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Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

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Acta Biomaterialia 2023年 170卷 344-359页

作者： Yeh, Ying-Yu Lin, Yi-Yun Wang, Ting-Teng Yeh, Yu-Jia Chiu, Ting-Hsiang Wang, Reuben Bai, Meng-Yi Yeh, Yi-Cheun Institute of Polymer Science and Engineering National Taiwan University Taipei Taiwan Institute of Biomedical Engineering National Taiwan University Taipei Taiwan Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Institute of Food Safety and Health National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Program National Taiwan University Taipei Taiwan GIP-TRIAD Master's Degree in Agro-Biomedical Science National Taiwan University Taipei Taiwan

Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-PEG) has been developed to fabricate PPS-based hydrogels;however, current PXS-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXS-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXS-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPS-based hydrogels for advanced biomedical applications. Statement of significance: Various strategies have been developed to fabricate poly(polyol sebacate) (PPS)-based hydrogels. However, current PPS-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-

关键词： Polyols

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A Proposed Model for Calculate the Number of Mammography Machines for the South-West Area of Mexico 9th

A Proposed Model for Calculate the Number of Mammography Mac...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Martinez-Licona, Fabiola M. Martinez-Vazquez, Cipactli M. Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexico City Mexico Universidad Autonoma Metropolitana Biomedical Engineering Academic Program Iztapalapa Mexico City Mexico

ISBN: (纸本)9783031494093

Breast cancer is a global health problem. Mexican statistics show that 28.2% of new cancer cases in women come from the breast, so efforts must be made to control the burden of the disease. Early detection is an essential part of the social programs aimed at female populations at potential risk, and mammography machines are the technology used to perform screening methods. The possible coverage of a region is mainly affected by the available technological resources. This paper presents a proposal model to determine the number of mammography machines required to meet the State’s requirements of Guerrero, Oaxaca and Chiapas, as those in which there are municipalities with the highest social backwardness. The socioeconomic and demographic determinants, as well as the screening mammography demand data, were extracted from official Mexican agencies. The model variables were selected from the categories of target population, epidemiological indicators and infrastructure. Under the author’s heuristic assumptions, the analytic hierarchy process produced the weight that led to selecting the final set of variables. The resource allocation principles were used to adapt the Resource Allocation Working Party (RAWP) focus formula from population to equipment to calculate the State Weighted Machines using the mentioned category adjustments. Model results with 2017 and 2020 data showed that, on average, 50% more mammography machines are needed to cover around 46% of the female population 50–64 years old in the studied States. Further study and analysis of the determinants of access to the service and the equipment proposals are necessary. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Resource allocation

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Analysis of Failure Causes in the Mammography Machines 9th

Analysis of Failure Causes in the Mammography Machines

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Hernandez-Contreras, Indira Martinez-Licona, Fabiola M. Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexico City Mexico Universidad Autonoma Metropolitana Biomedical Engineering Academic Program Iztapalapa Mexico City Mexico

ISBN: (纸本)9783031494093

Patient safety arises from the need to prevent and protect patients from avoidable mistakes. Two fundamental concepts that shape patient safety are error and adverse events, the consequences may range from potentially dangerous complications, slow recoveries, high medical costs, or unnecessary deaths. Breast cancer has become a global health problem with one of the most expensive burdens among non-communicative diseases. Since screening mammography is the most used method for tumor identification, patient safety applied to this technology is focused on delivering safe and effective service that results in an accurate and reliable diagnosis. This paper presents the analysis of the causes that can induce a potential failure in the mammography machine, and the actions to correct them. We used a risk analysis approach to identify the failures that may occur while using a mammography machine in screening programs. We extracted the information about the failures from specialized consultation and discussion forums and technical and operation manuals. We adapted the concepts of severity, occurrence, and detection involved in calculating the risk priority number according to the Failure Mode and Effects Analysis method, assigning them one of three levels (low, medium, and high). The adapted risk priority level was calculated from the averaged product of levels from the mentioned components. The results were mapped into an Ishikawa diagram, and an action procedure proposal was shown. The causes found are defined mainly concerning the handling of the equipment components, although causes related to the acquisition technique, patient handling, and availability of support information. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Risk assessment

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Modeling gut neuro-epithelial connections in a novel microfluidic device

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Microsystems & Nanoengineering 2023年第6期9卷 235-246页

作者： Jose M.de Hoyos-Vega Xi Yu Alan M.Gonzalez-Suarez Sisi Chen Arnaldo Mercado-Perez Eugene Krueger Jeric Hernandez Yaroslav Fedyshyn Brooke R.Druliner David R.Linden Arthur Beyder Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Enteric Neuroscience Program(ENSP) Mayo ClinicRochesterMNUSA Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMNUSA

The intestinal lumen is filled with diverse chemical and physical *** epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract ***,the neuro-epithelial connections remain poorly resolved,in part because the tools for orchestrating interactions between these cellular compartments are *** describe the development of a two-compartment microfluidic device for co-culturing enteric neurons with intestinal epithelial *** device contains epithelial and neuronal compartments connected by *** epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal *** demonstrated that organoids planarized effectively and retained epithelial phenotype for over a *** the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary afferent neurons(IPANs)from transgenic mice that expressed the fluorescent protein *** extended projections into microgrooves,surrounded and frequently made contacts with epithelial *** density and directionality of neuronal projections were enhanced by the presence of epithelial cells in the adjacent *** microfluidic device represents a platform that may,in the future,be used to dissect structure and function of neuro-epithelial connections in the gut and other organs(skin,lung,bladder,and others)in health and disease.

关键词： fluid bladder organs

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Computational Analysis of Mechanical Interactions between a Soft Robotic Device and a Skin-Muscle Phantom for Mechanotherapy 46

Computational Analysis of Mechanical Interactions between a ...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Ticllacuri, Victor Mio, Renato Biomedical Engineering Program PUCP-UPCH Lima Peru Pontificia Universidad Catolica del Peru Laboratory of Biomechanics and Applied Robotics Lima Peru Universidad Peruana Cayetano Heredia Laboratory of Biomedical Engineering Lima Peru University of Bayreuth Germany

ISBN: (纸本)9798350371499

Studying the soft robot-tissue mechanical interaction in muscle stimulation devices poses a significant challenge due to the complex behavior of the materials involved. To advance this field, this paper models computationally three types of soft elastomeric actuators designed to perform deep cyclic compression stimuli on human soft tissues for muscle rehabilitation by mechanotherapy. The analysis focuses on the interaction between a phantom representing transversely isotropic muscle and homogeneous skin, with a soft robotic device comprised of a hyperelastic actuator and a rigid support. Results from deformation, stress-strain and surface pressure analysis demonstrate efficient actuation, suggesting deep and focused stimulation on the muscle, while actuators exhibit reliable safety factors and load distribution, implying longer operational life. This lightweight and compact soft robotic device is suitable for integration into a wearable suit for targeted muscle groups stimulation in the lower limbs. Furthermore, this computational approach represents a significant advance in the biomechanical study of soft robot-human tissues interaction, with potential for generalization in similar biomedical device applications. Keywords - Soft Robotics, Mechanotherapy, Transversely Isotropic Muscle, Human-Robot interaction. © 2024 IEEE.

关键词： Phantoms

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Analyzing Significance of Facial Features for Detection of Parkinson's Disease via Static Images 4

Analyzing Significance of Facial Features for Detection of P...

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4th IEEE International Conference on Electronic Communications, Internet of Things and Big Data, ICEIB 2024

作者： Chiu, Chuang-Chien Yeh, Shoou-Jeng Sun, Yen-Chi Feng Chia University Department of Automatic Control Engineering Taichung Taiwan Cheng-Ching General Hospital Section of Neurology and Neurophysiology Taichung Taiwan Feng Chia University Master's Program of Biomedical Informatics and Biomedical Engineering Taichung Taiwan

ISBN: (纸本)9798350360721

Parkinson's disease (PD) is a neurodegenerative disorder often characterized by motor symptoms such as hypomimia, and a reduction in facial expression. We explored the significance of facial features in identifying PD through static images, focusing on detecting hypomimia. A dataset comprised of PD patients and healthy controls' static facial images were collected and analyzed. Facial feature detection was conducted using OpenCV and Dlib libraries for the precise localization of key landmarks. In the subsequent feature extraction, parameters such as symmetry, eye aspect ratio, mouth corner distance, muscle tension, and mouth aperture ratio were used. Through the standardization of these features, meaningful comparisons across diverse images were made. By analyzing hypomimia-related features alongside traditional facial parameters, the results provide a comprehensive understanding of the role of facial expressions in PD diagnosis. The findings suggested that examining facial features in static images enhances the accuracy of PD detection and understanding of the nuanced motor symptoms associated with the disease. © 2024 IEEE.

关键词： Feature extraction

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Beyond skills: building research capacity through cognitive apprenticeship and social capital

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Australasian Journal of engineering Education 2023年第1期28卷 97-109页

作者： Jensen, Karin J. Miller, Isabel M. Suresh, Deepthi E. Martin, Julie P. Department of Biomedical Engineering University of Michigan Ann ArborMI United States Engineering Education Research Program University of Michigan Ann ArborMI United States Engineering Education Transformations Institute University of Georgia AthensGA United States

International calls for building capacity in engineering education research (EER) as a discipline have led to the development of workshops, training programs, and resources for scholars to learn and practice EER. Building capacity in EER as a discipline depends not only on the research skills of scholars, but also their sustained engagement in the discipline through the development of strong social networks. Understanding how scholars develop robust social networks through mentorship will support building research capacity in the field. This study was designed to answer the research question: How do established engineering education researchers help new engineering education researchers build social capital for EER through mentoring relationships? It draws on semi-structured interviews leveraging critical incident technique conducted with nine participants: two mentors and seven mentees. The findings suggest that mentors serve critical roles in the professional development of engineering faculty (academics) in EER as a discipline, providing training in methods and theories, developing mentees’ social networks, and providing moral support for entering a new field. Building capacity efforts and related structured mentoring programs (and mentoring training) should emphasise the importance of developing mentees’ social networks to support sustained engagement in EER. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： engineering education

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Joint Coordination to Maintain Postural Balance Differs Between Preferred and Non-preferred Lower Limbs 9th

Joint Coordination to Maintain Postural Balance Differs Betw...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Rinaldin, C.D.P. Silva, V.A. Campos, D.P. Manffra, E.F. Pontifical Catholic University of Parana Graduate Program on Health Technology Rua Imaculada Conceição 1155 Curitiba Brazil Federal University of Technology Graduate Program in Biomedical Engineering Curitiba Brazil

ISBN: (纸本)9783031494062

The maintenance of postural balance depends on coordinated actions between the joints on both sides of the body. Although biomechanical modeling studies assume symmetry between the sides of the body in the control of postural balance, it is known that lateral preference makes the lower limbs functionally asymmetric in people without neurological impairment. However, it remains inconclusive whether the coordination between joint and segmental angles to maintain balance differs between the lower limbs according to lateral preference. The study investigated the coordination of joint and segmental angles for preferred (right) and non-preferred (left) lower limb movement for static and dynamic tasks during a single-legged postural task. Eighteen healthy young adults in single-legged upright posture were evaluated. The angular variability was assessed by analyzing the first eight principal components. The cross-correlation analysis between the main components and the angles examined showed that when the support on the ground was on the non-preferred lower limb, there was greater participation of the upper segments compared to the support of the preferred limb. The preferred support of the lower limb on the ground generated angular variability among the participants in the hip, knee, and ankle joints, that is, the most distal part of the body. There is a wide range of strategies for distributing the variability of the principal components between the original angles on the left side. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Degrees of freedom (mechanics)

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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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Downsizing and soft X-ray tomography for cellular uptake of interpenetrated metal-organic frameworks

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Journal of Materials Chemistry B 2024年第25期12卷 6079-6090页

作者： Yu, Yu-Sheng Liang, Yung-Yi Hsieh, Chia-Chun Lin, Zi-Jing Cheng, Po-Hsiu Cheng, Chih-Chan Chen, Shu-Ping Lai, Lee-Jene Wu, Kevin C.-W. National Taiwan University Department of Chemical Engineering Taipei Taiwan National Health Research Institute Institute of Biomedical Engineering and Nanomedicine Miaoli Taiwan Hsinchu Taiwan International Graduate Program of Molecular Science and Technology Taiwan International Graduate Program Academia Sinica Taipei Taiwan National Taiwan University Taipei Taiwan

Metal-organic frameworks (MOFs) are porous materials with potential in biomedical applications such as sensing, drug delivery, and radiosensitization. However, how to tune the properties of the MOFs for such applications remains challenging. Herein, we synthesized two MOFs, Zr-PEB and Hf-PEB. Zr-PEB can be classified as porous interpenetrated zirconium frameworks (PIZOFs) and Hf-PEB is its analogue. We controlled their sizes while maintaining their crystal structure by employing a coordination modulation strategy. They were designed to serve as sensitizer for X-ray therapy and as potential drug carriers. Comprehensive characterizations of the MOFs' properties have been conducted, and the in vitro biological impacts have been studied. Since viability assay showed that Hf-PEB was more biocompatible compared to Zr-PEB, the cellular uptake of Hf-PEB by cells was evaluated using both fluorescence microscopy and soft X-ray tomography (SXT), and the three-dimensional structure of Hf-PEB in cells was observed. The results revealed the potential of Zr-PEB and Hf-PEB as nanomaterials for biomedical applications and demonstrated that SXT is an effective tool to assist the development of such materials. © 2024 The Royal Society of Chemistry.

关键词： Organometallics

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