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检索条件"机构=Program for Computational Biology and Bioinformatics"
524 条 记 录,以下是131-140 订阅
排序:
Local two-sample testing over graphs and point-clouds by random-walk distributions
arXiv
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arXiv 2020年
作者: Landa, Boris Qu, Rihao Chang, Joseph Kluger, Yuval Program in Applied Mathematics Yale University Department of Pathology Yale University School of Medicine Department of Statistics and Data Science Yale University Interdepartmental Program in Computational Biology and Bioinformatics Yale University Department of Immunology Yale School of Medicine
Rejecting the null hypothesis in two-sample testing is a fundamental tool for scientific discovery. Yet, aside from concluding that two samples do not come from the same probability distribution, it is often of intere... 详细信息
来源: 评论
Uncertainty abounds, what now?
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Science 2025年 第6740期387卷 1261页
作者: Dov Greenbaum Mark Gerstein The reviewer is at the Zvi Meitar Institute for Legal Implications of Emerging Technologies The reviewer is at the Harry Radzyner Law School The reviewer is at the Dina Recanati School of Medicine Reichman University Herzliya Israel The reviewer is at the Department of Biomedical Informatics and Data Science The reviewer is at the Program in Computational Biology and Bioinformatics The reviewer is at the Department of Computer Science Yale University New Haven CT USA.
来源: 评论
Predictable clinical benefits without synergy in trials of combination therapies with immune checkpoint inhibitors
Research Square
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Research Square 2021年
作者: Palmer, Adam C. Izar, Benjamin Hwangbo, Haeun Sorger, Peter K. Department of Pharmacology Computational Medicine Program Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel HillNC United States Laboratory of Systems Pharmacology Harvard Program in Therapeutic Science Harvard Medical School BostonMA United States Department of Medicine Division of Hematology and Oncology Columbia University Medical Center Columbia Center for Translational Tumor Immunology New YorkNY United States Curriculum in Bioinformatics and Computational Biology University of North Carolina at Chapel Hill Chapel HillNC United States
Hundreds of clinical trials are currently underway testing combinations of Immune Checkpoint Inhibitors (ICIs) with other cancer therapies in the hope that combination therapy will be more effective than monotherapy. ... 详细信息
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SCA-AD, a Novel Method to Uniformly Identify Cells across Single-Cell RNA Sequencing Datasets, Applied to Adult and Pediatric Self-Renewing AML Cells
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Blood 2024年 144卷 2218-2218页
作者: Yoonkyu Lee Wen Wang Timothy K Starr Klara E Noble-Orcutt Chad L Myers Zohar Sachs Masonic Cancer Center University of Minnesota Minneapolis MN Bioinformatics and Computational Biology Program University of Minnesota Minneapolis MN Division of Hematology Oncology and Transplantation Department of Medicine University of Minnesota Minneapolis MN Department of Computer Science and Engineering University of Minnesota Minneapolis MN Department of Obstetrics Gynecology and Women's Health University of Minnesota Minneapolis MN
Introduction Single cell RNA sequencing (scRNAseq) is commonly used to determine cell identity. Several scRNAseq analysis methods are available. Most methods use arbitrary scores to represent the similarity of the que...
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Spectral Top-Down Recovery of Latent Tree Models
arXiv
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arXiv 2021年
作者: Aizenbud, Yariv Jaffe, Ariel Wang, Meng Hu, Amber Amsel, Noah Nadler, Boaz Chang, Joseph T. Kluger, Yuval Program in Applied Mathematics Yale University New HavenCT06511 United States Department of Computer Science Weizmann Institute of Science Rehovot76100 Israel Department of Statistics Yale University New HavenCT06520 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New HavenCT06511 United States Department of Pathology Yale University New HavenCT06511 United States
Modeling the distribution of high dimensional data by a latent tree graphical model is a prevalent approach in multiple scientific domains. A common task is to infer the underlying tree structure, given only observati... 详细信息
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Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma
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Biomedicine and Pharmacotherapy 2023年 第1期166卷 115429-115429页
作者: Hsieh, Chiao-Hui Huang, Chen-Tsung Cheng, Yi-Sheng Hsu, Chun-Hua Hsu, Wen-Ming Chung, Yun-Hsien Liu, Yen-Lin Yang, Tsai-Shan Chien, Chia-Yu Lee, Yu-Hsuan Huang, Hsuan-Cheng Juan, Hsueh-Fen Department of Life Science National Taiwan University Taipei Taiwan Center for Computational and Systems Biology National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Institute of Plant Biology National Taiwan University Taipei Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan
Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness.... 详细信息
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Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance
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Biomedicine and Pharmacotherapy 2024年 180卷 117569-117569页
作者: Kaewlert, Waleeporn Sakonsinsiri, Chadamas Lert-itthiporn, Worachart Mahalapbutr, Panupong Ali, Saba Rungrotmongkol, Thanyada Jusakul, Apinya Armartmuntree, Napat Pairojkul, Chawalit Feng, Guofei Ma, Ning Pinlaor, Somchai Murata, Mariko Thanan, Raynoo Department of Biochemistry Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Cholangiocarcinoma Research Institute Khon Kaen University Khon Kaen 40002 Thailand Center of Excellence in Structural and Computational Biology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Program in Bioinformatics and Computational Biology Graduated School Chulalongkorn University Bangkok 10330 Thailand The Center for Research and Development of Medical Diagnostic Laboratories Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen 40002 Thailand Department of Medical Science Amnatcharoen Campus Mahidol University Amnat Charoen 37000 Thailand Department of Pathology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Department of Environmental and Molecular Medicine Mie University Graduate School of Medicine Mie 514-8507 Japan Graduate School of Health Science Suzuka University of Medical Science Suzuka Mie 510-0226 Japan Department of Parasitology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand
Cholangiocarcinoma (CCA) is an oxidative stress-driven liver cancer with bile duct epithelial cell phenotypes and currently lacks effective treatments, making targeted drug therapy urgently needed. Oxidative stress pl... 详细信息
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APPROXIMATE BAYESIAN INFERENCE OF DIRECTED ACYCLIC GRAPHS IN biology WITH FLEXIBLE PRIORS ON EDGE STATES
arXiv
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arXiv 2019年
作者: Martin, Evan A. Fu, Audrey Qiuyan The Bioinformatics and Computational Biology Program University of Idaho United States The Bioinformatics and Computational Biology Program Department of Mathematics and Statistical Science Institute for Modeling Collaboration and Innovation Institute for Interdisciplinary Data Sciences University of Idaho United States
Graphical models or networks describe the statistical dependence among multiple variables and are widely used in biology (e.g., gene regulatory networks). Under appropriate assumptions, directed edges may represent ca... 详细信息
来源: 评论
Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex
SSRN
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SSRN 2024年
作者: Johansen, Nelson J. Kempynck, Niklas Zemke, Nathan R. Somasundaram, Saroja Winter, Seppe De Hooper, Marcus Dwivedi, Deepanjali Lohia, Ruchi Wehbe, Fabien Li, Bocheng Abaffyová, Darina Armand, Ethan J. Man, Julie De Eksi, Eren Can Hecker, Nikolai Hulselmans, Gert Konstantakos, Vasilis Mauduit, David Mich, John K. Partel, Gabriele Daigle, Tanya L. Levi, Boaz P. Zhang, Kai Tanaka, Yoshiaki Gillis, Jesse Ting, Jonathan T. Ben-Simon, Yoav Miller, Jeremy Ecker, Joseph R. Ren, Bing Aerts, Stein Lein, Ed S. Tasic, Bosiljka Bakken, Trygve E. Allen Institute for Brain Science SeattleWA98109 United States VIB Center for AI & Computational Biology VIB-KU Leuven Center for Brain and Disease Research KU Leuven Department of Human Genetics Leuven Belgium Center for Epigenomics Department of Cellular and Molecular Medicine University of California La Jolla San DiegoCA92093 United States Physiology Department Donnelly Centre for Cellular and Biomolecular Research University of Toronto TorontoON Canada Maisonneuve-Rosemont Hospital Research Centre University of Montreal MontrealQC Canada School of Life Sciences Westlake University Zhejiang Hangzhou China Bioinformatics and Systems Biology Program University of California La Jolla San DiegoCA92093 United States Westlake Laboratory of Life Sciences and Biomedicine Zhejiang Hangzhou China Department of Physiology and Biophysics University of Washington SeattleWA98195 United States Salk Institute for Biological Studies La Jolla CA92037 United States
Identifying cell type-specific enhancers in the brain is critical to building genetic tools for investigating the mammalian brain. computational methods for functional enhancer prediction have been proposed and valida... 详细信息
来源: 评论
Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes
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Science Advances 2025年 第22期11卷 eadv1071页
作者: Yi-Cheng Sin Breann Abernathy Zuo-fei Yuan Jason L. Heier Justin E. Gonzalez Laurie L. Parker Douglas G. Mashek Yue Chen Department of Biochemistry Molecular Biology and Biophysics University of Minnesota Twin Cities Minneapolis MN USA. Bioinformatics and Computational Biology Program University of Minnesota Twin Cities Minneapolis MN USA. Center for Proteomics and Metabolomics St. Jude Children’s Research Hospital Memphis TN USA. Department of Medicine Division of Diabetes Endocrinology and Metabolism University of Minnesota Twin Cities Minneapolis MN USA. Institute for the Biology of Aging and Metabolism University of Minnesota Twin Cities Minneapolis MN USA.
Environmental factors may affect gene expression through epigenetic modifications of histones and transcription factors. Here, we report that cellular uptake of sorbate, a common food preservative, induces lysine sorb...
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