检索结果-内蒙古大学图书馆

Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

引用

Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

来源：评论

学校读者我要写书评

暂无评论

Highly Integrated Multiplexing and Buffering Electronics for Large Aperture Ultrasonic Arrays

引用

biomedical engineering Frontiers 2022年第1期3卷 262-283页

作者： Robert Wodnicki Haochen Kang Di Li Douglas N.Stephens Hayong Jung Yizhe Sun Ruimin Chen Lai-Ming Jiang Nestor E.Cabrera-Munoz Josquin Foiret Qifa Zhou Katherine W.Ferrara Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Department of Biomedical Engineering University of CaliforniaDavisDavisCAUSA Molecular Imaging Program at Stanford University StanfordCAUSA USC Roski Eye Institute University of Southern CaliforniaLos AngelesCAUSA

Large aperture ultrasonic arrays can be implemented by tiling together multiple pretested modules of high-density acoustic arrays with closely integrated multiplexing and buffering electronics to form a larger aperture with high *** modular arrays can be used to implement large 1.75D array apertures capable of focusing in elevation for uniform slice thickness along the axial direction which can improve image *** important goal for large array tiling is obtaining high yield and sensitivity while reducing extraneous image *** have been developing tileable acoustic-electric modules for the implementation of large array apertures utilizing Application Specific Integrated Circuits(ASICs)implemented using 0.35μm high voltage(50 V)*** generations of ASICs have been designed and *** ASICs were integrated with high-density transducer arrays for acoustic testing and *** modules were further interfaced to a Verasonics Vantage imaging system and were used to image industry standard ultrasound *** first-generation modules comprise ASICs with both multiplexing and buffering electronics on-chip and have demonstrated a switching artifact which was visible in the images.A second-generation ASIC design incorporates low switching injection circuits which effectively mitigate the artifacts observed with the first-generation ***,we present the architecture of the two ASIC designs and module types as well imaging results that demonstrate reduction in switching artifacts for the second-generation devices.

关键词： Highly Large utilizing

来源：评论

学校读者我要写书评

暂无评论

Molecular Imprinted Polymer Based Optical Sensor for Methanol Vapor Detection

Molecular Imprinted Polymer Based Optical Sensor for Methano...

引用

Optica Sensing Congress 2023, AIS, FTS, HISE, Sensors, ES 2023 - Part of Optical Sensors and Sensing Congress 2023

作者： Leelasirinuwong, Mintra Denkasineecharoen, Phebe Yungyuentrrakoon, Pin Jitpratak, Pannathorn Kongsawang, Nuntaporn Pathak, Akhilesh Kumar Viphavakit, Charusluk Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Intelligent Control Automation of Process Systems Research Unit Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand

A molecular imprinted polymer-based optical sensor is proposed to detect methanol. The sensor is tested with different concentrations of methanal vapour for sensitivity and ethanol for selectivity. The result shows a ... 详细信息

ISBN: (纸本)9781957171241

关键词： Optical sensors

来源：评论

学校读者我要写书评

暂无评论

In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles

引用

Nano Research 2023年第1期16卷 1009-1020页

作者： Liqin Ren Yang Liu Tingfeng Yao Kytai TNguyen Baohong Yuan Ultrasound and Optical Imaging Laboratory Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Program the University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineering the University of Texas at ArlingtonArlingtonTX 76019USA

Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment *** particular,ultrasound switchable fluorescence(USF)imaging has been explored with improved imaging sensitivity and spatial resolution in centimeter-deep *** study achieved the size control of polymer-based and indocyanine green(ICG)encapsulated USF contrast agents,capable of accumulating in the tumor after intravenous *** nanoprobes varied in size from 58 to 321 *** bioimaging profiles demonstrated that the proposed nanoparticles can efficiently eliminate the background light from normal tissue and show a tumor-specific fluorescence enhancement in the BxPC-3 tumor-bearing mice models possibly via the enhanced permeability and retention *** vivo tumor USF imaging further demonstrated that these nanoprobes can effectively be switched“ON”with enhanced fluorescence in response to a focused ultrasound stimulation in the tumor microenvironment,contributing to the high-resolution USF ***,our findings suggest that ICG-encapsulated nanoparticles are good candidates for USF imaging of tumors in live animals,indicating their great potential in optical tumor imaging in deep tissue.

关键词： in vivo tumor imaging deep tissue near-infrared(NIR)imaging high resolution ultrasound-switchable fluorescence imaging indocyanine green(ICG)

来源：评论

学校读者我要写书评

暂无评论

Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein

Development of Hair Follicle Dermal Papilla Spheroids Encaps...

引用

biomedical engineering International Conference (BMEiCON)

作者： Phasin Srinualchai Thanchanok Khorporn Patsawee Sriboonaied Peerapat Thongnuek Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Biomedical Materials and Devices for Revolutionary Integrative Systems Engineering (BMD-RISE) Research Unit Faculty of Engineering Biomedical Engineering Research Center Chulalongkorn University Bangkok Thailand

ISBN: (数字)9798331505431

ISBN: (纸本)9798331505448

Hair follicles (HF) are important anatomical structures that are responsible for maintenance of the hair cycle. However, hair disease can affect the hair follicle directly with the modern treatment still riddled with side effects due to lack of full understanding of hair nature. The study aimed to investigate the effect of alginate hydrogel with extracellular matrix (ECM) protein encapsulation on activity of dermal papilla (DP) spheroids. The DP cells were aggregated to mimic its native spherical structure and introduced into alginate solution mixed with ECM. The mixture was then crosslinked with calcium chloride to form hydrogel. The encapsulation elevated alkaline phosphatase (ALP) activity, which is a DP molecular marker. This work demonstrates that DP encapsulation in alginate with ECM can manipulate DP spheroid activity.

关键词： Encapsulation Proteins Protein engineering Three-dimensional displays Hydrogels Peptides Hafnium Hair follicle Maintenance Extracellular

来源：评论

学校读者我要写书评

暂无评论

Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

引用

Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

来源：评论

学校读者我要写书评

暂无评论

Parameter Analysis on Sensitivity Encoding (SENSE) Algorithm for Parallel Imaging of Magnetic Resonance Imaging 5

Parameter Analysis on Sensitivity Encoding (SENSE) Algorithm...

引用

5th IEEE International Conference on Information Technology, Information Systems and Electrical engineering, ICITISEE 2021

作者： Ariani, Fitria Basari, Basari Universitas Indonesia Biomedical Engineering Program Departmen Of Electrical Engineering Faculty Of Engineering 16424 Indonesia Biomedical Engineering Program Departmen Of Electrical Engineering Faculty Of Engineering Universitas Indonesia Indonesia

ISBN: (纸本)9781665401968

Magnetic Resonance Imaging (MRI) is one of the most prominent medical imaging technologies for examining human bones and soft tissues. However, it has a shortcoming of long scan time. To overcome this problem, parallel imaging is used to reduce scan time by using multiple coil receivers and under-sampled k-space data which lead to aliasing and artifact images. Sensitivity Encoding (SENSE) is one of the parallel imaging algorithms that work in the image domain to unfolding the aliased images. However, the use of SENSE algorithm is limited by its parameter. This study aims to investigate how parameters in the SENSE algorithm influence MRI image reconstruction via simulation. During the simulation, we used a variation of number of coils (nc) and acceleration factor (R). In order to analyze the data, we use structural similarity index measure (SSIM) and mean squared error (MSE) as the image quality assessment (IQA) methods. According to the IQA parameter, the results showed that number of coils and acceleration factor are correlated. The best IQA result in SENSE reconstructed image comes from the variation of nc = 16 and R = 2, which has the lowest MSE value (0.01405) and the highest SSIM value (0.8384). A higher acceleration factor number causes more aliasing and noise while more number of coils can make the reconstruction image better. Nevertheless, number of coils with the right number of acceleration factor will result in a good reconstructed image. This study showed that SENSE is capable of retrieving good reconstruction images by using the right parameters. © 2021 IEEE.

关键词： Magnetic resonance imaging

来源：评论

学校读者我要写书评

暂无评论

Multiplexed Nanoscopy via Buffer Exchange

引用

ACS Nano 2024年第34期18卷 23445-23456页

作者： Chang, Ting-Jui Ben Yang, T. Tony Department of Electrical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei10617 Taiwan

Understanding cellular functions, particularly in their intricate complexity, can greatly benefit from the spatial mapping of diverse molecules through multitarget single-molecule localization microscopy (SMLM). Existing methodologies, primarily restricting the encoding dimensions to color and lifetime or requiring cyclic staining, often involve broad chromatic detection, specialized optical configurations, or sophisticated labeling techniques. Here, we propose a simple approach called buffer-exchange stochastic optical reconstruction microscopy (beSTORM), which introduces an additional dimension to differentiate between single molecules irrespective of their spectral properties. This method leverages the distinguishable photoblinking responses to distinct buffer conditions, offering a straightforward yet effective means of fluorophore discrimination. Through buffer exchanges, beSTORM achieves multitarget SMLM imaging with minimal crosstalk. Direct integration with expansion microscopy (ExM) demonstrates its capability to resolve up to six proteins at the molecular level within a single emission color without chromatic aberration. Overall, beSTORM presents a highly compatible imaging platform, promising significant advancements in highly multiplexed nanoscopy for exploring multiple targets in biological systems with nanoscale precision. © 2024 The Authors. Published by American Chemical Society.

关键词： Stochastic systems

来源：评论

学校读者我要写书评

暂无评论

A Physical-Based Artificial Neural Networks Compact Modeling Framework for Emerging FETs

引用

IEEE Transactions on Electron Devices 2024年第1期71卷 223-230页

作者： Yang, Ya-Shu Li, Yiming Kola, Sekhar Reddy Reddy National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory The Institute of Communications Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Institute of Communications Engineering Institute of Biomedical Engineering Department of Electronics and Electrical Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Hsinchu300093 Taiwan

We report a compact modeling framework based on the Grove-Frohman (GF) model and artificial neural networks (ANNs) for emerging gate-all-around (GAA) MOSFETs. The framework consists of two ANNs;the first ANN constructed with the drain current model not only can capture the main trend of device I - V characteristics but also can predict its variation even when the amount of training data for the ANN is insufficient or outside the range of applied biases. The second one is then designed to improve the model accuracy by further minimizing the errors between the target and the model outputs. We implement the proposed framework to accurately model emerging GAA nanosheet (NS) MOSFETs and complementary FETs (CFETs) without suffering from divergent issues in circuit simulation. In addition, nonphysical behaviors, such as nonzero current at zero bias, do not occur in the modeling framework. Compared to recently reported machine-learning (ML) models, our approach can achieve a similar level of model accuracy with merely 20% amount of the training data. © 1963-2012 IEEE.

关键词： Neural networks

来源：评论

学校读者我要写书评

暂无评论

Bioengineered gas vesicle nanostructure increases the ultrasound backscattered signal amplitude in presence of tumoral enzyme Cathepsin B

Bioengineered gas vesicle nanostructure increases the ultras...

引用

2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Garrute, Felipe Vianna Pacheco, Ana Beatriz F. Lu, George MacHado, João Carlos Federal University of Rio de Janeiro Biomedical Engineering Program Coope Rio de Janeiro Brazil Federal University of Rio de Janeiro Biophysics Institute Carlos Chagas Filho Rio de Janeiro Brazil Willian Rice University Bioscience Research Collaborative Houston United States Federal University of Rio de Janeiro Biomedical Engineering Program/COOPE Post-Graduation Program in Surgical Sciences Rio de Janeiro Brazil

ISBN: (纸本)9798350346459

Gas vesicles (GVs), nanostructure gas-filled protein-shelled compartments, act as ultrasound contrast agents (UCAs). Recent works report bioengineered GvpC, one of the shell proteins, potentializes interactions with specific molecules in tumor microenvironment. An important target of investigation is Cathepsin B (CTSB), an enzyme produced by several tumors. CTSB acts in the tumoral microenvironment to increase tumor growth and invasion. This work objective relied on bioengineering the GVs to promote the GvpC-CTSB interaction with a subsequent increase of ultrasound (US) signal backscattered. GvpC was engineered to contain a known CTSB cleavage sequence re-added in striped GV (ΔGV). Western Blot (WB) test was used to compare the GVwt (wild type) and GV∗ (GV engendered) before and after 24 hours reaction with CTSB. US images for PBS (negative control), GVtw, ΔGV, GV∗ and CTSB+GV∗, were obtained in 21MHz (5% total power) and regions-of-interest (ROIs) over the final B-mode image were determined. The WB test for GVwt resulted in mean (±SD) GvpC concentrations of 25169 (±8574) and 32873 (±9113) and GV∗ was 32487 (±6867) and 12763 (±2846), at t0 and t24, respectively. The US image gray level intensities for the ROIs related to the samples of PBS, GVwt, ΔGV, GV∗ and CTSB+GV∗ were 55.8 (±17.6), 47.4 (±16.6), 46.1 (±22.8) and 150.2 (±24), respectively. These results reveal an increase in the US signal backscattered from GV∗ after CTSV reaction. This increase is likely related to a direct GvpC degradation by CTSB, without affecting the GV∗ structure. In conclusion, high frequency US B-mode images showed the GV∗ with the potential to act as an UCA sensitive to the CTSB presence in tumoral microenvironment. © 2023 IEEE.

关键词： Ultrasonics

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：