We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We...
We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients with longer progression-free survival had increased immune-related signatures and validated proteins correlating with tumor-infiltrating lymphocytes in 65 tumors from an independent cohort of HGSOC patients, as well as with overall survival in an additional 126 HGSOC patient cohort. We identified that homologous recombination deficient (HRD) tumors are enriched in pathways associated with metabolism and oxidative phosphorylation that we validated in independent patient cohorts. We further identified that polycomb complex protein BMI-1 is elevated in HR proficient (HRP) tumors, that elevated BMI-1 correlates with poor overall survival in HRP but not HRD HGSOC patients, and that HRP HGSOC cells are uniquely sensitive to BMI-1 inhibition.
Indonesia is Island Based Country with 1.905 million kilometers per square area. This territory area watching by National Border Agencies consists of a collaboration of many departments and government organization to ...
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(纸本)9781538680674
Indonesia is Island Based Country with 1.905 million kilometers per square area. This territory area watching by National Border Agencies consists of a collaboration of many departments and government organization to make Indonesia strengthening the border. Indonesia has 6 neighboured country, Singapore, Malaysia, Philippine, Australia, Papua New Guinea, and Timor Leste. In Kepulauan Riau, have a direct border with Malaysia, Singapore, Vietnam, and Kamboja. This issue makes Kepulauan Riau have particular National Border Agencies from many Government Institution. In this research, conduct communication analysis between government Institution to run the task as National Border Agencies. The Analysis using Centrality from communication pattern in every institution. The centrality data clustering with meanshift to get a cluster of communication National Border Agencies.
A self-adaptive system can dynamically monitor and adapt its behavior to preserve or enhance its quality attributes under uncertain operating conditions. This article identifies key challenges for the development of m...
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In the current landscape of deep learning research, there is a predominant emphasis on achieving high predictive accuracy in supervised tasks involving large image and language datasets. However, a broader perspective...
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RS Ophiuchi (RS Oph) is a symbiotic recurrent nova that shows eruptive events roughly every 15 years. On August 8th, 2021, RS Oph erupted with its latest outburst. This event was detected by a wide range of multi-wave...
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Trivalent europium doped aluminium phosphate glasses with different alkali oxides (Li 2 O, Na 2 O and K 2 O) have been prepared by melt quenching technique at 1200 °C. Photoluminescence properties of the obtained...
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Trivalent europium doped aluminium phosphate glasses with different alkali oxides (Li 2 O, Na 2 O and K 2 O) have been prepared by melt quenching technique at 1200 °C. Photoluminescence properties of the obtained glasses have been studied and characterized. Also, Absorption and radiative properties of glasses are evaluated using the Judd–Ofelt (JO) theory. The emission spectra of all glasses remain the characteristic emission peak of Eu 3+ with a dominant peak at 612 nm, corresponding to the 5 D 0 → 7 F 2 transition by monitoring an excitation wavelength at 393 nm. In the present glass system it was found that lithium oxide has higher intensity of emission spectra than sodium oxide and potassium oxide. The JO intensity parameters (Ω 2 , Ω 4 , Ω 6 ) and subsequent radiative properties for the 5 D 0 → 7 F J (J = 1,2,3,4) transitions are determined. These glasses have potential candidate in the development as red laser source applications.
Health workers are increasingly harnessing mobile phones to develop their own solutions to work challenges. The mHEALTH-INNOVATE project aims to explore this topic further. In 2022, Healthcare Information for All orga...
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Health workers are increasingly harnessing mobile phones to develop their own solutions to work challenges. The mHEALTH-INNOVATE project aims to explore this topic further. In 2022, Healthcare Information for All organized an online discussion among health workers and other stakeholders to inform the project. Twenty-five people joined the discussion. Contributors' descriptions of the varieties of mobile phone use tallied with previous research, including for communication with patients and colleagues. In addition, they described increased mobile phone use in response to the COVID-19 pandemic and the increased need for communication, monitoring and reporting, including during lockdowns. Some solutions were health worker-initiated, including the establishment of WhatsApp groups. The discussion has helped develop a definition of informal mobile phone use.
Machine learning is a modern approach to problem-solving and task automation. In particular, machine learning is concerned with the development and applications of algorithms that can recognize patterns in data and us...
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Within the causal dynamical triangulations approach to the quantization of gravity, striking evidence has emerged for the dynamical reduction of spacetime dimension on sufficiently small scales. Specifically, the spec...
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