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Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

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The Lancet 2023年第10397期402卷 203-234页

作者： Ong, Kanyin Liane Stafford, Lauryn K. McLaughlin, Susan A. Boyko, Edward J. Vollset, Stein Emil Smith, Amanda E. Dalton, Bronte E. Duprey, Joe Cruz, Jessica A. Hagins, Hailey Lindstedt, Paulina A. Aali, Amirali Abate, Yohannes Habtegiorgis Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Mohsen ElHafeez, Samar Abd Abd-Rabu, Rami Abdulah, Deldar Morad Abdullah, Abu Yousuf Md Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abu-Gharbieh, Eman Abu-Zaid, Ahmed Adane, Tigist Demssew Adane, Denberu Eshetie Addo, Isaac Yeboah Adegboye, Oyelola A. Adekanmbi, Victor Adepoju, Abiola Victor Adnani, Qorinah Estiningtyas Sakilah Afolabi, Rotimi Felix Agarwal, Gina Aghdam, Zahra Babaei Agudelo-Botero, Marcela Arriagada, Constanza Elizabeth Aguilera Agyemang-Duah, Williams Ahinkorah, Bright Opoku Ahmad, Danish Ahmad, Rizwan Ahmad, Sajjad Ahmad, Aqeel Ahmadi, Ali Ahmadi, Keivan Ahmed, Ali Ahmed, Luai A. Ahmed, Syed Anees Ajami, Marjan Akinyemi, Rufus Olusola Al Hamad, Hanadi Al Hasan, Syed Mahfuz AL-Ahdal, Tareq Mohammed Ali Alalwan, Tariq A. Al-Aly, Ziyad AlBataineh, Mohammad T. Alcalde-Rabanal, Jacqueline Elizabeth Alemi, Sharifullah Ali, Hassam Alinia, Tahereh Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Amare, Firehiwot Ameyaw, Edward Kwabena Amiri, Sohrab Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Anjana, Ranjit Mohan Ansar, Adnan Ansari, Golnoosh Ansari-Moghaddam, Alireza Anyasodor, Anayochukwu Edward Arabloo, Jalal Aravkin, Aleksandr Y. Areda, Demelash Arifin, Hidayat Arkew, Mesay Armocida, Benedetta Arnlov, Johan Artamonov, Anton A. Arulappan, Judie Aruleba, Raphael Taiwo Arumugam, Ashokan Aryan, Zahra Asemu, Mulu Tiruneh Asghari-Jafarabadi, Mohammad Askari, Elaheh Asmelash, Daniel Astell-Burt, Thomas Athar, Mohammad Athari, Seyyed Shamsadin Atout, Maha Moh'd Wahbi Avila-Burgos, Leticia Awaisu, Ahmed Azadnajafabad, Sina Darshan, B.B. Babamohamadi, Hassan Badar, Muhammad Badawi, Alaa Badiye, Ashish D. Baghcheghi, Nayereh Baghe Institute for Health Metrics and Evaluation School of Medicine General Medicine Service Department of Veterans Affairs Seattle WA United States Department of Health Metrics Sciences School of Medicine Faculty of Medicine France Department of Clinical Governance and Quality Improvement Aleta Wondo Hospital Aleta Wondo Ethiopia Department of Nursing Woldia University Woldia Ethiopia Department of Nursing Department of Orthopedic Surgery Orthopaedic Surgery Social Determinants of Health Research Center Non-communicable Diseases Research Center Epidemiology Department Evidence-Based Practice Center Community and Maternity Nursing Unit University of Duhok Duhok Iraq School of Planning Faculty of Environment Department of Public Health Sciences Penn State College of Medicine Pennsylvania State University Hershey PA United States Biocomplexity Institute Virginia Tech Blacksburg VA United States College of Medicine Department of Public Health Laboratory Technology Sciences Department Department of Family and Community Health University of Health and Allied Sciences Ho Ghana Research Center for Immunodeficiencies Department of Biosciences and Nutrition Karolinska University Hospital Huddinge Sweden Clinical Sciences Department Department of Surgery Department of Surgery Department of Obstetrics & Gynecology College of Graduate Health Sciences University of Tennessee Memphis TN United States Department of Obstetrics & Gynecology Department of Clinical and Psychosocial Epidemiology Department of Anesthesia and Critical Care Centre for Social Research in Health Quality and Systems Performance Unit Cancer Institute NSW Sydney NSW Australia Department of Public Health and Tropical Medicine HIV and Infectious Diseases Department Jhpiego Abuja Nigeria Adolescent Research and Care Department Adolescent Friendly Research Initiative and Care Ado Ekiti Nigeria Department of Epidemiology Department of Epidemiology and Medical Statistics Department of Family Medicine McMaster University

Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined;these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs;defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims;type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative r

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Author Correction: Universal DNA methylation age across mammalian tissues

Nature aging

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Nature aging 2023年第11期3卷 1462页

作者： A T Lu Z Fei A Haghani T R Robeck J A Zoller C Z Li R Lowe Q Yan J Zhang H Vu J Ablaeva V A Acosta-Rodriguez D M Adams J Almunia A Aloysius R Ardehali A Arneson C S Baker G Banks K Belov N C Bennett P Black D T Blumstein E K Bors C E Breeze R T Brooke J L Brown G G Carter A Caulton J M Cavin L Chakrabarti I Chatzistamou H Chen K Cheng P Chiavellini O W Choi S M Clarke L N Cooper M L Cossette J Day J DeYoung S DiRocco C Dold E E Ehmke C K Emmons S Emmrich E Erbay C Erlacher-Reid C G Faulkes S H Ferguson C J Finno J E Flower J M Gaillard E Garde L Gerber V N Gladyshev V Gorbunova R G Goya M J Grant C B Green E N Hales M B Hanson D W Hart M Haulena K Herrick A N Hogan C J Hogg T A Hore T Huang J C Izpisua Belmonte A J Jasinska G Jones E Jourdain O Kashpur H Katcher E Katsumata V Kaza H Kiaris M S Kobor P Kordowitzki W R Koski M Krützen S B Kwon B Larison S G Lee M Lehmann J F Lemaitre A J Levine C Li X Li A R Lim D T S Lin D M Lindemann T J Little N Macoretta D Maddox C O Matkin J A Mattison M McClure J Mergl J J Meudt G A Montano K Mozhui J Munshi-South A Naderi M Nagy P Narayan P W Nathanielsz N B Nguyen C Niehrs J K O'Brien P O'Tierney Ginn D T Odom A G Ophir S Osborn E A Ostrander K M Parsons K C Paul M Pellegrini K J Peters A B Pedersen J L Petersen D W Pietersen G M Pinho J Plassais J R Poganik N A Prado P Reddy B Rey B R Ritz J Robbins M Rodriguez J Russell E Rydkina L L Sailer A B Salmon A Sanghavi K M Schachtschneider D Schmitt T Schmitt L Schomacher L B Schook K E Sears A W Seifert A Seluanov A B A Shafer D Shanmuganayagam A V Shindyapina M Simmons K Singh I Sinha J Slone R G Snell E Soltanmaohammadi M L Spangler M C Spriggs L Staggs N Stedman K J Steinman D T Stewart V J Sugrue B Szladovits J S Takahashi M Takasugi E C Teeling M J Thompson B Van Bonn S C Vernes D Villar H V Vinters M C Wallingford N Wang R K Wayne G S Wilkinson C K Williams R W Williams X W Yang M Yao B G Young B Zhang Z Zhang P Zhao Y Zhao W Zhou J Zimmermann J Ernst K Raj S Horvath Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Altos Labs San Diego Institute of Science San Diego CA USA. Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA USA. Department of Statistics University of California Riverside Riverside CA USA. Zoological SeaWorld Parks and Entertainment Orlando FL USA. Altos Labs Cambridge Institute of Science Cambridge UK. Bioinformatics Interdepartmental Program University of California Los Angeles CA USA. Department of Biological Chemistry University of California Los Angeles Los Angeles CA USA. Department of Biology University of Rochester Rochester NY USA. Department of Neuroscience Peter O'Donnell Jr. Brain Institute University of Texas Southwestern Medical Center Dallas TX USA. Department of Biology University of Maryland College Park MD USA. Loro Parque Fundacion Puerto de la Cruz Spain. Department of Biology University of Kentucky Lexington KY USA. Division of Cardiology Department of Internal Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Marine Mammal Institute Oregon State University Newport OR USA. School of Science and Technology Clifton Campus Nottingham Trent University Nottingham UK. School of Life and Environmental Sciences the University of Sydney Sydney New South Wales Australia. Department of Zoology and Entomology University of Pretoria Hatfield South Africa. Busch Gardens Tampa Tampa FL USA. Department of Ecology and Evolutionary Biology University of California Los Angeles Los Angeles CA USA. Rocky Mountain Biological Laboratory Crested Butte CO USA. Altius Institute for Biomedical Sciences Seattle WA USA. Epigenetic Clock Development Foundation Los Angeles CA USA. Center for Species Survival Smithsonian Conservation Biology Institute Front Royal VA USA. Department of Evolution Eco

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A Participant-Derived Xenograft Model of HIV Enables Long-Term Evaluation of Autologous Immunotherapies

SSRN

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SSRN 2020年

作者： McCann, Chase D. van Dorp, Christiaan H. Ward, Adam R. Danesh, Ali Dilling, Thomas R. Mota, Talia M. Zale, Elizabeth Patel, Shabnum Brumme, Chanson J. Dong, Winnie Jones, Douglas S. Andresen, Thomas L. Walker, Bruce D. Brumme, Zabrina L. Bollard, Catherine M. Perelson, Alan S. Irvine, Darrell J. Jones, R. Brad Weill Cornell Medicine Belfer Research Building Room 550 413 E 69th Street New YorkNY10021 United States Infectious Diseases Division Department of Medicine Weill Cornell Medical College New YorkNY United States Immunology & Microbial Pathogenesis Graduate Program Weill Cornell Graduate School of Medical Sciences New YorkNY United States Los Alamos National Laboratory Los AlamosNM United States Department of Microbiology Immunology & Tropical Medicine The George Washington University School of Medicine and Health Sciences WashingtonDC United States Milken Institute School of Public Health The George Washington University WashingtonDC United States Center for Cancer and Immunology Research Children’s National Health System WashingtonDC United States GW Cancer Center George Washington University WashingtonDC United States British Columbia Centre for Excellence in HIV/AIDS VancouverBC Canada Repertoire Immune Medicines CambridgeMA United States Ragon Institute of Massachusetts General Hospital MIT & Harvard University BostonMA United States Institute for Medical and Engineering Sciences MIT CambridgeMA United States Howard Hughes Medical Institute Chevy ChaseMD United States Faculty of Health Sciences Simon Fraser University BurnabyBC Canada Department of Material Science and Engineering MIT CambridgeMA United States Koch Institute for Integrative Cancer Research MIT CambridgeMA United States Department of Biological Engineering MIT CambridgeMA United States

HIV-specific CD8 + T-cells partially control viral replication and delay disease progression, but rarely provide lasting protection – largely due to immune escape. We show that engrafting mice with memory CD4+ T-cells from HIV + donors uniquely allows for the in vivo evaluation of autologous T-cell responses, while avoiding graft-versus-host disease and the need for human fetal tissues that limit other models. Treating HIV-infected mice with clinically-relevant HIV-specific T-cell products resulted in substantial reductions in viremia, which were augmented by engineering with IL-15 superagonist-containing nanogels. Ultimately, in vivo activity was limited by the selection of diverse escape mutations, recapitulating patterns seen in humans. By applying mathematical modeling, we show that the kinetics of the CD8 + T-cell response have a profound impact on the emergence and persistence of escape mutations. This ‘participant-derived xenograft’ model of HIV provides a powerful tool for studying HIV-specific immunological responses and facilitating the development of effective cell-based therapies. © 2020, The Authors. All rights reserved.

关键词： T-cells

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Influence of a program Combining Amusement and Exercise on Subjective Well-Being: Six-Month Intervention Study with a Complex-Type program for Community-Dwelling Elderly Subjects

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Open Journal of Preventive Medicine 2018年第8期8卷 266-281页

作者： Nami Kawabata Tadayuki Iida Hideki Miyaguchi Masafumi Kunishige Chinami Ishizuki Hiroko Hashimoto Yasuhiro Ito Toshihide Harada Program in Biological System Sciences Graduate School of Comprehensive Scientific Research Prefectural University of Hiroshima Shobara Japan Department of Rehabilitation/Occupational Therapist Faculty of Health Sciences Hiroshima Cosmopolitan University Hiroshima Japan Department of Physical Therapy Faculty of Health and Welfare Prefectural University of Hiroshima Mihara Japan Department of Human Behavior Science of Occupational Therapy Health Sciences Major Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Division of Occupational Therapy Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Occupational Therapy Faculty of Health Sciences Morinomiya University of Medical Sciences Osaka Japan School of Health Sciences Fujita Health University Toyoake Japan

Background: Health promotion for the elderly mainly targets improvements in physical function, and a lack of strengthening of subjective well-being as well as the creation of interaction-providing opportunities for activity and participation has been reported. Evaluations of positive and negative aspects for subjective well-being are needed. Elderly subjects were intervened through a 6-month complex-type program combining amusement and exercise and its influences on subjective well-being and physical and physiological functions were investigated. Methods: Subjects in this survey were 37 healthy elderly females living in M city, Hiroshima Prefecture (age: 69.7 ± 5.9 years old), and the survey was performed between September 2016 and March 2017. The complex-type program comprised amusement and exercise programs. The survey was performed at 4 time points during the intervention period: before the intervention and 1, 3, and 6 months during the intervention. Subjective well-being (Japanese version of the Subjective Well-being Inventory (SUBI): Mental health scores, Mental fatigue scores), salivary amylase levels, and the locomotive syndrome risk test (two-step test, stand-up test, and 25-question risk assessment) were surveyed at each time point. Regarding the duration of the intervention as a factor, changes in salivary amylase levels were analyzed using repeated measures one-way ANOVA and SUBI was tested using the Friedman test (EZR Ver 1.32). In addition, the relationship between the locomotive syndrome risk level and duration of the intervention was examined using Fisher’s test. Results: SUBI and the locomotive syndrome risk level significantly differed with time during the intervention. Slight changes were observed in salivary amylase levels during the intervention. Conclusion: The present results suggest that the complex-type program promoted interactions among community-dwelling elderly subjects and positively influenced the maintenance of and improvements in phys

关键词： Subjective Well-Being SUBI The Elderly Amusement Exercise

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THE ARCTIC

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BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY 2023年第9期104卷 S271-S321页

作者： Moon, T. A. Thoman, R. Druckenmiller, M. L. National Snow and Ice Data Center Cooperative Institute for Research in Environmental Sciences University of Colorado Boulder Colorado International Arctic Research Center University of Alaska Fairbanks Fairbanks Alaska Kawerak Inc. Nome Alaska National Park Service Fairbanks Alaska Norwegian Meteorological Institute Oslo Norway Northern Arizona University Flagstaff Arizona Biospherical Instruments Inc. San Diego California Geophysical Institute University of Alaska Fairbanks Fairbanks Alaska Plant Soils and Climate Department Utah State University Logan Utah Department of Arctic Ecology Norwegian Institute for Nature Research Trondheim Norway NOAA/NWS Alaska Region Anchorage Alaska Geology Department University Centre in Svalbard Svalbard Norway Atmospheric and Environmental Research Lexington Massachusetts Centre National de Recherches Météorologiques Météo-France/CNRS Toulouse France Climate Research Division Environment and Climate Change Canada Toronto Canada Norwegian Polar Institute Fram Centre Tromso Norway Caroline Danish Meteorological Institute Copenhagen Denmark Department of Physics University of Toronto Toronto Canada University of Virginia Charlottesville Virginia Geological Survey of Denmark and Greenland (GEUS) Copenhagen Denmark University of Liège Belgium Environment and Climate Change Canada Toronto Canada Arctic Centre University of Lapland Rovaniemi Finland ABR Inc. Fairbanks Alaska Forschungszentrum Jülich Jülich Germany Department of Geography and Lincoln Climate Research Group Lincoln United Kingdom Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Bremerhaven Germany Woodwell Climate Research Center Falmouth Massachusetts Finnish Meteorological Institute Helsinki Finland Norwegian Radiation and Nuclear Safety Østerås Norway Coastal Observation and Seabird Survey Team University of Washington Seattle Washington U.S. Fish and Wildlife Service Alaska Region Anchorage Alaska Korea Polar Rese

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Opportunities, barriers, and recommendations in down syndrome research

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Translational science of Rare Diseases 2020年第3-4期5卷 99-129页

作者： Hendrix, James A. Amon, Angelika Abbeduto, Leonard Agiovlasitis, Stamatis Alsaied, Tarek Anderson, Heather A. Bain, Lisa J. Baumer, Nicole Bhattacharyya, Anita Bogunovic, Dusan Botteron, Kelly N. Capone, George Chandan, Priya Chase, Isabelle Chicoine, Brian Cieuta-Walti, Cécile Deruisseau, Lara R. Durand, Sophie Esbensen, Anna Fortea, Juan Giménez, Sandra Granholm, Ann-Charlotte Mattie, Laura J. Head, Elizabeth Hillerstrom, Hampus Jacola, Lisa M. Janicki, Matthew P. Jasien, Joan M. Kamer, Angela R. Kent, Raymond D. Khor, Bernard Lawrence, Jeanne B. Lemonnier, Catherine Lewanda, Amy Feldman Mobley, William Moore, Paul E. Nelson, Linda Pollak Oreskovic, Nicolas M. Osorio, Ricardo S. Patterson, David Rasmussen, Sonja A. Reeves, Roger H. Roizen, Nancy Santoro, Stephanie Sherman, Stephanie L. Talib, Nasreen Tapia, Ignacio E. Walsh, Kyle M. Warren, Steven F. White, A. Nicole Wong, G. William Yi, John S. LuMind Idsc Foundation Burlington MA United States Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA United States Department of Psychiatry and Behavioral Sciences University of California Davis CA United States Department of Kinesiology Mississippi State University Mississippi State MS United States Heart Institute Department of Pediatrics Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati OH United States The Ohio State University College of Optometry Columbus OH United States Independent Science Writer Elverson PA United States Department of Neurology Boston Children's Hospital Harvard Medical School Boston MA United States Waisman Center University of Wisconsin-Madison Madison WI United States Department of Cell and Regenerative Biology School of Medicine and Public Health University of Wisconsin-Madison Madison WI United States Department of Microbiology Icahn School of Medicine at Mt. Sinai New York NY United States Department of Psychiatry Washington University School of Medicine St. Louis MO United States Kennedy Krieger Institute Baltimore MD United States Department of Neurosurgery Division of Physical Medicine and Rehabilitation University of Louisville School of Medicine Louisville KY United States Department of Pediatric Dentistry Boston Children's Hospital Boston MA United States Advocate Medical Group Adult Down Syndrome Center Park Ridge IL United States Department of Pediatrics University of Sherbrooke QC Canada Department of Biological Sciences Le Moyne College Syracuse NY United States Institut Jérôme Lejeune Crb BioJeL Paris France Department of Pediatrics University of Cincinnati College of Medicine Division of Developmental and Behavioral Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati OH United States Barcelona Down Medical Center Fundació Catalana de Síndrome de Down Barcelona Spain Multidisciplinary Sleep Unit

BACKGROUND: Recent advances in medical care have increased life expectancy and improved the quality of life for people with Down syndrome (DS). These advances are the result of both pre-clinical and clinical research but much about DS is still poorly understood. In 2020, the NIH announced their plan to update their DS research plan and requested input from the scientific and advocacy community. OBJECTIVE: The National Down Syndrome Society (NDSS) and the LuMind IDSC Foundation worked together with scientific and medical experts to develop recommendations for the NIH research plan. METHODS: NDSS and LuMind IDSC assembled over 50 experts across multiple disciplines and organized them in eleven working groups focused on specific issues for people with DS. RESULTS: This review article summarizes the research gaps and recommendations that have the potential to improve the health and quality of life for people with DS within the next decade. CONCLUSIONS: This review highlights many of the scientific gaps that exist in DS research. Based on these gaps, a multidisciplinary group of DS experts has made recommendations to advance DS research. This paper may also aid policymakers and the DS community to build a comprehensive national DS research strategy. © 2020-The authors. Published by IOS Press.

关键词： and Alzheimer's disease autism spectrum disorder autoimmune disease cognitive development congenital heart disease Down syndrome intellectual disability leukemia muscle hypotonia obesity obstructive sleep apnea periodontitis

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Publisher Correction: Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

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Nature genetics 2024年第12期56卷 2843页

作者： Sean J Jurgens Joel T Rämö Daria R Kramarenko Leonoor F J M Wijdeveld Jan Haas Mark D Chaffin Sophie Garnier Liam Gaziano Lu-Chen Weng Alex Lipov Sean L Zheng Albert Henry Jennifer E Huffman Saketh Challa Frank Rühle Carmen Diaz Verdugo Christian Krijger Juárez Shinwan Kany Constance A van Orsouw Kiran Biddinger Edwin Poel Amanda L Elliott Xin Wang Catherine Francis Richard Ruan Satoshi Koyama Leander Beekman Dominic S Zimmerman Jean-François Deleuze Eric Villard David-Alexandre Trégouët Richard Isnard Dorret I Boomsma Eco J C de Geus Rafik Tadros Yigal M Pinto Arthur A M Wilde Jouke-Jan Hottenga Juha Sinisalo Teemu Niiranen Roddy Walsh Amand F Schmidt Seung Hoan Choi Kyong-Mi Chang Philip S Tsao Paul M Matthews James S Ware R Thomas Lumbers Saskia van der Crabben Jari Laukkanen Aarno Palotie Ahmad S Amin Philippe Charron Benjamin Meder Patrick T Ellinor Mark Daly Krishna G Aragam Connie R Bezzina Department of Experimental Cardiology Amsterdam Cardiovascular Sciences Heart Failure & Arrhythmias Amsterdam UMC location University of Amsterdam Amsterdam the Netherlands. Cardiovascular Disease Initiative Broad Institute of MIT and Harvard Cambridge MA USA. Cardiovascular Research Center Massachusetts General Hospital Boston MA USA. Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland. European Reference Network for rare low prevalence and complex diseases of the heart: ERN GUARD-Heart Amsterdam the Netherlands. Department of Physiology Amsterdam UMC location Vrije Universiteit Amsterdam the Netherlands. Department of Medicine III Institute for Cardiomyopathies Heidelberg (ICH) University Hospital Heidelberg Heidelberg Germany. Site Heidelberg/Mannheim DZHK Heidelberg Germany. Research Unit on Cardiovascular Disorders Metabolism and Nutrition Team Genomics and Pathophysiology of Cardiovascular Disease Sorbone Université INSERM Paris France. ICAN Institute for Cardiometabolism and Nutrition Paris France. National Heart and Lung Institute Imperial College London London UK. MRC Laboratory of Medical Sciences Imperial College London London UK. Royal Brompton and Harefield Hospitals Guy's and St. Thomas' NHS Foundation Trust London UK. Institute of Cardiovascular Science University College London London UK. Institute of Health Informatics University College London London UK. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA. Palo Alto Veterans Institute for Research (PAVIR) Palo Alto Health Care System Palo Alto CA USA. Harvard Medical School Boston MA USA. Bioinformatics Core Facility Institute of Molecular Biology gGmbH (IMB) Mainz Germany. Department of Genetic Epidemiology Institute of Human Genetics University of Münster Münster Germany. Department of Cardiology University Heart and Vascular

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Correction to: Integrating isotopic, microbial, and modeling approaches to understand methane dynamics in a frequently disturbed deep reservoir in Taiwan

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Ecological Research 2018年第5期33卷 1083-1084页

作者： Masayuki Itoh Hisaya Kojima Pei-Chi Ho Chun-Wei Chang Tzong-Yueh Chen Silver Sung-Yun Hsiao Yuki Kobayashi Megumu Fujibayashi Shuh-Ji Kao Chih-hao Hsieh Manabu Fukui Noboru Okuda Takeshi Miki Fuh-Kwo Shiah Center for Southeast Asian Studies Kyoto University 46 Shimoadachi-cho Yoshida Sakyo-ku Kyoto 606-8501 Japan The Institute of Low Temperature Science Hokkaido University Kita-19 Nishi-8 Kita-ku Sapporo 060-0819 Japan Earth System Sciences Program Taiwan International Graduate Program Academia Sinica 128 Academia Road Section 2 Nankang Taipei 11529 Taiwan Earth System Sciences Program Taiwan International Graduate Program National Central University No. 300 Zhongda Rd Zhongli District Taoyuan 32001 Taiwan Institute of Marine Environment and Ecology National Taiwan Ocean University No. 2 Beining Road Zhongzheng District Keelung 202 Taiwan Institute of Earth Science Academia Sinica 128 Academia Road Section 2 Nankang Taipei 11529 Taiwan Faculty of Health Sciences Yamaguchi University Graduate School of Medicine 1-1-1 Minamikogushi Ube 755-8505 Japan Department of Biological Environment Akita Prefectural University 241-438 Aza Nakano Shimoshinjo Akita 010-0195 Japan State Key Laboratory of Marine Environmental Science Xiamen University 422 Siming S Rd Siming Qu Xiamen 361005 Fujian Sheng People's Republic of China Institute of Oceanography National Taiwan University No. 1 Sec. 4 Roosevelt Rd Taipei 10617 Taiwan Institute of Ecology and Evolutionary Biology Department of Life Science National Taiwan University No. 1 Sec. 4 Roosevelt Rd Taipei 10617 Taiwan Research Center for Environmental Changes Academia Sinica 128 Academia Road Section 2 Nankang Taipei 11529 Taiwan National Center for Theoretical Sciences No. 1 Sec. 4 Roosevelt Rd Taipei 10617 Taiwan Research Institute for Humanity and Nature 457-4 Motoyama Kamigamo Kita-ku Kyoto 603-8047 Japan

The article “Integrating isotopic, microbial, and modeling approaches to understand methane dynamics in a frequently disturbed deep reservoir in Taiwan”, written by Masayuki Itoh, Hisaya Kojima, Pei-Chi Ho, Chun-Wei Chang, Tzong-Yueh Chen, Silver Sung-Yun Hsiao, Yuki Kobayashi, Megumu Fujibayashi, Shuh-Ji Kao, Chih-hao Hsieh, Manabu Fukui, Noboru Okuda, Takeshi Miki, Fuh-Kwo Shiah, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 18 September 2017 without open access.

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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease

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Hepatology international 2024年第4期18卷 1178-1201页

作者： Huai Zhang Giovanni Targher Christopher D Byrne Seung Up Kim Vincent Wai-Sun Wong Luca Valenti Myer Glickman Jaime Ponce Christos S Mantzoros Javier Crespo Henning Gronbaek Wah Yang Mohammed Eslam Robert J Wong Mariana Verdelho Machado Ming-Lung Yu Omar M Ghanem Takeshi Okanoue Jun-Feng Liu Yong-Ho Lee Xiao-Yuan Xu Qiuwei Pan Meili Sui Amedeo Lonardo Yusuf Yilmaz Li-Yong Zhu Christophe Moreno Luca Miele Monica Lupsor-Platon Lei Zhao Teresa LeAnn LaMasters Robert G Gish Huijie Zhang Marius Nedelcu Wah Kheong Chan Ming-Feng Xia Fernando Bril Jun-Ping Shi Christian Datz Stefano Romeo Jian Sun Dan Liu Silvia Sookoian Yi-Min Mao Nahum Méndez-Sánchez Xiao-Yan Wang Nikolaos T Pyrsopoulos Jian-Gao Fan Yasser Fouad Dan-Qin Sun Cosimo Giannini Jin Chai Ze-Feng Xia Dae Won Jun Guo-Jing Li Sombat Treeprasertsuk Ying-Xu Li Tan To Cheung Faming Zhang George Boon-Bee Goh Masato Furuhashi Wai-Kay Seto Hui Huang Anna Di Sessa Qing-Hong Li Evangelos Cholongitas Le Zhang Themis Reverbel Silveira Giada Sebastiani Leon A Adams Wei Chen Xiaolong Qi Ivan Rankovic Victor De Ledinghen Wen-Jie Lv Masahide Hamaguchi Radwan Kassir Dirk Müller-Wieland Manuel Romero-Gomez Ying Xu Yi-Cong Xu Shi-Yao Chen Mohammad Kermansaravi Mohammad Shafi Kuchay Sander Lefere Chetan Parmar Gregory Y H Lip Chun-Jen Liu Fredrik Åberg George Lau Jacob George Shiv Kumar Sarin Jing-Ya Zhou Ming-Hua Zheng Department of Medical Record the First Affiliated Hospital of Wenzhou Medical University Wenzhou China. Metabolic Diseases Research Unit IRCCS Sacro Cuore - Don Calabria Hospital Negrar di Valpolicella Italy. Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton and University of Southampton Southampton General Hospital Southampton UK. Department of Internal Medicine Yonsei University Seoul Korea. Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China. Department of Pathophysiology and Transplantation University of Milan Milan Italy. Precision Medicine Biological Resource Center Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy. Health Analysis and Pandemic Insight Division Office for National Statistics London UK. Department Bariatric Surgery CHI Memorial Hospital Chattanooga TN USA. Beth Israel Deaconess Medical Center and Boston VA Healthcare System Harvard Medical School Boston MA USA. Gastroenterology and Hepatology Department Clinical and Traslational Research in Digestive Diseases Valdecilla Research Institute (IDIVAL) Marqués de Valdecilla University Hospital Santander Spain. Department of Hepatology and Gastroenterology Aarhus University Hospital 8200 Aarhus N Denmark. Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University Guangzhou China. Storr Liver Centre Westmead Institute for Medical Research Westmead Hospital and University of Sydney Sydney NSW Australia. Division of Gastroenterology and Hepatology Stanford University School of Medicine Veterans Affairs Palo Alto Healthcare System Palo Alto USA. Department of Gastroenterology Hospital de Vila Franca de Xira Vila Franca de Xira Portugal. School of Medicine and Doctoral Program of Clinical and Experimental Medicine College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat-sen Univers

BACKGROUND:With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11. METHODS:Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members. RESULTS:A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p = 0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%). CONCLUSIONS:This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.

关键词： Global survey ICD-11 MAFLD

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