Analysis of an individual’s immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends ...
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Document management system makes user to access information anytime and anywhere. The purpose of this research is to analyze what variables have impact on the intention to use of document management system. To achieve...
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Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raise...
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作者:
Chao, FengqingSamir, K.C.Ombao, HernandoStatistics Program
Computer Electrical And Mathematical Sciences And Engineering Division King Abdullah University Of Science And Technology 4700 KAUST Thuwal23955-6900 Saudi Arabia Asian Demographic Research Institute
Shanghai University Shangda Road Shanghai200444 China
International Institute For Applied Systems Analysis Schlossplatz 1 Laxenburg2361 Austria
Background: The sex ratio at birth (SRB;ratio of male to female births) in Nepal has been reported without imbalance on the national level. However, the national SRB could mask the disparity within the country. Given ...
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Background: The sex ratio at birth (SRB;ratio of male to female births) in Nepal has been reported without imbalance on the national level. However, the national SRB could mask the disparity within the country. Given the demographic and cultural heterogeneities in Nepal, it is crucial to model Nepal SRB on the subnational level. Prior studies on subnational SRB in Nepal are mostly based on reporting observed values from surveys and census, and no study has provided probabilistic projections. We aim to estimate and project SRB for the seven provinces of Nepal from 1980 to 2050 using a Bayesian modeling approach. Methods: We compiled an extensive database on provincial SRB of Nepal, consisting 2001, 2006, 2011, and 2016 Nepal Demographic and Health Surveys and 2011 Census. We adopted a Bayesian hierarchical time series model to estimate and project the provincial SRB, with a focus on modelling the potential SRB imbalance. Results: In 2016, the highest SRB is estimated in Province 5 at 1.102 with a 95% credible interval (1.044, 1.127) and the lowest SRB is in Province 2 at 1.053 (1.035, 1.109). During 1980-2016, the provincial SRB was around the same level as the national SRB baseline of 1.049. The SRB imbalance probabilities in all provinces are generally low and vary from 16% in Province 2 to 81% in Province 5. SRB imbalances are estimated to have begun at the earliest in 2001 in Province 5 with a 95% credible interval (1992, 2022) and the latest in 2017 (1998, 2040) in Province 2. We project SRB in all provinces to begin converging back to the national baseline in the mid-2030s. By 2050, the SRBs in all provinces are projected to be around the SRB baseline level. Conclusion: Our findings imply that the majority of provinces in Nepal have low risks of SRB imbalance for the period 1980-2016. However, we identify a few provinces with higher probabilities of having SRB inflation. The projected SRB is an important illustration of potential future prenatal sex discriminat
Rapid advancements in synthetic biology and nucleic acid synthesis, in particular concerns about its intentional or accidental misuse, call for more sophisticated screening tools to identify genes of interest within s...
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ISBN:
(纸本)9781728118680
Rapid advancements in synthetic biology and nucleic acid synthesis, in particular concerns about its intentional or accidental misuse, call for more sophisticated screening tools to identify genes of interest within short sequence fragments. One major gap in predicting genes of concern is the inadequacy of current tools and ontologies to describe the specific biological processes of pathogenic proteins. The objective of this work is to design software that sensitively assigns taxonomic classifications, functional annotations, and biological processes of interest to short nucleotide sequences of unknown origin (50bp-1,000bp). The overarching goal is to perform sensitive characterization of short sequences and highlight specific pathogenic biological processes of interest (BPoIs). The SeqScreen software executes these tasks in analytical workflows with Nextflow and outputs results in a tab-delimited report. Local and global alignments differentiate hits to taxonomically-related sequences from similar but unrelated sequences, and an ensemble approach leverages multiple tools and databases to assign a variety of functional terms to each query sequence. Final biological process assessments are made from the predicted functional annotations, which leverage information in pre-existing databases, as well as new custom biocurations. Machine learning models predict each biological process of interest on large protein databases before incorporation into the SeqScreen framework to streamline computational efficiency, ensure reproducible results, allow for version control, and facilitate the review of the automated predictions by expert biocurators. The SeqScreen source code is available at .
There have been many studies conducted related to Smart City, IT Governance and Big Data. In this study aims to find out how the relationship between the three and how to form a framework to explain it. The methodolog...
There have been many studies conducted related to Smart City, IT Governance and Big Data. In this study aims to find out how the relationship between the three and how to form a framework to explain it. The methodology used is qualitative by looking for some literature on smart city framework, IT Governance framework, and a Big Data framework. From these results, an overall picture of the relationship between the three is concluded, where Big Data has a role in IT Governance. and also the relationship of IT Governance to the realization of Smart City. And the final results of this study produce a framework to explain the relationship between Smart City, IT Governance and Big Data.
In clinical microbiology, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) is frequently employed for rapid microbial identification. However, rapid identification of antimic...
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In clinical microbiology, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) is frequently employed for rapid microbial identification. However, rapid identification of antimicrobial resistance (AMR) in Escherichia coli based on a large amount of MALDI-TOF MS data has not yet been reported. This may be because building a prediction model to cover all E. coli isolates would be challenging given the high diversity of the E. coli population. This study aimed to develop a MALDI-TOF MS-based, data-driven, two-stage framework for characterizing different AMRs in E. coli. Specifically, amoxicillin (AMC), ceftazidime (CAZ), ciprofloxacin (CIP), ceftriaxone (CRO), and cefuroxime (CXM) were used. In the first stage, we split the data into two groups based on informative peaks according to the importance of the random forest. In the second stage, prediction models were constructed using four different machine learning algorithms-logistic regression, support vector machine, random forest, and extreme gradient boosting (XGBoost). The findings demonstrate that XGBoost outperformed the other four machine learning models. The values of the area under the receiver operating characteristic curve were 0.62, 0.72, 0.87, 0.72, and 0.72 for AMC, CAZ, CIP, CRO, and CXM, respectively. This implies that a data-driven, two-stage framework could improve accuracy by approximately 2.8%. As a result, we developed AMR prediction models for E. coli using a data-driven two-stage framework, which is promising for assisting physicians in making decisions. Further, the analysis of informative peaks in future studies could potentially reveal new insights. Based on a large amount of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) clinical data, comprising 37,918 Escherichia coli isolates, a data-driven two-stage framework was established to evaluate the antimicrobial resistance of E. coli. Five antibiotics, including a
This paper examines the relationship between user pageview (PV) histories and their item-choice behavior on an e-commerce website. We focus on PV sequences, which represent time series of the number of PVs for each us...
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Optical imaging of genetically encoded calcium indicators is a powerful tool to record the activity of a large number of neurons simultaneously over a long period of time from freely behaving animals. However, determi...
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KAGRA, the underground and cryogenic gravitational-wave detector, was operated for its solo observation from February 25 to March 10, 2020, and its first joint observation with the GEO 600 detector from April 7 to Apr...
KAGRA, the underground and cryogenic gravitational-wave detector, was operated for its solo observation from February 25 to March 10, 2020, and its first joint observation with the GEO 600 detector from April 7 to April 21, 2020 (O3GK). This study presents an overview of the input optics systems of the KAGRA detector, which consist of various optical systems, such as a laser source, its intensity and frequency stabilization systems, modulators, a Faraday isolator, mode-matching telescopes, and a high-power beam dump. These optics were successfully delivered to the KAGRA interferometer and operated stably during the observations. The laser frequency noise was observed to limit the detector sensitivity above a few kilohertz, whereas the laser intensity did not significantly limit the detector sensitivity.
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