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5th International Conference on Medical and Health Informatics, ICMHI 2021

作者： Chang, Dun-Hao Chu, Po-Jui Li, Yi-Jhen Ning, Chun-Kai Chien, Ting-Ying Department of Information Management Yuan Ze University Taoyuan City Taiwan Department of Plastic and Aesthetic Surgery Far Eastern Memorial Hospital Taiwan Department of Computer Science and Engineering Yuan Ze University Taoyuan City Taiwan Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan Innovation Center for Big Data and Digital Convergence Yuan Ze University Taoyuan City Taiwan

ISBN: (纸本)9781450389846

Pressure ulcers (PUs) are a common problem associated with great morbidity and cost. Because of the lack of professional personnel in the institutions or home care system, the diagnosis and treatment of PUs were sometimes delayed. We aim to develop an automatic tissue classification and severity evaluation system of PUs using AI technology. All PU images were collected from patients in the Far Eastern Memorial Hospital (FEMH) in recent 3 years and labeled according to different tissue types. The labeled images were used to train the tissue segmentation model with U-net convolutional neural network (CNN). The percentage of the different tissue can be calculated automatically and would be compared with the manually labeled one. The output of tissue classification was transformed to a clinical decision support system (CDSS) with a rule-base formula. Our study showed that proposed system can classify each tissue automatically and reach an accuracy about 93.6%. However, the CDSS's accuracy rate was only 64% for the referral suggestion and 62% for the care recommendation. Hence, the system should be modified with more data and information. © 2021 ACM.

关键词： Tissue

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Terahertz Time-Domain Spectroscopy for Probing DC Conductivity of Single-Layer Graphene

Terahertz Time-Domain Spectroscopy for Probing DC Conductivi...

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Western New York Image Processing Workshop (WNYIPW)

作者： Debamitra Chakraborty Declan Walden Jing Cheng Julia Wallace Kiryl A. Niherysh Andrei V. Felsharuk Donats Erts Ivan Komissarov Roman Sobolewski Materials Science Graduate Program University of Rochester Rochester New York USA Laboratory for Laser Energetics Rochester New York USA Department of Physics and Astronomy University of Rochester Rochester New York USA Department of Biomedical Engineering University of Rochester Rochester New York USA Institute of Chemical Physics University of Latvia Riga Latvia Department of Microtechnology and Nanoscience Chalmers University of Technology Gothenburg Sweden Department of Electrical and Computer Engineering University of Rochester Rochester New York USA

We report preliminary results of extracting electrical parameters like DC conductivity, mobility, and carrier concentration of single-layer graphene using Terahertz time-domain spectroscopy (THz-TDS) in transmission geometry. We utilize a simple Drude model and its extension, the Drude-Smith model, capable of accommodating charge carrier scattering by optical and acoustic phonons to describe the complex conductivity in graphene. We observed that a significant area of the sample scanned followed the Drude-Smith behavior, while at a few locations, the simple Drude behavior prevailed. We identified possible reasons that might contribute to this observation, like defects, the presence of polymer residue on the sample, or the sample strain. This research sheds new light on our understanding of graphene's electrical properties and lays the foundation for future investigations addressing defects and contaminants in graphene samples.

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Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes

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Microsystems & Nanoengineering 2020年第1期6卷 494-506页

作者： Ashley A.Chapin Pradeep R.Rajasekaran David N.Quan Liangbing Hu Jens Herberholz William E.Bentley Reza Ghodssi Fischell Department of Bioengineering College ParkMD 20742USA Institute for Systems Research College ParkMD 20740USA Department of Materials Science and Engineering College ParkMD 20740USA Department of Psychology and Neuroscience and Cognitive Science Program College ParkMD 20740USA Institute for Bioscience and Biotechnology Research RockvilleMD 20850USA Robert E.Fischell Institute for Biomedical Devices RockvilleMD 20850USA Department of Electrical and Computer Engineering College ParkMD 20742USA

Gut–brain axis(GBA)communication relies on serotonin(5-HT)signaling between the gut epithelium and the peripheral nervous system,where 5-HT release patterns from the basolateral(i.e.,bottom)side of the epithelium activate nerve *** have been few quantitative studies of this gut-neuron signaling due to a lack of real-time measurement tools that can access the basolateral gut *** vitro platforms allow quantitative studies of cultured gut tissue,but they mainly employ offline and endpoint assays that cannot resolve dynamic molecular-release ***,we present the modification of a microporous cell culture membrane with carbon nanotube-coated gold(Au-CNT)electrodes capable of continuous,label-free,and direct detection of 5-HT at physiological *** characterization of single-walled carbon nanotube(SWCNT)-coated Au electrodes shows increased electroactive surface area,5-HT specificity,sensitivity,and saturation time,which are correlated with the CNT film drop-cast *** microliters of CNT films,with a 10-min saturation time,0.6μA/μM 5-HT sensitivity,and reliable detection within a linear range of 500 nM–10μM 5-HT,can be targeted for high-concentration,high-time-resolution 5-HT *** films(12.5μL)with a 2-h saturation time,4.5μA/μM 5-HT sensitivity,and quantitative detection in the linear range of 100 nM–1μM can target low concentrations with low time *** electrodes achieved continuous detection of dynamic diffusion across the porous membrane,mimicking basolateral 5-HT release from cells,and detection of cell-released 5-HT from separately cultured RIN14B cell ***-integrated cell culture systems such as this can improve in vitro molecular detection mechanisms and aid in quantitative GBA signaling studies.

关键词： release saturation dynamic

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CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation

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Journal of Controlled Release 2025年 384卷 113872页

作者： Kim, Sang Eun Bak, Soyeon Park, Jung Hee Lee, Ji Eun Lee, Yun Ji Park, Min Seok Ko, Soyeon Choi, Hani Jung, Kyung Hee Na, Kun Hong, Soon-Sun Department of Biomedical Science Program in Biomedical Science & Engineering and College of Medicine Inha University 3-ga Sinheung-dong Jung-gu Incheon22332 Korea Republic of Department of Biotechnology The Catholic University of Korea 43 Jibong-ro Wonmi-gu Gyeonggi-do Bucheon-si14662 Korea Republic of Department of BioMedical-Chemical Engineering The Catholic University of Korea 43 Jibong-ro Wonmi-gu Gyeonggi-do Bucheon-si14662 Korea Republic of

Receptor-interacting protein kinase 3 (RIP3)-mediated necroptosis has attracted interest as a potential target for cancer therapy as it boosts tumor immunogenicity. Here, we synthesized a pH-sensitive polymer (CA) by conjugating aminopropyl imidazole (API) to chondroitin sulfate (CHS) for RIP3 gene delivery. CA can target cancer cells due to the specific binding ability of CHS to CD44 which is overexpressed in cancer cells. In addition, the introduction of API conferred pH sensitivity, facilitating efficient endosomal escape and enhancing gene delivery efficiency. Increased levels of high mobility group box-1, EEA1, and Rab5 and high activation of RIP3/mixed-lineage kinase domain-like pseudokinase (MLKL) signaling were observed in the CA-shielded RIP3 complex (CA-PEI/RIP3)-treated groups. Significant tumor selectivity and ablation efficacy of CA-PEI/RIP3 were confirmed in A549 xenografts and LLC1 orthotopic lung cancer mouse models. Furthermore, CA-PEI/RIP3-induced necroptotic cell death could enhance the immune response by increasing phagocytosis of dendritic cells (DCs), resulting in large numbers of CD4+ and CD8+ T cells and mature DCs infiltrating tumor tissues and lymph nodes. Collectively, CA-PEI/RIP3 showed significant potential in cancer gene therapy due to the enhanced transfection efficiency and the tumor-targeting properties of CA, providing a safe and robust strategy to activate the immune response for cancer immunotherapy. © 2025 Elsevier B.V.

关键词： Cancer cells

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Machine learning for improved current-density reconstruction from two-dimensional vector magnetic images

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Physical Review Applied 2025年第3期23卷 034035-034035页

作者： Niko R. Reed Danyal Bhutto Matthew J. Turner Declan M. Daly Sean M. Oliver Jiashen Tang Kevin S. Olsson Nicholas Langellier Mark J.H. Ku Department of Physics University of Maryland College Park Maryland USA Quantum Technology Center University of Maryland College Park Maryland USA Joint Quantum Institute University of Maryland College Park Maryland USA Department of Biomedical Engineering Boston University Boston Massachusetts USA A. A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown Massachusetts USA Department of Electrical and Computer Engineering University of Maryland College Park Maryland USA The MITRE Corporation McLean Virginia 22102 USA Intelligence Community Postdoctoral Research Fellowship Program University of Maryland College Park Maryland 20742 USA Department of Physics Harvard University Cambridge Massachusetts USA Present address: VideaHealth Inc. Boston MA. Department of Materials Science and Engineering University of Delaware Newark Delaware 19716 USA Department of Physics and Astronomy University of Delaware Newark Delaware 19716 USA Present address: Northrop Grumman Mission Systems Linthicum Maryland 21090 USA.

The reconstruction of electrical current densities from magnetic field measurements is an important technique with applications in materials science, circuit design, quality control, plasma physics, and biology. Analytic reconstruction methods exist for planar currents, but break down in the presence of high-spatial-frequency noise or large standoff distance, restricting the types of systems that can be studied. Here, we demonstrate the use of a deep convolutional neural network for current density reconstruction from two-dimensional images of vector magnetic fields acquired by a quantum diamond microscope . Trained network performance significantly exceeds analytic reconstruction for data with high noise or large standoff distances. This machine learning technique can perform quality inversions on lower-signal-to-noise-ratio data, significantly reducing the data collection time and permitting reconstructions of weaker and three-dimensional current sources.

关键词： Signal to noise ratio

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Improving the Accuracy and Equity of Pulse Oximeters: Collaborative Recommendations

JACC: Advances

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JACC: Advances 2022年第4期1卷 100118-100118页

作者： Rathod, Megh Ross, Heather J. Franklin, Daniel Institute of Biomedical Engineering Faculty of Applied Science and Engineering University of Toronto Toronto ON Canada Translational Biology and Engineering Program Ted Rogers Center for Heart Research Toronto ON Canada Ted Rogers Center for Heart Research Peter Munk Cardiac Center University Health Network Toronto ON Canada Division of Cardiology Department of Medicine University of Toronto Toronto ON Canada

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engineering the Hydrogel Extracellular Matrix Composition for the Salivary Gland Microbubble Tissue Chip

SSRN

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SSRN 2022年

作者： Mereness, Jared A. Benoit, Danielle S.W. Piraino, Lindsay R. Chen, Chiao Yun Moyston, Tracey DeLouise, Lisa A. Ovitt, Catherine E. Department of Biomedical Engineering University of Rochester RochesterNY United States Department of Dermatology University of Rochester RochesterNY United States Department of Biomedical Genetics University of Rochester RochesterNY United States Materials Science Program University of Rochester RochesterNY United States Department of Chemical Engineering University of Rochester RochesterNY United States Center for Musculoskeletal Research University of Rochester RochesterNY United States Knight Campus Bioengineering Department University of Oregon EugeneOR United States

Salivary gland dysfunction resulting in xerostomia occurs in the majority of head and neck cancer patients treated with radiation therapy. Progress in determining the mechanism of radiation damage and methods for prevention has been hampered by the lack of in vitro salivary gland models. We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland tissue clusters encapsulated in matrix metalloproteinase (MMP)–degradable poly(ethylene glycol) hydrogels within arrays of ~320 Om diameter spherical cavities molded in PDMS. The SGm provides a functional and physiologically relevant salivary gland model well suited to high-throughput drug screening for radioprotective compounds. However, the utility of the SGm would significantly benefit from improved retention of acinar phenotype and function over longer culture durations. We hypothesize that tuning biochemical cues presented within the PEG hydrogel matrix will improve maintenance of acinar cell phenotype and function by mimicking the natural extracellular matrix microenvironment of the intact gland. Hydrogels formed using slower-degrading MMP-sensitive peptide crosslinkers showed >2-fold increase in sphere number formed at 48 hr, increased expression of acinar cell markers, and more robust response to calcium stimulation by the secretory agonist, carbachol, with reduced SGm tissue cluster disruption and outgrowth during prolonged culture. The incorporation of adhesive peptides containing RGD or IKVAV improved calcium flux response to secretory agonists at 14 days of culture. Tuning the hydrogel matrix improved cell aggregation, and promoted acinar cell phenotype, and stability of the SGm in long-term culture. Furthermore, combining this matrix with optimized media conditions synergistically improved retention of acinar cells in SGm. © 2022, The Authors. All rights reserved.

关键词： Polyethylene glycols

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Study on Ag(I) Loaded ZIF-8 and Ag(I) Ion Release in Artificial Seawater

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Materials 2023年第5期16卷 2040-2040页

作者： Tsai, Shang-Tien Tang, Wei-Cheng Wei, Yeu-Kuen Wu, Kevin C.-W. Program of Green Materials and Precision Devices National Taiwan University Taipei10617 Taiwan Material and Chemical Research Laboratories Industrial Technology Research Institute Hsinchu30011 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes 35 Keyan Road Miaoli35053 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan32003 Taiwan Yonsei Frontier Lab Yonsei University 50 Yonsei-ro Seoul03722 Korea Republic of

From a porous structure perspective, the one-stage de novo synthesis method and impregnation method were applied to synthesize Ag(I) ion-containing ZIF-8 samples. With the de novo synthesis method, Ag(I) ions could be located inside micropores or adsorbed on the external surface of the ZIF-8 by selecting AgNO3 in water or Ag2CO3 in ammonia solution as precursors, respectively. The ZIF-8 confining Ag(I) ion exhibited a much lower constant releasing rate than the Ag(I) ion adsorbed on the ZIF-8 surface in artificial seawater. As such, strong diffusion resistance in association with the confinement effect is contributed by ZIF-8’s micropore. On the other hand, the release of Ag(I) ions adsorbed on the external surface was diffusion limited. Therefore, the releasing rate would reach a maximum not increasing with Ag(I) loading in the ZIF-8 sample. © 2023 by the authors.

关键词： Ions

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Z-scheme S, B co-doped g-C3N4 nanotube@MnO2 heterojunction with visible-light-responsive for enhanced photodegradation of diclofenac by peroxymonosulfate activation

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Chemical engineering Journal 2023年第Part2期452卷

作者： Dung Nguyen, Manh Binh Nguyen, Thanh Hai Tran, Linh Giang Nguyen, Thuy Fatimah, Is Prasetyo Kuncoro, Eko Doong, Ruey-An Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan Institute of Aquatic Science and Technology National Kaohsiung University of Science and Technology Kaohsiung City81157 Taiwan Center of Crop Research for Adaptation to Climate Change Thai Nguyen University of Agriculture and Forestry Quyet Thang Ward Thai Nguyen City Viet Nam Department of Chemistry Faculty of Mathematics and Natural Science Universitas Islam Indonesia Kampus Terpadu UII J1. Kaliurang Km 14 Sleman Yogyakarta Indonesia Environmental Engineering Program Faculty of Science and Technology University of Airlangga Surabaya60115 Indonesia Institute of Analytical and Environmental Sciences National Tsing Hua University 101 Sec. 2 Kuang Fu Road Hsinchu30013 Taiwan

In this study, the manganese dioxide (MnO2) nanosheets were successfully embedded onto boron and sulfur co-doped g-C3N4 (CNBS) nanotubes to construct the flower-like core–shell CNBS@MnO2 heterojunction with Z-scheme structure for the enhanced photodegradation of diclofenac (DCF) in the presence of peroxymonosulfate (PMS) and 460-nm visible light. The CNBS@MnO2 provides large specific surface area and reduced interfacial resistance for rapid electron transport. Moreover, the redox cycling of Mn species effectively activates PMS to produce sulfate radicals for DCF photodegradation. The PMS-based photodegradation of DCF over CNBS@MnO2 displays the excellent photodegradation performance after 15 min of irradiation, and the efficiency is highly dependent on initial pH, ion species, and concentrations of PMS and DCF. The CNBS@MnO2 also shows its excellent stability and reusability over ten cycles. Besides, h+, O2●− and SO4●− are the dominantly reactive species for the enhanced degradation of DCF over Z-scheme CNBS@MnO2 heterojunction. The possible reaction mechanism as well as the degradation pathway of DCF over CNBS@MnO2 in the presence of PMS is also proposed. Results clearly highlight the superior photoactivity of Z-scheme CNBS@MnO2 toward micropollutant degradation by PMS activation, which can open an avenue to fabricate the g-C3N4 nanotube@metal oxide structure as an effective activator for water and wastewater purification. © 2022 Elsevier B.V.

关键词： Heterojunctions

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Tear Growth Mechanisms in High-Grade Bursal-Sided Partial Thickness Tears in the Rotator Cuff Measured with Full Volume Methods

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SSRN 2025年

作者： Villacís Núñez, Carla Nathaly Scheven, Ulrich Bedi, Asheesh Arruda, Ellen M. Department of Mechanical Engineering University of Michigan G.G. Brown Laboratory 2350 Hayward St. Ann ArborMI48109 United States Department of Orthopedic Surgery University of Michigan Taubman Health Care Center 2912 1500 E Medical Center Dr. Ann ArborMI48109 United States Department of Biomedical Engineering University of Michigan 1107 Carl A. Gerstacker Building 2200 Bonisteel Blvd Ann ArborMI48109 United States Program of Macromolecular Science and Engineering University of Michigan 1221 Beal Ave Ann ArborMI48109 United States 2464 Stone Rd. Ann ArborMI48105 United States

In this work, we evaluate the mechanical response of rotator cuff tendons with high-grade partial thickness tears through a novel full volume measurement technique. As opposed to traditional strain-measurement methods, which examine surfaces of the tendon or localized two-dimensional regions, we have probed three-dimensional strains including internal locations. Differences between the intact and torn states have been considered. The torn condition depicts sliding between cut/uncut tissue regions, revealing regions of high shear strain concentration at the boundaries of detached/attached tissue portions. At both submaximal and supramaximal force levels, the internal and inferior bands of the tendon show high shear strain magnitudes, which could indicate regions of high risk for tear propagation. Geometrical features which could explain strain distribution differences in their intact and torn conditions are also analyzed. Through the understanding of full volume displacement and strain distributions, our study elucidates why two-dimensional values might not represent the global behavior of the injured tendon, critical components of the Lagrangian strain tensor which have not been probed before, and important implications for surgical repairs. © 2025, The Authors. All rights reserved.

关键词： Tendons

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