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Cover Feature: Effect of UV Light Exposure Duration on the Removal of Exfoliation Agent Residues in Two-Dimensional Perovskite Nanosheets: An AFM Study (ChemPlusChem 3/2025)

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ChemPlusChem 2025年第3期90卷

作者： Fatma Pinar Gordesli-Duatepe Begümnur Küçükcan Özge Sağlam Department of Genetics and Bioengineering Izmir University of Economics Sakarya Cad. Izmir 35330 Turkey Bioengineering Graduate Program Graduate School Izmir University of Economics Sakarya Cad. Izmir 35330 Turkey Department of Mechanical Engineering Izmir University of Economics Sakarya Cad. Izmir 35330 Turkey

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Design Considerations for 3D Position Sensitive Scintillation Detectors that Achieve 100 ps Coincidence Time Resolution

Design Considerations for 3D Position Sensitive Scintillatio...

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2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021

作者： Pourashraf, Shirin Zhao, Zhixiang Gonzalez-Montoro, Andrea Cates, Joshua W. Yeon Won, Jun Sung Lee, Jae Levin, Craig S. Stanford University Department of Radiology StanfordCA94305 United States Shanghai Jiao Tong University School of Biomedical Engineering Shanghai China Lawrence Berkeley National Laboratory Applied Nuclear Physics Program BerkeleyCA94720 United States Seoul National University Department of Nuclear Medicine and Biomedical Sciences Seoul110-744 Korea Republic of Stanford University Molecular Imaging Program Departments of Radiology Bioengineering Physics and Electrical Engineering StanfordCA94305 United States

ISBN: (纸本)9781665421133

We have studied design considerations for three dimension positioning sensitive (3DPS) scalable TOF- PET detectors that achieve 100 ps coincidence time resolution (CTR). These scintillation detectors are based on 3×3×10 mm3 'LGSO' crystals side- coupled to arrays of 3×3 mm2 SiPMs. A CPLD is used to provide 3 mm positioning resolution along the length of each crystal element. Revised mixed-signal front-end electronics decreased the power dissipation by 200% and increased the detector packing fraction while preserving the CTR performance. A low timing jitter FPGA-based TDC was used for data acquisition of the timing channels. Measured CTR was 102.2 ± 1.3 ps FWHM using a 22Na point source. © 2021 IEEE.

关键词： Data acquisition

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Phased Array Beamforming Methods for Powering Biomedical Ultrasonic Implants

arXiv

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arXiv 2022年

作者： Benedict, Braeden C. Ghanbari, Mohammad Meraj Muller, Rikky UC Berkeley UC San Francisco Joint Program in Bioengineering BerkeleyCA94720 United States The Department of Electrical Engineering and Computer Sciences University of California Berkeley BerkeleyCA94720 United States The Chan Zuckerberg Biohub San FranciscoCA94158 United States

Millimeter-scale implants using ultrasound for power and communication have been proposed for a range of deep-tissue applications, including neural recording and stimulation. However, published implementations have shown high sensitivity to misalignment with the external ultrasound transducer. Ultrasonic beamforming using a phased array to these implants can improve tolerance to misalignment, reduce implant volume, and allow multiple implants to be operated simultaneously in different locations. This paper details the design of a custom planar phased array ultrasound system, which is capable of steering and focusing ultrasound power within a 3D volume. Analysis and simulation is performed to determine the choice of array element pitch, with special attention given to maximizing the power available at the implant while meeting FDA limits for diagnostic ultrasound. Time reversal is proposed as a computationally simple approach to beamforming that is robust despite scattering and inhomogeneity of the acoustic medium. This technique is demonstrated both in active drive and pulse-echo modes, and it is experimentally compared with other beamforming techniques by measuring energy transfer efficiency. Simultaneous power delivery to multiple implants is also demonstrated. Copyright © 2022, The Authors. All rights reserved.

关键词： Beamforming

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Performance of 500 liter stainless steel portable biogas anaerobic digester with agitator designed for the tropical developing country 11th

Performance of 500 liter stainless steel portable biogas ana...

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11th International Conference on Materials and Manufacturing Technology, ICMMT 2020

作者： Sebayuana, Kadek Nindhia, Tjokorda Gde Tirta Surata, I. Wayan Nindhia, Tjokorda Sari Shukla, Shailendra Kumar Khanal, Samir Kumar Master student at Ma ster Study Program of Mechanical Engineering Engineering Faculty Udayana University Jimbaran Bali80361 Indonesia Study Program of Mechanical Engineering Engineering faculty Udayana University Jimbaran Bali80361 Indonesia Faculty of Veterinary medicine Udayana University Denpasar Bali802232 Indonesia Departmen of Mechanical Engineering IIT Banaras Hindu University Varanasi221005 India Dept. of Molecular Biosciences and Bioengineering University of Hawaii at Manoa HonoluluHI96822 United States

ISBN: (纸本)9783035737226

This document it is established that 2 types of biogas anaerobic digester that usually found in developing country. First type is fixed dome type of anaerobic digester and secondly is floating drum biogas anaerobic digester. Both of this type have draw back that the anaerobic process is not completed with agitation process that yield low rate of biogas production. Other serious problem is the release of slurry cannot optimal. Some of the slurry will still remain stay in the anaerobic digester especially scum. To drain and cleaning the fixed dome or floating drum biogas anaerobic digester is mandatory to be done regularly that consume time and cost. The fixed dome types as well as floating drum type are usually not portable which cause no possibility to relocate in the new site. It is the purpose of this work to introduce portable biogas anaerobic digester that suitable for developing country with volume of digester around 500 liter of slurry. The requirement of agitator is facilitated, and the anaerobic digester is possible to be operated in batch system or continuous system. The material that is used for anaerobic digester is stainless steel 304 with tungsten inert gas welding technology that is used for the manufacturing. With this design the anaerobic digester are easy to be maintenance. The batch system can keep producing biogas until 52 day with total production of biogas around 3320 liters. The continuous system was conducted by releasing for about 5 liters slurry from the outlet and after that filled with new slurry with stirring with agitator was conducted for about 10 minutes for 3 times in a day (morning, noon, and evening). The result for continuous system is a linear biogas production with rate biogas production is around 51.7 liter/day (1550 liter/30days). © 2021 Trans Tech Publications Ltd, Switzerland.

关键词： Biogas

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Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia

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Bioactive Materials 2025年 51卷 559-574页

作者： Jeon, Sungmi Jeong, Seol-Ha Lee, Mi Hyun Seo, Jeong Wook Kim, Da-Seul Bassous, Nicole Joy Lozano Soto, Javier Alejandro Choi, Cholong Gonzalez, Montserrat Legorreta Nolasco Díaz, Elaine Belén Kim, Hyunho Shin, Su Ryon Park, Ji-Ung Department of Plastic and Reconstructive Surgery Seoul National University Boramae Hospital Seoul National University College of Medicine Seoul 07061 South Korea Division of Pediatric Plastic Surgery Seoul National University Children's Hospital Seoul National University College of Medicine Seoul 03080 South Korea Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School 02139 MA United States Institute of Medical and Biological Engineering Bio-max Institute Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 South Korea Tecnológico de Monterrey Escuela de Ingeniería y Ciencias Campus Monterrey Av. Eugenio Garza Sada 2501 Col. Tecnológico C.P. Monterrey Nuevo León 64700 Mexico School of Mechanical Engineering Korea University Seoul 02841 South Korea

In regenerative medicine, effective management of tissue ischemia in surgical skin flaps is crucial, yet challenging, particularly because inadequate blood flow often leads to necrosis at the distal flap tips. This study aimed to examine the therapeutic potential of catalase-coated oxygen-generating microparticles embedded in gelatin methacryloyl (cOMP-GelMA) hydrogel to establish an optimized environment conducive to tissue regeneration. Using a large 3 × 9 cm² rat random-pattern skin flap model, flap survival and regeneration were evaluated across four groups: control, pure GelMA hydrogel, and cOMP-GelMA hydrogel with two concentrations of cOMPs (0.2 % and 0.5 % w/v). These findings revealed that cOMP-GelMA comprising 0.2 % OMP significantly enhanced angiogenesis, arteriogenesis, mitochondrial biogenesis, and antioxidant capacity compared to 0.5 % cOMP-GelMA. Furthermore, the alleviation of the inflammatory response was more pronounced at lower cOMP concentrations than at higher concentrations. These results demonstrate that mild hypoxia, facilitated by moderate oxygen delivery, is beneficial for tissue repair and regeneration through peroxisome proliferator-activated receptor gamma coactivator 1-alpha- and hypoxia-inducible factor 1-alpha-dependent signaling pathways. This study highlights the innovative aspect of using a large-scale model to explore the therapeutic benefits of mild hypoxia and suggests that controlled oxygen delivery by cOMPs can improve the long-term functional recovery of ischemic tissues. © 2025 The Authors

关键词： Composite hydrogels Hypoxic Oxygen-generating microparticle Surgical skin flaps Tissue engineering

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De novo protein fold families expand the designable ligand binding site space

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PLoS Computational Biology 2021年第11期17卷 e1009620-e1009620页

作者： Pan, Xingjie Kortemme, Tanja Department of Bioengineering and Therapeutic Sciences University of California San Francisco San FranciscoCA United States UC Berkeley-UCSF Graduate Program in Bioengineering University of California San Francisco San FranciscoCA United States University of California San Francisco San FranciscoCA United States Chan Zuckerberg Biohub San FranciscoCA United States

A major challenge in designing proteins de novo to bind user-defined ligands with high affinity is finding backbones structures into which a new binding site geometry can be engineered with high precision. Recent advances in methods to generate protein fold families de novo have expanded the space of accessible protein structures, but it is not clear to what extend de novo proteins with diverse geometries also expand the space of designable ligand binding functions. We constructed a library of 25,806 high-quality ligand binding sites and developed a fast protocol to place ("match") these binding sites into both naturally occurring and de novo protein families with two fold topologies: Rossman and NTF2. Each matching step involves engineering new binding site residues into each protein "scaffold", which is distinct from the problem of comparing already existing binding pockets. 5,896 and 7,475 binding sites could be matched to the Rossmann and NTF2 fold families, respectively. De novo designed Rossman and NTF2 protein families can support 1,791 and 678 binding sites that cannot be matched to naturally existing structures with the same topologies, respectively. While the number of protein residues in ligand binding sites is the major determinant of matching success, ligand size and primary sequence separation of binding site residues also play important roles. The number of matched binding sites are power law functions of the number of members in a fold family. Our results suggest that de novo sampling of geometric variations on diverse fold topologies can significantly expand the space of designable ligand binding sites for a wealth of possible new protein functions. © 2021 Pan, Kortemme. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

关键词： Topology

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A Multi-objective Physiological Control for Continuous Flow Left Ventricular Assist Devices: Comparison of Estimator versus Sensor-based Feedback *

A Multi-objective Physiological Control for Continuous Flow ...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Bruno Santos Idágene Cestari Biomedical Engineering Graduate Program Polythecnic School of Engineering University of Sao Paulo Av. Prof. Luciano Gualberto Sao Paulo Brazil Department of Electrical in Federal Institute of Sao Paulo and Department of Information Technology Universidade São Judas Tadeu Sao Paulo Brazil Bioengineering Laboratory Instituto do Coração InCor Hospital das Clínicas HCFMUSP Sao Paulo Brazil Biomedical Engineering Graduate Program Polytechnic School of Engineering University of Sao Paulo Sao Paulo Brazil

Left Ventricular Assist Devices have been successfully used for the treatment of Congestive Heart failure in patients who are not eligible for heart transplantation. This paper describes the implementation and comparison of the performance of a pressure sensor-based feedback controller. The strategies were tested on a mock loop of the systemic circulation. The results show that the use of pressure sensors generated a more accurate response of the controller compared to the use of *** Relevance— The study describes the integration of a LVAD physiological controller to a dynamic wireless monitoring system.

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Biophysics of amplitude-modulated giga-hertz electromagnetic waves stimulation

Biophysics of amplitude-modulated giga-hertz electromagnetic...

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Asilomar Conference on Signals, Systems & Computers

作者： Fatima Ahsan Aravind C. Govindaraju Robert M. Raphael Taiyun Chi Sameer A. Sheth Wayne Goodman Behnaam Aazhang Department of Electrical and Computer Engineering Rice University Houston TX USA Applied Physics Graduate Program Smalley-Curly Institute Rice University Houston TX Department of Bioengineering Rice University Houston TX USA Department of Neurosurgery Baylor College of Medicine Houston TX USA Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA

This paper presents the biophysical modeling for neuronal stimulation caused by amplitude-modulated giga-hertz (GHz) electromagnetic (EM) waves. We model a 1D cable equation for electrical signal propagation in a vestibular ganglion neuronal fiber and use Hodgkin-Huxley formalism to model voltage-dependent channel conductances. We find out that for a given stimulation signal strength, the GHz waveform amplitude-modulated at a low frequency of Δf causes neuronal firing with the frequency of Δf whereas the continuous wave GHz did not elicit any neuronal firing. Moreover, the voltage-dependent channel gating dynamics of the Δf amplitude-modulated GHz stimulation matches that of a simple low frequency stimulation at Δf. Additionally, we find that the modulation depth controls the firing rate of the neurons. The significance of this property is that the amplitude modulation caused by the interference of two similar high frequency signals could be leveraged to focally excite neurons at depth without stimulating overlying cortical regions. These theoretical predictions based on the Hodgkin-Huxley model can later be tested experimentally.

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Monitoring gene expression in the brain with synthetic serum markers

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The Journal of the Acoustical Society of America 2024年第3_SUPPLEMENT期155卷 A22-A22页

作者： Jerzy O. Szablowski Joon Pyung Seo Sangsin Lee Shirin Nouraein Zhimin Huang James Kwon James S. Trippett Ryan Wang Bioengineering Rice Univ. 6500 Main St. MS 142 BRC 869 Houston TX 77005 js170@rice.edu Appl. Phys. Program Rice Univ. Houston TX Bioengineering Rice Univ. Houston TX

Blood tests are among the most common clinical tools due to their low cost, simplicity, and ability to observe many markers at once. However, currently, blood tests can only monitor a fraction of physiological processes that happen to have a serum marker. Here, we will present our work on the development of synthetic serum markers that can track gene expression in intact brain cells with a simple blood test. The synthetic marker approach has several advantages. First, detection of existing markers may be challenging due to their low levels in blood. With a synthetic marker, one can design a reporter that is easy to detect allowing for superior sensitivity. Second, there are large numbers of genes in each cell, but available brain imaging techniques can at most represent only a few signals (e.g., a few colors of fluorescent proteins, or types of MRI contrast). Synthetic serum markers use biochemical detection and can be designed to be massively multiplexed similarly to how thousands of proteins can be detected in blood simultaneously with mass spectrometry. Third, synthetic serum markers can surveil large brain regions, unlike invasive locally implanted devices. Finally, these markers have the potential for inexpensive and simple readout. We show applications of this concept with markers that can cross through an intact blood–brain barrier to report on gene expression and markers whose release from the brain relies on sonobiopsy to provide spatial selectivity.

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Monitoring Disease-Implicated Hydrogen Sulfide in Blood Using a Facile Deproteinization-Based Electrochemiluminescence Chemosensor System

SSRN

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SSRN 2023年

作者： Bak, Yecheol Anjong, Tikum Florence Kim, Jihwan Jeon, Sang Hyeon Park, Jihwan Lee, Kangwon Shin, Iksoo Kim, Sehoon Seoul02792 Korea Republic of Program in Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Department of Chemistry College of Natural Science Soongsil University Seoul156743 Korea Republic of Korea University Korea Republic of

Hydrogen sulfide (H2S), an antioxidant and cell signaling molecule, plays a critical role in redox reactions in the biological system, and its imbalances in blood levels have been implicated in various diseases. Here, we demonstrate a novel chemosensor-based "turn-on" electrochemiluminescence (ECL) system for the selective and sensitive detection of H2S in a type 1 diabetes rat model. Our luminogenic chemosensor (Probe) is a redox-stable cyclometalating iridium (III) complex with emission-quenching 2,4-dinitrophenyl ether (DNP) that shows a significant enhancement in emission intensity upon cleavage of DNP by selective reaction towards H2S. To achieve robust and reliable ECL emission of Probe for biological analysis, we developed a facile deproteinization protocol based on organic solvent-induced protein precipitation/syringe filtration that eliminates uncontrolled protein adsorption on the electrode surface from protein-rich biological samples. Our deproteinization-assisted ECL chemosensor system showed effectiveness in detecting disease-associated H2S levels in biological media with a linear response in the range of 0-250 µM (R2: 0.992), the limit of detection of 7.2 µM, and average signal-to-noise ratio of ~25. It enables reliable in vitro monitoring of H2S level changes in blood samples of a type 1 diabetes rat model. This strategy to integrate chemosensor-based ECL and facile deproteinization protocol provides a sensitive and rapid disease-monitoring platform for detecting small-molecule biomarkers that cannot be detected by conventional ECL sandwich immunoassays. © 2023, The Authors. All rights reserved.

关键词： Chemosensor

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