Developing high sensitivity multiparametric medical imaging tools constitutes one of the main research topics in radionuclide *** time-of-flight positron emission tomography (TOF-PET) scanners have shown potential in ...
We have designed a novel electronic readout with 24:1 multiplexing ratio of the timing channels that achieves 100 ps coincidence time resolution. The detector layer units comprise 2×4 arrays of 3×3×10 m...
In order to perform preoperative surgical planning, accurate segmentation of anatomical structures in cone-beam computed tomography (CBCT) images is required. However, this image segmentation is often impeded by metal...
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We have built a scalable mixed-signal readout circuit for a 3D position sensitive PET detector that achieves ~100 ps FWHM CTR. For this work we used individual 3×3×3 mm3 and 3×3×10 mm3 LGSO crystal...
Microinfarcts, the "invisible lesions", are prevalent in aged and injured brains and associated with cognitive impairments, yet their neurophysiological impact remains largely unknown. Using a multimodal chr...
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Understanding the process of learning in neural networks is crucial for improving their performance and interpreting their behavior. This can be approximately understood by asking how a model's output is influence...
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To achieve more accurate depth-of-interaction (DOI) response and 3D positioning of photoelectric or scattered events in our highly compact 100 ps CTR TOF-PET detector design, we have replaced a previously CPLD-based 3...
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ISBN:
(数字)9798350388152
ISBN:
(纸本)9798350388169
To achieve more accurate depth-of-interaction (DOI) response and 3D positioning of photoelectric or scattered events in our highly compact 100 ps CTR TOF-PET detector design, we have replaced a previously CPLD-based 3DPS approach with a 3D position sensitive charge-division scalable readout which better preserves our ∼100 ps FWHM CTR results. To validate the performance and compatibility of the readout with our mixed-signal TOF-PET design, we used $2 \times 4$ arrays of $3 \times 3 \times 10 \mathrm{~mm}^{3}$ LGSO crystals side-coupled to $4 \times 6$ arrays of $3 \times 3 \mathrm{~mm}^{2}$ SiPMs. By embedding this 3DPS readout in our scaled-up TOF-PET system, we resolved 3D interaction positions along the crystal array with an average 1.6 mm FWHM DOI resolution while easily preserving our 100 ps CTR and also saving the components, footprint, and subsequently the cost, power dissipation by 32% and at least 40% compared to our previous 3DPS CPLD-based and the common 3D Anger-based readouts, respectively.
We have developed a highly compact design for TOF-PET detector modules employing side-readout of scintillation crystal elements to achieve 100 ps CTR and 3D positioning of 511 keV interactions. Detector modules compri...
We have developed a highly compact design for TOF-PET detector modules employing side-readout of scintillation crystal elements to achieve 100 ps CTR and 3D positioning of 511 keV interactions. Detector modules comprise 16 layers, each containing 4 sub-units. Each detector layer sub-unit is a 2×4 array of 3×3×10 mm 3 LGSO elements side-coupled to a 6×4 array of 3×3 mm² SiPMs. To achieve high packing fraction, the electronic readout is implemented with a 4-layer rigid FR4 PCB that is only 0.4 mm thick and has a width matching the 6×4 SiPM array (13.3 mm). Among many features, the circuit multiplexes 24 SiPM timing channels into 1 to reduce the readout complexity. In new configuration reported here, all external connectors have been removed and replaced with 0.4 mm pitch fine connectors for scalable signal routing at the detector module level. The timing performance of this 24:1 multiplexed readout was measured in coincidence with a reference detector, resulting in average 107±1.3 ps FWHM CTR. Thus the proposed side-readout of scintillation crystal elements and readout electronics are now configured in a layer topology and achieve the performance that are scalable to large area detector modules for a ~100 ps CTR TOF-PET system.
Developing countries struggle with water quality management due to poor infrastructure, limited expertise, and financial constraints. The lack of consistent power further limits the adoption of modern water management...
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