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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Trends, noise and re-entrant long-term persistence in Arctic sea ice

Trends, noise and re-entrant long-term persistence in Arctic...

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作者： Agarwal, S. Moon, W. Wettlaufer, J.S. Department of Mathematics Indian Institute of Technology Guwahati Guwahati 781 039 Assam India Department of Geology and Geophysics Yale University New Haven CT 06520-8109 United States Department of Physics Yale University New Haven CT 06520-8109 United States Program in Applied Mathematics Yale University New Haven CT 06520-8109 United States NORDITA Roslagstullsbacken 23 10691 Stockholm Sweden

We examine the long-term correlations and multi-fractal properties of daily satellite retrievals of Arctic sea ice albedo and extent, for periods of approximately 23 years and 32 years, respectively. The approach harnesses a recent development called multi-fractal temporally weighted detrended fluctuation analysis, which exploits the intuition that points closer in time are more likely to be related than distant points. In both datasets, we extract multiple crossover times, as characterized by generalized Hurst exponents, ranging from synoptic to decadal. The method goes beyond treatments that assume a single decay scale process, such as a first-order autoregression, which cannot be justifiably fitted to these observations. Importantly, the strength of the seasonal cycle masks' long-term correlations on time scales beyond seasonal. When removing the seasonal cycle from the original record, the ice extent data exhibit white noise behaviour from seasonal to bi-seasonal time scales, whereas the clear fingerprints of the short (weather) and long (approx. 7 and 9 year) time scales remain, the latter associated with the recent decay in the ice cover. Therefore, long-term persistence is re-entrant beyond the seasonal scale and it is not possible to distinguish whether a given ice extent minimum/maximum will be followed by a minimum/maximum that is larger or smaller in magnitude. © 2012 The Royal Society.

关键词： Sea ice

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Thermal and athermal three-dimensional swarms of self-propelled particles

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Physical Review E 2012年第1期86卷 011136-011136页

作者： Nguyen H. P. Nguyen Eric Jankowski Sharon C. Glotzer Department of Mechanical Engineering University of Michigan Ann Arbor Michigan 48109 USA Department of Chemical Engineering University of Michigan Ann Arbor Michigan 48109 USA Department of Materials Science and Engineering University of Michigan Ann Arbor Michigan 48109 USA Applied Physics Program University of Michigan Ann Arbor Michigan 48109 USA

Swarms of self-propelled particles exhibit complex behavior that can arise from simple models, with large changes in swarm behavior resulting from small changes in model parameters. We investigate the steady-state swarms formed by self-propelled Morse particles in three dimensions using molecular dynamics simulations optimized for graphics processing units. We find a variety of swarms of different overall shape assemble spontaneously and that for certain Morse potential parameters at most two competing structures are observed. We report a rich “phase diagram” of athermal swarm structures observed across a broad range of interaction parameters. Unlike the structures formed in equilibrium self-assembly, we find that the probability of forming a self-propelled swarm can be biased by the choice of initial conditions. We investigate how thermal noise influences swarm formation and demonstrate ways it can be exploited to reconfigure one swarm into another. Our findings validate and extend previous observations of self-propelled Morse swarms and highlight open questions for predictive theories of nonequilibrium self-assembly.

关键词： MORSE theory MOLECULAR dynamics PHASE diagrams LANGEVIN equations COMPUTER simulation

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Erratum to: “Morphology based particle segregation by electrostatic charge” [J. Aerosol Sci. 39 (2008) 785–792]

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Journal of Aerosol Science 2013年 58卷 172-172页

作者： Rajan K. Chakrabarty Hans Moosmüller Mark A. Garro W. Patrick Arnott Jay G. Slowik Eben S. Cross Jeong-Ho Han Paul Davidovits Timothy B. Onasch Douglas R. Worsnop Chemical Physics Program University of Nevada Reno NV 89557 USA Desert Research Institute Nevada System of Higher Education Reno NV 89512 USA Division of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA Department of Physics University of Nevada Reno NV 89517 USA Department of Chemistry University of Toronto Ontario Canada M5S 3H6 Department of Chemistry Boston College Chestnut Hill MA 02467 USA Aerodyne Research Inc. Billerica MA 01821 USA

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Gripper synthesis for indirect manipulation of cells using Holographic Optical Tweezers

Gripper synthesis for indirect manipulation of cells using H...

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IEEE International Conference on Robotics and Automation (ICRA)

作者： Sagar Chowdhury Petr Svec Chenlu Wang Wolfgang Losert Satyandra K. Gupta Department of Mechanical Engineering and The Institute for Systems Research University of Maryland College Park MD USA Department of Mechanical Engineering University of Maryland College Park MD USA Biophysics Program University of Maryland College Park MD USA Department of Physics Institute for Physical Science and Technology and the Institute forResearch in Electronics and Applied Physics University of Maryland College Park MD USA

Optical Tweezers (OT) are used for highly accurate manipulations of biological cells. However, the direct exposure of cells to focused laser beam may negatively influence their biological functions. In order to overcome this problem, we generate multiple optical traps to grab and move a 3D ensemble of inert particles such as silica microspheres to act as a reconfigurable gripper for a manipulated cell. The relative positions of the microspheres are important in order for the gripper to be robust against external environmental forces and the exposure of high intensity laser on the cell to be minimized. In this paper, we present results of different gripper configurations, experimentally tested using our OT setup, that provide robust gripping as well as minimize laser intensity experienced by the cell. We developed a computational approach that allowed us to perform preliminary modeling and synthesis of the gripper configurations. The gripper synthesis is cast as a multi-objective optimization problem.

关键词： Grippers Laser beams Biomedical optical imaging Silicon compounds Robustness Force Holography

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Automated indirect transport of biological cells with optical tweezers using planar gripper formations

Automated indirect transport of biological cells with optica...

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IEEE International Conference on Automation Science and Engineering (CASE)

作者： Sagar Chowdhury Atul Thakur Chenlu Wang Petr Svec Wolfgang Losert Satyandra K. Gupta The Department of Mechanical Engineering and the Institute for Systems Research University of Maryland College Park MD USA The Department of Mechanical Engineering University of Maryland College Park MD USA The Biophysics Program University of Maryland College Park MD USA The Department of Physics Institute for Physical Science and Technology and the Institute for Research in Electronics and Applied Physics University of Maryland College Park MD USA

Optical tweezers are used for manipulation of micron-sized dielectric beads and cells. Some biological cells are vulnerable to photo damage if subjected to laser-based direct manipulation. In such cases, precise manipulation of these cells can be accomplished by using gripper formations made up of silica beads, which are actuated by optical tweezers. Manual indirect manipulation of cells using grippers made of optically trapped beads is a time consuming process or sometimes just impossible. This paper presents an approach for automated micromanipulation using gripper formations and heuristic based path planning for collision-free transport of biological cells. The objective of the developed planner is to transport target cells to their respective goal positions in the minimum time. we evaluated the performance of different gripper formations in terms of gripper stability, speed of transport, and required laser power using experiments.

关键词： Grippers Charge carrier processes Biomedical optical imaging Laser stability Laser beams Educational institutions

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Optical shock and blow-up of ultrashort pulses in transparent media

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Physical Review A 2012年第3期86卷 033806-033806页

作者： P. Whalen J. V. Moloney A. C. Newell K. Newell M. Kolesik Program in Applied Mathematics University of Arizona Tucson AZ 85721-0089 USA Arizona Center for Mathematical Sciences University of Arizona Tucson AZ 85721-0089 USA Department of Mathematics University of Arizona Tucson AZ 85721-0089 USA College of Optical Sciences University of Arizona Tucson AZ 85721-0089 USA Department of Physics Constantine the Philosopher University Nitra 94974 Slovakia

Ultrashort pulses can exhibit two distinctive types of singularity: self-focusing collapse and self-steepening shock. We examine various ultrashort pulse propagation models and their relative effectiveness in explaining these phenomena. In particular, the modified Kadomtsev-Petviashvilli equation of type 1 (MKP1) is examined in some detail. We show that MKP1 is not simply a few-cycle pulse model but is valid in a more general broad spectrum setting. Furthermore, we emphasize that the dispersion of the MKP1 model can result in poor estimation of frequency-dependent phenomena, such as harmonic generation, which occur far away from the carrier frequency. Some of this loss of accuracy can be removed by using a more general MKP1 dispersion relation.

关键词： SHOCK waves BLOWING up (Algebraic geometry) ULTRASHORT laser pulses TRANSPARENCY (Optics) OPTICAL materials PARTIAL differential equations DISPERSION SECOND harmonic generation

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Risk-driven migration and the collective-risk social dilemma

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Physical Review E 2012年第3期86卷 036101-036101页

作者： Xiaojie Chen Attila Szolnoki Matjaž Perc Evolution and Ecology Program International Institute for Applied Systems Analysis (IIASA) Schlossplatz 1 A-2361 Laxenburg Austria Institute of Technical Physics and Materials Science Research Centre for Natural Sciences Hungarian Academy of Sciences P. O. Box 49 H-1525 Budapest Hungary Faculty of Natural Sciences and Mathematics University of Maribor Koroška cesta 160 SI-2000 Maribor Slovenia

A collective-risk social dilemma implies that personal endowments will be lost if contributions to the common pool within a group are too small. Failure to reach the collective target thus has dire consequences for all group members, independently of their strategies. Wanting to move away from unfavorable locations is therefore anything but surprising. Inspired by these observations, we here propose and study a collective-risk social dilemma where players are allowed to move if the collective failure becomes too probable. More precisely, this so-called risk-driven migration is launched depending on the difference between the actual contributions and the declared target. Mobility therefore becomes an inherent property that is utilized in an entirely self-organizing manner. We show that under these assumptions cooperation is promoted much more effectively than under the action of manually determined migration rates. For the latter, we in fact identify parameter regions where the evolution of cooperation is greatly inhibited. Moreover, we find unexpected spatial patterns where cooperators that do not form compact clusters outperform those that do, and where defectors are able to utilize strikingly different ways of invasion. The presented results support the recently revealed importance of percolation for the successful evolution of public cooperation, while at the same time revealing surprisingly simple methods of self-organization towards socially desirable states.

关键词： SYSTEM analysis FINANCIAL management MATERIALS science SELF-organizing systems MATHEMATICAL programming MANAGEMENT science

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Rapid diagnosis of breast cancer cell with coherent anti-Stokes raman scattering microspectroscopy

Rapid diagnosis of breast cancer cell with coherent anti-Sto...

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Conference on Lasers and Electro-Optics

作者： Jang Hyuk Lee Ally Yoon Sang-Mo Shin Myoung-Kyu Oh Do-Kyeong Ko Graduate Program of Photonics and Applied Physics Gwangju Institute of Science and Technology Graduate program of Medical System Engineering Gwangju Institute of Science and Technology Advanced Photonics Research Institute Gwangju Institute of Science and Technology

A CARS microspectroscopy system was developed and applied to live breast cancer cells. CARS image and spectrum at C-H vibration stretching in lipid droplets differentiate cancer cell from normal cell.

ISBN: (纸本)9781467318396

关键词： Microscopy Spectroscopy Coherent anti-Stokes Raman scattering Medical and biological imaging

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A Directional Entropic Force Approach to Assemble Anisotropic Nanoparticles into Superlattices†

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Angewandte Chemie 2013年第52期125卷

作者： Kaylie L. Young Michelle L. Personick Michael Engel Pablo F. Damasceno Stacey N. Barnaby Reiner Bleher Tao Li Sharon C. Glotzer Byeongdu Lee Chad A. Mirkin Department of Chemistry and International Institute for Nanotechnology Northwestern University 2145 Sheridan Road Evanston IL 60208 (USA) Department of Chemical Engineering Department of Materials Science & Engineering Applied Physics Program University of Michigan North Campus Research Complex 2800 Plymouth Road Ann Arbor MI 48109 (USA) Department of Materials Science and Engineering Northwestern University 2200 Campus Drive Evanston IL 60208 (USA) X‐ray Science Division Argonne National Laboratory 9700 South Cass Avenue Argonne IL 60439 (USA)

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