This research aims to investigate a Homogenously Weighted Moving Average (HWMA) control chart for detecting minor and moderate shifts in the process mean. A mathematical model for the explicit formulae of the average ...
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作者:
Haseman, J.K.Wlnbush, J.S.Statistics and Biomathematics Branch
Biometry and Risk Assessment Program National Institute of Environmental Health Sciences North Carolina 27709 P.O. Box 12233 Research Triangle Park United States Division of Mathematics
Center for Food Safety and Applied Nutrition Food and Drug Administration Washington D.C 20204 United States
Use of Dual Control Groups to Estimate False Positive Rates in Laboratory Animal Carcinogenicity Studies. HASEMAN, J.K., WINBUSH, J.S., AND O'DONNELL, M.W., JR. (1986). Fun-dam. Appl. Toxicol. 7, 573-584. Tumor in...
Summary form only given. We used the finite-difference time-domain method to solve Maxwell equations. More specifically, we applied the non-dissipative Yee's algorithm with a duality relation between the spatial r...
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Charney and DeVore [J. Atmos. Sci. 36 (1979), 1205-1216] found multiple equilibrium states as a consequence of bottom topography in their pioneering work on the quasi-geostrophic barotropic flow over topography in a ...
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One of the most important problems occurring in ceramic tile industry is defective product problem. Defective ceramics leads to loss of income and waste of resources in enterprises. However, it is generally unknown wh...
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In this paper we consider the filtering of partially observed multi-dimensional diffusion processes that are observed regularly at discrete times. This is a challenging problem which requires the use of advanced numer...
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In today’s digital world,the most inevitable challenge is the protection of digital *** to the weak confidentiality preserving techniques,the existing world is facing several digital information *** make our digital d...
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In today’s digital world,the most inevitable challenge is the protection of digital *** to the weak confidentiality preserving techniques,the existing world is facing several digital information *** make our digital data indecipherable to the unauthorized person,a technique forfinding a crypto-graphically strong Substitution box(S-box)have *** S-box with sound cryptographic assets such as nonlinearity(NL),strict avalanche criterion(SAC),bit independence criteria(BIC),bit independence criteria of nonlinearity(BIC-NL),Bit independence criteria of Strict avalanche criteria(BIC-SAC),and Input/output XOR is considered as the robust *** Decision-Making Trial and Evaluation Laboratory(DEMATEL)approach of multi-criteria decision making(MCDM)is proposed forfinding the interrelation among cryptographic properties.A combination of two MCDM methods namely Entropy and multi-objective optimization based on ratio analysis(MOORA)is applied for the best S-box selection.A robust substitution box is selected for secure communications in cryptography by using the combination of DEMETAL selection criteria,entro-py weight assigning,and MOORA ranking *** combination of these three methods provides a fast selection procedure for the secure confusion *** offered selection method can also be utilized for the choice of the best cryptosystem with highly secure properties and resistive against all possible linear and differential attacks in the cryptanalysis.
Non-synonymous single nucleotide polymorphisms (nsSNPs), also known as missense SNPs, can seriously affect an individual’s vulnerability to numerous diseases, including cancer. In this study, we conducted a comprehen...
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Non-synonymous single nucleotide polymorphisms (nsSNPs), also known as missense SNPs, can seriously affect an individual’s vulnerability to numerous diseases, including cancer. In this study, we conducted a comprehensive in-silico analysis to examine the structural and functional implications of nsSNPs within the Folate Hydrolase 1(FOLH1) gene, which encodes the Prostate-Specific Membrane Antigen (PSMA). A total of 504 SNPs were retrieved, and after filtering, 15 pathogenic nsSNPs were identified using five different in-silico tools. Three of these SNPs—R255H (rs375565491), R255C (rs201789325), and G168E (rs267602926)—were consistently predicted to be pathogenic across all in-silico tools. MutPred2 was used to predict the structural and functional consequences of the identified mutations. The analysis revealed multiple alterations in the PSMA protein, including changes in helical conformations, glycosylation patterns, transmembrane properties, and solvent accessibility. Furthermore, I-Mutant 2.0 analysis demonstrated a decrease in protein stability for most nsSNPs, except for rs267602926 (G168E), which was predicted to increase stability. Conservation analysis using ConSurf revealed varying degrees of amino acid conservation, with R255H and R255C identified as highly conserved residues, indicating their potential functional and structural significance. Additionally, post-translational modification (PTM) analysis indicated that while phosphorylation and methylation sites remained unchanged, specific glycosylation sites were lost in two pathogenic mutant variants (R255H and R255C), potentially affecting PSMA function and adversely impacting prostate cancer. Our findings highlight the importance of in silico studies to investigate the structural and functional impacts of FOLH1 nsSNPs on the PSMA protein. Such in silico studies can deepen our understanding of the roles of nsSNPs in prostate cancer onset, progression, and drug resistance.
This work aims to numerically investigate the performance of the multiquadric (MQ) radial basis function in more general formats for image reconstruction applications. Desired features, i.e., accuracy and shape parame...
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