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3rd International Congress of Biomedical Engineering and bioengineering, CIIBBI 2024

作者： Baquero Silva, Laura Sofia Garzon Garzon, Maria Alejandra Vega-Medina, Lizeth Luengas, Carlos Paez Universidad El Bosque Faculty of Engineering Bioengineering Program Bogotá Colombia Universidad El Bosque Osiris and Bioaxis Bioengineering Program Bogotá Colombia Bogotá Colombia

ISBN: (纸本)9798331532352

Cataracts are a frequent cause of blindness in canines, and their timely diagnosis and treatment are crucial to preserve the animal's quality of life. Although surgery is the primary treatment, its success depends on the surgeon's skill;the extracapsular extraction technique, one of the most commonly used, presents intraoperative complications since cadaver training does not adequately replicate the ocular biomechanical properties. A simulator prototype has been developed for the training of this technique, which allows realistic practices and improves professional competence. The development involved the characterization of the eye and the surgical technique using a bibliographic and experimental review, as well as a biomechanical analysis of the eye considering the forces generated by the extraocular muscles and the force required for the initial incision in the sclera (2.36 N), which an electronic system will measure during the procedure. In the design stage, CAD tools, 3D printing, and casting techniques were used to obtain the parts that simulate the tissues, the mesocephalic head of the canine, and strain gauges were used to measure the force set using a Wheatstone bridge. A first evaluation showed improvements in terms of size and arrangement of the interchangeable parts. © 2024 IEEE.

关键词： Transplantation (surgical)

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Decoding Movement Initiation in a Brain-computer Interface for Real-Time Speech Synthesis 58

Decoding Movement Initiation in a Brain-computer Interface f...

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58th Asilomar Conference on Signals, Systems and Computers, ACSSC 2024

作者： Okomeng, Belinda Brumberg, Jonathan S. University of Kansas Bioengineering Program LawrenceKS66045 United States University of Kansas Department of Psychology Bioengineering Program LawrenceKS66045 United States

ISBN: (纸本)9798350354058

In this study, we conducted a time frequency analysis of EEG signals collected in a limb motor imagery brain-computer interface (BCI) paradigm to identify features useful for predicting and decoding onset and termination of imagined movement. Participants used the BCI to control a formant frequency speech synthesizer to produce three different vowel sounds. A previous analysis focused on decoding formant frequencies for BCI control. The results of this study found increases in theta-band amplitude (3-7 Hz) across all participants at the beginning and ending of motor imagery periods (approximately 500 ms after the onset cue and 500 ms after the termination cue). A Kalman Filter was then designed to decode the onset and termination signals from a calibration period and tested on the experimental EEG data recorded from each participant. Initial results show the Kalman filter predicted onset and termination from unseen data that correlates with increases in theta-band amplitude. Our findings, when combined with our prior formant frequency decoding, will improve the overall performance of the BCI by focusing the decoder only on time intervals during which participants are actively engaged in the BCI task. © 2024 IEEE.

关键词： Kalman filters

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Customized 3D-Printed Prototype Mold for Potential HDR Brachytherapy in Facial Non-Melanoma Skin Cancer 3

Customized 3D-Printed Prototype Mold for Potential HDR Brach...

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3rd International Congress of Biomedical Engineering and bioengineering, CIIBBI 2024

作者： Quevedo-Linares, Hector Vega-Medina, Lizeth Universidad El Bosque Osiris and Bioaxis - Bioengineering Program Bogotá Colombia

ISBN: (纸本)9798331532352

Surface mold brachytherapy (SMBT) is an appropriate and effective treatment for non-melanoma skin cancer (NMSC). Manual manufacturing methods allow the development of personalized molds. However, it causes inconsistencies in the dosimetry of the established treatment plan, mainly due to the air gaps between the patient dermal surface and the mold. This work is focused on developing a manufacturing methodology for a prototype of a custom mold through additive manufacturing for potential application in BT in patients with NMSC. © 2024 IEEE.

关键词： Dermatology

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Design and Development of a System to Wake Up People with Hearing Loss Based on Biodesign Methodology 3

Design and Development of a System to Wake Up People with He...

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3rd International Congress of Biomedical Engineering and bioengineering, CIIBBI 2024

作者： Camacho-Nino, Natalia Charry-Retavizca, Martin F. Cordoba-Fernandez, Guillermo Rodriguez-Duenas, William R. Pontificia Universidad Javeriana Bioengineering Program Faculty of Engineering Bogota110231 Colombia

ISBN: (纸本)9798331532352

Hearing loss represents 20% of the world's population, while in Colombia this condition reaches the 1,2%. It is a condition in which activities of daily living, such as waking up in the morning, can become a challenge. Some technologies have been implemented but difficulties such as the adaptability of the equipment, comfort regarding device design and effectiveness of the technology to wake the user remain in its use. Part of the success in the use of these technologies lies in a good needs identification stage, as is recommended for the Biodesign framework, a methodology to design and build health technologies. This work presents the design and development of an alternative system for the comfortable awakening of people with hearing loss, using the Biodesign methodology. The system obtained includes a tabletop device and a wireless portable instrument, with visual and tactile stimulation respectively. Preliminary results obtained show that the system is viable, and responds to basic needs identified. © 2024 IEEE.

关键词： Audition

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Phasor-FSTM:a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing

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Light(Science & Applications) 2025年第1期14卷 258-270页

作者： Luwei Wang Yue Chen Jiaqing Guo Xiaoyu Weng Wei Yan Jun Song Tong Ye Junle Qu Center for Biomedical Optics and Photonics&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen518060China The Photonics Center of Shenzhen University Shenzhen UniversityShenzhen518060China Department of Bioengineering CU-MUSC Bioengineering ProgramClemson UniversityCharlestonSouth Carolina29634USA

Multicolor microscopy and super-resolution optical microscopy are two widely used techniques that greatly enhance the ability to distinguish and resolve structures in cellular *** methods have individually transformed cellular imaging by allowing detailed visualization of cellular and subcellular structures,as well as organelle ***,integrating multicolor and super-resolution microscopy into a single method remains challenging due to issues like spectral overlap,crosstalk,photobleaching,phototoxicity,and technical *** challenges arise from the conflicting requirements of using different fluorophores for multicolor labeling and fluorophores with specific properties for super-resolution *** propose a novel multicolor super-resolution imaging method called phasor-based fluorescence spatiotemporal modulation(Phasor-FSTM).This method uses time-resolved detection to acquire spatiotemporal data from encoded photons,employs phasor analysis to simultaneously separate multiple components,and applies fluorescence modulation to create super-resolution ***-FSTM enables the identification of multiple structural components with greater spatial accuracy on an enhanced laser scanning confocal microscope using a single-wavelength *** demonstrate the capabilities of Phasor-FSTM,we performed two-color to four-color super-resolution imaging at a resolution of~λ/5 and observed the interactions of organelles in live cells during continuous imaging for a duration of over 20 *** method stands out for its simplicity and adaptability,seamlessly fitting into existing laser scanning microscopes without requiring multiple laser lines for excitation,which also provides a new avenue for other super-resolution imaging technologies based on different principles to build multi-color imaging systems with the requirement of a lower budget.

关键词： resolution lifetime simplicity

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Visualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient

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Microsystems & Nanoengineering 2023年第1期9卷 191-202页

作者： Kai Duan Mengyang Zhou Yong Wang Jose Oberholzer Joe F.Lo Department of Mechanical Engineering Bioengineering ProgramUniversity of Michigan at DearbornDearbornMI48128USA Department of Surgery/Transplant University of VirginiaCharlottesvilleVA22908USA

One distinct advantage of microfluidic-based cell assays is their scalability for multiple concentrations or *** scaling can be extremely powerful when combining multiple parameters and ***,in situ stimulation and detection eliminates variability between individual ***,conventional microfluidics must combat diffusion,which limits the spatial distance and time for molecules traveling through ***,we leveraged a multilayered microfluidic approach to integrate a novel oxygen gradient(0–20%)with an enhanced hydrogel sensor to study pancreatic beta *** enabled our microfluidics to achieve spatiotemporal detection that is difficult to achieve with traditional *** this device,we demonstrated the in situ detection of calcium,insulin,and ATP(adenosine triphosphate)in response to glucose and oxygen ***,insulin was quantified at levels as low as 25 pg/mL using our imaging ***,by analyzing the spatial detection data dynamically over time,we uncovered a new relationship between oxygen and beta cell *** observed an optimum oxygen level between 10 and 12%,which is neither hypoxic nor normoxic in the conventional cell culture *** results provide evidence to support the current islet oscillator *** future applications,this spatial microfluidic technique can be adapted for discrete protein detection in a robust platform to study numerous oxygen-dependent tissue dysfunctions.

关键词： hypoxic stimulation gradient

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In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles

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Nano Research 2023年第1期16卷 1009-1020页

作者： Liqin Ren Yang Liu Tingfeng Yao Kytai TNguyen Baohong Yuan Ultrasound and Optical Imaging Laboratory Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Program the University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineering the University of Texas at ArlingtonArlingtonTX 76019USA

Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment *** particular,ultrasound switchable fluorescence(USF)imaging has been explored with improved imaging sensitivity and spatial resolution in centimeter-deep *** study achieved the size control of polymer-based and indocyanine green(ICG)encapsulated USF contrast agents,capable of accumulating in the tumor after intravenous *** nanoprobes varied in size from 58 to 321 *** bioimaging profiles demonstrated that the proposed nanoparticles can efficiently eliminate the background light from normal tissue and show a tumor-specific fluorescence enhancement in the BxPC-3 tumor-bearing mice models possibly via the enhanced permeability and retention *** vivo tumor USF imaging further demonstrated that these nanoprobes can effectively be switched“ON”with enhanced fluorescence in response to a focused ultrasound stimulation in the tumor microenvironment,contributing to the high-resolution USF ***,our findings suggest that ICG-encapsulated nanoparticles are good candidates for USF imaging of tumors in live animals,indicating their great potential in optical tumor imaging in deep tissue.

关键词： in vivo tumor imaging deep tissue near-infrared(NIR)imaging high resolution ultrasound-switchable fluorescence imaging indocyanine green(ICG)

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Targeted chemotherapy via HER2-based chimeric antigen receptor(CAR)engineered T-cell membrane coated polymeric nanoparticles

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Bioactive Materials 2024年第4期34卷 422-435页

作者： Serkan Yaman Harish Ramachandramoorthy Priyanka Iyer Uday Chintapula Tam Nguyen Manoj Sabnani Tanviben Kotadia Soroush Ghaffari Laurentiu M.Pop Raquibul Hannan Jon A.Weidanz Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonTXUSA Department of Biology University of Texas at ArlingtonTXUSA Joint Bioengineering Program University of Texas Southwestern Medical CenterTXUSA Department of Radiation Oncology University of Texas Southwestern Medical CenterTXUSA Department of Kinesiology University of Texas at ArlingtonArlingtonTXUSA

Cell membrane-derived nanoparticles(NPs)have recently gained popularity due to their desirable features in drug delivery such as mimicking properties of native cells,impeding systemic clearance,and altering foreign body *** NP technology,adoptive immunotherapy has emerged due to its promise in cancer specificity and therapeutic *** this research,we developed a biomimetic drug carrier based on chimeric antigen receptor(CAR)transduced T-cell *** that purpose,anti-HER2 CAR-T cells were engineered via lentiviral transduction of anti-HER2 CAR coding lentiviral ***-HER2 CAR-T cells were characterized by their specific activities against the HER2 antigen and used for cell membrane ***-cancer drug Cisplatin-loaded poly(D,L-lactide-co-glycolic acid)(PLGA)NPs were coated with anti-human epidermal growth factor receptor 2(HER2)-specific CAR engineered T-cell ***-HER2 CAR-T-cell membrane-coated PLGA NPs(CAR-T-MNPs)were characterized and confirmed via fluorescent microscopy and flow ***-coated NPs showed a sustained drug release over the course of 21 days in physiological ***-loaded CAR-T-MNPs also inhibited the growth of multiple HER2+cancer cells in *** addition,in vitro uptake studies revealed that CAR-T-MNPs showed an increased uptake by A549 *** results were also confirmed via in vivo biodistribution and therapeutic studies using a subcutaneous lung cancer model in nude ***-T-MNPs localized preferentially at tumor areas compared to those of other studied groups and consisted of a significant reduction in tumor growth in tumor-bearing *** Conclusion,the new CAR modified cell membrane-coated NP drug-delivery platform has demonstrated its efficacy both in vitro and in ***,CAR engineered membrane-coated NP system could be a promising cell-mimicking drug carrier that could improve therapeutic outcomes of lung cancer treatments.

关键词： Nanoparticles CAR-T cells Membrane-based drug delivery Cancer chemotherapy

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Micro-electrode array (MEA) electrophysiological signal analysis by descriptive stochastic tests of the probability density structure

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Research on Biomedical Engineering 2025年第2期41卷 1-13页

作者： Faria, Vinícius Naves Rezende Ramos, Marina Abadia Martinoia, Sérgio Destro-Filho, João-Batista Postgraduate Program in Electrical Engineering Universidade Federal de MG Uberlândia Brazil Postgraduate Program in Biomedical Sciences Universidade Federal de MG Uberlândia Brazil Division of Informatics Bioengineering Robotics and System Engineering Università Degli Studi Di Genova Genova Italy

Purpose: The primary objective of this study is to present, analyze, and quantitatively characterize the electrical signals obtained from neuronal cultures coupled to micro-electrode arrays (MEAs). Special attention is given to the temporal evolution of electrical activity across distinct geometric regions of the MEA devices. Methods: The proposed methodology involves signal acquisition, classical analysis based on spike and burst detection, and, critically, the characterization of the probability density structure of the signals. This is achieved through the quantification of Gaussianity—expressed as the percentage of segments non-Gaussian (PSNG)—and stationarity— expressed as the percentage of segments non-stationary (PSNE). Results: Initial analyses showed that first-order power spectral density quantifiers lacked the statistical robustness required to effectively describe the complex components of MEA signals. In contrast, PSNG and PSNE demonstrated strong potential in capturing the different stages of neuronal culture development. Cluster analysis further supported the discriminative capacity of these quantifiers. Conclusion: The phase corresponding to decreased neuronal activity and onset of cell death—a biologically critical stage—exhibited the strongest correlation among the studied variables. These results suggest a discernible biological organization and highlight the relevance of PSNG and PSNE as promising tools for assessing neuronal culture dynamics. © The Author(s), under exclusive licence to The Brazilian Society of Biomedical Engineering 2025.

关键词： Cell death

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Decoding Movement Initiation in a Brain-computer Interface for Real-Time Speech Synthesis

Decoding Movement Initiation in a Brain-computer Interface f...

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Asilomar Conference on Signals, Systems & Computers

作者： Belinda Okomeng Jonathan S. Brumberg Bioengineering Program University of Kansas Lawrence KS Department of Psychology Bioengineering Program University of Kansas Lawrence KS

ISBN: (数字)9798350354058

ISBN: (纸本)9798350354065

In this study, we conducted a time frequency analysis of EEG signals collected in a limb motor imagery brain-computer interface (BCI) paradigm to identify features useful for predicting and decoding onset and termination of imagined movement. Participants used the BCI to control a formant frequency speech synthesizer to produce three different vowel sounds. A previous analysis focused on decoding formant frequencies for BCI control. The results of this study found increases in theta-band amplitude (3–7 Hz) across all participants at the beginning and ending of motor imagery periods (approximately 500 ms after the onset cue and 500 ms after the termination cue). A Kalman Filter was then designed to decode the onset and termination signals from a calibration period and tested on the experimental EEG data recorded from each participant. Initial results show the Kalman filter predicted onset and termination from unseen data that correlates with increases in theta-band amplitude. Our findings, when combined with our prior formant frequency decoding, will improve the overall performance of the BCI by focusing the decoder only on time intervals during which participants are actively engaged in the BCI task.

关键词： Electrodes Time-frequency analysis Scalp Motors Decoding Calibration Planning Kalman filters Oscillators Frequency control

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