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Biomedical Engineering and bioengineering (CI-IB&BI), IEEE International Congress of

作者： Natalia Camacho-Niño Martín F. Charry-Retavizca Guillermo Córdoba-Fernández William R. Rodríguez-Dueñas Bioengineering program Faculty of Engineering Pontificia Universidad Javeriana Bogota Colombia

ISBN: (数字)9798331532352

ISBN: (纸本)9798331532369

Hearing loss represents 20% of the world's population, while in Colombia this condition reaches the 1,2%. It is a condition in which activities of daily living, such as waking up in the morning, can become a challenge. Some technologies have been implemented but difficulties such as the adaptability of the equipment, comfort regarding device design and effectiveness of the technology to wake the user remain in its use. Part of the success in the use of these technologies lies in a good needs identification stage, as is recommended for the Biodesign framework, a methodology to design and build health technologies. This work presents the design and development of an alternative system for the comfortable awakening of people with hearing loss, using the Biodesign methodology. The system obtained includes a tabletop device and a wireless portable instrument, with visual and tactile stimulation respectively. Preliminary results obtained show that the system is viable, and responds to basic needs identified.

关键词： Wireless communication Surveys Wireless sensor networks Visualization Instruments Prototypes Auditory system Proposals Interviews Biomedical engineering

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Fast non-iterative algorithm for 3D point-cloud holography

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Optics Express 2023年第22期31卷 36468-36485页

作者： Ersaro, Nathan Tessema Yalcin, Cem Murray, Liz Kabuli, Leyla Waller, Laura Muller, Rikky Graduate Program in Bioengineering University of California Berkeley and University of California San Francisco BerkeleyCA94720 United States Department of Electrical Engineering and Computer Sciences University of California Berkeley BerkeleyCA94720 United States

Recently developed iterative and deep learning-based approaches to computer-generated holography (CGH) have been shown to achieve high-quality photorealistic 3D images with spatial light modulators. However, such approaches remain overly cumbersome for patterning sparse collections of target points across a photoresponsive volume in applications including biological microscopy and material processing. Specifically, in addition to requiring heavy computation that cannot accommodate real-time operation in mobile or hardware-light settings, existing sampling-dependent 3D CGH methods preclude the ability to place target points with arbitrary precision, limiting accessible depths to a handful of planes. Accordingly, we present a non-iterative point cloud holography algorithm that employs fast deterministic calculations in order to efficiently allocate patches of SLM pixels to different target points in the 3D volume and spread the patterning of all points across multiple time frames. Compared to a matched-performance implementation of the iterative Gerchberg-Saxton algorithm, our algorithm’s relative computation speed advantage was found to increase with SLM pixel count, reaching >100,000x at 512 × 512 array format. © 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Iterative methods

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Customized 3D-Printed Prototype Mold for Potential HDR Brachytherapy in Facial Non-Melanoma Skin Cancer

Customized 3D-Printed Prototype Mold for Potential HDR Brach...

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Biomedical Engineering and bioengineering (CI-IB&BI), IEEE International Congress of

作者： Héctor Quevedo-Linares Lizeth Vega-Medina Osiris & Bioaxis - Bioengineering Program Universidad El Bosque Bogotá Colombia

ISBN: (数字)9798331532352

ISBN: (纸本)9798331532369

Surface mold brachytherapy (SMBT) is an appropriate and effective treatment for non-melanoma skin cancer (NMSC). Manual manufacturing methods allow the development of personalized molds. However, it causes inconsistencies in the dosimetry of the established treatment plan, mainly due to the air gaps between the patient dermal surface and the mold. This work is focused on developing a manufacturing methodology for a prototype of a custom mold through additive manufacturing for potential application in BT in patients with NMSC.

关键词： Uncertainty Computed tomography Prototypes Manuals Three-dimensional printing Brachytherapy Manufacturing Dosimetry Surface treatment Skin cancer

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Tin-Silver Solder as an On-Demand Biodegradable Metallic Biomaterial

SSRN

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SSRN 2024年

作者： Goodwin, Charley M. Mace, Annsley O. Gilbert, Jeremy L. Clemson University Department of Bioengineering United States Clemson - Medical University of South Carolina Bioengineering Program CharlestonSC United States

Tin-Silver demonstrated in vivo corrosion in during its use in the Essure® permanent female sterilization device. To better understand the corrosion, Sn-Ag was cyclically polarized and interrupted with electrochemical impedance spectroscopy below, at and above the breakdown potential. Though initially-passive, polarization resistance, Rp, decreases 1000-fold and capacitance increases correspondingly during polarization. Upon reverse scanning, the measured Rp and capacitance did partially recover in PBS, though capacitance continued falling in cell culture media. The surface experienced pitting corrosion with deposition of tin-chlorides and tin-oxides. This study reveals that Sn-Ag may serve as an on-demand voltage-controlled degradable metallic biomaterial. © 2024, The Authors. All rights reserved.

关键词： Silver

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Modular, programmable RNA sensing using ADAR editing in living cells (vol 41, pg 482, 2023)

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NATURE BIOTECHNOLOGY 2023年第4期41卷 577-577页

作者： Kaseniit, K. Eerik Katz, Noa Kolber, Natalie S. Call, Connor C. Wengier, Diego L. Cody, Will B. Sattely, Elizabeth S. Gao, Xiaojing J. Department of Bioengineering Stanford University Stanford CA USA Department of Chemical Engineering Stanford University Stanford CA USA ChEM-H Chemistry/Biology Interface Training Program Stanford University Stanford CA USA Howard Hughes Medical Institute Stanford CA USA

With the increasing availability of single-cell transcriptomes, RNA signatures offer a promising basis for targeting living cells. Molecular RNA sensors would enable the study of and therapeutic interventions for specific cell types/states in diverse contexts, particularly in human patients and non-model organisms. Here we describe a modular, programmable system for live RNA sensing using adenosine deaminases acting on RNA (RADAR). We validate, and then expand, our basic design, characterize its performance, and analyze its compatibility with human and mouse transcriptomes. We identify strategies to boost output levels and improve the dynamic range. Additionally, we show that RADAR enables compact AND logic. In addition to responding to transcript levels, RADAR can distinguish disease-relevant sequence alterations of transcript identities, such as point mutations and fusions. Finally, we demonstrate that RADAR is a self-contained system with the potential to function in diverse organisms.

关键词： Gene targeting Molecular engineering in plants Nucleic-acid therapeutics Synthetic biology Translation

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TOWARDS SINGLE-CELL PROTEOFORM PROFILING: ON-CHIP ISOELECTRIC FOCUSING IN IMMOBILIZED PH GRADIENT GELS

TOWARDS SINGLE-CELL PROTEOFORM PROFILING: ON-CHIP ISOELECTRI...

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2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022

作者： Lomeli, Gabriela Herr, Amy E. UC Berkeley-UCSF Graduate Program in Bioengineering CA United States Department of Bioengineering University of California BerkeleyCA United States Chan Zuckerberg Biohub San FranciscoCA United States

ISBN: (纸本)9781940470047

Microfluidic tools are an essential capability in understanding cell-to-cell heterogeneity. Similarly, precision microanalytical tools can play an outsize role in measuring molecule-to-molecule heterogeneity, especially as protein post-translational modifications create proteoforms that execute regular and aberrant cellular functions. Although highly related, slight variations in protein charge contribute to proteoform heterogeneity. Electrophoretic methods, including immobilized pH gradient isoelectric focusing (IPG-IEF), provide the resolution to measure subtle protein-to-protein differences. However, conventional IPG-IEF can be low-throughput and requires large starting sample amounts, precluding single-cell analysis. Here, we present the first polydimethylsiloxane (PDMS)-based, immunoprobed, microfluidic IPG-IEF device to our knowledge. We demonstrate separation performance on par with our single-cell IEF device, including resolving analytes differing by only 0.1 pH. © 2022 TRF.

关键词： Electrophoresis

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Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12)

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Small GTPases 2022年第1期13卷 196-204页

作者： Ghanem, Neda Z. Matter, Michelle L. Ramos, Joe W. Cancer Biology Program University of Hawaii Cancer Center University of Hawaii at Mānoa Honolulu United States Molecular Biosciences and BioEngineering Graduate Program University of Hawaii at Mānoa Honolulu United States

The Ras homologous (Rho) protein family of GTPases (RhoA, RhoB and RhoC) are the members of the Ras superfamily and regulate cellular processes such as cell migration, proliferation, polarization, adhesion, gene transcription and cytoskeletal structure. Rho GTPases function as molecular switches that cycle between GTP-bound (active state) and GDP-bound (inactive state) forms. Leukaemia-associated RhoGEF (LARG) is a guanine nucleotide exchange factor (GEF) that activates RhoA subfamily GTPases by promoting the exchange of GDP for GTP. LARG is selective for RhoA subfamily GTPases and is an essential regulator of cell migration and invasion. Here, we describe the mechanisms by which LARG is regulated to facilitate the understanding of how LARG mediates functions like cell motility and to provide insight for better therapeutic targeting of these functions. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

关键词： ARHGEF12 GTPase LARG migration Rho RhoGef signal transduction

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Enhancing Biomedical Engineering Education Through Curricular Innovation: Developing Industry-Ready Engineers

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Biomedical Engineering Education 2025年 1-7页

作者： Boyd, Lawrence Bradley, Joe Gray, Marissa Keeling, Novella M. Ochia, Ruth Reuther, Katherine E. Department of Bioengineering Clemson University Clemson USA Department of Bioengineering | Carle Illinois College of Medicine University of Illinois Urbana-Champaign Urbana USA School of Engineering Brown University Providence USA Biomedical Engineering Program University of Colorado Boulder Boulder USA Department of Bioengineering Temple University Philadelphia USA Department of Bioengineering University of Pennsylvania Philadelphia USA Center for Health Devices and Technology University of Pennsylvania Philadelphia USA

Biomedical engineering (BME) curricula are necessarily broad and it has been reported that BME students can experience substantial barriers to their career attainment compared to other engineering majors. Challenges and curricular innovations for addressing industry needs were discussed in workshops held at the BME Education Summit. This event was attended by educators and BME industry representatives. Skills needed by employers included verbal and written communication, mechanical design, engineering competency, teamwork, initiative, and self-motivation. Areas reported to be not well addressed in the BME curriculum included manufacturing, design controls, drafting, regulatory affairs, and quality systems. Specialized master’s programs are one approach to meeting industry needs. Micro-credentialing and certificate programs are another proposed innovation for appropriately training biomedical engineers for careers in industry. Another approach is via formal entrepreneurship and commercialization training. This may include having specific course offerings, assignments, and case studies focused on entrepreneurship and commercialization; having guest speakers and representatives from industry integrated in the classroom; and teaching and mentoring from faculty with expertise in these areas. Specific next steps to align academic program offerings with industry needs include directly developing specialized programs with industry partners, assessing specialty programs by both academic and industrial entities, aligning specialty program outcomes with ABET student outcomes or encouraging graduate accreditation bodies to develop a framework that directly assesses specialty programs. There is a need among the BME community to establish a broad standard for collecting informative data regarding BME-graduate industry readiness from courses, programs, employers, and recent alumni.

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Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

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Mechanobiology in Medicine 2025年第1期3卷 57-67页

作者： Alexander M.Regner Maximilien DeLeon Kalin D.Gibbons Sean Howard Derek Q.Nesbitt Seyedeh F.Darghiasi Anamaria G.Zavala Trevor J.Lujan Clare K.Fitzpatrick Mary C.Farach-Carson Danielle Wu Gunes Uzer Mechanical and Biomedical Engineering Department Boise State UniversityUSA Department of Diagnostic and Biomedical Sciences UTHealth Houston School of DentistryUSA Department of Bioengineering Rice UniversityUSA Department of Biosciences Rice UniversityUSA Biomedical Engineering Program Boise State UniversityUSA

Aged individuals and astronauts experience bone loss despite rigorous physical *** mechanoresponse is in-part regulated by mesenchymal stem cells(MSCs)that respond to mechanical *** delivery of low intensity vibration(LIV)recovers MSC proliferation in senescence and simulated microgravity models,indicating that age-related reductions in mechanical signal delivery within bone marrow may contribute to declining bone *** answer this question,we developed a 3D bone marrow analog that controls trabecular geometry,marrow mechanics and external *** finite element(FE)models were developed to quantify strain environment within hydrogels during *** marrow analogs with gyroid-based trabeculae of scaffold volume fractions(SV/TV)corresponding to adult(25%)and aged(13%)mice were printed using polylactic acid(PLA).MSCs encapsulated in migration-permissive hydrogels within printed trabeculae showed robust cell populations on both PLA surface and hydrogel within a *** 14 days of LIV treatment(1 g,100 Hz,1 h/day),cell proliferation,type-I collagen(Collagen-I)and filamentous actin(F-actin)were quantified for the cells in the hydrogel *** LIV increased all measured outcomes,FE models predicted higher von Mises strains for the 13%SV/TV groups(0.2%)when compared to the 25%SV/TV group(0.1%).While LIV increased collagen-I volume 34%more in 13%SV/TV groups when compared to 25%SV/TV groups,collagen-I and F-actin measures remained lower in the 13%SV/TV groups when compared to 25%SV/TV counterparts,indicating that both LIV-induced strains and scaffold volume fraction(*** scaffold surface)affect cell behavior in the hydrogel ***,bone marrow analogs offer a robust and repeatable platform to study bone mechanobiology.

关键词： Mechanical signals Low-intensity vibration Mesenchymal stem cells 3D printing Mechanical modeling Tissue modeling

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In vitro evaluation of degradation,cytocompatibility and antibacterial property of polycaprolactone/hydroxyapatite composite coating on bioresorbable magnesium alloy

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Journal of Magnesium and Alloys 2022年第8期10卷 2252-2265页

作者： Zhang Chunyan Cheng Lan Lin Jiajia Sun Dongwei Zhang Jun Liu Huinan School of Materials Science&Engineering Chongqing University of TechnologyNo.69 Hongguang AvenueChongqing 400054China Department of Bioengineering and the Materials Science and Engineering ProgramUniversity of CaliforniaRiverside900 University AvenueMSE 205RiversideCA 92521USA

Polycaprolactone/hydroxyapatite(PCL/HA)composite coating was fabricated by a combination of hydrothermal and dipping methods to delay the degradation of Mg alloy AZ31 as bioresorbable *** PCL/HA coating was composed of nano rod-shape HA crystals and PCL filled in the space of HA *** with the single HA coating,the binding strength between the PCL/HA composite coating and Mg alloy was obviously improved and the PCL/HA coating still adhered to the surface of AZ31 substrate even after 38 days of *** electrochemical corrosion rate of HA coated sample was reduced by ten times after being filled by *** electrochemical impedance spectroscopy(EIS)and immersion test results showed that the PCL/HA composite coating could provide a more effective barrier for Mg substrate than the HA coating *** cytocompatibility and the antibacterial property of HA coating and PCL/HA coating were evaluated by culturing with bone marrow-derived mesenchymal stem cells(BMSCs)and methicillin-resistant staphylococcus aureus(MRSA)for 24 h under direct culture conditions,*** PCL/HA composite coating showed better BMSC cell compatibility,more suitable for BMSC adhesion than HA coating alone and showed a potential application prospect as a biological ***,from the perspective of clinical applications,the antibacterial property of PCL/HA composite coating needs to be further improved.

关键词： Mg alloy PCL/HA coating Corrosion resistance Cytocompatibility Antibacterial property

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