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检索条件"机构=Program for Computational Biology and Bioinformatics"
524 条 记 录,以下是201-210 订阅
排序:
Domain Adaptation via Rebalanced Sub-domain Alignment
arXiv
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arXiv 2023年
作者: Liu, Yiling Dong, Juncheng Jiang, Ziyang Aloui, Ahmed Li, Keyu Klein, Hunter Tarokh, Vahid Carlson, David Program in Computational Biology and Bioinformatics Duke University School of Medicine DurhamNC United States Department of Electrical and Computer Engineering Duke University DurhamNC United States Department of Civil and Environmental Engineering Duke University DurhamNC United States Department of Biostatistics and Bioinformatics Duke University DurhamNC United States
Unsupervised domain adaptation (UDA) is a technique used to transfer knowledge from a labeled source domain to a different but related unlabeled target domain. While many UDA methods have shown success in the past, th... 详细信息
来源: 评论
Incorporating Prior Knowledge into Neural Networks through an Implicit Composite Kernel
arXiv
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arXiv 2022年
作者: Jiang, Ziyang Zheng, Tongshu Liu, Yiling Carlson, David Department of Civil and Environmental Engineering Duke University United States Division of Natural and Applied Science Duke Kunshan University China Program in Computational Biology and Bioinformatics Duke University School of Medicine United States Department of Civil and Environmental Engineering Department of Biostatistics and Bioinformatics Department of Computer Science Duke University United States
It is challenging to guide neural network (NN) learning with prior knowledge. In contrast, many known properties, such as spatial smoothness or seasonality, are straightforward to model by choosing an appropriate kern... 详细信息
来源: 评论
Decomposition of dynamic transcriptomic responses during effector-triggered immunity reveals conserved responses in two distinct plant cell populations
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Plant Communications 2024年 第8期5卷 1-17页
作者: Xiaotong Liu Daisuke Igarashi Rachel A.Hillmer Thomas Stoddard You Lu Kenichi Tsuda Chad L.Myers Fumiaki Katagiri Department of Plant and Microbial Biology University of Minnesota-Twin CitiesSt PaulMN 55108USA Department of Computer Science and Engineering University of Minnesota-Twin CitiesMinneapolisMN 55455USA Bioinformatics and Computational Biology Graduate Program University of Minnesota-Twin CitiesMinneapolisMN 55455USA Institute for Innovation Ajinomoto Co.Inc.KawasakiJapan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Present address:225 S 6th St MinneapolisMN 55402USA Present address:Biotalys Inc.2520 Meridian Parkway Suite 480DurhamNC 27713USA Present address:Life Sciences Institute and Department of Cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA
Rapid plant immune responses in the appropriate cells are needed for effective defense against *** transcriptome analysis is often used to describe overall immune responses,collection of transcriptome data with suffic... 详细信息
来源: 评论
HiC-DC+ enables systematic 3D interaction calls and differential analysis for Hi-C and HiChIP
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Nature Communications 2021年 第1期12卷 3366页
作者: Sahin, Merve Wong, Wilfred Zhan, Yingqian Van Deynze, Kinsey Koche, Richard Leslie, Christina S. Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY United States Tri-Institutional Training Program in Computational Biology and Medicine New York NY United States Center for Epigenetics Research Memorial Sloan Kettering Cancer Center New York NY United States Bioinformatics Program University of California at San Diego San Diego CA United States
Recent genome-wide chromosome conformation capture assays such as Hi-C and HiChIP have vastly expanded the resolution and throughput with which we can study 3D genomic architecture and function. Here, we present HiC-D... 详细信息
来源: 评论
Entropic Optimal Transport Eigenmaps for Nonlinear Alignment and Joint Embedding of High-Dimensional Datasets
arXiv
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arXiv 2024年
作者: Landa, Boris Kluger, Yuval Ma, Rong Department of Electrical Engineering Yale University United States Program in Applied Mathematics Yale University United States Department of Biostatistics Harvard University United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University United States Department of Pathology Yale University School of Medicine United States
Embedding high-dimensional data into a low-dimensional space is an indispensable component of data analysis. In numerous applications, it is necessary to align and jointly embed multiple datasets from different studie... 详细信息
来源: 评论
Origin of Overstretching Transitions in Single-Stranded Nucleic Acids
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Physical Review Letters 2013年 第18期111卷 188302-188302页
作者: Zackary N. Scholl Mahir Rabbi David Lee Laura Manson Hanna S-Gracz Piotr E. Marszalek Program in Computational Biology and Bioinformatics Duke University Durham North Carolina 27708 USA Department of Mechanical Engineering and Materials Science Center for Biologically Inspired Materials and Material Systems Duke University Durham North Carolina 27708 USA Department of Molecular and Structural Biochemistry North Carolina State University Raleigh North Carolina 27708 USA
We combined single-molecule force spectroscopy with nuclear magnetic resonance measurements and molecular mechanics simulations to examine overstretching transitions in single-stranded nucleic acids. In single-strande... 详细信息
来源: 评论
Neural networks versus Logistic regression for 30 days all-cause readmission prediction
arXiv
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arXiv 2018年
作者: Allam, Ahmed Nagy, Mate Thoma, George Krauthammer, Michael Department of Quantitative Biomedicine University of Zurich Biomedical Informatics Group University Hospital of Zurich Program in Computational Biology and Bioinformatics Yale University Department of Pathology Yale School of Medicine Lister Hill National Center for Biomedical Communications National Library of Medicine
Heart failure (HF) is one of the leading causes of hospital admissions in the US. Readmission within 30 days after a HF hospitalization is both a recognized indicator for disease progression and a source of considerab... 详细信息
来源: 评论
Rapid Sampling of Hydrogen Bond Networks for computational Protein Design (vol 14, pg 2751, 2018)
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JOURNAL OF CHEMICAL THEORY AND COMPUTATION 2018年 第10期14卷 5434-5434页
作者: Maguire, Jack B. Boyken, Scott E. Baker, David Kuhlman, Brian [†] Program in Bioinformatics and Computational Biology University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States [‡] Department of Biochemistry University of Washington Seattle Washington 98195 United States [§] Institute for Protein Design University of Washington Seattle Washington 98195 United States [∥] Howard Hughes Medical Institute University of Washington Seattle Washington 98195 United States [⊥] Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States [#] Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States
Hydrogen bond networks play a critical role in determining the stability and specificity of biomolecular complexes, and the ability to design such networks is important for engineering novel structures, interactions, ... 详细信息
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Integrative modeling of transmitted and de novo variants identifies novel risk genes for congenital heart disease
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Quantitative biology 2021年 第2期9卷 216-227页
作者: Mo Li Xue Zeng Chentian Jin Sheng Chih Jin Weilai Dong Martina Brueckner Richard Lifton Qiongshi Lu Hongyu Zhao Department of Biostatistics Yale School of Public HealthNew HavenCT 06510USA Department of Genetics Yale UniversityNew HavenCT 06510USA Department of Molecular Cellular&Developmental BiologyYale UniversityCT 06510USA Department of Genetics Washington University School of MedicineSt LouisMO 63110USA Department of Pediatrics Yale UniversityNew HavenCT 06510USA Laboratory of Human Genetics and Genomics Rockefeller UniversityNew YorkNY 10065USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWl 53792USA Program of Computational Biology and Bioinformatics Yale UniversityNew HavenCT 06510USA
Background:Whole-exome sequencing(WES)studies have identified multiple genes enriched for de novo mutations(DNMs)in congenital heart disease(CHD)***,risk gene identification based on DNMs alone remains statistically c... 详细信息
来源: 评论
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour
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Nature 2025年 1-10页
作者: Tomomi M. Yoshida Mytien Nguyen Benjamin Y. Lu Di Xu Elizabeth Lin Daniel A. Waizman Mackenzie E. Coden Yifan Ma Kavita Israni-Winger Wenzhi Song Jafar Al Souz Joseph E. Craft Noah W. Palm David A. Hafler Andrew Wang Cuiling Zhang Le Zhang Katie N. Murray Anthony Russo Haowei Wang Jaime Grutzendler Biqing Zhu Hongyu Zhao Yann S. Mineur Joseph Luchsinger Marina R. Picciotto Sagar Bhatta Marcello Distasio Department of Immunobiology Yale School of Medicine New Haven CT USA Department of Rheumatology Allergy and Immunology Yale School of Medicine New Haven CT USA Department of Neurology Yale School of Medicine New Haven CT USA Department of Medicine (Section of Medical Oncology and Hematology) Yale School of Medicine New Haven CT USA Department of Neuroscience Yale School of Medicine New Haven CT USA Program of Computational Biology and Bioinformatics Yale University New Haven CT USA Department of Biostatistics School of Public Health Yale University New Haven CT USA Department of Psychiatry Yale School of Medicine New Haven CT USA Department of Pathology Yale School of Medicine New Haven CT USA Department of Ophthalmology and Visual Science Yale School of Medicine New Haven CT USA
Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells1. The contribution of the innate immune compartment in the meninges and the central nerv...
来源: 评论