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Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study

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environment International 2024年 183卷 108340页

作者： Chen, Ling-Wei Ng, Sharon Tint, Mya-Thway Michael, Navin Sadananthan, Suresh Anand Ong, Yi Ying Yuan, Wen Lun Chen, Ze-Ying Chen, Chia-Yang Godfrey, Keith M. Tan, Kok Hian Gluckman, Peter D. Chong, Yap-Seng eriksson, Johan G. Yap, Fabian Lee, Yung Seng Fortier, Marielle V. Velan, Sendhil S. Chan, Shiao-Yng Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei10055 Taiwan Master of Public Health Program College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei10055 Taiwan Singapore Institute for Clinical Sciences Agency for Science Technology and Research 30 Medical Drive 117609 Singapore Human Potential Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road 119228 Singapore Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health BostonMA United States ParisF-75004 France Institute of Food Safety and Health College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei10055 Taiwan MRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre University of Southampton & University Hospital Southampton NHS Foundation Trust Tremona Road SO16 6YD Southampton United Kingdom Duke-NUS Medical School 8 College Road 169857 Singapore Department of Reproductive Medicine KK Women's and Children Hospital Singapore Singapore Liggins Institute University of Auckland 85 Park Rd Grafton Auckland1023 New Zealand Department of Obstetrics & Gynaecology Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road 119228 Singapore Department of General Practice and Primary Health Care University of Helsinki Haartmaninkatu 8 Helsinki00290 Finland Folkhälsan Research Center Topeliusgatan 20 Helsinki00250 Finland Department of Pediatric Endocrinology KK Women's and Children's Hospital 100 Bukit Timah Road 229899 Singapore Khoo Teck Puat-National University Children's Medical Institute National University Health System 1E Kent Ridge Road 119228 Singapore Department of Diagnostic & Interventional Imaging KK Women's and Childre

Background: The influence of prenatal exposure to per- and poly- fluoroalkyl substances (PFAS) on birth size and offspring adiposity is unclear, especially for the newer, shorter-chained replacement PFAS. Methods: In the GUSTO multi-ethnic Singaporean mother-offspring cohort, 12 PFAS were measured in 783 cord plasma samples using ultra-performance-liquid chromatography-tandem-mass-spectrometer (UPLC-MS/MS). Outcomes included offspring anthropometry, other indicators of body composition/metabolic health, and MRI-derived abdominal adiposity (subset) at birth and 6 years of age. PFAS were modeled individually, in categories of long-chain and short-chain PFAS, and as scores of three principal components (PC) derived using PC analysis (PC1, PC2, and PC3 reflect predominant exposure patterns to "very-long-PFAS", "long-PFAS", and "short-PFAS", respectively). Associations with outcomes were assessed using multivariable linear regressions, adjusted for important covariates such as maternal sociodemographic and lifestyle factors. Results: Overall, cord PFAS levels showed either no or positive associations (mostly for long-chain PFAS) with birth weight, length and head circumference. In general, PFAS were associated with higher neonatal abdominal adiposity, driven by shorter-chain PFAS. Perfluoroheptanoic acid (PFHpA) was associated with higher volumes of superficial subcutaneous adipose tissue (sSAT) (3.75 [1.13, 6.37] mL per SD increase in PFAS) and internal adipose tissue (IAT) (1.39 [0.41, 2.38] mL). Higher levels of perfluorobutanesulfonic acid (PFBS), short-chain PFAS, and PC3 were associated with higher IAT volume (β range 1.22–1.41 mL/SD, all P © 2023 The Authors

关键词： Tissue

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Association of prognostic nutritional index with long-term mortality in patients receiving percutaneous coronary intervention for acute coronary syndrome: a meta-analysis

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Scientific Reports 2023年第1期13卷 1-10页

作者： Chang, Wei-Ting Sun, Cheuk-Kwan Wu, Jheng-Yan Yu, Chia-Hung Chang, Ying-Jen Lin, Ming-Chung Lan, Kuo-Mao Chen, I-Wen Hung, Kuo-Chuan Division of Cardiology Department of Internal Medicine Chi-Mei Medical Center Tainan City Taiwan Department of Biotechnology Southern Taiwan University of Science and Technology Tainan City Taiwan School of Medicine and Doctoral Program of Clinical and Experimental Medicine College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat-sen University Kaohsiung City Taiwan Department of Emergency Medicine E-Da Dachang Hospital I-Shou University Kaohsiung City Taiwan School of Medicine for International Students College of Medicine I-Shou University Kaohsiung City Taiwan Department of Nutrition Chi Mei Medical Center Tainan City Taiwan Department of Anesthesiology Chi Mei Medical Center No. 901 ChungHwa Road YungKung Dist Tainan City 71004 Taiwan Department of Anesthesiology Chi Mei Medical Center Liouying Tainan City Taiwan School of Medicine College of Medicine National Sun Yat-Sen University Kaohsiung City Taiwan

The predictive value of the prognostic nutritional index (PNI) for the long-term prognosis of patients with acute coronary syndrome (ACS) remains uncertain. Medline, embase, Cochrane Library, and Google Scholar were searched from inception until January 2023 to study the relationship between all-cause mortality risk and PNI in patients receiving percutaneous coronary intervention for ACS (i.e., primary outcome). Thirteen observational studies were included in this meta-analysis. Analysis of seven studies using PNI as a categorical variable showed a pooled hazard ratio (HR) of all-cause mortality of 2.97 (95% CI 1.65 to 5.34, p = 0.0003, I² = 89%, n = 11,245) for patients with a low PNI. The meta-analysis also showed a higher risk of major adverse cardiovascular events (MACes) in patients with a low PNI (HR 2.04;95% CI 1.59 to 2.61;p < 0.00001;I² = 21%;n = 8534). Moreover, advanced age, diabetes mellitus, and high Global Registry of Acute Coronary events risk scores were associated with a high risk of all-cause mortality, whereas a high body mass index was associated with a low risk of all-cause mortality. The results showed an association between a low PNI and an increased risk of long-term mortality in patients undergoing coronary interventions for ACS. Further randomized controlled trials are necessary to confirm these findings. © 2023, Springer Nature Limited.

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A study of Galactic Plane Planck Galactic cold clumps observed by SCOPe and the JCMT Plane Survey

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Monthly Notices of the Royal Astronomical Society 2024年第4期530卷 5192-5208页

作者： eden, D.J. Liu, Tie Moore, T.J.T. Di Francesco, J. Fuller, G. Kim, Kee-Tae Li, Di Liu, S.-Y. Plume, R. Tatematsu, Ken'ichi Thompson, M.A. Wu, Y. Bronfman, L. Butner, H.M. Currie, M.J. Garay, G. Goldsmith, P.F. Hirano, N. Johnstone, D. Juvela, M. Lai, S.-P. Lee, C.W. Mannfors, e.e. Olguin, F. Pattle, K. Park, Geumsook Polychroni, D. Rawlings, M. Rigby, A.J. Sanhueza, P. Traficante, A. Urquhart, J.S. Weferling, B. White, G.J. Yadav, R.K. Armagh Observatory and Planetarium College Hill ArmaghBT61 9DB United Kingdom Shanghai Astronomical Observatory Chinese Academy of Sciences 80 Nandan Road Shanghai200030 China Astrophysics Research Institute Liverpool John Moores University Liverpool Science Park iC2 146 Brownlow Hill LiverpoolL3 5RF United Kingdom NRC Herzberg Astronomy and Astrophysics 5071 West Saanich Rd VictoriaBCV9E 2E7 Canada Department of Physics and Astronomy University of Victoria VictoriaBCV8W 2Y2 Canada Jodrell Bank Centre for Astrophysics School of Physics and Astronomy The University of Manchester Oxford Road ManchesterM13 9PL United Kingdom Korea Astronomy and Space Science Institute 776 Daedeokdae-ro Yuseong-gu Daejon34055 Korea Republic of 217 Gajeong-ro Yuseong-gu Daejeon34113 Korea Republic of NationalAstronomicalObservatories ChineseAcademyofSciences Beijing100012 China Key Laboratory of Radio Astronomy Chinese Academy of Science Nanjing210008 China Academia Sinica Institute of Astronomy and Astrophysics 11F of AS/NTU Astronomy – Mathematics Building No.1 Section 4 Roosevelt Rd Taipei10617 Taiwan Department of Physics and Astronomy University of Calgary 2500 University Drive NW CalgaryABT2N 1N4 Canada Nobeyama Radio Observatory National Astronomical Observatory of Japan National Institutes of Natural Sciences Nobeyama Minamimaki Minamisaku Nagano384-1305 Japan Astronomical Science Program Graduate Institute for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan School of Physics and Astronomy University of Leeds LeedsLS2 9JT United Kingdom Department of Astronomy Peking University Beijing100871 China Astronomy Department Universidad de Chile Casilla 36-D Santiago7591245 Chile Department of Physics and Astronomy James Madison University MSC 4502 901 Carrier Drive HarrisonburgVA22807 United States RAL Space STFC Rutherford Appleton Laboratory Chilton Didcot OxfordshireOX11 0QX United Kingdom East Asian Obser

We have investigated the physical properties of Planck Galactic Cold Clumps (PGCCs) located in the Galactic Plane, using the JCMT Plane Survey (JPS) and the SCUBA-2 Continuum Observations of Pre-protostellar evolution (SCOPe) survey. By utilizing a suite of molecular-line surveys, velocities, and distances were assigned to the compact sources within the PGCCs, placing them in a Galactic context. The properties of these compact sources show no large-scale variations with Galactic environment. Investigating the star-forming content of the sample, we find that the luminosity-to-mass ratio (L/M) is an order of magnitude lower than in other Galactic studies, indicating that these objects are hosting lower levels of star formation. Finally, by comparing ATLASGAL sources that are associated or are not associated with PGCCs, we find that those associated with PGCCs are typically colder, denser, and have a lower L/M ratio, hinting that PGCCs are a distinct population of Galactic Plane sources. © 2024 The Author(s).

关键词： Stars

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Mobilizing evidence-based Knowledge for Sustainable Wetlands Co-management and Co-governance amidst increasing Anthropogenic and environmental Stressors: Key Lessons from Mityana District, Uganda

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environmental Challenges 2024年 17卷

作者： Matovu, Baker Lee, Ming-An Mammel, Mubarak Lukambagire, Isaac Lutalo, Bernard Mwangu, Alex Ronald Mwabvu, Bridget Mim, Tahmina Akther Bbira, Yasin Lubega, Yasin Muhoozi, Yosia Natural Resources Department Mityana District Local Government Mityana Uganda Department of Environmental Biology and Fisheries Science/Doctoral Degree Program in Ocean Resource and Environmental Changes/Center of Excellence for Oceans National Taiwan Ocean University No.2 Beining Rd. Zhongzheng Dist Keelung City 20224 Taiwan Department of Environmental Biology and Fisheries Science National Taiwan Ocean University No.2 Beining Rd. Zhongzheng Dist Keelung City 20224 Taiwan Amrita School for Sustainable Futures Amrita Vishwa Vidyapeetham Kerala Amritapuri India Department of Geography Uganda Martyrs University-Nkozi Mpigi Uganda Department of Humanities Education Kabale University Kabale Uganda VIT Business School Vellore Institute of Technology Tamil Nadu Vellore India District Natural Resources Office (DNRO) Mityana District Local Government Mityana Uganda King Faisal Bbuye Islamic Secondary School Mityana Uganda College of Agricultural and Environmental Sciences (CAES) Makerere University Kampala Uganda

Wetlands (covering about 1.5–1.6 billion hectares globally), are critical biodiversity and livelihood hotspots. Wetlands further replenish the global economy with $47.4 trillion/year worth of ecosystem services. By jealously guarding wetlands, progress toward sustainable development goals, and livelihood welfare are possible. Unfortunately, despite the promulgation of wetland governance mechanisms, 35 percent of the global natural wetlands have been lost since the 1970s. This could be worse in undocumented or explored wetland zones situated in remote tropical regions. In this study, we bring to the fore insights from 286 documents sourced from Scopus and engagements from 105 citizens in Mityana, to (i) map wetlands (including the current vulnerabilities and threats), and (ii) co-develop a wetlands management action pathway that could create sustainable co-management possibilities and sustainable livelihood futures. Findings revealed that although research on wetlands has increased for the last 31 years, since 2021, it has plummeted. In Uganda, wetland research and scholarship is predominantly situated around the Lake Victoria region. Most research focuses on natural or biological sciences. emerging policy themes and trending research topics are shifting from key wetland management paradigms. From a total of 105 sampled wetlands scattered across fourteen (14) sub-counties in the Mityana district, critical wetland issues were unraveled. Mityana is crossed by two wetland systems (Lake Wamala and River Mayanja dominated by permanent papyrus and seasonal swamps respectively. Wetlands offer unique livelihood, cultural assets/capitals, and ecological benefits (including cultural/aesthetics meaning). An unfathomable rate of degradation is evident. Anthropogenic factors are the predominant threat drivers, especially eucalyptus planting. The loss of culturally valuable wetlands has increased socio-cultural-ecological grief, such as around Lake Wamala. Micro-level management a

关键词： Anthropogenic and environmental stressors Mityana district Sustainable wetlands co-management and co-governance Sustainable Wetlands Management Action Pathway (SWeMAP) Uganda Wetland resources

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Investigating the Recovery of PVDF/TiO2 Photocatalyst for Methylene Blue Degradation

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Processes 2025年第5期13卷 1392-1392页

作者： Vi N. D. Nguyen Hoang-Jyh Leu Huy N. Q. Phan Tan-Trung Nguyen Dat H. M. Ngo Department of Chemical Engineering Feng Chia University Taichung 40744 Taiwan Master’s Program of Green Energy Science and Technology Feng Chia University Taichung 40744 Taiwan Center for Low-Temperature Plasma Sciences Nagoya University Nagoya 464-8603 Japan Department of Materials Science and Engineering Feng Chia University Taichung 40744 Taiwan Office of Academic Affairs Nha Trang University Nha Trang 57100 Vietnam Faculty of Mathematics and Computer Science University of Science Vietnam National University Ho Chi Minh 72711 Vietnam

The increasing environmental concerns over and demand for sustainable solutions have driven research into the efficient recovery and reuse of waste materials, particularly from photocatalysts used in wastewater treatment. This study addresses the critical challenge posed by used PVDF/TiO2 photocatalysts, which, if not properly managed, contribute to environmental pollution. A practical recovery technique based on the phase inversion method was developed to separate and purify PVDF, TiO2, and the solvent NMP from used composite materials. This method led to recovery rates of 95.17% for PVDF, 98.35% for NMP, and 67% for TiO2. The recycled photocatalyst was then reassembled and tested for its ability to degrade methylene blue, a common dye pollutant. A Box–Behnken design was employed to optimize the treatment conditions, ensuring the process was both efficient and reproducible. The regenerated material achieved up to 99.6% efficiency in the first cycle, with a slight reduction in efficiency observed across subsequent cycles, maintaining over 92% efficiency after 10 cycles. These findings confirm that effective recovery of photocatalytic materials is not only feasible but also beneficial in reducing waste and maintaining high treatment performance.

关键词： PVDF/TiO composite photocatalyst recovery recycling process sustainable photocatalysis

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Revisiting the Transit Timing and Atmosphere Characterization of the Neptune-mass Planet HAT-P-26 b

arXiv

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arXiv 2023年

作者： A-Thano, Napaporn Awiphan, Supachai Jiang, Ing-Guey Kerins, eamonn Priyadarshi, Akshay McDonald, Iain Joshi, Yogesh C. Chulikorn, Thansuda Hayes, Joshua J.C. Charles, Stephen Huang, Chung-Kai Rattanamala, Ronnakrit Yeh, Li-Chin Dhillon, Vik S. Department of Physics Institute of Astronomy National Tsing-Hua University Hsinchu30013 Taiwan National Astronomical Research Institute of Thailand 260 Moo 4 Donkaew Mae Rim Chiang Mai50180 Thailand Jodrell Bank Centre for Astrophysics University of Manchester Oxford Road ManchesterM13 9PL United Kingdom Department of Physical Sciences The Open University Walton Hall Milton KeynesMK7 6AA United Kingdom Manora Peak Nainital263001 India Department of Physics Faculty of Science Chulalongkorn University 254 Phayathai Road Pathumwan Bangkok10330 Thailand Institute of Astronomy and Astrophysics Academia Sinica No.1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan PhD Program in Astronomy Department of Physics and Materials Science Faculty of Science Chiang Mai University Chiang Mai50200 Thailand Department of Physics and General Science Faculty of Science and Technology Nakhon Ratchasima Rajabhat University Nakhon Ratchasima30000 Thailand Institute of Computational and Modeling Science National Tsing-Hua University Hsinchu30013 Taiwan Department of Physics and Astronomy University of Sheffield SheffieldS3 7RH United Kingdom Instituto de Astrofísica de Canarias Tenerife La LagunaE-38205 Spain

We present the transit timing variation (TTV) and planetary atmosphere analysis of the Neptune-mass planet HAT-P-26 b. We present a new set of 13 transit light curves from optical ground-based observations and combine them with light curves from the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST), Transiting exoplanet Survey Satellite (TeSS), and previously published ground-based data. We refine the planetary parameters of HAT-P-26 b and undertake a TTV analysis using 33 transits obtained over seven years. The TTV analysis shows an amplitude signal of 1.98 ± 0.05 minutes, which could result from the presence of an additional ∼ 0.02 MJup planet at the 1:2 mean-motion resonance orbit. Using a combination of transit depths spanning optical to near-infrared wavelengths, we find that the atmosphere of HAT-P-26 b contains (formula presented) of H2O with a derived temperature of (formula presented) K. Copyright © 2023, The Authors. All rights reserved.

关键词： Timing circuits

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Restoring Prohealing/Remodeling-Associated M2a/c Macrophages Using ON101 Accelerates Diabetic Wound Healing

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JID Innovations 2022年第5期2卷 100138-100138页

作者： Lin, Ching-Wen Chen, Chih-Chiang Huang, Wen-Yen Chen, Yen-Yu Chen, Shiou-Ting Chou, Hung-Wen Hung, Chien-Ming Chen, Wan-Jiun Lu, Chia-Sing Nian, Shi-Xin Chen, Shyi-Gen Chang, Hsuen-Wen Chang, Vincent H.S. Liu, Li-Ying Kuo, Ming-Liang Chang, Shun-Cheng Oneness Biotech Co. Ltd. Taipei Taiwan Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan Department of Dermatology School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Microbio Co. Ltd Taipei Taiwan NTU YongLin Institute of Health National Taiwan University Taipei Taiwan Division of Plastic and Reconstructive Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan TMU Laboratory Animal Center Office of Research and Development Taipei Medical University Taipei Taiwan Department of Physiology School of Medicine Taipei Medical University Taipei Taiwan The PhD Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Microbio Shanghai Co. Ltd. Shanghai China Division of Plastic Surgery Integrated Burn & Wound Care Center Department of Surgery Shuang-Ho Hospital Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan

Diabetic wounds exhibit chronic inflammation and delayed tissue proliferation or remodeling, mainly owing to prolonged proinflammatory (M1) macrophage activity and defects in transition to prohealing/proremodeling (M2a/M2c;CD206⁺ and/or CD163⁺) macrophages. We found that topical treatment with ON101, a plant-based potential therapeutic for diabetic foot ulcers, increased M2c-like (CD163⁺ and CD206⁺) cells and suppressed M1-like cells, altering the inflammatory gene profile in a diabetic mouse model compared with that in the controls. An in vitro macrophage-polarizing model revealed that ON101 directly suppressed CD80⁺ and CD86⁺ M1-macrophage polarization and M1-associated proinflammatory cytokines at both protein and transcriptional levels. Notably, conditioned medium collected from ON101-treated M1 macrophages reversed the M1-conditioned medium‒mediated suppression of CD206⁺ macrophages. Furthermore, conditioned medium from ON101-treated adipocyte progenitor cells significantly promoted CD206⁺ and CD163⁺ macrophages but strongly inhibited M1-like cells. ON101 treatment also stimulated the expression of GCSF and CXCL3 genes in human adipocyte progenitor cells. Interestingly, treatment with recombinant GCSF protein enhanced both CD206⁺ and CD163⁺ M2 markers, whereas CXCL3 treatment only stimulated CD163⁺ M2 macrophages. Depletion of cutaneous M2 macrophages inhibited ON101-induced diabetic wound healing. Thus, ON101 directly suppressed M1 macrophages and facilitated the GCSF- and CXCL3-mediated transition from M1 to M2 macrophages, lowering inflammation and leading to faster diabetic wound healing. © 2022 The Authors

关键词： ADPC adipocyte progenitor cell CM conditioned medium HFD high-fat diet HG high-glucose IHC immunohistochemistry iNOS inducible nitric oxide synthase M1-CM M1-associated conditioned medium m-Clo mannosylated clodronate STAT3 signal transducer and activator of transcription 3

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Development of anti-aflatoxin B1 nanobodies from a novel mutagenesis-derived synthetic library for traditional Chinese medicine and foods safety testing

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Journal of biological engineering 2023年第1期17卷 30页

作者： Yu-Ching Lee Gar-Hwa Lai Tsai-Yu Lin Tien-Sheng Tseng Tsung-Hsun Tsai Wang-Chuan Chen Cheng-Chung Lee Keng-Chang Tsai TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Orthopedics Kaohsiung Veterans General Hospital Kaohsiung Taiwan. Institute of Molecular Biology National Chung Hsing University Taichung Taiwan. Department of Psychiatry Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan. The School of Chinese Medicine for Post Baccalaureate I-Shou University Kaohsiung Taiwan. Department of Chinese Medicine E-Da Hospital Kaohsiung Taiwan. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. tkc@nricm.edu.tw. National Research Institute of Chinese Medicine Ministry of Health and Welfare No. 155-1 Sec. 2 Linong St. Beitou District Taipei 11221 Taiwan. tkc@nricm.edu.tw.

BACKGROUND:The main commercially available methods for detecting small molecules of mycotoxins in traditional Chinese medicine (TCM) and functional foods are enzyme-linked immunosorbent assay and mass spectrometry. Regarding the development of diagnostic antibody reagents, effective methods for the rapid preparation of specific monoclonal antibodies are inadequate. MeTHODS:In this study, a novel synthetic phage-displayed nanobody Golden Glove (SynaGG) library with a glove-like cavity configuration was established using phage display technology in synthetic biology. We applied this unique SynaGG library on the small molecule aflatoxin B1 (AFB1), which has strong hepatotoxicity, to isolate specific nanobodies with high affinity for AFB1. ReSULT:These nanobodies exhibit no cross-reactivity with the hapten methotrexate, which is recognized by the original antibody template. By binding to AFB1, two nanobodies can neutralize AFB1-induced hepatocyte growth inhibition. Using molecular docking, we found that the unique non-hypervariable complementarity-determining region 4 (CDR4) loop region of the nanobody was involved in the interaction with AFB1. Specifically, the CDR4's positively charged amino acid arginine directed the binding interaction between the nanobody and AFB1. We then rationally optimized the interaction between AFB1 and the nanobody by mutating serine at position 2 into valine. The binding affinity of the nanobody to AFB1 was effectively improved, and this result supported the use of molecular structure simulation for antibody optimization. CONCLUSION:In summary, this study revealed that the novel SynaGG library, which was constructed through computer-aided design, can be used to isolate nanobodies that specifically bind to small molecules. The results of this study could facilitate the development of nanobody materials to detect small molecules for the rapid screening of TCM materials and foods in the future.

关键词： Aflatoxin B1 Glove-like cavity Nanobody Nonhypervariable complementarity-determining region 4 loop Phage display technology

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Revisiting the Transit Timing and Atmosphere Characterization of the Neptune-mass Planet HAT-P-26 b

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Astronomical Journal 2023年第6期166卷 223页

作者： A-Thano, Napaporn Awiphan, Supachai Jiang, Ing-Guey Kerins, eamonn Priyadarshi, Akshay McDonald, Iain Joshi, Yogesh C. Chulikorn, Thansuda Hayes, Joshua J. C. Charles, Stephen Huang, Chung-Kai Rattanamala, Ronnakrit Yeh, Li-Chin Dhillon, Vik S Department of Physics Institute of Astronomy National Tsing-Hua University Hsinchu 30013 Taiwan National Astronomical Research Institute of Thail 260 Moo 4 Donkaew Mae Rim Chiang Mai 50180 Thailand Jodrell Bank Centre for Astrophysics University of Manchester Oxford Road Manchester M13 9PL United Kingdom Department of Physical Sciences The Open University Walton Hall Milton Keynes MK7 6AA United Kingdom Aryabhatta Research Institute of Observational Sciences (ARIES) Manora Peak Nainital 263001 India Department of Physics Faculty of Science Chulalongkorn University 254 Phayathai Road Pathumwan Bangkok 10330 Thailand Institute of Astronomy and Astrophysics Academia Sinica No.1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan PhD Program in Astronomy Department of Physics and Materials Science Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand Department of Physics and General Science Faculty of Science and Technology Nakhon Ratchasima Rajabhat University Nakhon Ratchasima 30000 Thailand Institute of Computational and Modeling Science National Tsing-Hua University Hsinchu 30013 Taiwan Department of Physics and Astronomy University of Sheffield Sheffield S3 7RH United Kingdom Instituto de Astrofísica de Canarias La Laguna Tenerife E-38205 Spain

We present a transit-timing variation (TTV) and planetary atmosphere analysis of the Neptune-mass planet HAT-P-26 b. We present a new set of 13 transit light curves from optical ground-based observations and combine them with light curves from the Wide Field Camera 3 on the Hubble Space Telescope, the Transiting exoplanet Survey Satellite, and previously published ground-based data. We refine the planetary parameters of HAT-P-26 b and undertake a TTV analysis using 33 transits obtained over seven years. The TTV analysis shows an amplitude signal of 1.98 ± 0.05 minutes, which could result from the presence of an additional ∼0.02 M _Jup planet at a 1:2 mean-motion resonance orbit. Using a combination of transit depths spanning optical to near-infrared wavelengths, we find that the atmosphere of HAT-P-26 b contains 2.4 − 1.6 + 2.9 % H₂O with a derived temperature of 590 − 50 + 60 K. © 2023. The Author(s). Published by the American Astronomical Society.

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effects of galaxy environment on merger fraction?

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Astronomy and Astrophysics 2024年 686卷

作者： Pearson, W.J. Santos, D.J.D. Goto, T. Huang, T.-C. Kim, S.J. Matsuhara, H. Pollo, A. Ho, S.C.-C. Hwang, H.S. Malek, K. Nakagawa, T. Romano, M. Serjeant, S. Suelves, L.e. Shim, H. White, G.J. National Centre for Nuclear Research Pasteura 7 Warszawa02-093 Poland Max Planck Institute for Extraterrestrial Physics Gießenbachstraße 1 Garching85748 Germany Institute of Astronomy National Tsing Hua University 101 Section 2. Kuang-Fu Road Hsinchu30013 Taiwan Department of Space and Astronautical Science Graduate University for Advanced Studies SOKENDAI Shonankokusaimura Hayama Miura District Kanagawa240-0193 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency 3-1-1 Yoshinodai Chuo-ku Kanagawa Sagamihara252-5210 Japan Research School of Astronomy and Astrophysics The Australian National University CanberraACT2611 Australia Centre for Astrophysics and Supercomputing Swinburne University of Technology PO Box 218 HawthornVIC3122 Australia OzGrav The Australian Research Council Centre of Excellence for Gravitational Wave Discovery HawthornVIC3122 Australia ASTRO3D The Australian Research Council Centre of Excellence for All-sky Astrophysics in 3D CanberraACT2611 Australia Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of INAF – Osservatorio Astronomico di Padova Vicolo dell’Osservatorio 5 Padova35122 Italy School of Physical Sciences The Open University Walton Hall Milton KeynesMK7 6AA United Kingdom Department of Earth Science Education Kyungpook National University 80 Daehak-ro Buk-gu Daegu41566 Korea Republic of Space Science and Technology Division RALSpace STFC Rutherford Appleton Laboratory Chilton DidcotOX11 0QX United Kingdom

Aims. In this work we examine how environment influences the merger fraction, from the low density field environment to higher density groups and clusters. We also study how the properties of a group or cluster, as well as the position of a galaxy in the group or cluster, influences the merger fraction. Methods. We identified galaxy groups and clusters in the North ecliptic Pole using a friends-of-friends algorithm and the local density. Once identified, we determined the central galaxies, group radii, velocity dispersions, and group masses of these groups and clusters. Merging systems were identified with a neural network as well as visually. With these identifications and properties of groups and clusters and merging galaxy identifications, we examined how the merger fraction changes as the local density changes for all galaxies as well as how the merger fraction changes as the properties of the groups or clusters change. Results. We find that the merger fraction increases as local density increases and decreases as the velocity dispersion increases, as is often found in the literature. A decrease in merger fraction as the group mass increases is also found. We also find that groups with larger radii have higher merger fractions. The number of galaxies in a group does not influence the merger fraction. Conclusions. The decrease in merger fraction as group mass increases is a result of the link between group mass and velocity dispersion. Hence, this decrease in merger fraction with increasing mass is a result of the decrease of merger fraction with velocity dispersion. The increasing relation between group radii and merger fraction may be a result of larger groups having smaller velocity dispersion at a larger distance from the centre or larger groups hosting smaller, infalling groups with more mergers. However, we do not find evidence of smaller groups having higher merger fractions. c The Authors 2024.

关键词： Galaxies

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