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11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021

作者： Upendra, Roshan Reddy Wentz, Brian Jamison Simon, Richard Shontz, Suzanne M. Linte, Cristian A. Center for Imaging Science Rochester Institute of Technology RochesterNY United States Biomedical Engineering Rochester Institute of Technology RochesterNY United States Bioengineering Program University of Kansas LawrenceKS United States Electrical Engineering and Computer Science University of Kansas LawrenceKS United States Information and Telecommunication Center University of Kansas LawrenceKS United States

ISBN: (纸本)9783030787097

Patient-specific left ventricle (LV) myocardial models have the potential to be used in a variety of clinical scenarios for improved diagnosis and treatment plans. Cine cardiac magnetic resonance (MR) imaging provides high resolution images to reconstruct patient-specific geometric models of the LV myocardium. With the advent of deep learning, accurate segmentation of cardiac chambers from cine cardiac MR images and unsupervised learning for image registration for cardiac motion estimation on a large number of image datasets is attainable. Here, we propose a deep leaning-based framework for the development of patient-specific geometric models of LV myocardium from cine cardiac MR images, using the Automated Cardiac Diagnosis Challenge (ACDC) dataset. We use the deformation field estimated from the VoxelMorph-based convolutional neural network (CNN) to propagate the isosurface mesh and volume mesh of the end-diastole (ED) frame to the subsequent frames of the cardiac cycle. We assess the CNN-based propagated models against segmented models at each cardiac phase, as well as models propagated using another traditional nonrigid image registration technique. Additionally, we generate dynamic LV myocardial volume meshes at all phases of the cardiac cycle using the log barrier-based mesh warping (LBWARP) method and compare them with the CNN-propagated volume meshes. © 2021, Springer Nature Switzerland AG.

关键词： Deformation

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Author Correction: Elastic electronics based on micromesh-structured rubbery semiconductor films (vol 5, pg 881, 2022)

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NATURE ELECTRONICS 2023年第1期6卷 86-86页

作者： Guan, Ying-Shi Ershad, Faheem Rao, Zhoulyu Ke, Zhifan da Costa, Ernesto Curty Xiang, Qian Lu, Yuntao Wang, Xu Mei, Jianguo Vanderslice, Peter Hochman-Mendez, Camila Yu, Cunjiang Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University Nanjing China Department of Mechanical Engineering University of Houston Houston TX USA Department of Biomedical Engineering Pennsylvania State University University Park PA USA Department of Biomedical Engineering University of Houston Houston TX USA Department of Engineering Science and Mechanics Pennsylvania State University University Park PA USA Materials Science and Engineering Program University of Houston Houston TX USA Department of Materials Science and Engineering Materials Research Institute Pennsylvania State University University Park PA USA Department of Chemistry Purdue University West Lafayette IN USA Regenerative Medicine Research Texas Heart Institute Houston TX USA Molecular Cardiology Research Laboratory Texas Heart Institute Houston TX USA

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A Prototype Coded Sensing SPECT designed for Ultra-high Sensitivity Imaging

A Prototype Coded Sensing SPECT designed for Ultra-high Sens...

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IEEE Symposium on Nuclear science (NSS/MIC)

作者： L. Cai S. Aggarwal K. Enninful Y. Chen S. Komarov D. Thorek A. K. Jha Y.-C. Tai Imaging Science Phd Program Washington University in St. Louis Saint Louis Missouri United States of America Department of Biomedical Engineering Washington University in St. Louis Saint Louis Missouri United States of America Mallinckrodt Institute of Radiology Washington University in St. Louis Saint Louis Missouri United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In this work, we discuss the design and development of an ultra-high sensitivity imaging system, Coded Sensing SPECT (CS-SPECT), dedicated to guide and optimize application of alpha particle-emitting radiopharmaceutical therapy ($\alpha$RPT). Alpha particles are highly potent and unlike conventional external beam therapy, they can be used in metastatic settings. Currently, the lack of information of radionuclide distribution hinders estimated internal absorbed dose from $\alpha$RPT, which calls for ultrasensitive SPECT technologies that can report reliable activity distribution under ultra-low count rate imaging conditions. The proposed CS-SPECT is based on an innovative design that incorporates the geometry of both conventional pinhole collimator and coded aperture. Aimed to decouple the dependence of resolution and sensitivity, the heavy metal collimator is replaced by scintillator crystals to serve dual purposes of increasing detected events and providing spatial information. The proposed detector module consists of a 9×9 array of crystal elements. Each crystal presents an alternating pattern of GAGG scintillator and acrylic. The depth of interaction (DOI) information is obtained through dual-ended readout system. Our experimental results are based on a working prototype CS module that has 8x8 detector columns and is fully functional under a broad range of energy (70 keV – more than 511 keV), which is well-suited for alpha particle emitter imaging applications. Furthermore, we performed a preliminary imaging study of Tc99m point source. The number of detected events by the whole detector module is 11-fold higher than that from the bottom detectors resembling a conventional pinhole camera alone, demonstrating a tremendous improvement in system sensitivity.

关键词： Temperature sensors Collimators Sensitivity Scintillators Prototypes Medical treatment Crystals

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Exfoliated MXene nanosheet by double layer forces for preparing magnetic adsorbents of toxic metal ions and recycling with hyperthermic effect

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Separation and Purification Technology 2024年 349卷

作者： Chen, Chih-Wei Chang, Chi-Jung Liaw, Shien-Kuei Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Division of Neurosurgery Department of Surgery Chi Mei Medical Center Tainan710 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Seatwen Taichung40724 Taiwan Department of Electronic and Computer Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine and Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

The conventional etching method for exfoliating MXene using hydrofluoric acid solution is time-consuming and inefficient in productivity. A double layer force is generated through polarization among the heterogeneous layers of MXene due to their different dielectric properties. The exfoliated MXene by the polarization method in an acidic solution was employed to synthesize magnetic MXene (MXFe) with Fe3O4 nanoparticles. MXFe was coated on polyacrylonitrile microspheres (PANs) as precursors (PAN@MXFe) by Pickering emulsion polymerization. The core@shell polyvinyltetrazole@MXFe (PVT@MXFe) was obtained as the adsorbent after subsequent cyano-tetrazole conversion of PAN@MFs for the removal of toxic metal ions. The maximum adsorption capacities of Hg(II) on the MXFe and PVT@MXFe coating 2 wt% of MXFe were 579 and 324 mg/g, respectively, indicating the high use efficiency of MXFe. At 8.5 kHz of high frequency, hyperthermia occurs on the PVT@MXFe, facilitating the desorption of the toxic metal ions from the adsorbents. Compared with reuse using an acidic solution, the PVT@MXFe can be reused repeatedly 10 times without obvious damage under the AMF. Our proposed polarization exfoliation method not only provides a novel methodology to exfoliate MXene but also develops an ideal adsorbent for universal adsorption, simple separation, stable regeneration, and low secondary pollution. © 2024 Elsevier B.V.

关键词： Synthesis (chemical)

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Doxycycline-laden fibrous microparticles as a therapeutic ingredient for etch-and-rinse adhesive systems: Effects on optical, physical and bonding properties to dentin

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Dental Materials 2025年第7期41卷 862-871页

作者： Silveira, Bianca Tatsch Piva, Evandro Paim, Julia Stela Xavier Bottino, Marco Cícero Münchow, Eliseu Aldrighi Graduate Program in Dentistry School of Dentistry Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2492 Porto Alegre Brazil Graduate Program in Dentistry School of Dentistry Federal University of Pelotas Rua Gonçalves Chaves 457 Pelotas Brazil Department of Biomedicine Health Basic Science Institute Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2600 Porto Alegre Brazil Department of Biomedical Engineering College of Engineering University of Michigan Ann Arbor United States Department of Conservative Dentistry School of Dentistry Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2492 Porto Alegre Brazil

Objectives: To evaluate the effects of the modification of an etch-and-rinse (ER) adhesive system with fibrous particles with or without doxycycline (DOX) as a therapeutic ingredient. Methods: Polymeric fibers were synthesized via electrospinning using a 10 wt% polymer solution based on poly-(Ε-caprolactone) (PCL). The PCL solution was separated into two aliquots: one was kept unchanged, and the other was laden with 25 wt% of DOX. Each electrospun fiber mat was further processed in a cryogenic impact mill to obtain small-sized fibrous particles, which were characterized with morphological, chemical (FTIR), and antibacterial activity (against Streptococcus mutans and Lactobacillus) analyses. The 2-step ER adhesive One-Step (Bisco) was separated into three aliquots: one was kept unmodified to serve as an unfilled control, and the other two aliquots were added with 20 wt% of DOX or PCL fibrous microparticles. The fiber-modified adhesives were tested for degree of conversion (DC), optical properties (color change [ΔE00], translucency, and refractive index [RI]), wettability properties, and bonding potential (microtensile bond strength/µTBS) to dentin after immediate testing and one-year of water storage. The data were statistically analyzed using ANOVA and Kruskal-Wallis tests with α= 5 %. The bond strength data was also analyzed using Weibull analysis. Results: The morphology of the PCL and DOX particles demonstrated a nonuniform diameter distribution similar to each other. While the PCL particles did not inhibit the growth of S. mutans and Lactobacillus, the DOX particles resulted in significant inhibition halos greater than chlorhexidine (control). The incorporation of the fibrous particles into the adhesive altered the color appearance of the material (ΔE00>1.8 – above the acceptability threshold);translucency was slightly reduced only in the PCL adhesive, and the RI was similar among the tested adhesives. DC was similar among the adhesive groups, but their wetting

关键词： Bond strength (chemical)

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Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

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Food science and Human Wellness 2024年第3期13卷 1698-1710页

作者： Young-Jin Choi Meiqi Fan Nishala Erandi Wedamulla Yujiao Tang Eun-Kyung Kim Department of Food Science and Nutrition Dong-A UniversityBusan 49315Republic of Korea Center for Silver-targeted Biomaterials Brain Busan 21 Plus programDong-A UniversityBusan 49315Republic of Korea Department of Health Sciences the Graduate School of Dong-A UniversityBusan 49315Republic of Korea Division of Food Bioscience College of Biomedical and Health SciencesKonkuk UniversityChungju 27478Republic of Korea Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla 90000Sri Lanka School of Bio-Science and Food Engineering Changchun University of Science and TechnologyChangchun 130600China Nutritional Education Major Graduate School of EducationDong-A UniversityBusan 49315Republic of Korea Nutrinomics Lab.Co. Ltd.Busan 49315Republic of Korea

We evaluated the effect of isoquercetin(quercetin-O-3-glucoside-quercetin,IQ)as a functional component of Abeliophyllum disistichum Nakai ethanol extract(ADLE)on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia(BPH).Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and *** was orally administered(1 or 10 mg/kg)to a testosterone propionate-induced BPH rat model,and its effects on the prostate weight were *** effect of IQ on androgen receptor(AR)signaling was analyzed in LNCaP *** IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also *** metabolites in ADLE were identified and quantified,which confirmed that ADLE contained abundant IQ(20.88 mg/g).IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model,and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent *** also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 *** BPH-1 cells,IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing ***,IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

关键词： Isoquercetin Benign prostatic hyperplasia Androgen receptor signaling PI3K/Akt/mtor pathway

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Lignocellulose aerogel and amorphous silica nanoparticles from rice husks

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Journal of Leather science and engineering 2021年第1期3卷 11-17页

作者： Zichao Wei Andrew T.Smith William R.T.Tait Jingjing Liu Hao Ding Hui Wang Weixing Wang Luyi Sun Polymer Program Institute of Materials ScienceUniversity of ConnecticutStorrsCT 06269USA Department of Chemical&Biomolecular Engineering University of ConnecticutStorrsCT 06269USA College of Materials Science and Engineering South China University of TechnologyGuangzhou 510640GuangdongChina Key Laboratory of Enhanced Heat Transfer and Energy Conservation of the Ministry of Education School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640GuangdongChina Department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA

Rice Husks(RHs)are one of the most abundant sources of biomass in the world due to rice *** and silica are two of the main components of RHs,which allow RHs to be applied in different *** can be partially dissolved in 1-butyl-3-methylimidazolium chloride(BMIMCl),which is a simple way of competing with the traditional extraction methods that suffer from high chemical consumption.A lignocellulose freeze gel is obtained via a cyclic liquid nitrogen freeze-thaw(NFT)***-functional self-assembled lignocellulose aerogel is obtained after CO_(2) supercritical *** on the aerogel’s special properties,two routes are developed for practical *** one hand,the aerogel is coated to exhibit a superhydrophobic property that can be applied as an absorbent for oil *** the other hand,a carbon aerogel is synthesized via a pyrolysis process,resulting in a porous amorphous *** residue after partially dissolving lignocellulose in BMIMCl is further calcined to obtain amorphous silica nanoparticles,achieving a comprehensive application of RHs.

关键词： Rice husks Lignocellulose Carbon aerogel Silica

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Microengineered platforms for characterizing the contractile function of in vitro cardiac models

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Microsystems & Nanoengineering 2022年第1期8卷 29-50页

作者： Wenkun Dou Manpreet Malhi Qili Zhao Li Wang Zongjie Huang Junhui Law Na Liu Craig A.Simmons Jason T.Maynes Yu Sun Department of Mechanical and Industrial Engineering University of TorontoTorontoON M5S 3G8Canada Program in Molecular Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Biochemistry University of TorontoTorontoON M5S 1A8Canada Institute of Robotics and Automatic Information System and the Tianjin Key Laboratory of Intelligent Robotics Nankai UniversityTianjin 300350China School of Mechanical&Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai 200444China Institute of Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada Translational Biology&Engineering Program Ted Rogers Centre for Heart ResearchTorontoON M5G 1M1Canada Department of Anesthesiology and Pain Medicine University of TorontoTorontoON M5S 1A8Canada Department of Anesthesia and Pain Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Electrical and Computer Engineering University of TorontoTorontoON M5S 3G4Canada Department of Computer Science University of TorontoTorontoON M5T 3A1Canada

Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology,disease modeling and drug cardiotoxicity as well as for therapeutic *** still exist in obtaining the complete capability of in situ sensing to fully evaluate the complex functional properties of cardiac cell/tissue *** to contractile strength(contractility)and beating regularity(rhythm)are particularly important to generate accurate,predictive *** new platforms and technologies to assess the contractile functions of in vitro cardiac models is essential to provide information on cell/tissue physiologies,drug-induced inotropic responses,and the mechanisms of cardiac *** this review,we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models,including single cardiomyocytes,2D monolayers of cardiomyocytes,and 3D cardiac *** characteristics and performance of current platforms are reviewed in terms of sensing principles,measured parameters,performance,cell sources,cell/tissue model configurations,advantages,and *** addition,we highlight applications of these platforms and relevant discoveries in fundamental investigations,drug testing,and disease ***,challenges and future outlooks of heart-on-a-chip platforms for in vitro measurement of cardiac functional properties are discussed.

关键词： cardiac contractile regularity

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Flake-like structure of SrTiO3 nanoparticles dispersed on graphene oxide: A selective and sensitive electrochemical sensor for determination of chloramphenicol in milk and honey samples

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Food Chemistry 2024年 444卷

作者： Sakaleshpur Kumar, Gagankumar Ballur Prasanna, Sanjay Lokesh Marenahalli, Bhuvan Shadakshari, Sandeep Arehalli Shivamurthy, Santhosh Rajabathar, Jothi Ramalingam Chimatahalli Shanthakumar, Karthik Han, Young-Kyu Department of Chemistry SJCE JSS Science and Technology University Karnataka570006 India Department of Energy and Materials Engineering Dongguk University-Seoul Seoul100-715 Korea Republic of Taipei10608 Taiwan International PhD Program for Biomedical Engineering Taipei Medical University 250 Wuxing St Taipei11031 Taiwan N.M.K.R.V. College for Women's Karnataka 560011 India Department of Chemistry College of Science King Saud University P.O. Box. 2455 Riyadh11451 Saudi Arabia

The use of Chloramphenicol (CAP), a potent antibiotic with broad-spectrum capabilities in food-producing animals has been restricted by the European Union and several other countries due to its severe side effects. Thus, CAP must be detected quickly and sensitively. In this investigation, the preparation of SrTiO3 nanoparticles was carried out utilizing a hydrothermal technique. The as-synthesized strontium titanate was decorated on the graphene oxide (SrTiO3/GO) using an ultrasonication method. An electrochemical sensor was developed by employing a modified electrode consisting of SrTiO3/GO, which can accurately detect CAP in food samples. The synergistic effect of SrTiO3 and GO could improve the peak current response. Remarkably, the SrTiO3/GO-modified glassy carbon electrode has a LOD and sensitivity of 6.08 µM nM and 2.771 µA·μM−1·cm−2, respectively. This modified electrode was evaluated in food samples and had an outstanding reaction with a high percentage of recovery, which makes it a potential electrocatalyst for CAP detection. © 2024 Elsevier Ltd

关键词： Titanium compounds

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Implantable Biosensor for Continuous Serotonin Detection in Freely Moving Crayfish 22

Implantable Biosensor for Continuous Serotonin Detection in ...

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22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

作者： Han, Jinjing Ho, Tawen Stine, Justin M. Straker, Michael A. Herberholz, Jens Ghodssi, Reza University Of Maryland Department Of Electrical And Computer Engineering College ParkMD United States University Of Maryland Institute For System Research College ParkMD United States University Of Maryland Robert E. Fischell Institute For Biomedical Devices College ParkMD United States University Of Maryland Department Of Psychology College ParkMD United States University Of Maryland Program In Neuroscience And Cognitive Science College ParkMD United States University Of Maryland Fischell Department Of Bioengineering College ParkMD United States

ISBN: (纸本)9784886864352

This work presents, for the first time, an implantable biosensor for continuous in vivo serotonin (5-HT) monitoring in freely moving crayfish. 5-HT is an important neurotransmitter that regulates animal behaviors. Conventional methods for detecting 5-HT do not provide real-time information. Our approach facilitates continuous electrochemical monitoring of 5-HT levels without impeding animal natural behavior. The sensing system shows a linear range of 0.4 - 1.2 μΜ with a sensitivity of 0.07 μA/μΜ for 5-HT detection. With a 3D-printed package, the sensor can be easily attached to crayfish dorsal carapace allowing electrodes implantation into crayfish heart to monitor neurohormonal dynamics of 5-HT. The implantable biosensor system displayed a significant increase in oxidation currents after 5-HT injections. The device successfully demonstrates the application for in vivo detection of 5-HT in the hemolymph (i.e., blood) of freely behaving crayfish underwater. © 2023 IEEJ.

关键词： Biosensing Electrochemical Device Electrochemistry Implantable Electrode In Vivo Sensing

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