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Strain transfer between a CPC coated strain gauge and cortical bone during bending†

Journal of biomedical Materials Research Part B: Applied Biomaterials 2002年第2期58卷

作者： Nicholas M. Cordaro Jeffrey A. Weiss John A. Szivek Biomedical Engineering Program The University of Arizona 1300 N. Mountain Rm. N509 Tucson Arizona 85721 Department of Bioengineering The University of Utah 50 S. Central Campus Dr. #2480 Salt Lake City Utah 84112 Department of Orthopedic Surgery The University of Arizona 1501 N. Campbell P.O. Box 245064 Tucson Arizona 85724–5064

The finite element method was used to simulate strain transfer from bone to a calcium phosphate ceramic (CPC) coated strain gauge. The model was constructed using gross morphometric and histological measurements obtained from previous experimental studies. Material properties were assigned based on experiments and information from the literature. Boundary conditions simulated experimental cantilever loading of rat femora. The model was validated using analytical solutions based on the theory of elasticity as well as direct comparison to experimental data obtained in a separate study. The interface between the bone and strain gauge sensing surface consisted of layers of polysulfone, polysulfone/CPC, and CPC/bone. Parameter studies examined the effect of interface thickness and modulus, gauge geometry, partial gauge debonding, and waterproofing on the strain transfer from the bone to the gauge sensing element. Results demonstrated that interface thickness and modulus have a significant effect on strain transfer. Optimal strain transfer was achieved for an interface modulus of approximately 2 GPa. Strain transfer decreased consistently with increasing interface thickness. Debonding along the lateral edges of the gauge had little effect, while debonding proximal and distal to the sensing element decreased strain transfer. A waterproofing layer decreased strain transfer, and this effect was more pronounced as the modulus or thickness of the layer increased. Based on these simulations, specific recommendations were made to optimize strain transfer between bone and CPC coated gauges for experimental studies. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 147–155, 2001

关键词： strain gauge bone strain measurement finite element analysis

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Macular pigments produced from microalga Chlorella sp. and applied to alleviate the pathogenic process in diabetic mice

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Algal Research 2024年 78卷

作者： Meng-Wei Lin Wei-Hong Chiu Cheng-Han Lin Dung-Huan Liu Pei-Ching Wu Chih-Sheng Lin Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 30068 Taiwan Doctoral Degree Program of Biomedical Science and Engineering College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 30068 Taiwan Department of Physical Medicine and Rehabilitation China Medical University Hospital Taichung 404 Taiwan Department of Chinese Medicine China Medical University Hospital Taichung 404 Taiwan

Macular pigments (MP), which consist of lutein and zeaxanthin, have antioxidant capabilities and are widely used in eye healthcare. However, few studies have focused on the protective mechanisms of MP against diabetes mellitus. In addition, the advantages of MP produced by microalgae include non-competition with grains for land, year-round harvesting, and rapid growth. Therefore, this study aims to investigate the MP produced and extracted from the microalga Chlorella sp. AT1 and assess its impact on mitigating retinopathy and atherosclerotic damage in diabetic apolipoprotein E -deficient mice (ApoE −/− ) subjected to high-fat diet and streptozotocin treatment. The results showed that the major components of MP were lutein and zeaxanthin in a 5:1 ratio. MP supplementation significantly reduced glucose tolerance and insulin resistance by 25 and 41 %, respectively, in comparison to the diabetic group. MP supplementation resulted in the moderation of various inflammatory cytokines and lowered the serum levels of disease markers in comparison to the control group. In addition, the expression levels of cellular antioxidant enzymes were significantly elevated, aligning with a reduction in lipid peroxidation after MP supplementation, in comparison to the diabetic group. Pathological changes in the outer nuclear layer and aortic plaques in diabetic ApoE −/− mice were significantly alleviated by MP supplementation. In summary, microalgal MP alleviated the symptoms of type 2 diabetes mellitus in the diabetic ApoE −/− mice. Consequently, MP holds the potential to serve as a beneficial ingredient in healthy food, contributing to biological efficacy by scavenging free radicals and stabilizing blood glucose levels.

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Corrigendum to “Navigating the site for embryo implantation: Biomechanical and molecular regulation of intrauterine embryo distribution” [Molecular Aspects of Medicine 34 (2013) 1024–1042]

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Molecular Aspects of Medicine 2013年第6期34卷 1257-1257页

作者： Qi Chen Ying Zhang David Elad Ariel J. Jaffa Yujing Cao Xiaoqin Ye Enkui Duan State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Department of Biomedical Engineering Faculty of Engineering Tel-Aviv University Tel-Aviv 69978 Israel Ultrasound Unit in Obstetrics and Gynecology Lis Maternity Hospital Tel-Aviv Medical Center Tel-Aviv 64239 and Sackler Faculty of Medicine Tel-Aviv University Tel-Aviv 69978 Israel Department of Physiology and Pharmacology College of Veterinary Medicine & Interdisciplinary Toxicology Program The University of Georgia Athens GA 30602 USA

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Water distribution and permeability of zebrafish embryos,Brachydanio rerio

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Journal of Experimental Zoology Part A: Ecological and Integrative Physiology 1998年第6期278卷

作者： M. Hagedorn F. W. Kleinhans R. Freitas J. Liu E. W. Hsu D. E. Wildt W. F. Rall Smithsonian Institution National Zoological Park and Conservation and Research Center Washington DC 20008 Department of Physics Indiana University–Purdue University Indianapolis Indianapolis Indiana 46202 Department of Mechanical Engineering University of Texas Austin Texas 78712 Cryobiology Research Institute Methodist Hospital of Indiana Inc. Indianapolis Indiana 46202 Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore Maryland 21205 Veterinary Resources Program National Center for Research Resources National Institutes of Health Bethesda Maryland 20892

Teleost embryos have not been successfully cryopreserved. To formulate successful cryopreservation protocols, the distribution and cellular permeability to water must be understood. In this paper, the zebrafish ( Brachydanio rerio ) was used as a model for basic studies of the distribution to permeability to water. These embryos are a complex multi-compartmental system composed of two membrane-limited compartments, a large yolk (surrounded by the yolk syncytial layer) and differentiating blastoderm cells (each surrounded by a plasma membrane). Due to the complexity of this system, a variety of techniques, including magnetic resonance microscopy and electron spin resonance, was used to measure the water in these compartments. Cellular water was distributed unequally in each compartment. At the 6-somite stage, the percent water (V/V) was distributed as follows: total in embryo = 74%, total in yolk = 42%, and total in blastoderm = 82%. A one-compartment model was used to analyze kinetic, osmotic shrinkage data and determine a phenomenological water permeability parameter, L p , assuming intracellular isosmotic compartments of either 40 or 300 mosm. This analysis revealed that the membrane permeability changed ( P < 0.05) during development. During the 75% epiboly to 3-somite stage, the mean membrane permeability remained constant (L p = 0.022 ± 0.002 μm x min -1 atm -1 [mean ± S.E.M.] assuming isosmotic is 40 mosm or L p = 0.049 ± 0.008 μm x min -1 atm -1 assuming isosmotic is 300 mosm). However, at the 6-somite stage, Lp increased twofold (L p = 0.040 ± 0.004 μm x min -1 atm -1 assuming isosmotic is 40 mosm or L p = 0.100 ± 0.017 μm x min -1 atm -1 assuming isosmotic is 300 mosm). Therefore, the low permeability of the zebrafish embryo coupled with its large size (and consequent low area to volume ratio) led to a very slow osmotic response that should be considered before formulating cryopreservation protocols. J. Exp. Zool. 278:356–371, 1997. © 1997 Wiley-Liss, Inc.

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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells

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Nature biotechnology 2024年第3期42卷 529页

作者： Hui Kwon Kim Goosang Yu Jinman Park Seonwoo Min Sungtae Lee Sungroh Yoon Hyongbum Henry Kim Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. Electrical and Computer Engineering Seoul National University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Graduate School of Data Science Seoul National University Seoul Republic of Korea. Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac. Severance Biomedical Science Institute Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of NanoScience and Technology Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac.

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Neuroprosthetics: Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling (Adv. Mater. 20/2021)

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Advanced Materials 2021年第20期33卷

作者： Hyunseon Seo Sang Ihn Han Kang-Il Song Duhwan Seong Kyungwoo Lee Sun Hong Kim Taesung Park Ja Hoon Koo Mikyung Shin Hyoung Won Baac Ok Kyu Park Soong Ju Oh Hyung-Seop Han Hojeong Jeon Yu-Chan Kim Dae-Hyeong Kim Taeghwan Hyeon Donghee Son School of Medicine Sungkyunkwan University Suwon 16419 Republic of Korea Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology Seoul 02792 Republic of Korea Center for Nanoparticle Research Institute of Basic Science (IBS) Seoul 08826 Republic of Korea School of Chemical and Biological Engineering Seoul National University Seoul 08826 Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation Daegu 41061 Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan University Suwon 16419 Republic of Korea Department of Electrical and Computer Engineering Inter-University Semiconductor Research Center Seoul National University Seoul 08826 Republic of Korea Department of Materials Science and Engineering Korea University Seoul 02841 Republic of Korea Interdisciplinary Program for Bioengineering Seoul National University Seoul 08826 Republic of Korea Department of Biomedical Engineering SKKU Institute for Convergence Sungkyunkwan University Suwon 16419 Republic of Korea Center for Neuroscience Imaging Research Institute for Basic Science (IBS) Suwon 16419 Republic of Korea Department of Superintelligence Engineering Sungkyunkwan University Suwon 16419 Republic of Korea

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Correction to: Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection

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Clinical proteomics 2023年第1期20卷 16页

作者： Dilana E Staudt Heather C Murray David A Skerrett-Byrne Nathan D Smith M Fairuz B Jamaluddin Richard G S Kahl Ryan J Duchatel Zacary P Germon Tabitha McLachlan Evangeline R Jackson Izac J Findlay Padraic S Kearney Abdul Mannan Holly P McEwen Alicia M Douglas Brett Nixon Nicole M Verrills Matthew D Dun School of Biomedical Sciences and Pharmacy College of Health Medicine and Wellbeing University of Newcastle Callaghan NSW 2308 Australia. Precision Medicine Research Program Hunter Medical Research Institute New Lambton Heights NSW 2305 Australia. School of Environmental and Life Sciences College of Engineering Science and Environment University of Newcastle Callaghan NSW 2308 Australia. Infertility and Reproduction Research Program Hunter Medical Research Institute New Lambton Heights NSW 2305 Australia. Analytical and Biomolecular Research Facility (ABRF) Research Services University of Newcastle Callaghan NSW 2308 Australia. School of Biomedical Sciences and Pharmacy College of Health Medicine and Wellbeing University of Newcastle Callaghan NSW 2308 Australia. matt.dun@newcastle.edu.au. Precision Medicine Research Program Hunter Medical Research Institute New Lambton Heights NSW 2305 Australia. matt.dun@newcastle.edu.au.

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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Research Square

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Research Square 2021年

作者： Zhang, Martin Jinye Hou, Kangcheng Pasaniuc, Bogdan Price, Alkes L. Dey, Kushal K. Jagadeesh, Karthik A. Weinand, Kathryn Sakaue, Saori Taychameekiatchai, Aris Rao, Poorvi Pisco, Angela Oliveira Zou, James Wang, Bruce Gandal, Michael Raychaudhuri, Soumya Harvard University United States Osaka University Japan Department of Epidemiology Harvard T.H. Chan School of Public Health BostonMA United States Program in Medical and Population Genetics Broad Institute of MIT and Harvard CambridgeMA United States Bioinformatics Interdepartmental Program University of California Los Angeles Los AngelesCA United States Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Center for Data Sciences Brigham and Women’s Hospital BostonMA United States Division of Genetics Department of Medicine Brigham and Women’s Hospital Harvard Medical School BostonMA United States Division of Rheumatology Inflammation and Immunity Department of Medicine Brigham and Women’s Hospital Harvard Medical School BostonMA United States Department of Biomedical Informatics Harvard Medical School BostonMA United States Department of Medicine and Liver Center University of California San Francisco San FranciscoCA United States Developmental and Stem Cell Biology Graduate Program University of California San Francisco San FranciscoCA United States Chan Zuckerberg Biohub San FranciscoCA United States Department of Electrical Engineering Stanford University Palo AltoCA United States Department of Biomedical Data Science Stanford University Palo AltoCA United States Department of Psychiatry David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Program in Neurobehavioral Genetics Semel Institute David Geffen School of Medicine University of California Los Angeles Los AngelesCA United States Versus Arthritis Centre for Genetics and Genomic

Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we introduce single-cell Disease Relevance Score (scDRS), an approach that links scRNA-seq with polygenic risk of disease at individual cell resolution;scDRS identifies individual cells that show excess expression levels for genes in a disease-specific gene set constructed from GWAS data. We determined via simulations that scDRS is well-calibrated and powerful in identifying individual cells associated to disease. We applied scDRS to GWAS data from 74 diseases and complex traits (average N =341K) in conjunction with 16 scRNA-seq data sets spanning 1.3 million cells from 31 tissues and organs. At the cell type level, scDRS broadly recapitulated known links between classical cell types and disease, and also produced novel biologically plausible findings. At the individual cell level, scDRS identified subpopulations of disease-associated cells that are not captured by existing cell type labels, including subpopulations of CD4+ T cells associated with inflammatory bowel disease, partially characterized by their effector-like states;subpopulations of hippocampal CA1 pyramidal neurons associated with schizophrenia, partially characterized by their spatial location at the proximal part of the hippocampal CA1 region;and subpopulations of hepatocytes associated with triglyceride levels, partially characterized by their higher ploidy levels. At the gene level, we determined that genes whose expression across individual cells was correlated with the scDRS score (thus reflecting co-expression with GWAS disease genes) were strongly enriched for gold-standard drug target and Mendelian disease genes. © 2021, CC BY.

关键词： RNA

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Erratum to: Open-source, small-animal magnetic resonance-guided focused ultrasound system

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Journal of therapeutic ultrasound 2016年第1期4卷 29页

作者： Megan E Poorman Vandiver L Chaplin Ken Wilkens Mary D Dockery Todd D Giorgio William A Grissom Charles F Caskey Department of Biomedical Engineering Vanderbilt University PMB 351631 2301 Vanderbilt Place Nashville TN 37235 USA. Department of Biomedical Engineering Vanderbilt University PMB 351631 2301 Vanderbilt Place Nashville TN 37235 USA Chemical and Physical Biology Program Vanderbilt University 1161 21st Avenue South Nashville TN 37232 USA. Institute of Imaging Science Vanderbilt University 1161 21st Avenue South Nashville TN 37232 USA. Institute of Imaging Science Vanderbilt University 1161 21st Avenue South Nashville TN 37232 USA Department of Radiology Vanderbilt University 1161 21st Avenue South Nashville TN 37232 USA.

[This corrects the article DOI: 10.1186/s40349-016-0066-7.].

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Monolithic total disc replacement made of polyurethane lattice based on anatomical features

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AIP Conference Proceedings 2022年第1期2537卷

作者： Muhammad Hanif Nadhif Joshua Yoshihiko Tampubolon Muhammad Irsyad Tri Kurniawati Ahmad Jabir Rahyussalim 1Medical Physics Department Faculty of Medicine Universitas Indonesia DKI Jakarta 10430 Indonesia 2Medical Technology Cluster Indonesia Medical Education and Research Institute (IMERI) Faculty of Medicine Universitas Indonesia DKI Jakarta 10430 Indonesia 3Biomedical Engineering Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 Indonesia 4Stem Cells and Tissues Engineering (SCTE) Research Cluster Indonesian Medical Education and Research Institute (IMERI) Faculty of Medicine Universitas Indonesia DKI Jakarta 10340 Indonesia 5Deparment of Orthopedics and Traumatology Faculty of Medicine/Ciptomangunkusumo Central Hospital Universitas Indonesia DKI Jakarta 10430 Indonesia

Lower back pain (LBP) is included in the top 10 contributors to the overall disease burden. One of the etiologies of LBP is the intervertebral disc (IVD) degeneration, which in some cases, needs to be replaced with an artificial disc, the so-called total disc replacement (TDR). Unfortunately, TDR might provide post-surgical complications, including the failure in the metal-polymer assembly of TDR. The failure was argued due to the rigidity of the metal part and the shape of TDR that was not fully compliant with the anatomical features. Due to these complications, we proposed PU and monolithic construct to be alternative materials and comply with anatomical relevance. This study designed and developed a monolithic TDR made of PU lattices based on anatomical features. We focused on the IVDs in the lumbar section of the spine. The design step consisted of 3 phases: segmentation of DICOM files of IVDs using a 3D Slicer software, alignment using an Autodesk Meshmixer software, and lattice design using an Autodesk Inventor software. The manufacturing step started with a configuration setup in Simplify3D, software for computer-aided manufacturing (CAM) in 3D printing. The lattice features were fabricated using a Creality CP01 3D printer with two types of PU filaments: TPU 87A and TPU 95A. The printing results were able to construct the external curvature of the IVDs. Unfortunately, the microscopic measurement results showed that struts and holes’ dimensions deviated from the design, which must be resolved in the next studies.

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