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SSRN 2022年

作者： Mereness, Jared A. Benoit, Danielle S.W. Piraino, Lindsay R. Chen, Chiao Yun Moyston, Tracey DeLouise, Lisa A. Ovitt, Catherine E. Department of Biomedical Engineering University of Rochester RochesterNY United States Department of Dermatology University of Rochester RochesterNY United States Department of Biomedical Genetics University of Rochester RochesterNY United States Materials Science Program University of Rochester RochesterNY United States Department of Chemical Engineering University of Rochester RochesterNY United States Center for Musculoskeletal Research University of Rochester RochesterNY United States Knight Campus Bioengineering Department University of Oregon EugeneOR United States

Salivary gland dysfunction resulting in xerostomia occurs in the majority of head and neck cancer patients treated with radiation therapy. Progress in determining the mechanism of radiation damage and methods for prevention has been hampered by the lack of in vitro salivary gland models. We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland tissue clusters encapsulated in matrix metalloproteinase (MMP)–degradable poly(ethylene glycol) hydrogels within arrays of ~320 Om diameter spherical cavities molded in PDMS. The SGm provides a functional and physiologically relevant salivary gland model well suited to high-throughput drug screening for radioprotective compounds. However, the utility of the SGm would significantly benefit from improved retention of acinar phenotype and function over longer culture durations. We hypothesize that tuning biochemical cues presented within the PEG hydrogel matrix will improve maintenance of acinar cell phenotype and function by mimicking the natural extracellular matrix microenvironment of the intact gland. Hydrogels formed using slower-degrading MMP-sensitive peptide crosslinkers showed >2-fold increase in sphere number formed at 48 hr, increased expression of acinar cell markers, and more robust response to calcium stimulation by the secretory agonist, carbachol, with reduced SGm tissue cluster disruption and outgrowth during prolonged culture. The incorporation of adhesive peptides containing RGD or IKVAV improved calcium flux response to secretory agonists at 14 days of culture. Tuning the hydrogel matrix improved cell aggregation, and promoted acinar cell phenotype, and stability of the SGm in long-term culture. Furthermore, combining this matrix with optimized media conditions synergistically improved retention of acinar cells in SGm. © 2022, The Authors. All rights reserved.

关键词： Polyethylene glycols

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Study on Ag(I) Loaded ZIF-8 and Ag(I) Ion Release in Artificial Seawater

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Materials 2023年第5期16卷 2040-2040页

作者： Tsai, Shang-Tien Tang, Wei-Cheng Wei, Yeu-Kuen Wu, Kevin C.-W. Program of Green Materials and Precision Devices National Taiwan University Taipei10617 Taiwan Material and Chemical Research Laboratories Industrial Technology Research Institute Hsinchu30011 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes 35 Keyan Road Miaoli35053 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan32003 Taiwan Yonsei Frontier Lab Yonsei University 50 Yonsei-ro Seoul03722 Korea Republic of

From a porous structure perspective, the one-stage de novo synthesis method and impregnation method were applied to synthesize Ag(I) ion-containing ZIF-8 samples. With the de novo synthesis method, Ag(I) ions could be located inside micropores or adsorbed on the external surface of the ZIF-8 by selecting AgNO3 in water or Ag2CO3 in ammonia solution as precursors, respectively. The ZIF-8 confining Ag(I) ion exhibited a much lower constant releasing rate than the Ag(I) ion adsorbed on the ZIF-8 surface in artificial seawater. As such, strong diffusion resistance in association with the confinement effect is contributed by ZIF-8’s micropore. On the other hand, the release of Ag(I) ions adsorbed on the external surface was diffusion limited. Therefore, the releasing rate would reach a maximum not increasing with Ag(I) loading in the ZIF-8 sample. © 2023 by the authors.

关键词： Ions

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Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer’s disease pathology

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Alzheimer's Research and Therapy 2025年第1期17卷 1-18页

作者： Fan, Kang-Chen Lin, Chen-Ching Chiu, Yen-Ling Koh, Seong-Ho Liu, Yi-Chien Chuang, Yi-Fang School of Medicine National Yang Ming Chiao Tung University 155 Sec. 2 Linong St. Beitou Dist Taipei 112304 Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University 155 Sec. 2 Linong St. Beitou Dist Taipei 112304 Taiwan Department of Medical Research Far Eastern Memorial Hospital 21 Sec. 2 Nanya S. Rd. Banqiao Dist New Taipei 220216 Taiwan Graduate Program in Biomedical Informatics Graduate Institute of Medicine Yuan Ze University 135 Yuan-Tung Rd. Zhongli Dist Taoyuan 32003 Taiwan Graduate Institute of Clinical Medicine National Taiwan University 1 Sec. 4 Roosevelt Rd. Da’an Dist Taipei 106319 Taiwan Department of Neurology College of Medicine Hanyang University Guri Hospital 153 Kyougchun-ro Gyeonggi-do Guri-si 11923 South Korea Department of Translational Medicine Graduate School of Biomedical Science & Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul 04763 South Korea Department of Neurology Cardinal Tien Hospital 362 Zhongzheng Rd. Xindian Dist New Taipei 23148 Taiwan Institute of Public Health National Yang Ming Chiao Tung University 155 Sec. 2 Linong St. Beitou Dist Taipei 112304 Taiwan Department of Psychiatry Far Eastern Memorial Hospital 21 Sec. 2 Nanya S. Rd. Banqiao Dist New Taipei 220216 Taiwan

Background: Emerging evidence highlights the bidirectional communication between the gut microbiota and the brain, suggesting a potential role for gut dysbiosis in Alzheimer’s disease (AD) pathology and cognitive decline. Existing literature on gut microbiota lacks species-level insights. This study investigates gut microbiota alterations in mild cognitive impairment (MCI), focusing on their association with comprehensive AD biomarkers, including amyloid burden, tau pathology, neurodegeneration, and cognitive performance. Methods: We analyzed fecal samples from 119 individuals with MCI and 320 cognitively normal controls enrolled in the Taiwan Precision Medicine Initiative on Cognitive Impairment and Dementia cohort. Shotgun metagenomic sequencing was conducted with taxonomic profiling using MetaPhlAn4. Amyloid burden and plasma pTau181 were quantified via PET imaging and Simoa assays, respectively, while APOE genotyping was performed using TaqMan assays. Microbial diversity, differential abundance analysis, and correlation mapping with neuropsychological and neuroimaging measures were conducted to identify gut microbiota species signatures associated with MCI and AD biomarkers. Results: We identified 59 key microbial species linked to MCI and AD biomarkers. Notably, species within the same genera, such as Bacteroides and Ruminococcus, showed opposing effects, while Akkermansia muciniphila correlated with reduced amyloid burden, suggesting a protective role. Functional profiling revealed microbial pathways contributing to energy metabolism and neuroinflammation, mediating the relationship between gut microbes and brain health. Co-occurrence network analyses demonstrated complex microbial interactions, indicating that the collective influence of gut microbiota on neurodegeneration. Conclusions: Our findings challenge genus-level microbiome analyses, revealing species-specific modulators of AD pathology. This study highlights gut microbial activity as a potential ther

关键词： Alzheimer’s disease pathology Amyloid PET APOE Gut microbiome Gut-brain axis Mild cognitive impairment Plasma pTau181 Shotgun metagenomics

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Z-scheme S, B co-doped g-C3N4 nanotube@MnO2 heterojunction with visible-light-responsive for enhanced photodegradation of diclofenac by peroxymonosulfate activation

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Chemical engineering Journal 2023年第Part2期452卷

作者： Dung Nguyen, Manh Binh Nguyen, Thanh Hai Tran, Linh Giang Nguyen, Thuy Fatimah, Is Prasetyo Kuncoro, Eko Doong, Ruey-An Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan Institute of Aquatic Science and Technology National Kaohsiung University of Science and Technology Kaohsiung City81157 Taiwan Center of Crop Research for Adaptation to Climate Change Thai Nguyen University of Agriculture and Forestry Quyet Thang Ward Thai Nguyen City Viet Nam Department of Chemistry Faculty of Mathematics and Natural Science Universitas Islam Indonesia Kampus Terpadu UII J1. Kaliurang Km 14 Sleman Yogyakarta Indonesia Environmental Engineering Program Faculty of Science and Technology University of Airlangga Surabaya60115 Indonesia Institute of Analytical and Environmental Sciences National Tsing Hua University 101 Sec. 2 Kuang Fu Road Hsinchu30013 Taiwan

In this study, the manganese dioxide (MnO2) nanosheets were successfully embedded onto boron and sulfur co-doped g-C3N4 (CNBS) nanotubes to construct the flower-like core–shell CNBS@MnO2 heterojunction with Z-scheme structure for the enhanced photodegradation of diclofenac (DCF) in the presence of peroxymonosulfate (PMS) and 460-nm visible light. The CNBS@MnO2 provides large specific surface area and reduced interfacial resistance for rapid electron transport. Moreover, the redox cycling of Mn species effectively activates PMS to produce sulfate radicals for DCF photodegradation. The PMS-based photodegradation of DCF over CNBS@MnO2 displays the excellent photodegradation performance after 15 min of irradiation, and the efficiency is highly dependent on initial pH, ion species, and concentrations of PMS and DCF. The CNBS@MnO2 also shows its excellent stability and reusability over ten cycles. Besides, h+, O2●− and SO4●− are the dominantly reactive species for the enhanced degradation of DCF over Z-scheme CNBS@MnO2 heterojunction. The possible reaction mechanism as well as the degradation pathway of DCF over CNBS@MnO2 in the presence of PMS is also proposed. Results clearly highlight the superior photoactivity of Z-scheme CNBS@MnO2 toward micropollutant degradation by PMS activation, which can open an avenue to fabricate the g-C3N4 nanotube@metal oxide structure as an effective activator for water and wastewater purification. © 2022 Elsevier B.V.

关键词： Heterojunctions

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Tear Growth Mechanisms in High-Grade Bursal-Sided Partial Thickness Tears in the Rotator Cuff Measured with Full Volume Methods

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SSRN 2025年

作者： Villacís Núñez, Carla Nathaly Scheven, Ulrich Bedi, Asheesh Arruda, Ellen M. Department of Mechanical Engineering University of Michigan G.G. Brown Laboratory 2350 Hayward St. Ann ArborMI48109 United States Department of Orthopedic Surgery University of Michigan Taubman Health Care Center 2912 1500 E Medical Center Dr. Ann ArborMI48109 United States Department of Biomedical Engineering University of Michigan 1107 Carl A. Gerstacker Building 2200 Bonisteel Blvd Ann ArborMI48109 United States Program of Macromolecular Science and Engineering University of Michigan 1221 Beal Ave Ann ArborMI48109 United States 2464 Stone Rd. Ann ArborMI48105 United States

In this work, we evaluate the mechanical response of rotator cuff tendons with high-grade partial thickness tears through a novel full volume measurement technique. As opposed to traditional strain-measurement methods, which examine surfaces of the tendon or localized two-dimensional regions, we have probed three-dimensional strains including internal locations. Differences between the intact and torn states have been considered. The torn condition depicts sliding between cut/uncut tissue regions, revealing regions of high shear strain concentration at the boundaries of detached/attached tissue portions. At both submaximal and supramaximal force levels, the internal and inferior bands of the tendon show high shear strain magnitudes, which could indicate regions of high risk for tear propagation. Geometrical features which could explain strain distribution differences in their intact and torn conditions are also analyzed. Through the understanding of full volume displacement and strain distributions, our study elucidates why two-dimensional values might not represent the global behavior of the injured tendon, critical components of the Lagrangian strain tensor which have not been probed before, and important implications for surgical repairs. © 2025, The Authors. All rights reserved.

关键词： Tendons

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Spinal functional Magnetic Resonance Imaging (fMRI) on Human Studies: A Literature Review

Spinal functional Magnetic Resonance Imaging (fMRI) on Human...

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2019 Advances in science and engineering Technology International Conferences, ASET 2019

作者： Al-Momani, Sajedah Dhou, Salam Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Computer Science and Engineering Biomedical Engineering Graduate Program Biosciences and Bioengineering Research Institute American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781538682715

Spinal functional Magnetic Resonance Imaging (fMRI) is a newly emerging non-invasive imaging technique that has been introduced to study the Blood Oxygenation Level Dependent (BOLD) changes in the spinal cord associated with a certain activity or even at rest. Spinal fMRI is also used to assess the treatment of many dysfunctions affect the spinal cord such as spinal cord injury (SCI) and Multiple sclerosis (MS). The purpose of this paper is to propose a literature review of spinal fMRI studies performed on healthy human volunteers. The studies reviewed are divided based on the paradigm being performed during image acquisition into (1) studies under activities and stimulus which are further classified according to the type of the stimuli, and (2) studies at resting state. Moreover, the limitations of spinal fMRI and how to tackle them are discussed. © 2019 IEEE.

关键词： Magnetic resonance imaging

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A Whole Head Ultra-High Density Diffuse Optical Tomography System for Naturalistic and Resting State Functional Human Brain Mapping

A Whole Head Ultra-High Density Diffuse Optical Tomography S...

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Optics and the Brain, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life sciences 2023

作者： Fogarty, Morgan Rafferty, Sean M. O’Sullivan, Anthony C. Svoboda, Calamity F. Markow, Zachary E. Richter, Edward J. George, Tessa King, Kelsey Wilhelm, Dana Tripathy, Kalyan Trobaugh, Jason W. Eggebrecht, Adam T. Culver, Joseph P. Imaging Science Program Washington University in St. Louis 1 Brookings Drive St. LouisMO63130 United States Department of Biomedical Engineering Washington University in St. Louis 1 Brookings Drive St. LouisMO63130 United States Department of Neuroscience Washington University in St. Louis 1 Brookings Drive St. LouisMO63130 United States Department of Electrical and Systems Engineering Washington University in St. Louis 1 Brookings Drive St. LouisMO63130 United States Department of Radiology Washington University in St. Louis 1 Brookings Drive St. LouisMO63130 United States Department of Physics Washington University in St. Louis 1 Brookings Drive St. LouisMO63130 United States

High-density diffuse optical tomography uses a dense array of overlapping measurements that provides functional brain images validated against fMRI. We doubled this optode density, improving resolution and expanding t... 详细信息

ISBN: (纸本)9781957171210

关键词： Diffuse optical tomography Functional imaging Image quality Magnetic resonance imaging Near infrared spectroscopy Optical imaging

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Inorganic Ions Activate Lineage-Specific Gene Regulatory Networks to Drive Stem Cells Differentiation

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SSRN 2023年

作者： Kersey, Anna L. Gaharwar, Akhilesh K. Singh, Irtisha Department of Biomedical Engineering College of Engineering Texas A&M University College StationTX77843 United States Department of Cell Biology and Genetics College of Medicine Texas A&M University College StationTX77843 United States Interdisciplinary Program in Genetics Texas A&M University College StationTX77843 United States Center for Remote Health Technologies and Systems Texas A&M University College StationTX77843 United States Department of Material Science and Engineering Dwight Look College of Engineering Texas A&M University College StationTX77843 United States

Ions released from inorganic biomaterials play a vital role in defining cell identity. However, the effect of inorganic ions on cellular functions has yet to be investigated at the transcriptomic level, representing a critical knowledge gap in the development of next-generation of bioactive materials. To address this gap, we investigated the impact of various inorganic ions including silver, copper, titanium, and platinum on human stem cells. Our finding showed that silver and copper induce osteogenic and chondrogenic differentiation respectively, through enrichment of ion-dependent signaling pathways. Specifically, silver effectively induced Wnt and MAPK signaling, which are vital for osteogenesis. On the other hand, copper specifically stimulated TGFβ signaling, while suppressing JAK-STAT signaling, thereby promoting chondrogenesis. In contrast, platinum, tantalum, and titanium ions didn't stimulate regenerative responses. Titanium displayed minimal gene expression changes, demonstrating its relative inertness, while platinum and tantalum induced oxidative stress. These findings are further supported by gene and protein level validation using traditional techniques. Together, our findings highlight the potential of inorganic biomaterials in revolutionizing tissue regeneration strategies, which currently rely largely on growth factors and small molecule therapeutics. © 2023, The Authors. All rights reserved.

关键词： Stem cells

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Ranking Magnetic Colloid Performance for Magnetic Particle Imaging and Magnetic Particle Hyperthermia

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Advanced Functional Materials 2025年第2期35卷 2412321页

作者： Carlton, Hayden Salimi, Marzieh Arepally, Nageshwar Bentolila, Gabriela Sharma, Anirudh Bibic, Adnan Newgren, Matt Goodwill, Patrick Attaluri, Anilchandra Korangath, Preethi Bulte, Jeff W.M. Ivkov, Robert Department of Radiation Oncology and Molecular Radiation Sciences the Johns Hopkins University School of Medicine BaltimoreMD21231 United States Russell H. Morgan Department of Radiology and Radiological Science Division of MR Research the Johns Hopkins University School of Medicine BaltimoreMD21205 United States Cellular Imaging Section and Vascular Biology Program Institute for Cell Engineering the Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Mechanical Engineering School of Science Engineering and Technology The Pennsylvania State University – Harrisburg HarrisburgPA17057 United States F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Inc. BaltimoreMD21205 United States Magnetic Insight Inc. AlamedaCA94502 United States Department of Biomedical Engineering the Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Chemical & Biomolecular Engineering Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States Department of Oncology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine BaltimoreMD21287 United States Department of Mechanical Engineering Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States

Magnetic particle imaging (MPI) is an emerging modality that can address longstanding technological challenges encountered with magnetic particle hyperthermia (MPH) cancer therapy. MPI is a tracer technology compatible with MPH for which magnetic nanoparticles (MNPs) provide signal for MPI and heat for MPH. Identifying whether a specific MNP formulation is suitable for both modalities is essential for clinical implementation. Current models predict that functional requirements of each modality impose conflicting demands on nanoparticle magnetic properties. This objective here is to develop a measurement and ranking scheme based on end-use performance to streamline evaluation of candidate MNP formulations. The measured MPI point-spread function (PSF) and specific loss power (SLP) is combined to generate a single numerical value for comparison on a relative ranking scale, or figure of merit (FoM). 12 aqueous iron-containing formulations are evaluated, including FDA-approved (parenteral) iron-containing colloids. MNPs with high (Synomag-D70: 123.4), medium (Synomag-D50: 63.2), and low (NanoXact: 0.147) FoM values are selected for in vivo validation of the selection scheme in subcutaneous 4T1 tumors. Results demonstrate that the proposed ranking accurately assessed the relative performance of MNPs for MPI and MPH. Data demonstrated that image quality and tumor temperature rise increased with FoM ranking, validating predictions. It isshown that the MPI signal correlated with MNP concentration in tissue. Computational heat transfer models anchored on tumor MPI data harmonized with experimental results to within an average of 2 °C when MNP content estimated from MPI data is included. Computational studies emphasized the importance of post-injection MNP quantitation and MPI spatial resolution. © 2024 The Author(s). Advanced Functional Materials published by Wiley-VCH GmbH.

关键词： Hyperthermia therapy

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Correction: Reconsidering invasion history of common land snails in Japan through genome-wide analyses

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Biological Invasions 2023年第11期25卷 3551-3552页

作者： Hirano, Takahiro Yamazaki, Daishi Ito, Shun Sato, Mitsuhiko P. Matsuo, Ayumi Saito, Takumi Nishi, Hirotaka Ye, Bin Dong, Zhengzhong Van Tu, Do Shau-Hwai, Aileen Tan Suyama, Yoshihisa Chiba, Satoshi Center for Northeast Asian Studies Tohoku University Sendai Japan Graduate School of Life Sciences Tohoku University Sendai Japan Biology Program Faculty of Science University of the Ryukyus Okinawa Japan Faculty of Agriculture and Marine Science Kochi University Nankoku Japan Department of Environmental Science Faculty of Science Toho University Funabashi Japan Kazusa DNA Research Institute Kisarazu Japan Kawatabi Field Science Center Graduate School of Agricultural Science Tohoku University Osaki Japan Department of Botany and Zoology Faculty of Science Masaryk University Brno Czech Republic Toyohashi Museum of Natural History Toyohashi Japan Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China Agricultural Experiment Station Zhejiang University Hangzhou China Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology Hanoi Vietnam Graduate University of Science and Technology Vietnam Academy of Science and Technology Hanoi Vietnam School of Biological Sciences Universiti Sains Malaysia Penang Malaysia Centre for Marine and Coastal Studies Universiti Sains Malaysia Penang Malaysia

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