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Pathogen inhibition and indication by gelatin nonwoven mats with incorporation of polyphenol derivatives

RSC Advances 2023年第45期13卷 31602-31615页

作者： Bai, By Meng-Yi Wang, Ting-Teng Chen, Xin-An Wu, Chia-Chun Graduate Institute of Biomedical Engineering and Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology TR-917 AAEON Building No. 43 Keelung Rd. Sec. 4 Da'an Dist. Taiwan Taipei City10607 Taiwan Adjunct Appointment to the National Defense Medical Center Taiwan Taipei11490 Taiwan Institute of Prevention Medicine National Defense Medical Center Taiwan Taipei11490 Taiwan

There is a need for non-pharmaceutical intervention methods that can prevent and indicate the risk of airborne disease spread. In this study, we developed a nonwoven mat based on the polyphenol gallic acid, which can inhibit pathogens growth and also indicate pathogen levels in the surrounding environment. Using nuclear magnetic resonance, Fourier-transform infrared spectroscopy, and high-performance liquid chromatography, we characterized this novel gelatin-based nonwoven mat and investigated the mechanism governing its ability to indicate pathogen levels. We demonstrated that the incorporation of gallic acid serves a vital role in indicating the presence of bacteria, causing the nonwoven mat to change in color from white to brown. We have proposed a plausible mechanism for this color change behavior based on a reaction of gallic acid with components excreted by bacteria, including glutamate, valine, and leucine. The concentrations of these components reflect the bacterial counts, enabling a real-time indication of pathogen levels in the surrounding air. In summary, the nonwoven mat presented herein can serve as an excellent antibacterial agent and as an indicator of nearby bacteria for fabricating personal protection equipment like filtration mask. © 2023 The Royal Society of Chemistry.

关键词： Bacteria

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Evaluation of fluoride concentration in toothpastes with antimicrobial molecules commercialized in Brazil

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Research on biomedical engineering 2021年第1期37卷 9-14页

作者： Medeiros, Maria da Conceição de Araújo Valadas, Lídia Audrey Rocha Lotif, Mara Assef Leitão Bottenberg, Peter Marciano, Fernanda Roberta Biomedical Engineering Postgraduate Program Brazil University São Paulo Brazil Development and Technological Innovation in Medicines Postgraduate Program Federal University of Ceara Fortaleza Brazil Brussels Belgium

Purpose: This study aimed to analyze the fluoride concentrations in different dentifrices with antimicrobial and natural molecules marketed in Brazil. Thus, 12 dentifrices were selected to be analyzed for the concentration of total fluoride (TF), total soluble fluoride (TSF) and ionizable fluoride (IF). Methods: Two tubes of each brand were purchased at different locations. The samples were analyzed in duplicates using an ion-specific electrode and the concentrations were determined in μg F/g. Results: The TF of all calcium carbonate dentifrices showed averages below 1500 ppm F. Regarding TSF, only one toothpaste had an average above 1000 ppm F−, while the IF values were almost 500 ppm F. In the analysis of fluoride in dentifrices which present silica as abrasive, the TF presented averages below 1500 ppm F, while the TSF all presented averages close to 1000 ppm F−, and the IF values varied from close to 500 ppm to more than 1000 ppm F. In dentifrices whose formulation contained calcium carbonate associated with silica or other formulations such as sodium bicarbonate, the TF, TSF, and IF values were all above 1000 ppm F. Conclusion: The evaluated dentifrices generally showed TF concentrations lower than those declared on the packaging;however, the TSF content remained close to 1000 ppm F. It can be concluded that the analyzed dentifrices with antimicrobial molecules showed values close to those suggested regarding anti-caries effect. © 2020, Sociedade Brasileira de Engenharia Biomedica.

关键词： Calcium carbonate

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Prototyping a Flowmeter for a Continuous Positive Airway Pressure Device 9th

Prototyping a Flowmeter for a Continuous Positive Airway ...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Motta-Ribeiro, Gabriel C. Giannella-Neto, Antonio Programa Doutor Empreendedor Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro Rio de Janeiro Brazil Biomedical Engineering Program Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9783031494062

Continuous positive airway pressure (CPAP) is an effective therapy for obstructive sleep apnea. Although the controlled variable in CPAP devices is pressure, flow measurement can supplement monitoring of therapy effectiveness. Here, we describe desired sensor characteristics, application constraints and a theoretical framework for designing a differential pressure flowmeter for a CPAP device. Our aim is to validate this framework through experimental verification of the permanent pressure loss and flow-pressure curve of a 3D-printed prototype. Pressure at patient interface was less than 5% lower than that measured before the restrictive element, despite pressure drop in such element being always above that threshold. The predicted quadratic flow-pressure relationship was achieved with a 97% approximation. These findings indicate that the type of restrictive element chosen for the prototype, a Venturi tube, is suitable for the application, and the used framework is adequate for sensor design. However, refinements to the current geometry are needed to adjust flow sensibility and the fitting to other CPAP device’s components. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Flowmeters

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MecLung—A Respiratory System Mechanical Simulator 9th

MecLung—A Respiratory System Mechanical Simulator

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Motta-Ribeiro, G.C. Pino, A.V. Castro Pinto, F.A.N. dos Santos, T.P. Mattos, G.M. Vale, M.J.O. Giannella-Neto, A. Fundação Coordenação de Projetos Pesquisas e Estudos Tecnológicos—COPPETEC Rio de Janeiro Brazil Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Mechanical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil ECCO Engenharia Clínica Consultoria Ltda Rio de Janeiro Brazil

ISBN: (纸本)9783031494062

MecLung is a mechanical simulator. It consists of a metal cylinder provided with a tight piston controlled by a motor and programmed to simulate resistances and compliances of the human respiratory system. Additionally, the simulator presents spontaneous activity resembling respiratory muscular drive. Resistances and compliances in the range of 5 to 50 hPa/l/s and 10 to 50 ml/hPa, respectively, covering the clauses of the ABNT ISO 80601-2-12 to test the performance of mechanical ventilators for adults, were tested. The airways pressure, flow rate and volume waveforms are available for the user through digital data at 200 Hz sampling frequency. The motion equation applied to the data recovers the mechanical impedances with an accuracy of 2% for pressure and volume-controlled mechanical ventilation. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Ventilation

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mRNA vaccines: Past, present, future

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Asian Journal of Pharmaceutical Sciences 2022年第4期17卷 491-522页

作者： Mia Karam Georges Daoud Biomedical Engineering Program Maroun Semaan Faculty of Engineering and ArchitectureBeirut 11072020Lebanon Department of Biochemistry and Molecular Genetics Faculty of MedicineBeirut 11072020Lebanon Department of Anatomy Cell Biologyand Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 11072020Lebanon

mRNA vaccines have emerged as promising alternative platforms to conventional *** ease of production,low cost,safety profile and high potency render them ideal candidates for prevention and treatment of infectious diseases,especially in the midst of *** challenges that face in vitro transcribed RNA were partially amended by addition of tethered adjuvants or co-delivery of naked mRNA with an adjuvanttethered ***,it wasn’t until recently that the progress made in nanotechnology helped enhance mRNA stability and delivery by entrapment in novel delivery systems of which,lipid *** continuous advancement in the fields of nanotechnology and tissue engineering provided novel carriers for mRNA vaccines such as polymeric nanoparticles and *** studies have shown the advantages of adopting mRNA vaccines for viral diseases and cancer in animal and human ***-amplifying mRNA is considered today the next generation of mRNA vaccines and current studies reveal promising *** review provides a comprehensive overview of mRNA vaccines used in past and present studies,and discusses future directions and challenges in advancing this vaccine platform to widespread clinical use.

关键词： mRNA vaccine Virus Cancer Nanoparticles COVID-19

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Microvolt T-Wave and Ventricular Repolarization Duration Alternans 9th

Microvolt T-Wave and Ventricular Repolarization Duration Alt...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Winkert, Thaís Nadal, Jurandir Benchimol-Barbosa, Paulo Roberto Biomedical Engineering Program COPPE Institute Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Hospital Universitário Pedro Ernesto Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9783031494031

The ventricular tachyarrhythmia is an important cause of sudden cardiac death, impacting economic, social, and health systems. Microvolt T-wave alternans (MTWA) represent transmural gradient alternation in phase-3 ventricular action potential duration, leading to T-wave amplitude shortening in every other beat. The T-peak T-end interval (TpTe) represents the terminal ventricular repolarization duration and is explained by differences in phase-3 repolarization times from ventricular epicardial to endocardial fibers. Whether TpTe alternation occurs in patients with MTWA is unknown. This work investigated whether terminal ventricular repolarization duration alternation is present in MTWA patients. Seven 12-lead ECG records from Physionet T-wave Alternans Database were analyzed. The TpTe alternans was assessed in even and odds beats, in a series of 128 consecutive beats. In even and odd beats, TpTe intervals were ensembled and averaged, and the magnitude of TpTe alternans was defined as the difference between averages (ΔTpTe). The MTWA was quantified by the difference between the average peak of the T-wave in even and odd beats. ΔTpTe and MTWA were compared by Pearson’s coefficient. Even and odd beats on TpTe alternans and MTWA were compared with non-paired Student t-tests. ΔTpTe positively correlated with MTWA (r = 0.5;p © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

关键词： Electrocardiograms

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Corrigendum to "Effect of cell imprinting on viability and drug susceptibility of breast cancer cells to doxorubicin" [Acta Biomaterialia, 2020, 113, 119-129] (Acta Biomaterialia (2020) 113 (119–129), (S1742706120303287), (10.1016/***.2020.06.007))

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Acta Biomaterialia 2025年 198卷 571-572页

作者： Shahriyari, Fatemeh Janmaleki, Mohsen Sharifi, Shahriar Hesar, Milad Eyvazi Hoshian, Sasha Taghiabadi, Reza Razaghian, Ahmad Ghadiri, Majid Peirovi, Afshin Mahmoudi, Morteza Nezhad, Amir Sanati Khademhosseini, Ali Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School CambridgeMA United States Division of Health Sciences & Technology Harvard-Massachusetts Institute of Technology Massachusetts Institute of Technology CambridgeMA United States Department of Materials Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran Biomedical Engineering Graduate Program University of Calgary Canada Precision Health Program and Department of Radiology Michigan State University East LansingMI48824 United States RWTH Aachen University Templergraben 55 Aachen52062 Germany Department of Chemistry and Materials Science Aalto University School of Chemical Engineering Espoo Finland Department of Mechanical Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran Nano-Biotechnology Department Pasteur Institute of Iran Tehran Iran Departments of Bioengineering Chemical and Biomolecular Engineering and Radiological Sciences Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California – Los Angeles Los AngelesCA United States Terasaki Institute for Biomedical Innovation Los AngelesCA United States

The authors regret to report that the images for panels h (Plain PDMS) and I (MCF7-imprinted PDMS) in Fig. 3 were mistakenly taken from the same dataset, resulting in the omission of the correct image in panel h for the Plain PDMS day 7 image. We sincerely apologize for this error. For an accurate representation, please see the corrected Fig. 3 provided here along with its original figure caption. This does not affect the validity of the statistical analyses or the overall conclusions drawn from the study. © 2025

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Using textile capacitive sensors to train synchronized movement of hands

Using textile capacitive sensors to train synchronized movem...

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2024 IEEE International Conference on Consumer Electronics, ICCE 2024

作者： Yang, Chang-Ming Wu, Shu-Cing Chen, Shih-Hung Wu, Ze-We Liao, Kuo-Cheng Chen, Chi-Chun Ming Young Biomedical Corp. Miaoli Taiwan National Chin-Yi University of Technology Program Prospective Technology of Electrical Engineering and Computer Science Taichung Taiwan National Chin-Yi University of Technology Dept. of Computer Science and Information Engineering Taichung Taiwan National Chin-Yi University of Technology Dept. of Electronic Engineering Taichung Taiwan

ISBN: (纸本)9798350324136

This study introduced a capacitive sensing interactive game platform aimed at promoting emotional stability, which we have named the 'Sunrise and Sunset' game. This game primarily consists of two pieces of regular textile fabric enveloping conductive silver fabric. A microcontroller was employed to extract the sensed capacitive values, and a game named 'Sunrise and Sunset' is designed to complement the slow raising and lowering of both hands. The development of this gaming platform has the potential to offer a novel method of emotional management, particularly in high-stress living environments. It can serve as an effective relaxation tool, aiding individuals in emotional balance, anxiety reduction, and stress alleviation. Simultaneously, this platform can contribute to the promotion of mental well-being, providing an engaging and beneficial means for people to manage their emotions and moods. © 2024 IEEE.

关键词： capacitive sensing emotional stability game relaxation tool silver fabric

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Electronically Scanned Large Apertures for Interventional and Diagnostic Liver

Electronically Scanned Large Apertures for Interventional an...

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2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Wodnicki, Robert Zhang, Junhang Zhou, Qifa Foiret, Josquin Notard, Christophe Ferrara, Katherine W. University of Southern California Dept. of Biomedical Engineering Los AngelesCA United States Molecular Imaging Program Stanford University StanfordCA United States Vermon S.A. Tours France

ISBN: (纸本)9798350346459

We have developed a handheld 1,024-element large area 2D array probe integrated with high voltage multiplexing ASIC modules with row-multiplexed imaging in orthogonal azimuthal and elevational planes with image data computed and displayed on a commercially available 32 channel configurable ultrasound system. Here we demonstrate real-time orthogonal imaging of small structures at high resolution in water with the 1,024-element array. We have also integrated modular imaging electronics with a newly designed 4,096-element 4 times larger aperture acoustic array (83 mm × 16 mm aperture with 650 μm azi. × 500 μm elev. element pitch) with 128 elements in azimuth and 32 rows in elevation. The two arrays were interfaced to an open-platform ultrasound imaging system using custom-designed multiplexing ASICs and imaged with plane waves at Fc = 2.5 MHz. © 2023 IEEE.

关键词： Synthetic apertures

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Building a Brain Computer Interface (BCI) Using Electroencephalogram (EEG) Signals' Classification

Building a Brain Computer Interface (BCI) Using Electroencep...

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International Conference on Advances in biomedical engineering (ICABME)

作者： Mohammad Nabil Younis Sary Haj Sleiman Salma Khadra Amira Zaylaa Alaa Daher Mohammad Ayache Depatment of Electrical and Computer Engineering Beirut Arab University Biomedical Program Debbieh Lebanon

Development of Brain Computer Interface (BCI) has been rapid since the mid 1990‘s. There are three criteria for BCI, (i) comfortability and possession of a suitable signal acquisition device, (ii) system validation and dissemination, and (iii) reliability and potentiality. As there are no BCI possessing the optimal criteria, it was essential to consider building a new one. Thereby, the paper investigates building BCI based on the utilization of EEG signals to translate brainwave patterns into actionable commands. The primary objective is to enhance communication capabilities for individuals afflicted with neurological disorders, empowering them to command external devices and engage more effectively with their surroundings. We built our model on EEG online dataset for the purpose of feature extraction and classification. Statistical features and Discrete Wavelet Transform (DWT) have been applied for feature selection. Multi-Layer Perceptron (MLP) and Radial Basis Function (RBF) were the classifiers involved. Results showed that the proposed architecture of MLP and RBF were able to classify the EEG signals into two classes (open eye and closed eye). Results also showed that the proposed approach, which is based on the combination of statistical features and DWT for features selection using AF3 and AF4 channels by the application of MLP, has 98% succession rate. BCI system based on Arduino circuit has been built after the classification Further algorithms and system evaluation need to be considered as future work.

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