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MecLung—A Respiratory System Mechanical Simulator 9th

MecLung—A Respiratory System Mechanical Simulator

9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Motta-Ribeiro, G.C. Pino, A.V. Castro Pinto, F.A.N. dos Santos, T.P. Mattos, G.M. Vale, M.J.O. Giannella-Neto, A. Fundação Coordenação de Projetos Pesquisas e Estudos Tecnológicos—COPPETEC Rio de Janeiro Brazil Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Mechanical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil ECCO Engenharia Clínica Consultoria Ltda Rio de Janeiro Brazil

ISBN: (纸本)9783031494062

MecLung is a mechanical simulator. It consists of a metal cylinder provided with a tight piston controlled by a motor and programmed to simulate resistances and compliances of the human respiratory system. Additionally, the simulator presents spontaneous activity resembling respiratory muscular drive. Resistances and compliances in the range of 5 to 50 hPa/l/s and 10 to 50 ml/hPa, respectively, covering the clauses of the ABNT ISO 80601-2-12 to test the performance of mechanical ventilators for adults, were tested. The airways pressure, flow rate and volume waveforms are available for the user through digital data at 200 Hz sampling frequency. The motion equation applied to the data recovers the mechanical impedances with an accuracy of 2% for pressure and volume-controlled mechanical ventilation. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Ventilation

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mRNA vaccines: Past, present, future

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Asian Journal of Pharmaceutical Sciences 2022年第4期17卷 491-522页

作者： Mia Karam Georges Daoud Biomedical Engineering Program Maroun Semaan Faculty of Engineering and ArchitectureBeirut 11072020Lebanon Department of Biochemistry and Molecular Genetics Faculty of MedicineBeirut 11072020Lebanon Department of Anatomy Cell Biologyand Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 11072020Lebanon

mRNA vaccines have emerged as promising alternative platforms to conventional *** ease of production,low cost,safety profile and high potency render them ideal candidates for prevention and treatment of infectious diseases,especially in the midst of *** challenges that face in vitro transcribed RNA were partially amended by addition of tethered adjuvants or co-delivery of naked mRNA with an adjuvanttethered ***,it wasn’t until recently that the progress made in nanotechnology helped enhance mRNA stability and delivery by entrapment in novel delivery systems of which,lipid *** continuous advancement in the fields of nanotechnology and tissue engineering provided novel carriers for mRNA vaccines such as polymeric nanoparticles and *** studies have shown the advantages of adopting mRNA vaccines for viral diseases and cancer in animal and human ***-amplifying mRNA is considered today the next generation of mRNA vaccines and current studies reveal promising *** review provides a comprehensive overview of mRNA vaccines used in past and present studies,and discusses future directions and challenges in advancing this vaccine platform to widespread clinical use.

关键词： mRNA vaccine Virus Cancer Nanoparticles COVID-19

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Prototyping a Flowmeter for a Continuous Positive Airway Pressure Device 9th

Prototyping a Flowmeter for a Continuous Positive Airway ...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Motta-Ribeiro, Gabriel C. Giannella-Neto, Antonio Programa Doutor Empreendedor Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro Rio de Janeiro Brazil Biomedical Engineering Program Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9783031494062

Continuous positive airway pressure (CPAP) is an effective therapy for obstructive sleep apnea. Although the controlled variable in CPAP devices is pressure, flow measurement can supplement monitoring of therapy effectiveness. Here, we describe desired sensor characteristics, application constraints and a theoretical framework for designing a differential pressure flowmeter for a CPAP device. Our aim is to validate this framework through experimental verification of the permanent pressure loss and flow-pressure curve of a 3D-printed prototype. Pressure at patient interface was less than 5% lower than that measured before the restrictive element, despite pressure drop in such element being always above that threshold. The predicted quadratic flow-pressure relationship was achieved with a 97% approximation. These findings indicate that the type of restrictive element chosen for the prototype, a Venturi tube, is suitable for the application, and the used framework is adequate for sensor design. However, refinements to the current geometry are needed to adjust flow sensibility and the fitting to other CPAP device’s components. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Flowmeters

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Microvolt T-Wave and Ventricular Repolarization Duration Alternans 9th

Microvolt T-Wave and Ventricular Repolarization Duration Alt...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Winkert, Thaís Nadal, Jurandir Benchimol-Barbosa, Paulo Roberto Biomedical Engineering Program COPPE Institute Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Hospital Universitário Pedro Ernesto Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9783031494031

The ventricular tachyarrhythmia is an important cause of sudden cardiac death, impacting economic, social, and health systems. Microvolt T-wave alternans (MTWA) represent transmural gradient alternation in phase-3 ventricular action potential duration, leading to T-wave amplitude shortening in every other beat. The T-peak T-end interval (TpTe) represents the terminal ventricular repolarization duration and is explained by differences in phase-3 repolarization times from ventricular epicardial to endocardial fibers. Whether TpTe alternation occurs in patients with MTWA is unknown. This work investigated whether terminal ventricular repolarization duration alternation is present in MTWA patients. Seven 12-lead ECG records from Physionet T-wave Alternans Database were analyzed. The TpTe alternans was assessed in even and odds beats, in a series of 128 consecutive beats. In even and odd beats, TpTe intervals were ensembled and averaged, and the magnitude of TpTe alternans was defined as the difference between averages (ΔTpTe). The MTWA was quantified by the difference between the average peak of the T-wave in even and odd beats. ΔTpTe and MTWA were compared by Pearson’s coefficient. Even and odd beats on TpTe alternans and MTWA were compared with non-paired Student t-tests. ΔTpTe positively correlated with MTWA (r = 0.5;p © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

关键词： Electrocardiograms

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Using textile capacitive sensors to train synchronized movement of hands

Using textile capacitive sensors to train synchronized movem...

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2024 IEEE International Conference on Consumer Electronics, ICCE 2024

作者： Yang, Chang-Ming Wu, Shu-Cing Chen, Shih-Hung Wu, Ze-We Liao, Kuo-Cheng Chen, Chi-Chun Ming Young Biomedical Corp. Miaoli Taiwan National Chin-Yi University of Technology Program Prospective Technology of Electrical Engineering and Computer Science Taichung Taiwan National Chin-Yi University of Technology Dept. of Computer Science and Information Engineering Taichung Taiwan National Chin-Yi University of Technology Dept. of Electronic Engineering Taichung Taiwan

ISBN: (纸本)9798350324136

This study introduced a capacitive sensing interactive game platform aimed at promoting emotional stability, which we have named the 'Sunrise and Sunset' game. This game primarily consists of two pieces of regular textile fabric enveloping conductive silver fabric. A microcontroller was employed to extract the sensed capacitive values, and a game named 'Sunrise and Sunset' is designed to complement the slow raising and lowering of both hands. The development of this gaming platform has the potential to offer a novel method of emotional management, particularly in high-stress living environments. It can serve as an effective relaxation tool, aiding individuals in emotional balance, anxiety reduction, and stress alleviation. Simultaneously, this platform can contribute to the promotion of mental well-being, providing an engaging and beneficial means for people to manage their emotions and moods. © 2024 IEEE.

关键词： capacitive sensing emotional stability game relaxation tool silver fabric

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Building a Brain Computer Interface (BCI) Using Electroencephalogram (EEG) Signals' Classification

Building a Brain Computer Interface (BCI) Using Electroencep...

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International Conference on Advances in biomedical engineering (ICABME)

作者： Mohammad Nabil Younis Sary Haj Sleiman Salma Khadra Amira Zaylaa Alaa Daher Mohammad Ayache Depatment of Electrical and Computer Engineering Beirut Arab University Biomedical Program Debbieh Lebanon

Development of Brain Computer Interface (BCI) has been rapid since the mid 1990‘s. There are three criteria for BCI, (i) comfortability and possession of a suitable signal acquisition device, (ii) system validation and dissemination, and (iii) reliability and potentiality. As there are no BCI possessing the optimal criteria, it was essential to consider building a new one. Thereby, the paper investigates building BCI based on the utilization of EEG signals to translate brainwave patterns into actionable commands. The primary objective is to enhance communication capabilities for individuals afflicted with neurological disorders, empowering them to command external devices and engage more effectively with their surroundings. We built our model on EEG online dataset for the purpose of feature extraction and classification. Statistical features and Discrete Wavelet Transform (DWT) have been applied for feature selection. Multi-Layer Perceptron (MLP) and Radial Basis Function (RBF) were the classifiers involved. Results showed that the proposed architecture of MLP and RBF were able to classify the EEG signals into two classes (open eye and closed eye). Results also showed that the proposed approach, which is based on the combination of statistical features and DWT for features selection using AF3 and AF4 channels by the application of MLP, has 98% succession rate. BCI system based on Arduino circuit has been built after the classification Further algorithms and system evaluation need to be considered as future work.

关键词：

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Electronically Scanned Large Apertures for Interventional and Diagnostic Liver

Electronically Scanned Large Apertures for Interventional an...

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2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Wodnicki, Robert Zhang, Junhang Zhou, Qifa Foiret, Josquin Notard, Christophe Ferrara, Katherine W. University of Southern California Dept. of Biomedical Engineering Los AngelesCA United States Molecular Imaging Program Stanford University StanfordCA United States Vermon S.A. Tours France

ISBN: (纸本)9798350346459

We have developed a handheld 1,024-element large area 2D array probe integrated with high voltage multiplexing ASIC modules with row-multiplexed imaging in orthogonal azimuthal and elevational planes with image data computed and displayed on a commercially available 32 channel configurable ultrasound system. Here we demonstrate real-time orthogonal imaging of small structures at high resolution in water with the 1,024-element array. We have also integrated modular imaging electronics with a newly designed 4,096-element 4 times larger aperture acoustic array (83 mm × 16 mm aperture with 650 μm azi. × 500 μm elev. element pitch) with 128 elements in azimuth and 32 rows in elevation. The two arrays were interfaced to an open-platform ultrasound imaging system using custom-designed multiplexing ASICs and imaged with plane waves at Fc = 2.5 MHz. © 2023 IEEE.

关键词： Synthetic apertures

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Temperature-Dependent Hydrogen Modulations of Ultra-Scaled a-IGZO Thin Film Transistor Under Gate Bias Stress

IEEE Open Journal of Nanotechnology

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IEEE Open Journal of Nanotechnology 2024年 5卷 9-16页

作者： Aslam, Muhammad Chang, Shu-Wei Chuang, Min-Hui Chen, Yi-Ho Lee, Yao-Jen Li, Yiming Parallel and Scientific Computing Laboratory National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electrical Engineering National Cheng Kung University Tainan701401 Taiwan Institute of Communications Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Pioneer Semiconductor Innovation National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan

Recently, a-IGZO has advanced toward the next-generation electronics system because of its compatibility with complementary metal oxide semiconductor (CMOS) and back-end-of-line (BOEL) based systems. A systematic electrical characterization of a-IGZO TFT related to reliability issues, such as positive bias temperature stress (PBTS) and negative bias temperature stress (NBTS), would entitle its integration into novel electronics systems. Unexpectedly, PBTS is characterized by the transition of positive Vth shift to negative Vth shift (ΔVth, the positive shift followed by the stress and temperature activated negative shift). This transition is attributed to charge trapping/trap-site generations and hydrogen migration to the active layer. The ΔVth shift mechanism depends on the temperature and voltage stress. On the other hand, a negative ΔVth shift has been observed during the NBTS operation and could be attributed to the hole trapping at the interface of GI/IGZO. An effective suppression of the gate leakage current has also been observed during reliability tests. Simulation results reveal a pronounced potential at the edges of source and drain regions, and considered the origin of hydrogen migration into the IGZO layer. Thermal image results also reveal the strong temperature/potential distribution at the edges of the source/drain regions, indorsing the simulation results. © 2020 IEEE.

关键词： Oxide semiconductors

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Adaptive Neuro-Fuzzy Inference System As New Real-Time Approach for Parkinson Seizures Prediction 4

Adaptive Neuro-Fuzzy Inference System As New Real-Time Appro...

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4th International Conference on Bio-engineering for Smart Technologies, BioSMART 2021

作者： Daher, Alaa Yassin, Sally Alsamra, Hadi Ali, Hassan Abou Beirut Arab University Biomedical Engineering Program Faculty of Engineering Electrical and Computer Engineering Department Debbieh Lebanon

ISBN: (纸本)9781665408103

Parkinson's disease, as a definition, is a neurological condition that affects the brain and causes tremors, stiffness, and difficulties walking, balancing, and coordinating. Symptoms of Parkinson's disease normally appear gradually and worsen with time. People with Parkinson's disease may have difficulties walking and speaking as the condition develops. Numerous recent studies have shown a direct association between Parkinson's disease and the incident of having epileptic seizures, which is defined to be a burst of the uncontrollable electrical activity of the brain cells, that is associated with an increased risk of sudden unexplained deaths. This project aims to obtain a real-time seizure prediction system for Parkinson's disease patients based on the electroencephalogram (EEG) signals, enabling the detection of a seizure before it happens. This will hopefully save them from risky situations or sudden death, as they will be alerted and have the time enabling them to be prepared and take the needed precautions and steps to prevent the seizure from happening. For this project, we've used the Neural Network and the ANFIS ('udaptive neuro-fuzzy inference system '') to process and analyze the electroencephalogram (EEG) data signals of the Parkinson patients to detect seizures starting point. © 2021 IEEE.

关键词： Brain

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A Simple Microfluidic Redox Cycling-Based Device for High-Sensitive Detection of Dopamine Released from Pc12 Cells

SSRN

引用

SSRN 2023年

作者： Şen, Mustafa Avcı, İpek Department of Biomedical Engineering Izmir Katip Celebi University Izmir Turkey Department of Biomedical Engineering Graduate Program Izmir Katip Celebi University Izmir Turkey

Here, a microfluidic redox cycle-based chip device (MRECD) was fabricated for high-sensitive and selective electrochemical detection of dopamine (DA). Briefly, ITO electrodes, each with a 3x3 mm working area, were fabricated using photolithography and dry etching processes. ITO electrodes were then modified with AuNPs to increase sensitivity. To fabricate MRECD with AuNPs (AuNPs- MRECD), one AuNPs-ITO was mounted and fixed on top of another using a PET film spacer to define a microfluidic channel for solution delivery. The device was electrochemically characterized in comparison to a device made of bare ITO electrodes (B-MRECD). According to the results, AuNPs- MRECD showed better redox cycling efficiency than B-MRECD with an amplification factor (Af ) of 49.9 and a collection efficiency (Ce) of 98.97 %. AuNPs-MRECD was then tested for sensitive and selective detection of DA, in which case the device displayed an LOD of 27.9 M over a linear detection range of 50 to 1000 nM based on reduction current. Finally, the device was successfully applied to the detection of DA released from PC12 cells, suggesting that the device is a promising tool for evaluating dopaminergic cells and the effects of dopaminergic drugs. © 2023, The Authors. All rights reserved.

关键词： Redox reactions

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