Natsuhisa Oka Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University 1-1 Yanagido Gifu 501-1193 Japan Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Andalas Padang 25163 Indonesia Doctoral Program at the Faculty of Pharmacy Universitas Airlangga Surabaya 60115 Indonesia Natural Product Medicine Research and Development Institute of Tropical Disease Universitas Airlangga Surabaya 60286 Indonesia Department of Pharmaceutical Sciences Faculty of Pharmacy Universitas Airlangga Surabaya 60115 Indonesia Institute for Glyco-core Research (iGCORE) Gifu University 1-1 Yanagido Gifu 501-1193 Japan Center for One Medicine Innovative Translational Research (COMIT) Institute for Advanced Study Gifu University 1-1 Yanagido Gifu 501-1193 Japan

Novel hydroxychloroquine (HCQ)-sugar conjugates were evaluated for their antimalarial activity against chloroquine-sensitive ( Pf 3D7) and multi-resistant ( Pf Dd2) strains of Plasmodium falciparum , cytotoxicity, and hydrolytic stability. HCQ-galactose conjugate with a 1,2-orthioester linkage exhibited the highest activity against Pf 3D7 (IC 50 value of 0.018 ± 0.001 μg/mL). Per- O -acetyl-β- d -glucopyranosyl-HCQ exhibited the highest activity against Pf Dd2 (IC 50 = 0.20 ± 0.02 μg/mL), while also maintaining comparable activity against Pf 3D7. Orthoester-linked conjugates were gradually hydrolyzed in human serum, resulting in HCQ release, which may contribute to their high activity. Glycosidic bond-linked conjugates showed high hydrolytic stability, retaining a certain level of activity, possibly without releasing HCQ. Toxicity assessments using the BHK21 cell line indicated significantly lower cytotoxicity for all HCQ-sugar conjugates compared to HCQ.

关键词： Glycosylation Hydroxychloroquine Malaria Plasmodium falciparum Sugar conjugate

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Degradation performance and microencapsulation of hydrolytic bacterial consortium formulated as bioremediation agent of liquid biomedical waste

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IOP Conference Series: Earth and Environmental Science 2021年第1期743卷

作者： S N Ethica A Firmansyah E Purwaningrum N Hidayati S I Muchlissin A Sukeksi A R Sulistyaningtyas D S Zilda S Darmawati A Sabdono Magister Study Program of Medical Laboratory Science Universitas Muhammadiyah Semarang Central Java Indonesia. Faculty of Fisheries and Marine Sciences Universitas Diponegoro Semarang Central Java Indonesia Medical Laboratory Technology Diploma Study Program Faculty of Nursing and Health Sciences Universitas Muhammadiyah Semarang Central Java Indonesia Research and Development Center for Marine and Fishery Product Processing and Biotechnology Ministry of Maritime Affairs and Fisheries of Indonesia

This study aimed to develop bioremediation agent with bacterial cells as components for the treatment of biomedical wastes from two hospitals in Semarang City (Central Java), i.e. Roemani Muhammadiyah (coded R1) and Wongsonegoro (coded R2). Single isolates and consortium of indigenous hydrolytic bacteria characterized as multiple hydrolytic enzyme producers with low-to non-pathogenic properties obtained from previous study were tested for their degradation performance. The degradation performance test is necessary to formulate components of bacterial consortium as bioremediation agent. The tests were conducted on the selected bacteria as single isolate and as consortium. The six bacteria tested as single colonies and as consortium were Bacillus velezensis R1.3, B. amyloliquefaciens R1.6, B. amyloliquefaciens R1.14, B. velezensis R1.16, B. licheniformis R2.5, and B. amyloliquefaciens R2.9. Degradation performance on biomedical waste mainly containing organic matters was assessed based on water pollution parameters on 4.0-L samples. They included a control, 6 samples treated with bacteria as single colonies, a sample treated with bacteria as indigenous consortium and a sample treated with bacteria as mixed consortium. Parameters of wastewater pollution measured included COD (Chemical Oxygen Demand), BOD (Biological Oxygen Demand), TSS (Total Soluble Solid), NH3, and PO4. Next, encapsulation of a bacterial consortium as the best condition for degradation was also carried out using maltodextrin to allow storage and preservation of the bioremediation agent for longer period. The encapsulated product was visualized in SEM images to evaluate its quality. The results showed that a consortium comprising 4 indigenous bacterial isolates from R1 hospital could decrease BOD of biomedical wastewater by 85% and TSS by 43%. Those from R2 showed performance in reducing PO4 by 21%. This study demonstrated that compared to single isolates and mixed bacterial consortium tested, the ind

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