Osteochondral(OC)repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral *** contrast to the current surgical approaches which...
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Osteochondral(OC)repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral *** contrast to the current surgical approaches which yield only short-term relief of symptoms,tissue engineering strategy has been shown more promising outcomes in treating OC defects since its emergence in the *** particular,the use of multizonal scaffolds(MZSs)that mimic the gradient transitions,from cartilage surface to the subchondral bone with either continuous or discontinuous compositions,structures,and properties of natural OC tissue,has been gaining momentum in recent *** the latest developments in the field,this review offers a comprehensive summary of recent advances,current hurdles,and future perspectives of OC repair,particularly the use of MZSs including bilayered,trilayered,multilayered,and gradient scaffolds,by bringing together onerous demands of architecture designs,material selections,manufacturing techniques as well as the choices of growth factors and cells,each of which possesses its unique challenges and opportunities.
Amputation involves the removal of a limb or part of it. In the case of the lower extremity, amputation affects the ankle joint and the metatarsophalangeal and intertarsal joints, improving the foot's adaptability...
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作者：
Saad, Mohammed AyadJaafar, RosminaChellappan, Kalaivani
Faculty of Engineering and Built Environment Department of Electrical Electronics and System Engineering Selangor Bangi43600 Malaysia Al-Kitab University
Department of Medical Instrumentations Technique Engineering Kirkuk36001 Iraq Universitas Airlangga
Biomedical Engineering Study Program Faculty of Science and Technology Surabaya60115 Indonesia
Efficient data collection in wireless sensor networks (WSNs) is crucial. While traditional approaches rely on stationary data sinks, the use of mobile sinks, like unmanned aerial vehicles (UAVs), has shown promise in ...
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Corrosion is a detrimental persistent industrial conundrum that can cause the failure of operating equipment and weakening of construction assemblies, thus threatening the lives of humans, and accelerating the consump...
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Cutaneous Lupus Erythematosus (CLE) is a form of lupus that affects the skin and is highly sensitive to ultraviolet (UV) light. UV-B. in particular. can trigger inflammation and apoptosis in CLE patients. making a sun...
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Retinal ganglion cells(RGCs)receive synaptic inputs through their dendritic trees in the inner plexiform layer(IPL)and convey the visual information via their axons which form the optic nerve to the brain(Sanes and Ma...
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Retinal ganglion cells(RGCs)receive synaptic inputs through their dendritic trees in the inner plexiform layer(IPL)and convey the visual information via their axons which form the optic nerve to the brain(Sanes and Masland,2015).In glaucoma,RGCs and their axons degenerate and die,leading to irreversible vision loss and eventually blindness if left untreated(Quigley,2016).
Development of Brain Computer Interface (BCI) has been rapid since the mid 1990's. There are three criteria for BCI, (i) comfortability and possession of a suitable signal acquisition device, (ii) system validatio...
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Background: Acute respiratory distress syndrome (ARDS) is a severe condition where lung alveoli fill with fluid, depriving organs of oxygen and risking death. Mechanical ventilation is conventional for oxygen therapy,...
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Background: Acute respiratory distress syndrome (ARDS) is a severe condition where lung alveoli fill with fluid, depriving organs of oxygen and risking death. Mechanical ventilation is conventional for oxygen therapy, but extracorporeal membrane oxygenation (ECMO) may be needed for refractory ARDS cases. This study aims to compare ECMO's impact on mortality and hospital stay versus conventional treatment for patients aged 12 or older with moderate or severe ARDS in intensive care units (ICUs). Methodology: Four independent reviewers followed the PRISMA-P method for the review. The key question used the PICOS tool. Databases searched included Cochrane Library, Bireme, MEDLINE, EMBASE, Web of Science, Scielo, LILACS, and grey literature to minimize publication bias. Selected papers were randomized controlled trials (RCTs) without language restrictions, meeting predefined inclusion and exclusion criteria. RoB-2 assessed bias risk, and GRADE evaluated evidence quality. Mortality was analyzed using a fixed-effect PETO method (odds ratio), and hospital stay was treated as a continuous variable using inverse variance and standardized mean difference (SMD). Results: We found 3,774 articles and selected 6 studies with 1,050 participants. Of these, 519 were allocated to the intervention group (ECMO) and 531 to the conventional treatment group (MV). The risk of bias for 3 studies was "some concerns," and 3 were "high risk of bias," mainly due to "deviations from intended/planned interventions" and "selection of reported outcomes." The primary outcomes for 30-day, 60-day, 90-day, and 180-day mortality showed odds ratios of 0.90 (95% CI: 0.66–1.21), 0.78 (95% CI: 0.50–1.21), 0.90 (95% CI: 0.66–1.21), and 0.62 (95% CI: 0.36–1.06) respectively, with low heterogeneity (I2 0.10). The secondary outcomes for a total length of stay and ICU stay showed standardized mean differences of 0.39 (95% CI: 0.13–0.65) and 0.33 (95% CI: 0.05–0.60) respectively, with substantial heterogeneity (I2
Chronic kidney disease worldwide is currently on the rise and is a serious health problem. One of the important components that must be monitored is the Blood Leak Detector (BLD). In hemodialysis machines, BLD has an ...
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In this study, we developed a novel surface-enhanced Raman scattering (SERS) substrate formed by depositing silver nanoparticles (AgNPs) on a silver thin film-coated photoresist (PR) microcone array. The semiconductor...
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