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Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application

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Journal of Pharmaceutical Analysis 2023年第7期13卷 691-693页

作者： Dan Li Zhou Fang Qiang Shi Nicholas Zhang Binsheng Gong Weida Tong Ahmet F.Coskun Joshua Xu Division of Bioinformatics and Biostatistics National Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGA30332USA Machine Learning Graduate Program Georgia Institute of TechnologyAtlantaGA30332USA Division of Systems Biology National Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Interdisciplinary Bioengineering Graduate Program Georgia Institute of TechnologyAtlantaGA30332USA Parker H.Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGA30332USA

Reducing the use of animal models in drug development and safety assessment has long been supported by the *** and Drug Administration(FDA).The report by Royal Society for the Prevention of Cruelty to Animals indicates that in 2020,experiments involved the use of over 100 million animals,with the United States leading the list by utilizing 20 million *** ethical considerations associated with animal testing and the costs in terms of time and money,animal models are not always effective in predicting human reactions to drug *** animal testing has been the traditional method for assessing the safety and efficacy of drugs.

关键词： money utilizing testing

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Quantifying gait intralimb coordination patterns in individuals with different levels of diabetic neuropathy: a vector coding analysis

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Research on Biomedical Engineering 2023年第1期39卷 311-319页

作者： Milan, Michelle Bazilio De Villa, Guilherme Augusto Gomes Suda, Eneida Yuri Sacco, Isabel de Camargo Neves Vieira, Marcus Fraga Bioengineering and Biomechanics Laboratory Federal University of Goiás Avenida Esperança S/N Campus Samambaia Goiânia Goiás74690-900 Brazil Postgraduate Program in Physiotherapy Universidade Ibirapuera São Paulo Brazil Laboratory of Biomechanics of Movement and Human Posture University of São Paulo São Paulo Brazil

Purpose: Diabetic peripheral neuropathy (DPN) is among the most frequent complications of diabetes mellitus, triggering sensorimotor alterations that affect the gait. Thus, the objective was to assess how different levels of severity of diabetic peripheral neuropathy affect the lower limb inter-joint coordination pattern and coordination variability (CAV) during gait. Methods: Data from a previous study were re-analyzed using vector coding technique for assessing inter-joint coordination. The sample consisted of 60 individuals aged 45–65 years, divided into 4 groups: control (CTRL;n = 13), diabetics without neuropathy (DIAB;n = 18), mild neuropathy (MILD;n = 7), and severe neuropathy (SVRE;n = 22). The individuals walked barefoot on a 10-m walkway for kinematic data acquisition, from which joint angles were calculated. Next, couple angle and its variability were calculated for the following joint pairs: hip–knee, hip–ankle, and knee–ankle. Results: For hip–knee pair, higher CAV was found for the SVRE group at initial swing phase (p = 0.002), whereas lower CAV for the MILD and DIAB groups at initial contact (p = 0.031) and propulsion phases (p = 0.007), respectively. For knee–ankle pair, higher CAV was found for the DIAB group at initial contact (p = 0.029). For hip–ankle pair, higher CAV was found for the DIAB group at initial contact (p = 0.003) and midstance (p = 0.035), for the SVRE group at propulsion phase (p © 2023, The Author(s), under exclusive licence to The Brazilian Society of Biomedical Engineering.

关键词： Data acquisition

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Engineering Distance Learning: The Promise and Challenges of Microfluidics

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Biomedical Engineering Education 2023年第2期3卷 267-278页

作者： Levis, Megan Hyland, Clare Zartman, Jeremiah Chemical and Biomolecular Engineering Department The University of Notre Dame Notre Dame USA Bioengineering Graduate Program The University of Notre Dame Notre Dame USA

The recent trend of expanding online education in science and engineering creates the need for remote experiential learning opportunities. Microfluidic devices show great promise in fulfilling that need because they are small, transportable, cheap, and use safe volumes of reagents to complete experiments. The rapid increase of microfluidic devices for point-of-care diagnostics serves as a proof of concept for remote learning applications. This perspective highlights potential scenarios and issues that need to be considered in translating multimodal microfluidics into educational settings. Several educational scenarios are developed, and a Strengths, Weaknesses, Opportunities, and Threats gap analysis highlights the barriers and opportunities for implementing microfluidics in the classroom or in online education formats. Providing students with microfluidic competencies in increasing diverse educational formats will create new opportunities as the microfabrication and diagnostics industries continue to grow.

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Meta-Analysis of the Expansion in the Field of Structural Biology of ABC Transporters

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BioDesign Research 2022年第1期2022卷 124-135页

作者： Soomi Kim Teena Bajaj Cole Chabon Eric Tablante Tatyana Kulchinskaya Tae Seok Moon Ruchika Bajaj Stem Cell Technology Certificate Program City College of San FranciscoUSA Biotechnology Certificate Program City College of San FranciscoUSA Comparative Biochemistry Program University of California BerkeleyUSA Department of Energy Environmental and Chemical EngineeringWashington University in St.LouisUSA Department of Bioengineering and Therapeutics Sciences University of California San FranciscoUSA

ABC transporters are molecular machines which power the solute transport using ATP *** structural biology of ABC transporters has been exploding for the last few years,and this study explores timelines and trends for various attributes such as structural tools,resolution,fold,sources,and group *** study also evidences the significance of mammalian expression systems,advancements in structural biology tools,and the developing interest of group leaders across the world in the remarkably progressing *** field started in 2002 and bloomed in 2016,and COVID years were really productive to the ***,the study explores 337 structures of 58 unique ABC transporters deposited in the PDB database from which P-glycoprotein has the largest number of ***,62%of total structures are determined at the resolution of 3-4Åand 53%of structures belong to fold IV *** progressive advancements in the field,the field is shifting from prokaryotic to eukaryotic sources and X-ray crystallography to cryoelectron *** the nutshell,this study uniquely provides the detailed snapshot of the field of structural biology of ABC transporters with real-time data.

关键词： uniquely really shifting

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Evaluation of a 3D Position Sensitive Time-of-flight PET Detector Unit with CPLD-based Frontend Electronics

Evaluation of a 3D Position Sensitive Time-of-flight PET Det...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Z. Zhao H.S. Shim C. Levin Radiology Department Stanford University Stanford California United States of America Seoul National University Interdisciplinary program of bioengineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

This study introduces and evaluates a stackable side-readout detector unit with second-generation frontend electronics for near 100 ps CTR Time-of-Flight 3D Position Sensitive (TOF-3DPS) detectors. This design utilizes a timing signal multiplexing scheme based on RF amplifiers and summing circuits to achieve 24:1 timing multiplexing and employs complex programmable logic devices (CPLDs) to facilitate high-precision energy measurement, and photon depth of interaction (DOI) positioning for single and multi-interaction inter-crystal scatter (ICS) events across different crystal elements within a detector unit. Experimental results with a single layer sub-unit comprising a $4 \times 2$ array of $3 \times 3 \times 10 \mathrm{~mm}^{3}$ LYSO:Ce crystals side-coupled with a $4 \times 6$ array of $3.16 \times 3.16 \mathrm{~mm}^{2}$ SiPMs yielded a 9.88 ± 0.86% energy resolution and a Coincidence Timing Resolution (CTR) of $121.28 \pm 3.35$ ps FWHM. Electrical collimation measurements performed at different positions along the 10 mm length of one crystal element produced a $1.44 \pm 0.44 \mathrm{~mm}$ FWHM DOI resolution. Additionally, electronic collimation of different columns in a detector unit revealed ICS event ratios for scatter to adjacent columns from the collimated column of 6.90%, 10.46%, 10.85%, and 5.33%, respectively. The side-readout detector layer sub-unit and the corresponding frontend circuitry have a footprint of only $27 \mathrm{~mm} \times 95 \mathrm{~mm}$, making it easy to stack and form a multi-layer TOF-3DPS block detector.

关键词： Multiplexing Temperature sensors Semiconductor device measurement Three-dimensional displays Semiconductor detectors Energy resolution Summing circuits

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ELASTOMERIC CYCLIC OLEFIN COPOLYMER (ECOC) CHARACTERIZATION AND APPLICATION AS MICROFLUIDIC VALVES FOR INTEGRATED SYSTEMS 26

ELASTOMERIC CYCLIC OLEFIN COPOLYMER (ECOC) CHARACTERIZATION ...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Childers, Katie Hupert, Mateusz L. Soper, Steven A. Bioengineering Program University of Kansas KS United States Center for BioModular Multiscale Systems for Precision Medicine KS United States Biofluidica Inc. CA United States

ISBN: (纸本)9781733419048

To integrate microfluidic devices into a single autonomous fluidic system, valves are used to connect different components, direct fluid, and control introduction of reagents. Microfluidic valves typically consist of thin elastomeric membranes bonded to a substrate layer containing fluidic networks. The elastomer commonly consists of PDMS. Here, we present elastomeric cyclic olefin copolymer (eCOC, TOPAS E-140) and its use as a membrane for microfluidic valves. We show a proof-of-concept in a system connecting two modules in series and allowing autonomous flow throughout the system for at-home testing of COVID-19 and other applications. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： COVID-19

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Single-photon emission from colloidal perovskite nanocrystals

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National Science Review 2025年第05期 10-14页

作者： Qingsen Zeng Shinyoung Hwang Hyeree Kim Tae-Woo Lee Department of Materials Science and Engineering Seoul National University Research Institute of Advanced Materials Seoul National University Interdisciplinary Program in Bioengineering Seoul National University SN Display Co.Ltd Institute of Engineering Research Soft Foundry Research Institute of Advanced Materials Seoul National University

A single-photon source (SPS) is a device that emits individual photons sequentially. SPSs are fundamental to the progress of quantum information technologies, in which photons convey quantum information. Photons have properties such as polarization, and spatial and temporal modes, which can be used to encode quantum information.

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A Computational Infrastructure for Analyzing Tuberculosis Research Data in Brazil

A Computational Infrastructure for Analyzing Tuberculosis Re...

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21st International Conference on Informatics, Management, and Technology in Healthcare, ICIMTH 2023

作者： Mozini, Mariana Bernardi, Filipe Mioto, Ana Clara Cassão, Victor Kritski, Afrânio Alves, Domingos Ribeirão Preto Medical School University of São Paulo Ribeirão Preto Brazil Bioengineering Postgraduate Program University of São Paulo São Carlos Brazil Faculty of Medicine Federal University of Rio de Janeiro Brazil

ISBN: (纸本)9781643684000

Tuberculosis (TB) is one of the infectious diseases that currently causes the most deaths, with 6.4 million new cases recorded in 2021. Although it is a curable disease, drug-resistant strains emerge due to a lack of hygiene and low-quality or inappropriate medications, among other factors. With this in mind, the World Health Organization initiated the End TB Strategy campaign to improve the health system in the fight against tuberculosis. For this, reliable and high-quality health data is necessary to create effective public policies. However, despite technological advancements such as emerging concepts like Big Data and the Internet of Things, generating health information faces several obstacles. Therefore, the present work aims to describe a pipeline for TB research in Brazil to contribute to obtaining high-quality data. © 2023 The authors and IOS Press.

关键词： Tubes (components)

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Label-Free Classification of L-Histidine Vs Artificial Human Sweat Using Laser Scribed Electrodes and a Multi-Layer Perceptron Neural Network

Label-Free Classification of L-Histidine Vs Artificial Human...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： William García-Rodríguez Andrés Saavedra-Ruiz Pedro J. Resto-Irizarry Department of Mechanical Engineering University of Puerto Rico Mayagüez PR USA Bioengineering Graduate Program University of Puerto Rico Mayagüez PR USA

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

A challenge in wearable technology lies in the realtime monitoring of molecular biomarkers associated with human health. Electrochemical sensors are one of the most useful tools for this purpose and are commonly used in health monitoring devices. Electrochemical biosensing is particularly convenient when used in user-friendly, low-cost devices for testing noninvasive body fluids such as sweat and saliva. However, achieving high selectivity and specificity in measurements depends on the complexity of the biomarker and the stability of the biomarker capture molecule. In this study, laser-scribed electrodes (LSEs) were manufactured using a CO2 laser cutter on Polyimide for the label-free classification of sweat components. Cyclic voltammetry experiments were performed on artificial human sweat and the sweat component L-Histidine. The resulting voltammogram data served as input to train a Multi-Layer Perceptron Neural Network (MLP-NN) algorithm capable of classifying L-Histidine and artificial sweat.

关键词： Electrodes Neural networks Measurement by laser beam Polyimides Laser stability Sensors Molecular biomarkers Laser beam cutting Monitoring Testing

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A proposal for a set of attributes relevant for web portal data quality: The brazilian rare disease network case

A proposal for a set of attributes relevant for web portal d...

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2022 International Conference on ENTERprise Information Systems, CENTERIS 2022 - International Conference on Project MANagement, ProjMAN 2022 and International Conference on Health and Social Care Information Systems and Technologies, HCist 2022

作者： Bernardi, Filipe Andrade Alves, Domingos Neiva, Mariane Barros Yamada, Diego Bettiol Lima, Vinicius Costa Vinci, Andre Thomazini, Giovane Rijo, Rui Felix, Têmis Maria Bioengineering Postgraduate Program University of Sao Paulo Sao Carlos Brazil Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto Brazil Polytechnic Institute of Leiria Portugal Medical Genetics Service Porto Alegre Clinics Hospital Porto Alegre Brazil

Despite widespread growth in the use and complexity of web portals, insufficient attention is paid to their quality. Thus, this paper aims to describe the validation process of the Brazilian Network of Rare Diseases Portal and identify a set of data quality attributes required for psychometric evaluations that will support the portal implementation. This protocol describes a cross-sectional study of mixed nature divided into three steps: A usability evaluation, a Delphi consensus, and an electronic service quality assessment. Also, the RE-AIM model will be applied at various stages of evaluative research. We hope the improvement carried out during the validation of RARAS can contribute to the dissemination of knowledge in the area and include, based on scientific knowledge and clinical experts, offering clear, attractive, and accessible information for the population. A research gap exists in determining components of integrated e-service quality, usability, and user experience evaluation model in general, and for rare disease web portals, in particular. Users of the RARAS Portal need to get validated content and the required reliab online services without doing exhaustive searches or visiting multiple sources, with the main focus on e-service quality. © 2022 The Authors. Published by ELSEVIER B.V.

关键词： Portals

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