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8th Southern programmable Logic Conference, SPL 2012

作者： Pereira, Maicon Carlos Viera, Paulo Viniccius Raabe, André Luis Alice Zeferino, Cesar Albenes Master Program on Applied Computer Science University of Vale Do Itajaí UNIVALI Itajaí Brazil

ISBN: (纸本)9781467301862

Design of digital circuits and systems are topics covered in undergraduate courses on computer science, computer Engineering, and Electrical Engineering. Simple processor architectures are used as example of digital systems to apply and integrate the concepts studied in these courses. In this paper, we discuss the use of a simple processor named BIP (Basic Instruction-set Processor) in courses on digital circuits and systems design. BIP is distinguished from similar processors because it was developed by applying a multidisciplinary approach in order to allow its use in introductory courses on computer programming and in several other courses in the computer science area. © 2012 IEEE.

关键词： Field programmable gate arrays (FPGA)

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The differential geometry of shape from shading: Biology reveals curvature structure

The differential geometry of shape from shading: Biology rev...

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2012 IEEE computer Society Conference on computer Vision and Pattern Recognition Workshops, CVPRW 2012

作者： Kunsberg, Benjamin Zucker, Steven W. Applied Mathematics Program Yale University United States Departments of Computer Science and Applied Mathematics Yale University United States

ISBN: (纸本)9781467316118

Shape from shading is a classical inverse problem in computer vision. We introduce a novel mathematical formulation for calculating local surface shape based on covariant derivatives, rather than the customary integral minimization or P.D.E approaches. Motivated by neurobiology, we introduce the shading flow field (the tangent map to the image isophotes) between the image and the surface levels. Just as in the perceptual organization of texture, we use the parallel transport of our shading flow field to move the isophote field at different points on the unknown surface to a single point, amassing restrictions on our surface curvatures. Under simplifying assumptions we solve exactly for the light source/surface pairs needed for a local image patch to have a given shading flow. The magnitude of the brightness gradient then restricts this family to a single light source and surface estimate pair, up to the concave/convex ambiguity and an additional elliptical/saddle ambiguity. Example calculations illustrate our approach. © 2012 IEEE.

关键词： Flow fields

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Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches

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computers in Biology and Medicine 2025年 190卷 110044-110044页

作者： Saif, Ahmed Islam, Md. Tarikul Raihan, Md. Obayed Yousefi, Niloofar Rahman, Md. Ajijur Faridi, Hafeez Hasan, Al Riyad Hossain, Mirza Mahfuj Saleem, Rasha Mohammed Albadrani, Ghadeer M. Al-Ghadi, Muath Q. Ahasan Setu, Md. Ali Kamel, Mohamed Abdel-Daim, Mohamed M. Aktaruzzaman, Md. Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi6205 Bangladesh Department of Genetic Engineering and Biotechnology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Jashore7408 Bangladesh Department of Pharmaceutical Sciences College of Health Sciences and Pharmacy Chicago State University ChicagoIL United States Department of Industrial Engineering and Management Systems University of Central Florida USA OrlandoFL United States Department of Pharmacy Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Computer Science and Engineering Faculty of Engineering and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Laboratory Medicine Faculty of Applied Medical Sciences Al-Baha University Al-Baha65431 Saudi Arabia Department of Biology College of Science Princess Nourah bint Abdulrahman University 84428 Riyadh11671 Saudi Arabia Department of Zoology College of Science King Saud University P.O. Box 2455 Riyadh11451 Saudi Arabia Department of Microbiology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Medicine and Infectious Diseases Faculty of Veterinary Medicine Cairo University Giza12211 Egypt Department of Pharmaceutical Sciences Pharmacy Program Batterjee Medical College P.O. Box 6231 Jeddah21442 Saudi Arabia Pharmacology Department Faculty of Veterinary Medicine Suez Canal University Ismailia41522 Egypt

Cancer remains a significant global health challenge, with the Cell Division Cycle 7 (CDC7) protein emerging as a potential therapeutic target due to its critical role in tumor proliferation, survival, and resistance. However, a comprehensive analysis of CDC7 across multiple cancers is lacking, and existing therapeutic options have come with limited clinical success. The aim of this is to integrate a comprehensive pan-cancer analysis of CDC7 with the identification of novel marine-derived inhibitors, bridging the understanding of CDC7's role as a prognostic biomarker and therapeutic target across diverse cancer types. In this study, we conducted a pan-cancer analysis of CDC7 across 33 tumor types using publicly available datasets to evaluate its expression, genetic alterations, immune interactions, survival, and prognostic significance. Additionally, a marine-derived compound library of 31,492 molecules was screened to identify potential CDC7 inhibitors using chemoinformatics and machine learning. The top candidates underwent rigorous evaluations, including molecular docking, pharmacokinetics, toxicity, Density Functional Theory (DFT) calculations, and Molecular Dynamics (MD) simulations. The findings revealed that CDC7 is overexpressed in several cancers and is associated with poor survival outcomes and unfavorable prognosis. Enrichment analysis linked CDC7 to critical DNA replication pathways, while its role in modulating tumor-immune interactions highlighted its potential as a target for immunotherapy. Among all tested compounds, Tetrahydroaltersolanol D (CMNPD21999) exhibited the strongest binding affinity and stability, along with better drug-likeness and zero toxicity. These attributes highlight its potential as a promising drug candidate for CDC7 inhibition and future cancer treatment development. Furthermore, additional in vitro and in vivo studies are required to confirm the effectiveness of this drug candidate against the CDC7 protein. © 2025

关键词： Gene expression

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Improving bilateral negotiation with evolutionary learning

Improving bilateral negotiation with evolutionary learning

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2008 12th International Conference on computer Supported Cooperative Work in Design, CSCWD

作者： Romanhuki, Emerson Fuckner, Marcio Enembreck, Fabrício Ávila, Bráulio Scalabrin, Edson E. PUCPR Pontifical Catholic University of Parana Graduate Program on Applied Computer Science Curitiba PR Brazil

ISBN: (纸本)9781424416509

This paper proposes an approach to generate offers and counter-offers in a bilateral negotiation process between cognitive agents with the learning machine capacities. The approach is configured, as each participant of a negotiation process improve their satisfaction degree, gaining knowledge from prior experience, i.e., in the next negotiation session, each participant can individually use this knowledge to redefine the configuration parameters of strategies and tactics to generate offers and counter-offers. Each agent refines their strategies using a genetic algorithm application based on the historical offers and counter-offer exchanges dataset. This context can lead to a new dimension in CSCW System Development. This approach was tested in a simulated bilateral negotiation environment, which involved, for example, a buyer agent and a seller agent. The discussions about the results confront different negotiation sessions comparing agents provided with strategy and tactics reconfiguration capabilities and agents using static strategies and tactics. © 2008 IEEE.

关键词： Genetic algorithms

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A method to automatically identify road centerlines from georeferenced smartphone data

A method to automatically identify road centerlines from geo...

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14th Brazilian Symposium on GeoInformatics, GEOINFO 2013

作者： Costa, George Henrique Rangel Baldo, Fabiano Graduate Program in Applied Computing Computer Science Department UDESC Santa Catarina State University Joinville Brazil

Digital road maps have gained fundamental role in population's daily life, so they need to be accurate and up-to-date. A viable solution is to generate maps by processing GPS data. However, one of the most challenging tasks regarding this approach is how to extract road centerlines from the cloud of georeferenced GPS points. The literature presents various methods that do it, but none have been found that is prepared for the continuous update of the map and refinement of its roads' accuracy. In this context, the objective of this work is to propose a method to identify road centerlines using an evolutive algorithm in order to generate and update road maps. This work uses as source of data GPS traces collected by smartphones. Although suitable to obtain a large amount of georeferenced data, these devices bring the additional problem of identifying the transport vehicle used along each trace. Preliminary results indicate that the method's performance is satisfactory, with an average variation of 2.95 meters in relation to satellite images.

关键词： Smartphones

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Possibilities to use the practice of telemedicine in actual technological conditions to remote areas

Possibilities to use the practice of telemedicine in actual ...

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25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society

作者： Kmeteuk, O de Amorim, MF Graduate Program in Applied Computer Science Exact Sciences and Technology Center Pontifical Catholic University of Paraná Brazil

ISBN: (纸本)0780377893

One of the main factors that impede the practice of the telemedicine is not the lack of new technologies for the communication, but the lack of studies on the use of the technology already installed in the distant areas, in way to be used of a rational way. The objective of the telemedicine is to provide help to the cares with the health with quality the distant areas of the great attendance centers. Therefore, it cannot ignore the fact that these areas do not make use of point technologies for communication. Then, it is justified the need to accomplish studies that facilitate the practice of the independent telemedicine of the installed technology. Then, the objective of this work is to use as pilot an unit of remote health, contributing with a support system that allows the practice of the telemedicine using the technology of available transmission in the respective place, avoiding that the factor cost is a barrier for the telemedicine projects and can begin an improvement process in the quality of the attendance in units of distant health of the great centers of medical attendance.

关键词： telemedicine support system

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Sub-fingerprint masking for a robust audio fingerprinting system in a real-noise environment for portable consumer devices

Sub-fingerprint masking for a robust audio fingerprinting sy...

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2010 International Conference on Consumer Electronics, ICCE 2010

作者： Son, Wooram Cho, Hyun-Tae Yoon, Kyoungro Program in Radiation Applied Life Science Seoul National University Korea Republic of Department of Computer Science and Engineering Konkuk University Korea Republic of

ISBN: (纸本)9781424443161

The robustness of audio fingerprinting system in a noisy environment is a principal challenge in the area of content-based audio retrieval, especially for use in portable consumer devices. Our new audio fingerprint method using sub-fingerprint masking based on the predominant pitch extraction increases the accuracy of the audio fingerprinting system in a noisy environment dramatically, while requiring much less computing power compared to the expanded hash table lookup method, where the searching complexity increases by the factor of 33 times the degree of expansion. ©2010 IEEE.

关键词： Computing power

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Parallel and nondeterministic time complexity classes: Preliminary report 5th

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5th International Colloquium on Automata, Languages and programming, ICALP 1978

作者： Savitch, Walter J. Computer Science Program Department of Applied Physics and Information Science University of California at San Diego La JollaCA92093 United States

ISBN: (纸本)9783540088608

A random access machine model that has parallel processing and string manipulation is introduced. It is shown that NP is equal to the class of sets accepted by this model in nondeterministic time 0(log n), and this result is generalized to arbitrary time classes. A well-behaved subclass of the class of parallel, nondeter-ministic programs is analyzed. © 1978, Springer-Verlag.

关键词： computers

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Graphs of processors

Graphs of processors

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International Workshop on Graph-Grammars and Their Application to computer science and Biology, 1978

作者： Savitch, Walter J. Computer Science Program Department of Applied Physics and Information Science University of California at San Diego La JollaCA92093 United States

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Signal Analysis of the Singing Voice: Low-Order Representations of Singer Identity 26

Signal Analysis of the Singing Voice: Low-Order Representati...

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26th International computer Music Conference, ICMC 2000

作者： Mellody, Maureen Wakefield, Gregory H. Applied Physics Program University of Michigan United States Department of Electrical Engineering and Computer Science University of Michigan United States

Signals from 12 soprano and mezzo-soprano singers are analyzed with the modal distribution, a high-resolution time-frequency analysis method, to obtain measures of instantaneous amplitude and frequency of the signals’ partial components. These estimates are used to construct singer-specific transfer functions for each vowel and pitch analyzed. An AR approximation to a residual representation of these transfer functions is determined. This low-order residual approximation is used in a hierarchical clustering experiment. Using this representation, functions from each singer for a given vowel tend to cluster into a single class before classes collapse across singers. This result suggests that the low-order residual approximation captures singer-specific features in the sung signals. © 2000 ICMC. All Rights Reserved.

关键词： Transfer functions

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