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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Xuanteng Yan Marie-Hélène Boudrias Georgios D. Mitsis Graduate Program in Biological and Biomedical Engineering McGill University Montréal Canada School of Physical & Occupational Therapy McGill University Montréal Canada Department of Bioengineering McGill University Montréal Canada

There is increasing evidence that the effects of non-invasive brain stimulation can be maximized when the applied intervention matches internal brain oscillations. Extracting individual brain oscillations is thus a necessary step for implementing personalized brain stimulation. In this context, different methods have been proposed for obtaining subject-specific spectral peaks from electrophysiological recordings. However, comparing the results obtained using different approaches is still lacking. Therefore, in the present work, we examined the following methodologies in terms of obtaining individual motor-related EEG spectral peaks: fast Fourier Transform analysis, power spectrum density analysis, wavelet analysis, and a principal component based time-frequency analysis. We used EEG data obtained when performing two different motor tasks – a hand grip task and a hand opening- and-closing task. Our results showed that both the motor task type and the specific method for performing the analysis had considerable impact on the extraction of subject-specific oscillation spectral *** Relevance—This exploratory study provides insights into the potential effects of using different methods to extract individual brain oscillations, which is important for designing personalized brain-machine-interfaces.

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Camera-based Motion Correction for PET/MR Brain Imaging

Camera-based Motion Correction for PET/MR Brain Imaging

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2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022

作者： Fisher, Jonathan Groll, Andrew Kim, Chris C. Innes, Derek Levin, Craig S. Stanford University Department of Electrical Engineering CA United States Molecular Imaging Program Stanford University Department of Radiology CA United States Stanford University Department of Computer Science CA United States Stanford University Physics Electrical Engineering and Bioengineering Department of Radiology CA United States

ISBN: (纸本)9781665488723

In this work, we evaluated the performance of a camera-based rigid body motion correction solution in PET studies. We compared the image quality obtained by reconstructing a static phantom scan to those obtained by reconstructing a moving phantom scan with and without applying motion correction. Our suggested solution uses a camera to track a 3D marker attached to the object to be imaged (in this work, a resolution phantom). This data was incorporated in the multiple acquisition frames (MAF) image reconstruction algorithm to compensate for motion. While we got multiple spatially shifted replicas of the resolution phantom in the motion study's reconstructed image when motion correction was not applied, the motion-corrected image was comparable to the static image, with some degradation in spatial resolution (3.2-4.2 vs. 2.8-3.2 mm) and lower peak to valley ratio (indicating lower contrast to noise ratio). The context of the results presented is in PET/MR imaging, but in principle, this motion compensation method could be used in any type of medical imaging modality. © 2022 IEEE.

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AllWeather-UsableWearable Dual Energy Harvester for Outdoor Sustainable Operation

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SusMat 2025年第1期5卷 159-170页

作者： Yeongju Jung Jiyong Ahn Ji-Seok Kim Junhyuk Bang Minwoo Kim Seongmin Jeong Jinwoo Lee Seonggeun Han Il-Kwon Oh Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulRepublic of Korea National Creative Research Initiative for Functionally Antagonistic Nano-Engineering Department of Mechanical EngineeringSchool of Mechanical and Aerospace EngineeringKorea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Mechanical Roboticsand Energy EngineeringDongguk UniversitySeoulRepublic of Korea Device Solutions Research Samsung ElectronicsHwaseong-siRepublic of Korea Institute of Engineering Research/Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoulRepublic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoulRepublic of Korea

Sustainable power sources for outdoor wearable electronics are essential for the continuous operation of wearable ***,the current lack of engineering design that can harvest energy regardless of weather conditions presents a significant *** this regard,this study introduces a wearable,breathable all-weather usable dual energy harvester(AWuDEH)that can seamlessly generate electrical energy regardless of weather *** this study,the AWuDEH integrated with the thermoelectric generator and the droplet-based electricity generator is *** AWuDEH,especially engineered with a bi-functional top substrate for radiative cooling and electrification,achieves sustainable energy harvesting outdoors,thereby addressing the conventional challenge associated with the necessity for separate energy harvesters tailored to outdoor usage contingent on weather *** device reaches a maximum power output of 14.6μW cm^(-2)under simulated sunny conditions and generates a much more enhanced thermoelectric power of 74.78μW cm^(-2)and a droplet-based electric power of 256.25 mW m^(-2)in rainy *** proof,this study developed self-powered wearable electronics capable of acquiring physiological signals in simulated outdoor *** study presents a promising advancement in wearable technology,offering a potent solution for sustainable energy harvesting independent of weather conditions.

关键词： all-weather usable droplet-based electricity generator hybrid architecture outdoor sustainable operation thermoelectric generator

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Comparative Analysis of Scaffold Fibre Diameter-Modulated Responses on Immortalized and Primary Thyroid Cells: Implications for Thyroid Regeneration

SSRN

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SSRN 2023年

作者： Heim, Maria Handley, Ella-Louise Emmerson, Elaine Callanan, Anthony Institute of Bioengineering School of Engineering University of Edinburgh Faraday Building King’s Buildings Colin Maclaurin Road EdinburghEH9 3DW United Kingdom Program in Craniofacial Biology

Primary hypothyroidism results from thyroid gland damage, commonly due to radiotherapy for head and neck cancer. Primary hypothyroidism severely impacts patient quality of life and is expected to increase in incidence due to the aging population and rising cancer survivor rates. Tissue engineering approaches are starting to emerge as a potential treatment. Electrospinning techniques have yet to be investigated in conjunction with thyroid tissue. Her, electrospun polycaprolactone scaffolds with varying fibre diameters were fabricated and their effects on immortalized human thyrocytes (Nthy-ori 3-1) and primary murine thyroid cells were investigated. Four groups of scaffolds were produced with fibre diameters ranging from approximately 0.5µm to 4µm, to understand the impact of these microenvironments on their potential for thyroid regeneration. Results showed that fibre size influence mechanical properties, porosity and cell response. *** 3-1 cells performed best on medium-sized fibres while primary cells preferred larger fibres. Nonetheless, smaller fibre diameters encouraged the secretion of collage-like fibrils, potentially indicating favourable conditions for regeneration. This study highlights the potential of electrospun PCL scaffolds as promising candidates for tissue engineering applications in the treatment of primary hypothyroidism. The findings demonstrate the importance of considering cell-type specific responses when designing biomaterials for tissue-engineered solutions for thyroid regeneration. Further research is necessary to elucidate the underlying mechanisms and optimize scaffold properties for successful thyroid tissue regeneration. © 2023, The Authors. All rights reserved.

关键词： Electrospinning

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Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

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Advanced Science 2025年第0期 e2417003页

作者： Jin, Yifu He, Fei Rathore, Haad Sun, Yingchu Zhang, Jia-ao Li, Xinyu Yin, Rongkang Zhu, Hanlin Xie, Chong Luan, Lan Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Neuroengineering Initiative Rice University HoustonTX77005 United States Applied Physics Program Rice University HoustonTX77005 United States Department of Bioengineering Rice University HoustonTX77005 United States

Microinfarcts, the "invisible lesions", are prevalent in aged and injured brains and associated with cognitive impairments, yet their neurophysiological impact remains largely unknown. Using a multimodal chronic neural platform that combines functional microvasculature imaging with spatially resolved neural recording, the neurovascular effect of a single microinfarct is investigated. Unlike larger strokes, microinfarcts induced only temporary suppression of neural activity with minimal cell death, with recovery paralleling vasculature remodeling at the infarct core. Neural activity is more severely suppressed at the shallower cortical layer despite milder vascular damage compared to deeper layers, and the excitability of fast-spiking interneurons attenuation is accompanied by heightened bursting of regular spiking neurons. Spike phase locking at the low-gamma band is disrupted, indicating a lasting impairment of long-range assembly communication. These results highlight the subtle yet significant neurovascular disruptions of a single microinfarct. © 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH.

关键词： Flexible electronics

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Interoperability at healthcare institutions in Brazil: framework for identify maturity stages

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Procedia Computer Science 2024年 239卷 2316-2321页

作者： Leandro Vasques Rui Rijo Domingos Alves Bioengineering Postgraduate Program University of São Paulo Brazil School of Technology and Management Polytechnic Institute of Leiria Portugal CINTESIS – Center for Health Technology and Services Research Portugal INESCC – Institute for Systems and Computers Engineering at Coimbra Portugal Ribeirão Preto Medical School University of São Paulo Brazil

There is a growing support from data management and analysis in the clinical and operational support at health services, impacting positively the patient outcome. Studies report that data management provides gains in productivity and raises the value of health services [1]. In this context, the interoperability of information systems (IS) at the environment of health services assumes an important role in spreading information and supporting different activities and procedures. The Brazilian government, through its Unified Health System (Sistema Único de Saúde – SUS), aimed to support and organize the growing use of data technology in the healthcare sector, formalizing protocols and concepts of interoperability used in both public and private health systems. Through applying this MF, it is expected to identify the state of interoperability at Brazilian healthcare institutions, defining a comparative scenario that allows the alignment of efforts in its strategic development in healthcare services, benefiting users and healthcare network.

关键词： Interoperability Framework Healthcare

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Maximum Likelihood Estimation for LOR Identification of Positron + Prompt Gamma Ray Emitters in Multiplexed PET (mPET)

Maximum Likelihood Estimation for LOR Identification of Posi...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： S. J. Zou G. Chinn C. S. Levin Electrical Engineering Stanford University Stanford California United States of America Stanford University Radiology Stanford California United States of America Electrical Engineering Bioengineering Physics Molecular Imaging Program Stanford University Radiology Stanford California United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

For many diseases applications, it is beneficial to simultaneously observe multiple biomarkers at a time. However, current PET systems are unable to image multiple tracers in one session due to annihilation photons being indistinguishable across radiotracers. However with the utilization of one or more positron emitting radionuclides that also emit a prompt gamma (positron + prompt gamma ray emitter), the latter signal can be used to unmix the tracer signals and facilitate multiplex PET or mPET. With the use of prompt-gamma-positron emitters, an issue arises with the correct identification of the two annihilation photons in a triple photon coincidence. In this work, we present a maximum likelihood estimation (MLE) framework that uses spatial, timing, and energy information to return the most probable line of response (LOR). We validate our method using simulated data. Results indicate we can achieve > 99% accuracy at identifying the correct LOR for a 22 Na source.

关键词： Multiplexing Maximum likelihood estimation Microwave integrated circuits Semiconductor detectors Gamma-rays Positrons Timing

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High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets

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Journal of Energy Chemistry 2022年第4期31卷 814-823页

作者： Jiae Um Seung Uk Yoon Hoseong Kim Beom Sik Youn Hyoung-Joon Jin Hyung-Kyu Lim Young Soo Yun Program in Environmental and Polymer Engineering Inha Universityncheon 22212 South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Gangwon-do 24341 South Korea KU-KIST Graduate School of Converging Science and Technologyea University 145 Anam-roSeongbuk-guSoul02841 South Korea Department of Integrative Energy Engineering 145 Anam-roSongbuk-guKorea UniversitySeoul 02841 South Korea

The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage *** is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage ***,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic ***-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À).

关键词： Turbostratic graphite Graphene nanosheet Defective carbon Anode Potassium-ion batteries

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The use of hydrogel microspheres as cell and drug delivery carriers for bone,cartilage,and soft tissue regeneration

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Biomaterials Translational 2024年第3期5卷 236-256页

作者： Chung-Hsun Lin Jesse RSrioudom Wei Sun Malcolm Xing Su Yan Le Yu Jian Yang Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPAUSA Department of Bioengineering University of PennsylvaniaPhiladelphiaPAUSA Leicester International Institute Dalian University of TechnologyPanjinLiaoning ProvinceChina Department of Mechanical Engineering University of ManitobaWinnipegCanada Division of Biological and Biomedical Systems University of Missouri-Kansas CityKansas CityMOUSA Biomedical Engineering Program Westlake UniversityHangzhouZhejiang ProvinceChina Research Centre for Industries of the Future Westlake UniversityHangzhouZhejiang ProvinceChina

Bone,cartilage,and soft tissue regeneration is a complex process involving many cellular activities across various cell *** remain the“gold standard”for the regeneration of these ***,the use of autografts is associated with many disadvantages,including donor scarcity,the requirement of multiple surgeries,and the risk of *** development of tissue engineering techniques opens new avenues for enhanced tissue ***,the expectations of tissue engineering scaffolds have gone beyond merely providing physical support for cell *** scaffolds should also provide biological cues to actively boost tissue *** a new type of injectable biomaterial,hydrogel microspheres have been increasingly recognised as promising therapeutic carriers for the local delivery of cells and drugs to enhance tissue *** to traditional tissue engineering scaffolds and bulk hydrogel,hydrogel microspheres possess distinct advantages,including less invasive delivery,larger surface area,higher transparency for visualisation,and greater flexibility for ***,we review the materials characteristics of hydrogel microspheres and compare their fabrication approaches,including microfluidics,batch emulsion,electrohydrodynamic spraying,lithography,and mechanical ***,based on the different requirements for bone,cartilage,nerve,skin,and muscle tissue regeneration,we summarize the applications of hydrogel microspheres as cell and drug delivery carriers for the regeneration of these ***,hydrogel microspheres are regarded as effective therapeutic delivery carriers to enhance tissue regeneration in regenerative ***,significant effort is required before hydrogel microspheres become widely accepted as commercial products for clinical use.

关键词： drug delivery fabrication techniques hydrogel microspheres microgels tissue regeneration

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Biomass-Based Discrete Furan Oligomers as Materials for Electrochromic Devices

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ACS Sustainable Chemistry and Engineering 2024年第1期12卷 459-469页

作者： Atayde, Eduardo C. Fong, Guan-Lun Yeh, Jyun-Yi Matsagar, Babasaheb M. Wang, Yu-Cheng Chen, De-Chian Peng, Chi-How Li, Yi-Pei Yamauchi, Yusuke Ho, Kuo-Chuan Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program (TIGP-MST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan Department of Chemistry National Tsing Hua University No. 101 Sec. 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Sustainable Chemical Science and Technology Program Taiwan International Graduate Program (TIGP-SCST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensl Brisbane 4072 QLD Australia Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan Institute of Polymer Science and Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd. Taipei 10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University No. 135 Yuandong Rd. Taoyuan 320 Taiwan

Electrochromic devices (ECDs) are materials that can undergo reversible changes in transmittance when exposed to different applied potentials. While many conjugated heterocyclic oligomers, such as oligothiophenes, have been developed for this purpose, there is no reported study on the use of discrete oligomeric furans as ECD materials. In this work, we introduce a furan trimer that can be utilized as a discrete electrochromic material, which transitions from light yellow to red and has a very high coloration efficiency of 1940 cm²/C at 507 nm. We propose that the reversible π-stack formation of the oligomer radical cations is behind this phenomenon, as evidenced by both experimental and computational results. The derivability of this oligomer from biomass and its facile synthesis make it an interesting alternative for other existing organic electrochromic materials. © 2023 American Chemical Society

关键词： electrochromism furan oligomer hydroxyalkylation−alkylation reaction solvatochromism π-stacks

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