The motor impairments that stroke patients experience as a primary contributor to death and disability also impact their quality of life. Due to its characteristics as complex muscle signals, the Electromyograph (EMG)...
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Objective: Analyze the static degradation time of polydioxanone (PDO) threads with or without the association of microfocused ultrasound, which are techniques for aesthetic purposes. Materials and Methods: In vitro as...
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Nowadays, industrial processes are creating increasing demands for optimized and efficient sensing systems and require high reliability and a short time interval for information delivery. This paper presents an embedd...
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The precise detection of cephalometric landmarks on two-dimensional (2D) radiographs or three-dimensional (3D) computed tomography (CT) images is a fundamental step in various medical fields, especially in research on...
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Treatments of disuse-induced muscle atrophy entail unmet clinical needs due to the lack of medical devices capable of mimicking physicians manual therapies. Therefore, in this paper we develop and model a wearable sof...
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This study presents a smart guidewire developed to measure the pressure inside blood vessels during minimally invasive surgery. The use of pressure sensor guidewires enables the medical doctor to make a judgement of t...
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Transplanting cell cultured brown adipocytes(BAs)represents a promising approach to prevent and treat obesity(OB)and its associated metabolic disorders,including type 2 diabetes mellitus(T2DM).However,transplanted BAs...
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Transplanting cell cultured brown adipocytes(BAs)represents a promising approach to prevent and treat obesity(OB)and its associated metabolic disorders,including type 2 diabetes mellitus(T2DM).However,transplanted BAs have a very low survival rate in *** enzymatic dissociation during the harvest of fully differentiated BAs also loses significant *** is a critical need for novel methods that can avoid cell death during cell preparation,transplantation,and in ***,we reported that preparing BAs as injectable microtissues could overcome the *** found that 3D culture promoted BA differentiation and UCP-1 expression,and the optimal initial cell aggregate size was 100μ*** microtissues could be produced at large scales via 3D suspension assisted with a PEG hydrogel and could be *** microtissues could survive in vivo for long *** alleviated body weight and fat gain and improved glucose tolerance and insulin sensitivity in high-fat diet(HFD)-induced OB and T2DM *** microtissues impacted multiple organs,secreted protein factors,and influenced the secretion of endogenous *** our best knowledge,this is the first report on fabricating human BA microtissues and showing their safety and efficacy in T2DM *** proposal of transplanting fabricated BA microtissues,the microtissue fabrication method,and the demonstration of efficacy in T2DM mice are all *** results show that engineered 3D human BA microtissues have considerable advantages in product scalability,storage,purity,safety,dosage,survival,and efficacy.
In the context of diagnostic reference levels (DRLs), typical values of mean glandular dose were established from a survey of mammographic examinations performed in a university hospital in Curitiba, Paraná, Braz...
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Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and *** decades,treatment modalities for these disorders have focused o...
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Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and *** decades,treatment modalities for these disorders have focused on addressing neuronal malfu nction,which has resulted in the failure of *** studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory ***,the major immune component of the central nervous system (CNS),undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al.,2022).
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