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Enhanced diabetic wound healing using platelet-derived extracellular vesicles and reduced graphene oxide in polymer-coordinated hydrogels

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Journal of Nanobiotechnology 2023年第1期21卷 1-17页

作者： Hao, Ping-Chien Burnouf, Thierry Chiang, Chih-Wei Jheng, Pei-Ru Szunerits, Sabine Yang, Jen-Chang Chuang, Er-Yuan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Univ. Lille CNRS Centrale Lille Univ. Polytechnique Hauts-de-France UMR 8520 IEMN LilleF- 59000 France Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei110-52 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Impaired wound healing is a significant complication of diabetes. Platelet-derived extracellular vesicles (pEVs), rich in growth factors and cytokines, show promise as a powerful biotherapy to modulate cellular proliferation, angiogenesis, immunomodulation, and inflammation. For practical home-based wound therapy, however, pEVs should be incorporated into wound bandages with careful attention to delivery strategies. In this work, a gelatin-alginate hydrogel (GelAlg) loaded with reduced graphene oxide (rGO) was fabricated, and its potential as a diabetic wound dressing was investigated. The GelAlg@rGO-pEV gel exhibited excellent mechanical stability and biocompatibility in vitro, with promising macrophage polarization and reactive oxygen species (ROS)-scavenging capability. In vitro cell migration experiments were complemented by in vivo investigations using a streptozotocin-induced diabetic rat wound model. When exposed to near-infrared light at 2 W cm− 2, the GelAlg@rGO-pEV hydrogel effectively decreased the expression of inflammatory biomarkers, regulated immune response, promoted angiogenesis, and enhanced diabetic wound healing. Interestingly, the GelAlg@rGO-pEV hydrogel also increased the expression of heat shock proteins involved in cellular protective pathways. These findings suggest that the engineered GelAlg@rGO-pEV hydrogel has the potential to serve as a wound dressing that can modulate immune responses, inflammation, angiogenesis, and follicle regeneration in diabetic wounds, potentially leading to accelerated healing of chronic wounds. © 2023, BioMed Central Ltd., part of Springer Nature.

关键词： Platelets

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Dental Imaging Using a Higher Signal-to-Noise Ratio Optical Coherence Tomography System

Dental Imaging Using a Higher Signal-to-Noise Ratio Optical ...

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2023 IEEE International Conference on Electrical, Computer and Energy Technologies, ICECET 2023

作者： Azeez, Akeem. A. Mezgebo, Biniyam Franca, Rodrigo Sherif, Sherif S. University of Manitoba Biomedical Engineering Graduate Program Winnipeg Canada University of Manitoba Dept. of Electrical and Computer Engineering Winnipeg Canada University of Manitoba Dept. of Restorative Dentistry Winnipeg Canada

ISBN: (纸本)9798350327816

This paper presents an optical coherence tomography (OCT) system in conjunction with a novel image reconstruction technique employed for in vitro imaging of human teeth. The primary goal is to enhance the signal-to-noise ratio (SNR) in the obtained images. The study entails a comparative analysis between the conventional Fast Fourier Transform (FFT) OCT image reconstruction method and a newly introduced scaled nonuniform discrete Fourier transform (NDFT) approach. The findings reveal that the NDFT method consistently delivers superior results in terms of peak signal-to-noise ratio (PSNR) and overall image quality, even when dealing with redundant and nonuniform frequency domain samples. In light of these results, this paper concludes that integrating NDFT into OCT procedures has the potential to significantly enhance the quality of image reconstructions, thereby fostering its broader application in the field of dental imaging. © 2023 IEEE.

关键词： dental imaging frame theory image reconstruction Optical Coherence Tomography (OCT) signal processing

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Stellate silicon microneedles for rapid point-of-care melanoma exosome isolation and detection via a lateral flow assay

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Biosensors and Bioelectronics 2025年 285卷 117560页

作者： Smith, Scott M. Kumari, Abha Marvar, Joseph P. Onukwugha, Nna-Emeka Kang, Yoon-Tae Nagrath, Sunitha Department of Chemical Engineering and Biomedical Engineering Biointerfaces Institute Translational Oncology Program University of Michigan Ann ArborMI48109 United States

Melanoma is the most aggressive type of skin cancer with high mortality rates. Early diagnosis is crucial because it significantly improves treatment outcomes, but conventional methods relying on dermoscopy and lesion biopsy have limitations in accuracy during early stages and are invasive. Liquid biopsies offer a minimally invasive alternative, particularly for routine screening. The abundance of cancer cell-driven extracellular vesicles in interstitial fluid can be utilized for point-of-care cancer diagnostics. Here, we developed a stellate silicon microneedle patch, the ExoPatch, coated with Annexin V functionalized hydrogel to isolate melanoma-specific exosomes. The ExoPatch captures exosomes directly from the skin, followed by dissolution of the hydrogel to release the exosomes, which are then detected using a lateral flow immunoassay specific to melanoma markers (MCAM and MCSP). After validating with cell line derived extracellular vesicles and testing with mouse tissue, the ExoPatch isolated 11.5 times more protein from melanoma tissue compared to healthy tissue. Additionally, the ExoPatch effectively distinguished between melanoma and healthy tissues, with its specificity confirmed through Western Blot and electron microscopy analysis. The ExoPatch with melanoma mouse samples produced a 3.5-fold higher signal in the lateral flow immunoassay compared to that of healthy controls. The ExoPatch presents a promising point-of-care diagnostic tool for melanoma, offering significant advantages in terms of rapidness, minimal invasiveness, and ease of use. It has the potential to enhance early detection and routine monitoring in melanoma patients, ultimately improving patient outcomes by reducing the reliance on traditional, invasive biopsies. © 2025

关键词： Biopsy

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Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

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Highly Integrated Multiplexing and Buffering Electronics for Large Aperture Ultrasonic Arrays

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biomedical engineering Frontiers 2022年第1期3卷 262-283页

作者： Robert Wodnicki Haochen Kang Di Li Douglas N.Stephens Hayong Jung Yizhe Sun Ruimin Chen Lai-Ming Jiang Nestor E.Cabrera-Munoz Josquin Foiret Qifa Zhou Katherine W.Ferrara Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Department of Biomedical Engineering University of CaliforniaDavisDavisCAUSA Molecular Imaging Program at Stanford University StanfordCAUSA USC Roski Eye Institute University of Southern CaliforniaLos AngelesCAUSA

Large aperture ultrasonic arrays can be implemented by tiling together multiple pretested modules of high-density acoustic arrays with closely integrated multiplexing and buffering electronics to form a larger aperture with high *** modular arrays can be used to implement large 1.75D array apertures capable of focusing in elevation for uniform slice thickness along the axial direction which can improve image *** important goal for large array tiling is obtaining high yield and sensitivity while reducing extraneous image *** have been developing tileable acoustic-electric modules for the implementation of large array apertures utilizing Application Specific Integrated Circuits(ASICs)implemented using 0.35μm high voltage(50 V)*** generations of ASICs have been designed and *** ASICs were integrated with high-density transducer arrays for acoustic testing and *** modules were further interfaced to a Verasonics Vantage imaging system and were used to image industry standard ultrasound *** first-generation modules comprise ASICs with both multiplexing and buffering electronics on-chip and have demonstrated a switching artifact which was visible in the images.A second-generation ASIC design incorporates low switching injection circuits which effectively mitigate the artifacts observed with the first-generation ***,we present the architecture of the two ASIC designs and module types as well imaging results that demonstrate reduction in switching artifacts for the second-generation devices.

关键词： Highly Large utilizing

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Molecular Imprinted Polymer Based Optical Sensor for Methanol Vapor Detection

Molecular Imprinted Polymer Based Optical Sensor for Methano...

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Optica Sensing Congress 2023, AIS, FTS, HISE, Sensors, ES 2023 - Part of Optical Sensors and Sensing Congress 2023

作者： Leelasirinuwong, Mintra Denkasineecharoen, Phebe Yungyuentrrakoon, Pin Jitpratak, Pannathorn Kongsawang, Nuntaporn Pathak, Akhilesh Kumar Viphavakit, Charusluk Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Intelligent Control Automation of Process Systems Research Unit Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand

A molecular imprinted polymer-based optical sensor is proposed to detect methanol. The sensor is tested with different concentrations of methanal vapour for sensitivity and ethanol for selectivity. The result shows a ... 详细信息

ISBN: (纸本)9781957171241

关键词： Optical sensors

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In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles

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Nano Research 2023年第1期16卷 1009-1020页

作者： Liqin Ren Yang Liu Tingfeng Yao Kytai TNguyen Baohong Yuan Ultrasound and Optical Imaging Laboratory Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Program the University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineering the University of Texas at ArlingtonArlingtonTX 76019USA

Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment *** particular,ultrasound switchable fluorescence(USF)imaging has been explored with improved imaging sensitivity and spatial resolution in centimeter-deep *** study achieved the size control of polymer-based and indocyanine green(ICG)encapsulated USF contrast agents,capable of accumulating in the tumor after intravenous *** nanoprobes varied in size from 58 to 321 *** bioimaging profiles demonstrated that the proposed nanoparticles can efficiently eliminate the background light from normal tissue and show a tumor-specific fluorescence enhancement in the BxPC-3 tumor-bearing mice models possibly via the enhanced permeability and retention *** vivo tumor USF imaging further demonstrated that these nanoprobes can effectively be switched“ON”with enhanced fluorescence in response to a focused ultrasound stimulation in the tumor microenvironment,contributing to the high-resolution USF ***,our findings suggest that ICG-encapsulated nanoparticles are good candidates for USF imaging of tumors in live animals,indicating their great potential in optical tumor imaging in deep tissue.

关键词： in vivo tumor imaging deep tissue near-infrared(NIR)imaging high resolution ultrasound-switchable fluorescence imaging indocyanine green(ICG)

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Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein

Development of Hair Follicle Dermal Papilla Spheroids Encaps...

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biomedical engineering International Conference (BMEiCON)

作者： Phasin Srinualchai Thanchanok Khorporn Patsawee Sriboonaied Peerapat Thongnuek Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Biomedical Materials and Devices for Revolutionary Integrative Systems Engineering (BMD-RISE) Research Unit Faculty of Engineering Biomedical Engineering Research Center Chulalongkorn University Bangkok Thailand

ISBN: (数字)9798331505431

ISBN: (纸本)9798331505448

Hair follicles (HF) are important anatomical structures that are responsible for maintenance of the hair cycle. However, hair disease can affect the hair follicle directly with the modern treatment still riddled with side effects due to lack of full understanding of hair nature. The study aimed to investigate the effect of alginate hydrogel with extracellular matrix (ECM) protein encapsulation on activity of dermal papilla (DP) spheroids. The DP cells were aggregated to mimic its native spherical structure and introduced into alginate solution mixed with ECM. The mixture was then crosslinked with calcium chloride to form hydrogel. The encapsulation elevated alkaline phosphatase (ALP) activity, which is a DP molecular marker. This work demonstrates that DP encapsulation in alginate with ECM can manipulate DP spheroid activity.

关键词： Encapsulation Proteins Protein engineering Three-dimensional displays Hydrogels Peptides Hafnium Hair follicle Maintenance Extracellular

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Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

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Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

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Parameter Analysis on Sensitivity Encoding (SENSE) Algorithm for Parallel Imaging of Magnetic Resonance Imaging 5

Parameter Analysis on Sensitivity Encoding (SENSE) Algorithm...

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5th IEEE International Conference on Information Technology, Information Systems and Electrical engineering, ICITISEE 2021

作者： Ariani, Fitria Basari, Basari Universitas Indonesia Biomedical Engineering Program Departmen Of Electrical Engineering Faculty Of Engineering 16424 Indonesia Biomedical Engineering Program Departmen Of Electrical Engineering Faculty Of Engineering Universitas Indonesia Indonesia

ISBN: (纸本)9781665401968

Magnetic Resonance Imaging (MRI) is one of the most prominent medical imaging technologies for examining human bones and soft tissues. However, it has a shortcoming of long scan time. To overcome this problem, parallel imaging is used to reduce scan time by using multiple coil receivers and under-sampled k-space data which lead to aliasing and artifact images. Sensitivity Encoding (SENSE) is one of the parallel imaging algorithms that work in the image domain to unfolding the aliased images. However, the use of SENSE algorithm is limited by its parameter. This study aims to investigate how parameters in the SENSE algorithm influence MRI image reconstruction via simulation. During the simulation, we used a variation of number of coils (nc) and acceleration factor (R). In order to analyze the data, we use structural similarity index measure (SSIM) and mean squared error (MSE) as the image quality assessment (IQA) methods. According to the IQA parameter, the results showed that number of coils and acceleration factor are correlated. The best IQA result in SENSE reconstructed image comes from the variation of nc = 16 and R = 2, which has the lowest MSE value (0.01405) and the highest SSIM value (0.8384). A higher acceleration factor number causes more aliasing and noise while more number of coils can make the reconstruction image better. Nevertheless, number of coils with the right number of acceleration factor will result in a good reconstructed image. This study showed that SENSE is capable of retrieving good reconstruction images by using the right parameters. © 2021 IEEE.

关键词： Magnetic resonance imaging

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