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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Lomeli, Gabriela Herr, Amy E. UC Berkeley-UCSF Graduate Program in Bioengineering CA United States Department of Bioengineering University of California BerkeleyCA United States Chan Zuckerberg Biohub San FranciscoCA United States

ISBN: (纸本)9781733419031

Gradients play a key role in mimicking biological conditions in situ and in separating biological species for analysis. Current methods to generate microscale gradients typically require high reagent consumption and enclosed microfluidic devices. Here, we introduce a simple and controllable method to generate stable immobilized gradients in a hydrogel-filled PDMS channel using only 7 µL of reagent. The versatile fabrication technique forms gradients of compounds containing an abstractable hydrogen (C-H) bond. Moreover, the PDMS can be detached from the glass substrate for open access to the gradient gel. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Hydrogels

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Interoperability at healthcare institutions in Brazil: Framework for identify maturity stages

Interoperability at healthcare institutions in Brazil: Frame...

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2023 International Conference on ENTERprise Information Systems, CENTERIS 2023 - International Conference on Project MANagement, ProjMAN 2023 - International Conference on Health and Social Care Information Systems and Technologies, HCist 2023

作者： Vasques, Leandro Rijo, Rui Alves, Domingos Bioengineering Postgraduate Program University of São Paulo Brazil School of Technology and Management Polytechnic Institute of Leiria Portugal CINTESIS - Center for Health Technology and Services Research Portugal Portugal INESCC - Institute for Systems and Computers Engineering at Coimbra Portugal Portugal Ribeirão Preto Medical School University of São Paulo Brazil

There is a growing support from data management and analysis in the clinical and operational support at health services, impacting positively the patient outcome. Studies report that data management provides gains in productivity and raises the value of health services [1]. In this context, the interoperability of information systems (IS) at the environment of health services assumes an important role in spreading information and supporting different activities and procedures. The Brazilian government, through its Unified Health System (Sistema Unico de Saude - SUS), aimed to support and organize the growing use of data technology in the healthcare sector, formalizing protocols and concepts of interoperability used in both public and private health systems. Through applying this MF, it is expected to identify the state of interoperability at Brazilian healthcare institutions, defining a comparative scenario that allows the alignment of efforts in its strategic development in healthcare services, benefiting users and healthcare network. © 2024 The Author(s). Published by Elsevier B.V.

关键词： Electronic health record

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Effect of strained yogurt on the physico-chemical, texture, and sensory properties of low-fat frozen desserts

Food Chemistry Advances

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Food Chemistry Advances 2023年 2卷

作者： Bullock, Yanni Gruen, Ingolf Division of Food Systems and Bioengineering (Food Science Program) University of Missouri Columbia MO United States

In this study, strained yogurt was used as a functional ingredient in a low-fat frozen dessert formulation. Frozen dessert formulations with set yogurt (10-20%) and strained yogurt (10-20%) were optimized using a completely randomized design. Dependent variables included melting rate, overrun, pH, titratable acidity, various macronutrients, various textural attributes, and consumer acceptance questions. The results demonstrated multiple significant effects on most of the dependent variables. Samples with higher concentrations of yogurt, regardless of yogurt type, led to a decrease in the melting rate, overrun, and pH. The lowest melting rate was observed in the formulation containing 20% strained yogurt and 80% ice cream mix. There was a significant difference in total acceptance between the control sample that contained no yogurt and the sample containing 20% strained yogurt and 80% ice cream mix (P<0.001). Based on all the data, the optimum content of strained yogurt was determined to be 10% in frozen dessert formulations. © 2022 The Author(s)

关键词： Consumer acceptance Frozen dessert Physicochemical properties Strained yogurt

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Development of a Computational Simulator of the Physiological Control of Ventricular Assist Devices (VADs) 9th

Development of a Computational Simulator of the Physiologica...

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9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022

作者： Santos, B.J. Cestari, I.A. Biomedical Engineering Graduate Program Escola Politécnica de Engenharia Universidade de Sao Paulo Sao Paulo Brazil Federal Institute of Sao Paulo Sao Paulo Brazil Bioengineering Division—Heart Institute Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil

ISBN: (纸本)9783031494000

Congestive Heart Failure (CHF) is a significant global health issue and considered the most debilitating form of Heart Failure with the heart unable to efficiently pump enough blood to the body, resulting in a high risk of mortality. Left Ventricular Assist Devices (LVADs) are utilized for providing mechanical circulatory assistance for patients with CHF. LVADs can generate pulsatile or continuous flows. Continuous flow LVADs may induce a more physiological flow pattern with some degree of pulsatility when the device is operated using a physiological type of controller. We present a computational simulator that can be used to compare hemodynamic responses of a simulated patient implanted with a LVAD, operated with or without a physiological controller. The computational simulator described here includes: (i) simulations of the patient’s condition;(ii) mathematical models of the estimators and sensors;and (iii) LVAD physiological control algorithms. The application of the simulator allowed us to investigate the performance of physiological control strategies considering various scenarios for LVAD applications. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Controllers

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Slit-Wall Differentiation Method for Depth-of-Interaction Measurement for PET

Slit-Wall Differentiation Method for Depth-of-Interaction Me...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： D. Lee H. Hemmati M. Yi S.I. Kwon University of California Davis Biomedical Engineering Davis California United States of America Seoul National University Interdisciplinary Program in Bioengineering College of Engineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In positron emission tomography (PET), accurately measuring the Depth-of-Interaction (DOI) of 511 keV gamma ray interactions is essential for improving spatial resolution in small animal PET, especially at off-center detector positions. DOI resolution can be improved by modifying crystal structures, reflectors, or by using dual readout techniques. Most methods, except for the more electronics-intensive dual side readout, increase light sharing among pixels, thereby reducing photon availability per pixel. This study introduces a novel Slit-Wall Differentiation (SWD) method, designed to restrict light sharing to just four adjacent pixels, thus enhancing DOI accuracy. The SWD method involves placing strategic slits on the adjacent faces of each pixel, controlling light sharing depending on the DOI position. DOI information is calculated from the output patterns of Silicon Photomultiplier (SiPM) arrays. The effectiveness of the proposed method was validated through GATE simulations (vGATE 9.2) using a $3 \times 3$ Lutetium-Yttrium Oxyorthosilicate (LYSO) array with enhanced specular reflectors (ESRs). An LYSO array fabricated based on the proposed configuration was successfully prepared. For practical validation, an experimental setup using a 4 $\times 4$ NUV-HD-MT (Broadcom) SiPM array is also configured.

关键词： Temperature measurement Photomultipliers Semiconductor device measurement Semiconductor detectors Position measurement Silicon Positron emission tomography

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OLIGONUCLEOTIDE FUNCTIONALIZED POLYACRYLAMIDE BEADS FOR AMPLIFICATION BASED BIOMARKER DETECTION 25

OLIGONUCLEOTIDE FUNCTIONALIZED POLYACRYLAMIDE BEADS FOR AMPL...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Chaves, Rodrigo Cotrim Streets, Aaron University of California BerkeleyCA United States UC Berkeley UCSF Graduate Program in Bioengineering CA United States

ISBN: (纸本)9781733419031

Single-cell quantitative biomarker analysis is a powerful technique for studying tissue heterogeneity, but commonly used staining techniques cannot detect markers with lower than 100 target molecules per cell [1]. Here we report a droplet microfluidic platform for encapsulation of samples in Polyacrylamide (PA) hydrogel beads, and staining for fluorescence analysis. This is achieved by functionalizing the PA with oligonucleotides designed to capture biomarkers of interest, and amplifying targets through PCR, enabling sensitive detection of DNA, RNA or protein molecules with low copy number for quantification of cellular populations with traditional flow cytometry. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Oligonucleotides

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FPGA-Based Single-Input Time-to-Digital Converter with Rise Time Correction and Sub-2 ps Resolution for Precision Timing Applications

FPGA-Based Single-Input Time-to-Digital Converter with Rise ...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： D. Lee M. Yi S.I. Kwon Biomedical Engineering University of California Davis Davis California United States of America Seoul National University Interdisciplinary Program in Bioengineering College of Engineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In numerous fields, including physics, industry, and medical technology, the precise measurement of extremely short time intervals, such as those below 100 ps, is essential. This research introduces an innovative FPGA-based time-to-digital converter (TDC) implemented on the UltraScale+ platform (VCU118, Xilinx). The UltraScale+ platform improves upon timing resolution by incorporating a CARRY8 primitive cell as a delay element, an improvement over the CARRY4, which was widely used in previous platforms. Through the novel end-of-propagation (EOP) technique, the implemented TDC achieves an average bin size of 1.11 ps, demonstrating significant resource efficiency compared to other reported FPGA-based TDCs. This study details the design, implementation, and empirical validation of the TDC. Additionally, a unique feature of the proposed TDC is its ability to measure the input pulse width and apply rise time correction without requiring additional inputs. To demonstrate its practical applicability, the developed TDC was connected to the output of an ultrafast Cherenkov-Radiator-Integrated (CRI)-MCP-PMT after evaluating its electrical performance. The preliminary coincidence timing resolution of a pair of CRI-MCP-PMTs shows improvements from 107 ps to 73 ps (FWHM) with the proposed rise time correction. These advancements highlight the potential of the TDC not only for next-generation medical applications but also for its transformative impact in applications demanding ultra-precise timing.

关键词： Industries Semiconductor device measurement Microwave integrated circuits Image resolution Semiconductor detectors Pulse measurements Medical services

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Synthesis of Flexible Cellulose Based Bioelectrode for Neural Sensing Applications

Synthesis of Flexible Cellulose Based Bioelectrode for Neura...

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2024 Advances in Science and Engineering Technology International Conferences, ASET 2024

作者： Alex, Meera Ali, Amaal Abdulraqeb Al Othman, Amani Al Nashash, Hasan Al-Sayah, Mohammed H. Biosciences and Bioengineering Program American University of Sharjah Sharjah United Arab Emirates Chemical and Biological Engineering Deapartment American University of Sharjah Sharjah United Arab Emirates American University of Sharjah Electrical Engineering Deapartment Sharjah United Arab Emirates American University of Sharjah Biology Chemistry and Environmental Sciences Deapartment Sharjah United Arab Emirates

ISBN: (纸本)9798350344134

Bioelectrodes act as pivotal interfaces between soft neural tissues and external devices for sensing or stimulating purposes. Conventionally, metals such as platinum and iridium have been utilized as bioelectrode materials. However, challenges in interfacing, design and implementation led to the exploration of alternative materials. These challenges include: biocompatibility, mechanical mismatches between tissues and electrodes, cost, reliability, durability in body fluids, and sustainability. This study proposes to synthesize and characterize natural-based cellulose bioelectrodes as flexible, viable, cost-effective, and sustainable substitute for conventional metal-based bioelectrodes, particularly in neural/muscle sensing applications. We report the synthesis of a composite cellulosebased bioelectrode using Polydimethylsiloxane (PDMS) and glycerol at varying compositions. The fabricated electrode was characterized electrochemically to determine its bulk impedance, conductivity, and charge storage density. Results show that the cellulose-based biomaterial containing 23% cellulose, 7% glycerol, and 70% PDMS exhibits a bulk impedance of 0.732 kΩ and a conductivity of 1.8×10-3 S/cm. The flexible electrode could store a charge of 0.589 mC/cm2 which is lower than the safe limit for some tissues. © 2024 IEEE.

关键词： Tissue

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INTEGRATED AND MODULAR SYSTEM FOR MICROFLUIDIC AFFINITY ISOLATION AND LABEL-LESS ENUMERATION OF SARS-COV-2 FROM SALIVA SAMPLES 26

INTEGRATED AND MODULAR SYSTEM FOR MICROFLUIDIC AFFINITY ISOL...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Gamage, Sachindra S.T. Vaidyanathan, Swarnagowri Pahattuge, Thilanga Childers, Katie Wijerathne, Harshani Hupert, Matt Witek, Malgorzata Soper, Steven Department of Chemistry The University of Kansas LawrenceKS66045 United States Bioengineering program The University of Kansas LawrenceKS66045 United States BioFluidica Inc. San DiegoCA United States

ISBN: (纸本)9781733419048

关键词： Coronavirus

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Study of Novel Photodetectors and Electronics to Enhance Coincidence Time Resolution of BGO-based PET Detectors

Study of Novel Photodetectors and Electronics to Enhance Coi...

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2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022

作者： Gonzalez-Montoro, Andrea Pourashraf, Shirin Cates, Joshua W Levin, Craig S Stanford University Department of Radiology StanfordCA94305 United States Lawrence Berkeley National Laboratory Applied Nuclear Physics Program BerkeleyCA94720 United States Stanford University Departments of Radiology Molecular Imaging Program Bioengineering Physics and Electrical Engineering CA94305 United States

ISBN: (纸本)9781665488723

Developing high sensitivity multiparametric medical imaging tools constitutes one of the main research topics in radionuclide *** time-of-flight positron emission tomography (TOF-PET) scanners have shown potential in this context. One of the most attractive solutions that have been proposed to improve the coincidence time resolution (CTR) of TOF-PET scanners includes exploiting the small population of promptly emitted light photons (i.e., Cherenkov photons). Bismuth germanate (BGO) is a legacy detection material for PET which exhibits a moderate Cherenkov yield. which new advancements in ultra-violet (UV) light sensitive photosensor technologies and associated detection techniques can exploit for fast timing. It has been demonstrated that exploiting the BGO-Cherenkov component may simultaneously facilitate high 511 keV photon detection sensitivity with excellent CTR, thus enabling high sensitivity, low cost TOF-PET systems. Accessing the timing information from these Cherenkov photons requires enhanced photodetector technology combined with low noise and fast readout electronics, as well as specific data post-processing *** this summary, we report the CTR evaluation of different length BGO crystals coupled to UV enhanced SiPMs and custom designed electronics. Average CTR values of 156 ± 6, 188 ± 5, 228 ± 8 and 297 ± 8 ps CTR FWHM have been achieved for 3 × 3 × 3, × 5, × 10, and × 15 mm3 BGO crystal with chemically processed surface finishes. © 2022 IEEE.

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