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ASME 2012 Summer Bioengineering Conference, SBC 2012

作者： Schrank, Elisa S. Razzook, Alexander Takahashi, Kota Tierney, John Gillespie Jr., John W. Hitch, Lester Wallace, Kevin Moore, Rick Higginson, Jill S. Stanhope, Steven J. Department of Mechanical Engineering University of Delaware Newark DE 19810 United States Department of Kinesiology and Applied Physiology University of Delaware Newark DE 19810 United States Biomechanics and Movement Science Program University of Delaware Newark DE 19810 United States Center for Composite Materials University of Delaware Newark DE 19810 United States Advanced Design and Manufacturing ECBC Aberdeen Proving Ground MD 21010 United States

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A dynamic systems approach to production management in the automotive industry

A dynamic systems approach to production management in the a...

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International Conference on Advances in Production Management Systems, APMS 2010

作者： Teles, Vasco Restivo, Francisco University of Porto Faculty of Engineering Portugal MIT Portugal Program Engineering Design and Advanced Manufacturing Portugal LIACC Artificial Intelligence and Computer Science Laboratory Austria

ISBN: (纸本)9788864930077

Based on network theories, dynamic systems were previously thought to act randomly. However, it is now understood that they present particular signals pointing to characteristics of order and auto-organization (Barabási 2007). Discovering those signals of interaction within complex networks is then a challenge to these studies. In this work, while doing an analogy to the automotive industry, we explore the possibility to apply phase space tools to recognize patterns in a plot of data in dynamic systems, where deterministic chaos behaviour may occur. This behaviour is mainly related to decision-making within complex networks, where a tipping point situation can lead to dramatic changes in the otherwise stable system.

关键词： Automotive industry

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In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH

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International Journal of Peptides 2011年第1期2011卷 834525页

作者： Biyani, Madhu Futakami, Masae Kitamura, Koichiro Kawakubo, Tomoyo Suzuki, Miho Yamamoto, Kenji Nishigaki, Koichi Department of Functional Materials Science Graduate School of Science and Engineering Saitama University Saitama 338-8570 255 Shimo-Okubo Japan City Area Program Saitama Metropolitan Area Saitama Small and Medium Enterprises Development Corporation Chuo-Ku Saitama 338-0001 2-3-2 Kamiochiai Japan Rational Evolutionary Design of Advanced Biomolecules Saitama (REDS) Group Saitama Small Enterprise Promotion Corporation No. 552 Saitama Industrial Technology Center Saitama 333-0844 3-12-18 Kami-Aoki Kawaguchi Japan Janusys Corporation No. 508 Saitama Industrial Technology Center Saitama 333-0844 3-12-18 Kami-Aoki Kawaguchi Japan Proteolysis Research Laboratory Graduate School of Pharmaceutical Sciences Kyushu University Higashi-Ku Fukuoka 812-8582 Japan

The aspartic protease cathepsin E has been shown to induce apoptosis in cancer cells under physiological conditions. Therefore, cathepsin E-activity-enhancing peptides functioning in the physiological pH range are valuable potential cancer therapeutic candidates. Here, we have used a general in vitro selection method (evolutionary rapid panning analysis system (eRAPANSY)), based on inverse substrate-function link (SF-link) selection to successfully identify cathepsin E-activity-enhancing peptide aptamers at neutral pH. A successive enrichment of peptide activators was attained in the course of selection. One such peptide activated cathepsin E up to 260, had a high affinity (KD;300nM), and had physiological activity as demonstrated by its apoptosis-inducing reaction in cancerous cells. This method is expected to be widely applicable for the identification of protease-activity-enhancing peptide aptamers. Copyright © 2011 Madhu Biyani et al.

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New creep region and mechanism in hexagonal close-packed metals

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Journal of Physics: Conference Series 2010年第1期240卷

作者： T Matsunaga T Kameyama S Ueda E Sato Department of Space and Astronautical Science School of Physical Sciences Graduate University for Advanced Studies Sagamihara Kanagawa 229-8510 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Sagamihara Kanagawa 229-8510 Japan Department of Materials Engineering School of Engineering University of Tokyo Bunkyo Tokyo 113-8656 Japan Department of Aerospace Engineering Faculty of System Design Tokyo Metropolitan University Hino Tokyo 191-0065 Japan

Only hexagonal close-packed (h.c.p.) materials show creep behaviour significantly at ambient temperature or less even below their 0.2% proof stresses with their stress exponents of 3.0 and their apparent activation energies of 20 kJ/mol. Transmission electron microscopy revealed dislocation arrays as a planar slip without any tangled dislocations inside each grain. Atomic force microscopy and electron backscatter diffraction pattern analyses brought about the occurrence of grain boundary sliding. The grain-size exponent was evaluated as 1.0, which means grain boundaries work as the barrier of the dislocation motion. Ambient-temperature creep of h.c.p. materials is schematically illustrated as that lattice dislocations move inside each grain without any obstacles and then pile up at grain boundaries. To continue the creep deformation, these dislocations are absorbed by grain boundaries to accommodate the internal stress and lead to grain boundary sliding.

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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Cover Picture: The Innovation Potential of Bulk Nanostructured materials (Adv. Eng. Mater. 7/2007)

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advanced engineering materials 2007年第7期9卷

作者： R. Z. Valiev M. J. Zehetbauer Y. Estrin H. W. Höppel Y. Ivanisenko H. Hahn G. Wilde H. J. Roven X. Sauvage T. G. Langdon Institute of Physics of Advanced Materials Ufa State Aviation Technical University 12 K. Marx str. Ufa 450000 Russia Physics of Nanostructured Materials Faculty of Physics University of Vienna Boltzmanngasse 5 A-1090 Wien Austria ARC Centre of Excellence in Design in Light Alloys Department of Materials Engineering Monash University Clayton Vic. 3800 Australia Institute I: Allgemeine Werkstoffeigenschaften Department of Materials Science and Engineering Universität Erlangen-Nürnberg Martensstrasse 5 91058 Erlangen Germany Forschungszentrum Karlsruhe Institut für Nanotechnologie (INT) Postfach 36 40 76021 Karlsruhe Germany Institut für Materialphysik University of Münster Wilhelm-Klemm-Str. 10 D-48149 Münster Germany Department of Materials Science and Engineering Norwegian University of Science and Technology N-7491 Trondheim Norway Groupe de Physique des Matériaux -UMR CNRS 6634 Institute of Medical Research Université de Rouen 76801 Saint-Etienne-du-Rouvray France Materials Research Group School of Engineering Sciences University of Southampton Southampton SO17 1BJ U.K

The cover demonstrates the innovation potential of bulk nanostructured materials obtained by severe plastic deformation (SPD) in various industrial sectors. The microstructure of Al wire processed by continuous SPD processing in ECAP-Conform together with a schematic illustration of an ECAP-Conform set-up are shown in the background. Further information about the perspectives of commercialization of bulk nanostructured materials produced by SPD processing can be found in the review paper by R. Z. Valiev et al. on page 527. The innovation potential is high for bulk nanostructured materials (BNM) produced by methods of severe plastic deformation and accordingly this report focuses on very recent developments demonstrating the potential of using BNM for advanced and functional applications in engineering and medicine.

关键词： Nanostructured materials Severe plastic deformation Ultrafine grained materials

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ZnO:Ga-Based transparent conductive films: An attractive potential for use in flat panel display

ZnO:Ga-Based transparent conductive films: An attractive pot...

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6th Pacific Rim Conference on Ceramic and Glass Technology

作者： Yamamoto, Tetsuya Yamada, Takahiro Sakemi, Toshiyuki Shirakata, Sho Osada, Minoru Kishimoto, Seiichi Awai, Kiyoshi Makino, Hisao Mitsunaga, Tooru Kochi University of Technology Research Institute Materials Design Center 185 Miyanokuchi Tosayamada-cho Kamigun Kochi 782-8501 Japan Research and Development Center Sumitomo Heavy Industries Ltd. 5-2 Soubiraki-cho Niihama Ehime 792-8588 Japan Faculty of Engineering Ehime University Bunkyo-cho Matsuyama Ehime 790-9577 Japan Advanced Materials Laboratory National Institute for Materials Science Tsukuba Ibaraki 305-0044 Japan Application Laboratory Rigaku Corporation 3-9-12 Matsubara-cho Akishima-shi Tokyo 196-8666 Japan

ISBN: (纸本)047008295X

The advantageous features of polycrystalline gallium (Ga)-doped ZnO (GZO) films, being cost-effective and easy to fabricate on a production scale, make them very attractive potential for use in transparent conductive electrode in flat display panel and thin film solar cells. In this work, GZO films have been prepared by reactive plasma deposition with non-traveling and traveling substrate mechanism. We have succeeded in fabricating 180 nm GZO films with low resistivity of 2.7 × 10-4 Ωcm and high transmittance more than 90 % in the visible wave length region on a glass substrate at temperature of 200 with a size up to 1m × 1m. On the basis of the analysis of data obtained by theoretical prediction and experimental study concerning micro-structural properties for GZO films, such as which sites Ga donors occupy, we have shown how to obtain electrical and optical properties required for application controlling the main process parameters, oxygen partial pressure.

关键词： Conductive films

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Cover Picture: Macromol. Biosci. 6/2006

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Macromolecular Bioscience 2006年第6期6卷

作者： Hak Soo Choi Tooru Ooya Nobuhiko Yui School of Materials Science and the 21st Century COE Program Japan Advanced Institute of Science and Technology 1‐1 Asahidai Nomi Ishikawa 923‐1292 Japan Department of Medicine Harvard Medical School 330 Brookline Avenue SL‐B05 Boston MA 02215 USA Department of Intelligent Design System Engineering Biotechnology Research Center Toyama Prefecrural University 5180 Kurokawa Imizu Toyama 939‐0398 Japan

Cover: The figure shows the formation of a block‐selective polyrotaxane composed of PEI‐b‐PEG‐b‐PEI copolymer by pH‐controlled threading of cyclodextrins (CDs) onto the copolymer. While the CD threads indiscriminately at high pH onto the entire block copolymer, lowering the pH to 4.4 in the presence of 9‐anthraldehyde results in expulsion of the macrocycles from the PEI blocks and capping of the rotaxane by a one‐pot sequence. Further details can be found in the article by H. S. Choi, T. Ooya, and N. Yui * on page 420.

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Alignment of liquid crystals on a photosensitive substrate studied by surface optical second-harmonic generation

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Physical Review E 2000年第4期61卷 R3310(R)-R3310(R)页

作者： I. Drevenšek Olenik M. W. Kim A. Rastegar Th. Rasing Faculty of Mathematics and Physics University of Ljubljana Jadranska 19 SI 1000 Ljubljana SloveniaJ. Stefan’ Institute Jamova 39 SI 1001 Ljubljana Slovenia Research Institute for Materials University of Nijmegen Toernooiveld 1 6525 ED Nijmegen The Netherlands Department of Advanced Materials Engineering Korea Advanced Institute of Science and Technology Seoul Korea Nijmegen SON Research Institute for Molecular Structures Design and Synthesis University of Nijmegen Toernooiveld 1 6525 ED Nijmegen The Netherlands

The adsorption kinetics and orientational ordering of 4′−n−octyl−4-cyanobiphenyl (8CB) liquid crystal films evaporated onto photosensitive poly(vinyl-cinnamate) (PVCN) substrates were investigated by surface optical second-harmonic generation. The adsorption rate of the first monolayer decreases with increasing degree of photochemical modification of the polymer. The in-plane orientational anisotropy of the 8CB films grown on unidirectionally photopolymerized PVCN substrates is considerably lower than the intrinsic surface orientational anisotropy of these substrates, which can explain the generally found weak surface anchoring of liquid crystals on PVCN alignment layers.

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engineering the environmentally sound warship for the twenty-first century

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NAVAL ENGINEERS JOURNAL 1999年第3期111卷 189-217页

作者： Markle, SP Gill, SE McGraw, PS Udr. Stephen P. Markle USN is a career Engineering Duty officer assigned to Naval Sea Systems Command Arlington Virginia where he is Deputy Directs Environmental Programs Division (SEA 03L1 B). He is responsible fm program management activities associated with all ahat environmental protection equipment design and selection of environmental protection equipment and systems fm future surface ship designs (DD 21 CVN 7Z CW LPD 17) and serves on several teams designed to promote Nay wide awarmss of environmental protection requirements and Nay programs to meet these challenges. He is a 1993 graduate of the Naval Construction and Engineering Program at the Massachusetts Institute of Technology where he received a naval engineers degree and master of science in mechanical engineering. His interest in environmental issues predates his undergraduate studies at Syracuse Universityl State University of New Ymk College of Environmental Science and Fmestry where he received a bachelm of science degree in fmest engineering from the School of Environmental and Resource Engineering. LCdx Markle has qualified as a Surface Warfare Officer and in submarines through the Engineering Duty Dolphin Program he is a member of the Acquisition Professional Community and a graduate of the Defense Systems Management College Advanced Program Managers Course. He is a professional engineer registered in the State of New York and is a member ofthe American Society of Naval Engineers National Society of Professional Engineers American Society for Testing and Materials Society of Naval Architects and Marine Engineers and Society of Automotive Engineers. Peter 5. McGraw is current the Acting Branch Head ofthe Solid Waste Management Branch (Code 634) of the Environmental Quality Dwrtment of the Naval Surfice Warfare Centel: Carderock Division. As such he is responsible for among other things: the Shipboard Advanced Incinerator RDT&E Program the Submarine Plastic Waste RDT&E Program Solid Waste Processing Equipment Design Acquisitio

The past twenty-five years has been marked by the introduction ed marine environmental regulations that have had a profound effect on how ships are designed, built and operated. Ships being designed and built today must accommodate not only current regulations but anticipate those enacted over their thirty to fifty year life cycles. U.S. Chief of Naval Operations, Office of Environmental, Safety and Health (CNO N45) has articulated a vision for the Environmentally Sound Warship of the Twenty-first Century. This vision incorporates the "Sense of Congress" for a naval ship designed to operate in full compliance with environmental regulations worldwide. The task of the Navy engineering team is to translate this vision into reality;a ship capable of prevailing in time of war and able to conduct operations in all areas of the globe, unencumbered by special procedures for environmental compliance. The keys to this warship design are the early integration of environmentally sound principles, materials, and processes into the ship acquisition process;minimization of both hazardous materials and generation of post shipboard consumer waste during operation;adaptation of integrated systems to reduce the volume of wastes and enhance processing efficiency;reduced manpower requirements;and crew indoctrination in environmental protection.

关键词： Ships Environmental regulations engineering ARTICULATED Navy environmental security

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