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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： S. J. Zou G. Chinn C. S. Levin Electrical Engineering Stanford University Stanford California United States of America Stanford University Radiology Stanford California United States of America Electrical Engineering Bioengineering Physics Molecular Imaging Program Stanford University Radiology Stanford California United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

For many diseases applications, it is beneficial to simultaneously observe multiple biomarkers at a time. However, current PET systems are unable to image multiple tracers in one session due to annihilation photons being indistinguishable across radiotracers. However with the utilization of one or more positron emitting radionuclides that also emit a prompt gamma (positron + prompt gamma ray emitter), the latter signal can be used to unmix the tracer signals and facilitate multiplex PET or mPET. With the use of prompt-gamma-positron emitters, an issue arises with the correct identification of the two annihilation photons in a triple photon coincidence. In this work, we present a maximum likelihood estimation (MLE) framework that uses spatial, timing, and energy information to return the most probable line of response (LOR). We validate our method using simulated data. Results indicate we can achieve > 99% accuracy at identifying the correct LOR for a 22 Na source.

关键词： Multiplexing Maximum likelihood estimation Microwave integrated circuits Semiconductor detectors Gamma-rays Positrons Timing

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High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets

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Journal of Energy Chemistry 2022年第4期31卷 814-823页

作者： Jiae Um Seung Uk Yoon Hoseong Kim Beom Sik Youn Hyoung-Joon Jin Hyung-Kyu Lim Young Soo Yun Program in Environmental and Polymer Engineering Inha Universityncheon 22212 South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Gangwon-do 24341 South Korea KU-KIST Graduate School of Converging Science and Technologyea University 145 Anam-roSeongbuk-guSoul02841 South Korea Department of Integrative Energy Engineering 145 Anam-roSongbuk-guKorea UniversitySeoul 02841 South Korea

The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage *** is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage ***,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic ***-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À).

关键词： Turbostratic graphite Graphene nanosheet Defective carbon Anode Potassium-ion batteries

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The use of hydrogel microspheres as cell and drug delivery carriers for bone,cartilage,and soft tissue regeneration

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Biomaterials Translational 2024年第3期5卷 236-256页

作者： Chung-Hsun Lin Jesse RSrioudom Wei Sun Malcolm Xing Su Yan Le Yu Jian Yang Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPAUSA Department of Bioengineering University of PennsylvaniaPhiladelphiaPAUSA Leicester International Institute Dalian University of TechnologyPanjinLiaoning ProvinceChina Department of Mechanical Engineering University of ManitobaWinnipegCanada Division of Biological and Biomedical Systems University of Missouri-Kansas CityKansas CityMOUSA Biomedical Engineering Program Westlake UniversityHangzhouZhejiang ProvinceChina Research Centre for Industries of the Future Westlake UniversityHangzhouZhejiang ProvinceChina

Bone,cartilage,and soft tissue regeneration is a complex process involving many cellular activities across various cell *** remain the“gold standard”for the regeneration of these ***,the use of autografts is associated with many disadvantages,including donor scarcity,the requirement of multiple surgeries,and the risk of *** development of tissue engineering techniques opens new avenues for enhanced tissue ***,the expectations of tissue engineering scaffolds have gone beyond merely providing physical support for cell *** scaffolds should also provide biological cues to actively boost tissue *** a new type of injectable biomaterial,hydrogel microspheres have been increasingly recognised as promising therapeutic carriers for the local delivery of cells and drugs to enhance tissue *** to traditional tissue engineering scaffolds and bulk hydrogel,hydrogel microspheres possess distinct advantages,including less invasive delivery,larger surface area,higher transparency for visualisation,and greater flexibility for ***,we review the materials characteristics of hydrogel microspheres and compare their fabrication approaches,including microfluidics,batch emulsion,electrohydrodynamic spraying,lithography,and mechanical ***,based on the different requirements for bone,cartilage,nerve,skin,and muscle tissue regeneration,we summarize the applications of hydrogel microspheres as cell and drug delivery carriers for the regeneration of these ***,hydrogel microspheres are regarded as effective therapeutic delivery carriers to enhance tissue regeneration in regenerative ***,significant effort is required before hydrogel microspheres become widely accepted as commercial products for clinical use.

关键词： drug delivery fabrication techniques hydrogel microspheres microgels tissue regeneration

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A proposal for a set of attributes relevant for Web portal data quality: The Brazilian Rare Disease Network case

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Procedia Computer Science 2023年 219卷 1316-1324页

作者： Filipe Andrade Bernardi Domingos Alves Mariane Barros Neiva Diego Bettiol Yamada Vinicius Costa Lima André Vinci Giovane Thomazini Rui Rijo Têmis Maria Felix Bioengineering Postgraduate Program University of São Paulo São Carlos Brazil Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto Brazil Polytechnic Institute of Leiria Medical Genetics Service Porto Alegre Clinics Hospital Porto Alegre Brazil

Despite widespread growth in the use and complexity of web portals, insufficient attention is paid to their quality. Thus, this paper aims to describe the validation process of the Brazilian Network of Rare Diseases Portal and identify a set of data quality attributes required for psychometric evaluations that will support the portal implementation. This protocol describes a cross- sectional study of mixed nature divided into three steps: A usability evaluation, a Delphi consensus, and an electronic service quality assessment. Also, the RE-AIM model will be applied at various stages of evaluative research. We hope the improvement carried out during the validation of RARAS can contribute to the dissemination of knowledge in the area and include, based on scientific knowledge and clinical experts, offering clear, attractive, and accessible information for the population. A research gap exists in determining components of integrated e-service quality, usability, and user experience evaluation model in general, and for rare disease web portals, in particular. Users of the RARAS Portal need to get validated content and the required reliable online services without doing exhaustive searches or visiting multiple sources, with the main focus on e-service quality.

关键词： Rare Diseases Data Quality Implementation Science Software Validation User-Centered Design

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Biomass-Based Discrete Furan Oligomers as Materials for Electrochromic Devices

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ACS Sustainable Chemistry and Engineering 2024年第1期12卷 459-469页

作者： Atayde, Eduardo C. Fong, Guan-Lun Yeh, Jyun-Yi Matsagar, Babasaheb M. Wang, Yu-Cheng Chen, De-Chian Peng, Chi-How Li, Yi-Pei Yamauchi, Yusuke Ho, Kuo-Chuan Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program (TIGP-MST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan Department of Chemistry National Tsing Hua University No. 101 Sec. 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Sustainable Chemical Science and Technology Program Taiwan International Graduate Program (TIGP-SCST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensl Brisbane 4072 QLD Australia Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan Institute of Polymer Science and Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd. Taipei 10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University No. 135 Yuandong Rd. Taoyuan 320 Taiwan

Electrochromic devices (ECDs) are materials that can undergo reversible changes in transmittance when exposed to different applied potentials. While many conjugated heterocyclic oligomers, such as oligothiophenes, have been developed for this purpose, there is no reported study on the use of discrete oligomeric furans as ECD materials. In this work, we introduce a furan trimer that can be utilized as a discrete electrochromic material, which transitions from light yellow to red and has a very high coloration efficiency of 1940 cm²/C at 507 nm. We propose that the reversible π-stack formation of the oligomer radical cations is behind this phenomenon, as evidenced by both experimental and computational results. The derivability of this oligomer from biomass and its facile synthesis make it an interesting alternative for other existing organic electrochromic materials. © 2023 American Chemical Society

关键词： electrochromism furan oligomer hydroxyalkylation−alkylation reaction solvatochromism π-stacks

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Medical Knowledge-Enabled Multi-Task Learning for Gastric Cancer Survival Prediction

Medical Knowledge-Enabled Multi-Task Learning for Gastric Ca...

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IEEE International Symposium on Biomedical Imaging

作者： Degan Hao Qiong Li Yudong Zhang Shandong Wu Intelligent Systems Program University of Pittsburgh Pittsburgh PA USA The First Affiliated Hospital With Nanjing Medical University Nanjing PR China Dept. of Radiology Dept. of Biomedical Informatics and Dept. of Bioengineering University of Pittsburgh Pittsburgh PA USA

ISBN: (数字)9798350313338

ISBN: (纸本)9798350313345

Accurate cancer survival prediction can inform patient prognostication and treatment planning. Multi-source clinical data, including radiological images and pathological markers, demand effective machine learning strategies to make smart use of these data to enhance patient outcome. In this work, we proposed a novel strategy of translating multi-task learning to clinical applications for gastric cancer survival prediction, by leveraging the established medical knowledge of abdominal CT images and pathological staging markers to construct meaningful auxiliary tasks for joint learning with the target task. In implementing our method for survival prediction, we also customized a convolutional neural network to account for censored data. We evaluated our method with extensive experiments on a large cohort of 1,061 gastric cancer patients for both overall and progression-free survival prediction, showing superior performance when compared to multi-input learning and two state-of-the-art prediction methods. As an additional benefit, our method also enables survival prediction even before surgery. Source code is available at https://***/usernameoliver/***.

关键词： Pathology Accuracy Source coding Surgery Prediction methods Multitasking Planning

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Pushing the Limit of BGO-based Dual-ended Cherenkov PET Detector Through Photon Transit Time Correction

Pushing the Limit of BGO-based Dual-ended Cherenkov PET Dete...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： M. Yi G.-B. Ko J.S. Lee Interdisciplinary Program in Bioengineering Seoul National University Seoul Republic of Korea Integrated Major in Innovative Medical Science Seoul National University Seoul Republic of Korea Brightonix Imaging Inc. Seoul Republic of Korea

The rising production costs of commonly used lutetium-based fast scintillators and the development of silicon photomultipliers technology have made BGO a promising candidate for time-of-flight positron emission tomography (TOF PET) detectors due to its ability to generate prompt Cherenkov photons. However, using BGO as a hybrid scintillator presents challenges due to low photon statistics and a distribution that does not conform well to a single Gaussian. To mitigate this, a proposal was made to increase the likelihood of detecting the first Cherenkov photons by positioning two photosensors in opposition at the entrance and exit faces of the scintillator [1]. In the other hand, compensating for the photon transit time spread is known to enhance the timing performance of the dual-ended BGO Cherenkov TOF PET detector [2]. A 3 × 3 × 15 mm 3 unpolished BGO sample was prepared and tested. The high-frequency dual-ended BGO detector was implemented and coincidence events were acquired against a 3 × 3 × 3 mm 3 LYSO:Ce:Mg reference detector. The timing performance of dual-ended BGO detectors were analyzed using bottom, top, meantime, and adaptive timestamp methods. Through a depth-of-interaction based (DOI-based) correction of photon transit time spread, we demonstrated a further improvement in timing resolution of dual-ended BGO-based Cherenkov TOF PET detector with adaptive arrival time pickoff. The use of a dual-ended configuration resulted in a significant improvement in timing resolution compared to a single-ended readout configuration, particularly in terms of FWTM value. Although polishing the crystal surface was still favorable in terms of FWHM value, compensating for photon travel time by taking advantage of DOI information from unpolished crystals with relatively higher light loss enabled further enhancement in timing performance the polished crystals.

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Motion Correction for Cardiac PET via Parametric Image Optical Flow

Motion Correction for Cardiac PET via Parametric Image Optic...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： S. J. Zou G. Chinn C. S. Levin Electrical Engineering Stanford University Stanford California United States of America Radiology Stanford University Stanford California United States of America Radiology Electrical Engineering Bioengineering Physics Molecular Imaging Program Stanford University Stanford California United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

Motion correction (MC) is crucial in cardiac positron emission tomography (PET) to mitigate artifacts caused by cardiac, respiratory, and body motion. Motion correction not only improves image quality also leads to accurate quantification of cardiac health. In this study, we explore the effectiveness of optical flow based motion correction for gated cardiac PET. We present a novel method of joint estimation and denoising of parametric *** also present preliminary results of parametric image based optical flow MC, a novel MC method. By jointly denoising and estimating parametric images we see a $\lt4 \mathrm{~dB}$ increase in PSNR for Patlak $K$ image compared to no denoising and see at least a 1 dB PSNR gain with our MC method over all noise scenarios.

关键词： Image quality Microwave integrated circuits Semiconductor detectors Noise reduction Noise Estimation Logic gates

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Preliminary Results to Predict Tuberculosis Outcomes Applying Traditional and Automated Machine Learning Models

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Procedia Computer Science 2023年 219卷 1365-1372页

作者： Ana Clara de Andrade Mioto Mariana Tavares Mozini Renan Barbieri Segamarchi Giovane Thomazini Soares Pedro Emilio Andrade Martins Victor Cassão Luís Gustavo Barichello Ferrassini Newton Shydeo Brandão Miyoshi Domingos Alves Lariza Laura de Oliveira Bioengineering Postgraduate Program University of São Paulo São Carlos Brazil Ribeirão Preto Medical School University of São Paulo Ribeirão Preto Brazil University Center Barão de Mauá Ribeirão Preto Brazil

Tuberculosis (TB) remains one of the most lethal infectious diseases in the world and, despite being preventable and curable, kills 4.500 people daily, according to the World Health Organization (WHO). Brazil, being a country heavily affected by TB, works to improve social intervention programs, since the decrease in the patients vulnerability seems to have a positive effect for the cure of TB. The Brazilian public health system records data on TB treatment that can guide actions and interventions. In this context, machine learning (ML) algorithms have been used successfully to analyze health and medicine (H&M) datasets. An emerging area of ML called Automated Machine Learning (Auto-ML) was tested in this analysis to predict the following TB results: good and bad outcomes. Our results indicate that it is possible to build reasonable ML models with the available data.

关键词： Tuberculosis Bad Outcomes Machine Learning Automate modeling

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FET-based nanobiosensors for the detection of smell and taste

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Science China(Life Sciences) 2020年第8期63卷 1159-1167页

作者： Dongseok Moon Yeon Kyung Cha So-ong Kim Seongyeon Cho Hwi Jin Ko Tai Hyun Park School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea

Various nanobiosensors composed of biomaterials and nanomaterials have been developed,due to their demonstrated advantage of showing high *** various biomaterials for biological recognition elements of the nanobiosensor,sensory receptors,such as olfactory and taste receptors,are promising biomaterials for developing nanobiosensors,because of their high selectivity to target ***-effect transistors(FET)with nanomaterials such as carbon nanotube(CNT),graphene,and conducting polymer nanotube(CPNT),can be combined with the biomaterials to enhance the sensitivity of ***,many efforts have been made to develop nanobiosensors using biomaterials,such as olfactory receptors and taste receptors for detecting various smells and *** review focuses on the biomaterials and nanomaterials used in nanobiosensor systems and studies of various types of nanobiosensor platforms that utilize olfactory receptors and taste receptors which could be applied to a wide range of industrial fields,including the food and beverage industry,environmental monitoring,the biomedical field,and anti-terrorism.

关键词： nanobiosensor olfactory receptor taste receptor field-effect transistor(FET)

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