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IEEE International Conference on Systems, Man, and Cybernetics

作者： Carlos N. Silla Celso A. A. Kaestner Post-Graduate Program in Informatics (PPGI) Federal University of Technology of Paraná (UTFPR-CP) Cornélio Procópio Brazil Post-Graduate Program in Applied Computer Science (PPGCA) Federal University of Technology of Paraná (UTFPR) Curitiba Brazil

ISBN: (纸本)9781479906505

In this paper we address the task of hierarchical bird species identification from audio recordings. We evaluate three types of approaches to deal with hierarchical classification problems: the flat classification approach, the local-model per parent node classifier approach and the global-model hierarchical-classification approach. For the flat and local-model classification approach we employ the classic Naive Bayes algorithm. For the global-model approach we use the Global Model Naive Bayes (GMNB) algorithm. As in the classical Naive Bayes, the algorithm computes prior probabilities and likelihoods, but these computations take into account the hierarchical classification scenario: it assumes that any example which belongs to a given class will also belong to all its ancestor classes. In the current application, the employed class hierarchy is the standard scientific taxonomy of birds used in Biology. In order to deal with the bird songs we obtain features by computing several acoustic quantities from intervals of the audio signal. We conduct three experiments in order to compare the three different approaches to the hierarchical bird species identification problem. Our experimental results show that the use of the GMNB hierarchical classification algorithm outperforms both the flat and local-model approaches (Using the Hierarchical F-measure metric);hence the use of a global-model approach (such as the GMNB) can be a feasible way to improve the classification performance for problems with a large number of classes.

关键词： Bird species identification Audio classification Hierarchical classification Hierarchical Naive Bayes classifier bird species Hierarchical Bayes Audio recordings audio signals Songs

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Proceedings from the 9th annual conference on the science of dissemination and implementation: Washington, DC, USA. 14-15 December 2016

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Implement Sci 2017年第SUPPL 1期12卷 48-48页

作者： David Chambers Lisa Simpson Gila Neta Ulrica von Thiele Schwarz Antoinette Percy-Laurry Gregory A. Aarons Ross Brownson Amanda Vogel Shannon Wiltsey Stirman Kenneth Sherr Rachel Sturke Wynne E. Norton Allyson Varley Cynthia Vinson Lisa Klesges Suzanne Heurtin-Roberts M. Rashad Massoud Leighann Kimble Arne Beck Claire Neely Jennifer Boggs Carmel Nichols Wen Wan Erin Staab Neda Laiteerapong Nathalie Moise Ravi Shah Susan Essock Margaret Handley Amy Jones Jay Carruthers Karina Davidson Lauren Peccoralo Lloyd Sederer Todd Molfenter Ashley Scudder Sarah Taber-Thomas Kristen Schaffner Amy Herschell Eva Woodward Jeffery Pitcock Mona Ritchie JoAnn Kirchner Julia E. Moore Sobia Khan Shusmita Rashid Jamie Park Melissa Courvoisier Sharon Straus Daniel Blonigen Allison Rodriguez Luisa Manfredi Andrea Nevedal Joel Rosenthal David Smelson Christine Timko Nicole Stadnick Jennifer Regan Miya Barnett Anna Lau Lauren Brookman-Frazee Erick Guerrero Karissa Fenwick Yinfei Kong Gregory Aarons Rebecca Lengnick-Hall Benjamin Henwood Nina Sayer Craig Rosen Robert Orazem Brandy Smith Lindsey Zimmerman David Lounsbury Rachel Kimerling Jodie A. Trafton Steven Lindley Rahul Bhargava Hal Roberts Laura Gibson Gabriel J. Escobar Vincent Liu Benjamin Turk Arona Ragins Patricia Kipnis Ashley Ketterer Gruszkowski Michael W. Kennedy Emily Rentschler Drobek Lior Turgeman Aleksandra Sasha Milicevic Terrence L. Hubert Larissa Myaskovsky Youxu C. Tjader Robert J. Monte Kathryn G. Sapnas Edmond Ramly Diane R Lauver Christie M Bartels Shereef Elnahal Andrea Ippolito Hillary Peabody Carolyn Clancy Randall Cebul Thomas Love Douglas Einstadter Shari Bolen Brook Watts Vera Yakovchenko Angela Park William Lukesh Donald R. Miller David Thornton Mari-Lynn Drainoni Allen L. Gifford Shawna Smith Julia Kyle Mark S Bauer Daniel Eisenberg Celeste Liebrecht Michelle Barbaresso Amy Kilbourne Elyse Park Giselle Perez Jamie Ostroff Sarah Greene Michael Parchman Brian Austin Eric Larson Stefanie Ferreri Chris Shea Megan Smith Kea Turner Jennifer Bacci Kyle Bigham Geoffr Division of Cancer Control and Population Sciences National Cancer Institute Rockville MD 20850 USA AcademyHealth Washington DC 20009 USA Department of Learning Informatics Management and Ethics Karolinska Institutet Stockholm 17177 Sweden Department of Psychiatry University of California San Diego San Diego CA 92093 USA George Warren Brown School of Social Work Washington University in St. Louis St. Louis MO 63130 USA Center for Global Health National Cancer Institute Rockville MD 20850 USA Dissemination and Training Division VA National Center for PTSD Palo Alto CA 94305 USA Department of Global Health University of Washington Seattle WA 98105 USA Center for Global Health Studies Fogarty International Center National Institutes of Health Bethesda MD 20912 USA School of Public Health University of Alabama at Birmingham Birmingham AL 35243 USA School of Public Health University of Memphis Memphis TN 38152 USA USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project Bethesda Maryland 20814 USA Institute for Health Research Kaiser Permanente Denver CO 80231 USA ICSI Institute for Clinical Systems Improvement Bloomington MN 55425 USA Medicine University of Chicago Chicago IL 60637 USA Medicine Columbia University Medical Center New York NY 10032 USA Psychiatry Columbia University New York NY 10032 USA General Internal Medicine Epidemiology and Biostatistics University of California San Francisco San Francisco CA 94110 USA New York State Office of Mental Health New York NY 10001 USA Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA Center for Health Enhancement System Studies University of Wisconsin Madison WI 53706 USA Department of Psychiatry University of Pittsburgh Pittsburgh PA 15213 USA Psychology University at Buffalo Buffalo NY 14260 USA Department of Psychology West Virginia University Morgantown WV 26506 USA MIRECC VA North Little Rock AR 72114 USA QUERI for Team-Based Behavioral Health Centr

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Erratum to: Methods for evaluating medical tests and biomarkers

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Diagnostic and prognostic research 2017年第1期1卷 11页

作者： Gowri Gopalakrishna Miranda Langendam Rob Scholten Patrick Bossuyt Mariska Leeflang Anna Noel-Storr James Thomas Iain Marshall Byron Wallace Penny Whiting Clare Davenport Gowri GopalaKrishna Isabel de Salis Sue Mallett Robert Wolff Richard Riley Marie Westwood Jos Kleinen Gary Collins Hans Reitsma Karel Moons Antonia Zapf Annika Hoyer Katharina Kramer Oliver Kuss J Ensor J J Deeks E C Martin R D Riley Gerta Rücker Susanne Steinhauser Martin Schumacher Joie Ensor Kym Snell Brian Willis Thomas Debray Jon Deeks Lavinia Ferrante di Ruffano Sian Taylor-Phillips Chris Hyde Stuart A Taylor Gauraang Batnagar Lavinia Ferrante Di Ruffano Farah Seedat Aileen Clarke Sarah Byron Frances Nixon Rebecca Albrow Thomas Walker Carla Deakin Zhivko Zhelev Harriet Hunt Yaling Yang Lucy Abel James Buchanan Thomas Fanshawe Bethany Shinkins Laure Wynants Jan Verbakel Sabine Van Huffel Dirk Timmerman Ben Van Calster Aeliko Zwinderman Jason Oke Jack O'Sullivan Rafael Perera Brian Nicholson Hannah L Bromley Tracy E Roberts Adele Francis Denniis Petrie G Bruce Mann Kinga Malottki Holly Smith Lucinda Billingham Alice Sitch Oke Gerke Mie Holm-Vilstrup Eivind Antonsen Segtnan Ulrich Halekoh Poul Flemming Høilund-Carlsen Bernard G Francq Jac Dinnes Julie Parkes Walter Gregory Jenny Hewison Doug Altman William Rosenberg Peter Selby Julien Asselineau Paul Perez Aïssatou Paye Emilie Bessede Cécile Proust-Lima Christiana Naaktgeboren Joris de Groot Anne Rutjes Johannes Reitsma Emmanuel Ogundimu Jonathan Cook Yannick Le Manach Yvonne Vergouwe Romin Pajouheshnia Rolf Groenwold Karen Moons Linda Peelen Daan Nieboer Bavo De Cock Micael J Pencina Ewout W Steyerberg Jennifer Cooper Nick Parsons Chris Stinton Steve Smith Andy Dickens Rachel Jordan Alexandra Enocson David Fitzmaurice Peymane Adab Charles Boachie Gaj Vidmar Karoline Freeman Martin Connock Rachel Court Carl Moons Jessica Harris Andrew Mumford Zoe Plummer Kurtis Lee Barnaby Reeves Chris Rogers Veerle Verheyden Gianni D Angelini Gavin J Murphy Jeremy Huddy Melody Ni Katherine Good Graham Cooke 1Department of Clinical Epidemiology Biostatistics & Bioinformatics Academic Medical Center University of Amsterdam Amsterdam The Netherlands. 2Cochrane Netherlands Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht Netherlands. 234Department of Clinical Epidemiology Biostatistics & Bioinformatics Academic Medical Center University of Amsterdam Amsterdam The Netherlands. 49Department of Clinical Epidemiology Biostatistics & Bioinformatics Academic Medical Center University of Amsterdam Amsterdam The Netherlands. 3Cochrane Dementia and Cognitive Improvement Group University of Oxford Oxford UK. 4EPPI-Centre Department of Social Science University College London London UK. 5Division of Health and Social Care Research King's College London London UK. 6College of Computer and Information Science Northeastern University Boston USA. 13University Hospitals Bristol NHS Foundation Trust School of Social and Community Medicine Bristol UK. 275Institute of Applied Health Research University of Birmingham Birmingham UK. 9Department of Clinical Epidemiology Biostatistics & Bioinformatics Academic Medical Center University of Amsterdam Amsterdam The Netherlands. 10School of Social and Community Medicine University of Bristol Bristol UK. 179Institute of Applied Health Research University of Birmingham Birmingham UK. 12Kleijnen Systematic Reviews Ltd York UK. 25Research Institute for Primary Care and Health Sciences Keele University Keele UK. 188Centre for Statistics in Medicine Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK. 191Julius Center for Health Sciences and Primary Care University Medical Center Utrecht 3584 CG Utrecht Netherlands. 237Julius Center for Health Sciences and Primary Care University Medical Center Utrecht 3584 CG Utrecht Netherlands. 18Department of Medical Statistics University Medical Center Göttingen Göttingen Germany. 19Institute for B

[This corrects the article DOI: 10.1186/s41512-016-0001-y.].

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Towards the applied hybrid model in decision making: Support the early diagnosis of type 2 diabetes

Towards the applied hybrid model in decision making: Support...

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3rd International Conference on Information Computing and Applications, ICICA 2012

作者： Menezes, Andrea Carvalho Pinheiro, Placido Rogerio Pinheiro, Mirian Caliope Dantas Cavalcante, Tarcísio Pequeno Graduate Program in Applied Informatics Av. Washington Soares 1321 - Bl J Sl 30 60.811-905 Fortaleza Brazil

ISBN: (纸本)9783642340611

A hybrid model, combining Bayesian network and a multicriteria method, is presented in order to assist with the decision making process about which questions would be more attractive to the definition of the diagnosis of Diabetes type 2. We have proposed the application of an expert system structured in probability rules and structured representations of knowledge in production rules and probabilities (Artificial Intelligence - AI). The importance of the early diagnosis associated with the appropriate treatment is to decrease the chance of developing the complications of diabetes, reducing the impact on our society. Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. © 2012 Springer-Verlag.

关键词： Expert systems

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World Congress Integrative Medicine & Health 2017: Part one: Berlin, Germany. 3-5 May 2017

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BMC Complement Altern Med 2017年第SUPPL 1期17卷 322-322页

作者： Benno Brinkhaus Torkel Falkenberg Aviad Haramati Stefan N. Willich Josephine P. Briggs Merlin Willcox Klaus Linde Töres Theorell Lisa M. Wong Jeffrey Dusek Darong Wu David Eisenberg Bettina Berger Kathi Kemper Beate Stock-Schröer Hedda Sützl-Klein Rosaria Ferreri Gary Kaplan Harald Matthes Gabriele Rotter Elad Schiff Zahi Arnon Eckhard Hahn Christina M. Luberto David Martin Silke Schwarz Diethard Tauschel Andrew Flower Harsha Gramminger Hedwig H. Gupta S. N. Gupta Annette Kerckhoff Christian S. Kessler Andreas Michalsen Eun S. Kim Eun H. Jang Rana Kim Sae B. Jan Martin Mittwede Wiebke Mohme Eran Ben-Arye Massimo Bonucci Bashar Saad Thomas Breitkreuz Elio Rossi Rejin Kebudi Michel Daher Samaher Razaq Nahla Gafer Omar Nimri Mohamed Hablas Gunver Sophia Kienle Noah Samuels Michael Silbermann Lena Bandelin Anna-Lena Lang Eva Wartner Christoph Holtermann Maxwell Binstock Robert Riebau Edin Mujkanovic Holger Cramer Romy Lauche Andres Michalsen Lesley Ward Dominik Irnich Wolfram Stör Geoffrey Burnstock Hans-Georg Schaible Thomas Ots Jost Langhorst Tobias Sundberg Catherina Amarell Melanie Anheyer Marion Eckert Mercedes Ogal Annette Schönauer Birgit Reisenberger Bernhard Brand Dennis Anheyer Gustav Dobos Matthias Kroez Aldo Ammendola Jun J. Mao Claudia Witt Yufei Yang Miriam Oritz Markus Horneber Petra Voiß Alexandra von Rosenstiel Catharina Amarell Friedemann Schad Marc Schläppi Matthias Kröz Arndt Büssing Gil Bar-Sela David Avshalomov Samuel Attias Sian Cotton Miek Jong Mats Jong Christian Scheffer Friedrich Edelhäuser Abdullah AlBedah Myeong Soo Lee Mohamed Khalil Keiko Ogawa Yoshiharu Motoo Junsuke Arimitsu Masao Ogawa Genki Shimizu Rainer Stange Karin Kraft Kenny Kuchta Kenji Watanabe D Bonin Harald Gruber Sabine Koch Urs Pohlmann Christine Caldwell Barbara Krantz Ria Kortum Lily Martin Lisa S. Wieland Ben Kligler Susan Gould-Fogerite Yuqing Zhang John J. Riva Michael Lumpkin Emily Ratner Liu Ping Pei Jian Gesa-Meyer Hamme Xiaosong Mao Han Chouping Sven Schröder Josef Hummelsberger Michael Wullinger Marc Brodzky Chr Institute for Social Medicine Epidemiology and Health Economics Charité – Universitätsmedizin Berlin Berlin Germany Department of Neurobiology Care Sciences and Society Division of Nursing Research Group Integrative Care Karolinska Institutet Stockholm Sweden I C – The Integrative Care Science Center Järna Sweden Department of Biochemistry Molecular and Cellular Biology Georgetown University Medical Center Washington DC USA Department of Medicine Georgetown University Medical Center Washington DC USA NCCIH NIH Bethesda MD USA Department of Primary Care and Population Sciences University of Southampton Aldermoor Health Centre Coxford Rd Southampton 2016 5ST UK Institute of General Practice Technical University Munich Munich Germany Department of Neuroscience Karolinska Institute Stockholm Sweden Stress Research Institute Stockholm University Stockholm Sweden Arts and Humanities Initiative Harvard Medical School Boston MA 02115 USA Psychosomatic medicine Neuropsychology Allina Health Minneapolis MN USA nd Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China Department of Nutrition Harvard University T H Chan School of Public Health Boston MA 02115 USA Department of Health University of Witten/Herdecke Witten/Herdecke Germany OSU Blacklick OH USA Carstens-Foundation and FORUM D-45276 Essen Germany ESIHR (European Society for Integrative Health Care) A-1070 Vienna Austria Hospital Centre of Integrated Medicine Hospital of Pitiglian o ASL SudEst Toscana Grosseto Italy The Kaplan Center for Integrative Medicine Georgetown University McLean VA USA Hospital Havelhöhe Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité University Hospital Berlin Germany Internal medicine and Complementary medicine service Bnai Zion Medical Center Haifa Israel Complementary-Integrative Surgery Service Bnai Zion Medical Center Haifa Israel The Emek Yezreel Academic College Yezreel Valley Israel Medicine

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A novel application of crossover operator to a hybrid optimization framework: Investigation into cutting problems

A novel application of crossover operator to a hybrid optimi...

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Congress on Evolutionary Computation

作者： Rommel Dias Saraiva Plácido Rogério Pinheiro State University of Ceará Fortaleza Brazil Graduate Program in Applied Informatics University of Fortaleza-UNIFOR Fortaleza Brazil

ISBN: (纸本)9781467315104

The Generate and Solve (GS) is a hybrid optimization framework that combines a metaheuristic engine (genetic algorithm), which works as a generator of reduced instances of the original optimization problem, and an integer programming solver. GS has been recently introduced in the literature and achieved promising results in cutting and packing problem instances. In this paper, we present a novel application of crossover operator, the Uniform Order-Based Crossover, to the GS framework. As a means to assess the potentialities behind the novel application, we provide as instantiation of the framework for dealing specifically with the constrained two-dimensional non-guillotine cutting problem. Computational experiments performed over standard benchmark problems are reported and discussed here, evidencing the effectiveness of the novel operator.

关键词： Genetic algorithms Optimization Biological cells Heuristic algorithms Integer linear programming Search problems Hybrid power systems

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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

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Scientific data 2017年第1期4卷 170179页

作者： Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmu Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts USA. Program in Medical and Population Genetics Broad Institute Cambridge Massachusetts USA. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor Michigan USA. Wellcome Trust Centre for Human Genetics Nuffield Department of Medicine University of Oxford Oxford UK. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts USA. Department of Statistics University of Oxford Oxford UK. Genetics of Complex Traits University of Exeter Medical School University of Exeter Exeter UK. MRC Epidemiology Unit Institute of Metabolic Science University of Cambridge Cambridge UK. Department of Twin Research and Genetic Epidemiology King's College London London UK. Oxford Centre for Diabetes Endocrinology and Metabolism Radcliffe Department of Medicine University of Oxford Oxford UK. Department of Human Genetics Wellcome Trust Sanger Institute Hinxton Cambridgeshire UK. School of Computer Science McGill University Montreal Quebec Canada. McGill University and Génome Québec Innovation Centre Montreal Quebec Canada. Human Genetics Center The University of Texas Graduate School of Biomedical Sciences at Houston The University of Texas Health Science Center at Houston Houston Texas USA. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA. National Heart Lung and Blood Institute's Framingham Heart Study Framingham Massachusetts USA. Medical Genomics and Metabolic Genetics Branch National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA. Department of Biostatistics Harvard School of Public Health Boston Massachusetts USA. Chronic Disease Epidemiology Swiss Tropical and Public Health Institute University of Basel Basel Switzerland. Institute of Genetic Epidemiology Helmholtz Zentrum München German R

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

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Proceedings of the 3rd IPLeiria's International Health Congress Abstracts

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BMC HEALTH SERVICES RESEARCH 2016年第3期16卷 111-242页

作者： [Anonymous] Health Sciences Research Unit: Nursing Collegue of College of Health Technology of Coimbra Coimbra Portugal Sisters Hospitallers of the Sacred Heart of Jesus Casa de Saúde Rainha Santa Isabel Coimbra Portugal Research Unit for Sport and Physical Activity Faculty of Sport Sciences and Physical Education University of Coimbra Coimbra Portugal Complementary Sciences- INESCC Coimbra Portugal CUF Hospitals Lisbon Portugal Breast Unit Champalimaud Clinical Center Lisbon Portugal Swiss Centre for Medical Simulation & Swiss Association of Simulation in Healthcare Basel Switzerland Basel University Hospital Basel Switzerland HELPO Association Cascais Portugal Centro de Linguística Universidade de Lisboa Lisboa Portugal Centro Superior de Estudios Universitarios La Salle Madrid Spain Universidade da Madeira Funchal Portugal Serviço de Saúde da Região Autónoma da Madeira E.P.E. Funchal Portugal Escola Superior de Enfermagem de Lisboa Lisboa Portugal Instituto Superior Miguel Torga Coimbra Portugal Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo Comportamental Universidade de Coimbra Coimbra Portugal Escola Superior de Saúde de Leiria & Unidade de Investigação em Saúde Instituto Politécnico de Leiria Leiria Portugal National School of Public Health & Centro de Investigação em Saúde Pública Universidade Nova de Lisboa Lisboa Portugal Agrarian Superior School Polytechnic Institute of Viseu Viseu Portugal Laboratory of Microbiology Department of Biological Sciences Faculty of Pharmacy University of Porto Porto Portugal Unit for Multidisciplinary Biomedical Research Institute of Biomedical Sciences Abel Salazar University of Porto Porto Portugal Agrupamento de Centros de Saúde (ACES) Baixo Mondego Figueira da Foz Portugal Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal Centro de Salud La Paz Badajoz España Centro de Salud San Fernando Badajoz España Complejo Hospitalario Universitario de Badajoz Badajoz España Hospital Don Beni

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region of Príncipe, São Tomé and Príncipe Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Bonfim, Carina Silva S6 Safety culture of the patient: a reflexion about the therapeutic approach on the patient with vocal pathology Débora Franco S7 About wine, fortune cookies and patient experience Jesús Alcoba González O1 The psychological impact on the emergency crews after the disaster event on February 20, 2010 Helena G. Jardim, Rita Silva O2 Musculoskeletal disorders in midwives Cristina L. Baixinho, Mª Helena Presado, Mª Fátima Marques, Mário E. Cardoso O3 Negative childhood experiences and fears of compassion: Implications for psychological difficulties in adolescence Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto O4 Optimal age to give the first dose of measles vaccine in Portugal João G. Frade, Carla Nunes, João R. Mesquita, Maria S. Nascimento, Guilherme Gonçalves O5 Functional assessment of elderly in primary care Conceição Castro, Alice Mártires, Mª João Monteiro, Conceição Rainho O6 Smoking and coronary events in a population of Spanish health-care centre: An observational study Francisco P. Caballero, Fatima M. Monago, Jose T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco B. Ramirez O7 Prevalence of musculoskeletal injuries in Por

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Applying a Goal programming Model to Support the Selection of Artifacts in a Testing Process

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Advances in Software Engineering 2012年第1期2012卷

作者： Andreia Rodrigues da Silva Fernando Rodrigues de Almeida Júnior Placido Rogerio Pinheiro Graduate Program in Applied Informatics University of Fortaleza (UNIFOR) Avenue Washington Soares 1321 60811-341 Fortaleza CE Brazilunifor.br

This paper proposes the definition of a goal programming model for the selection of artifacts to be developed during a testing process, so that the set of selected artifacts is more viable to the reality of micro and small enterprises. This model was based on the IEEE Standard 829, which establishes a set of artifacts that must be generated throughout the test activities. Several factors can influence the definition of this set of artifacts. Therefore, in order to consider such factors, we developed a multicriteria model that helps in determining the priority of artifacts according to the reality of micro and small enterprises.

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Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion

Copy number variation detection in whole-genome sequencing d...

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第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者：席瑞斌 Angela G Hadjipanayis Lovelace J.Luquette Tae-Min Kim Eunjung Lee Jianhua Zhang Mark D.Johnson Donna M.Muzny David A.Wheeler Richard A.Gibbs Raju Kucherlapati Peter J.Park Center for Biomedical Informatics Harvard Medical SchoolBostonMassachusetts 02115USA Division of Genetics Brigham andWomen's HospitalBostonMA 02115 The Belfer Institute for Applied Cancer Science Dana-Farber Cancer InstituteBostonMA 02115 Department of Neurological Surgery Brigham and Women Hospital and Harvard Medical SchoolBostonMassachusetts 02115 Genome Sequencing Center Baylor College of MedicineHoustonTX Division of Genetics Brigham and Women's HospitalBostonMA 02115 Department of Genetics Harvard Medical SchoolBostonMA 02115 Children's Hospital Informatics Program BostonMassachusetts 02115USA

DNA copy number variations(CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human *** this study, we developed an algorithm to detect CNVs from whole-genome sequencing data and applied it to a newly sequenced glioblastoma genome with a matched *** read-depth algorithm,called BIC-seq,can accurately and efficiently identify CNVs via minimizing the Bayesian information criterion(BIC).Using BIC-seq,we identified hundreds of CNVs as small as 40 bp in the cancer genome sequenced at 10X coverage,while we could only detect large CNVs(>15 Kb) in the array CGH profiles for the same *** percent(14/16) of the small variants tested(110 bp to 14 Kb) were experimentally validated by quantitative PCR,demonstrating high sensitivity and true positive rate of the *** also extended the algorithm to detect recurrent CNVs in multiple samples as well as deriving error bars for breakpoints using a Gibbs sampling approach.

关键词： Bayesian Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion

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