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arXiv 2022年

作者： Li, Yueming Jiang, Ying Lan, Lu Ge, Xiaowei Cheng, Ran Zhan, Yuewei Chen, Guo Shi, Linli Wang, Runyu Zheng, Nan Yang, Chen Cheng, Ji-Xin Department of Mechanical Engineering Boston University BostonMA02215 United States Graduate Program for Neuroscience Boston University BostonMA02215 United States Department of Electrical and Computer Engineering Boston University BostonMA02215 United States Department of Chemistry Boston University BostonMA02215 United States Department of Biomedical Engineering Boston University BostonMA02215 United States Division of Materials Science and Engineering Boston University BostonMA02215 United States

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter-level. Here, we report optically-generated focused ultrasound (OFUS) for non-invasive brain stimulation with ultrahigh precision. OFUS is generated by a soft optoacoustic pad (SOAP) fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film. SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83 µm, which is two orders of magnitude smaller than that of conventional transcranial focused ultrasound (tFUS). Here, we show effective OFUS neurostimulation in vitro with a single ultrasound cycle. We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo. An acoustic energy of 0.6 mJ/cm2, four orders of magnitude less than that of tFUS, is sufficient for successful OFUS neurostimulation. OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision non-invasively. Copyright © 2022, The Authors. All rights reserved.

关键词： Silicones

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Shape Anisotropy-Governed High-Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs

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Small 2024年第5期20卷 2305300-2305300页

作者： Nigam, Saumya Mohapatra, Jeotikanta Makela, Ashley V. Hayat, Hanaan Rodriguez, Jessi Mercedes Sun, Aixia Kenyon, Elizabeth Redman, Nathan A. Spence, Dana Jabin, George Gu, Bin Ashry, Mohamed Sempere, Lorenzo F. Mitra, Arijit Li, Jinxing Chen, Jiahui Wei, Guo-Wei Bolin, Steven Etchebarne, Brett Liu, J. Ping Contag, Christopher H. Wang, Ping Precision Health Program Michigan State University East LansingMI48824 United States Department of Radiology College of Human Medicine Michigan State University East LansingMI48824 United States Department of Physics The University of Texas at Arlington ArlingtonTX76019 United States Michigan State University East LansingMI48824 United States Department of Biomedical Engineering College of Engineering Michigan State University East LansingMI48824 United States Human Biology Program College of Natural Science Michigan State University East LansingMI48824 United States Department of Obstetrics Gynecology and Reproductive Sciences College of Human Medicine Michigan State University East LansingMI48824 United States Department of Materials Science and Engineering National Cheng Kung University Tainan City701 Taiwan Department of Mathematics College of Natural Science Michigan State U niversity East LansingMI48824 United States Department of Electrical and Computer Engineering College of Engineering Michigan State University East LansingMI48824 United States Department of Biochemistry and Molecular Biology College of Natural Science Michigan State University East LansingMI48824 United States Department of Pathobiology and Diagnostic Investigation College of Veterinary Medicine Michigan State University East LansingMI48824 United States Osteopathic Medical Specialties College of Osteopathic Medicine Michigan State University East LansingMI48824 United States Department of Microbiology and Molecular Genetics Michigan State University East LansingMI48824 United States

Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) has shown extensive lung manifestations in vulnerable individuals, putting lung imaging and monitoring at the forefront of early detection and treatment. Magnetic particle imaging (MPI) is an imaging modality, which can bring excellent contrast, sensitivity, and signal-to-noise ratios to lung imaging for the development of new theranostic approaches for respiratory diseases. Advances in MPI tracers would offer additional improvements and increase the potential for clinical translation of MPI. Here, a high-performance nanotracer based on shape anisotropy of magnetic nanoparticles is developed and its use in MPI imaging of the lung is demonstrated. Shape anisotropy proves to be a critical parameter for increasing signal intensity and resolution and exceeding those properties of conventional spherical nanoparticles. The 0D nanoparticles exhibit a 2-fold increase, while the 1D nanorods have a > 5-fold increase in signal intensity when compared to VivoTrax. Newly designed 1D nanorods displayed high signal intensities and excellent resolution in lung images. A spatiotemporal lung imaging study in mice revealed that this tracer offers new opportunities for monitoring disease and guiding intervention. © 2023 The Authors. Small published by Wiley-VCH GmbH.

关键词： Nanorods

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Lower limb joint angular phase plane coordination analysis on standard maximum vertical jump

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Gait & Posture 2021年 90卷 205-206页

作者： Rodrigues, C. Correia, M. Abrantes, J. Rodrigues, B. Nadal, J. INESC TEC - Institute for Systems and Computer Engineering- Technology and Science C-BER - Centre for Biomedical Engineering Research Porto Portugal University of Porto Faculty of Engineering Porto Portugal Lusófona University CICANT Centre for Research in Applied Communication Culture and New Technologies- MovLab Laboratory of Technologies for Interactions and Interfaces Lisbon Portugal Federal University of Pernambuco Department of Electronic and Systems Recife Brazil Federal University of Rio de Janeiro Biomedical Engineering Program Rio de Janeiro Brazil

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Multimaterial 3D Nanoprinting of a 2 Fr Soft Robotic Microcatheter for Transarterial Chemoembolization of Liver Cancer

Multimaterial 3D Nanoprinting of a 2 Fr Soft Robotic Microca...

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IEEE International Conference on Soft Robotics (RoboSoft)

作者： Bailey M. Felix Jordi T. Andreou Sarah McHugh Jack E. McCann Olivia M. Young Molly A. Carton Dheeraj Gandhi Miroslaw Janowski Mark Fuge Axel Kreiger Clifford R. Weiss Christopher R. Bailey Ryan D. Sochol Fischell Department of Bioengineering University of Maryland College Park MD USA Department of Mechanical Engineering University of Maryland College Park MD USA Department of Diagnostic Radiology and Nuclear Medicine Program in Image Guided Neurointerventions University of Maryland School of Medicine Baltimore MD USA Department of Mechanical Engineering ETH Zurich Zurich Switzerland Department of Mechanical Engineering Johns Hopkins University Baltimore MD USA The Russell H. Morgan Department of Radiology and Radiological Science Division of Vascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore MD USA Maryland Robotics Center University of Maryland College Park MD USA Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park MD USA

ISBN: (数字)9798331520205

ISBN: (纸本)9798331520212

Transarterial chemoembolization (TACE)—i.e., the delivery of chemotherapeutics directly into the vasculature of liver tumors—necessitates the use of guidewire-microcatheter systems to navigate tortuous vascular networks. These guide-wires and microcatheters typically lack effective steering controls, making successful navigation through geometrically complex anatomy challenging. Recent advancements in the area of soft microrobotics could offer a pathway to remotely steerable microcatheters at size scales relevant to TACE procedures; however, the difficulties associated with fabricating such systems have represented a critical hurdle. To overcome this barrier, here we present a multimaterial additive nanomanufacturing— or "three-dimensional (3D) nanoprinting"—strategy to achieve steerable soft robotic microcatheters that not only facilitate on-demand regulation of catheter tip deflection, but also comprise 2 French (Fr) outer dimensions (i.e., ⌀ = 666 μm) that are suitable for clinical chemoembolization of liver cancers. Specifically, we use "Two-Photon Direct Laser Writing (DLW)" to 3D nanoprint 1.5 mm-tall microcatheters capable of unidirectional tip bending of approximately 140° as well as mediating delivery of a fluidic payload. Experimental results for navigating the soft robotic microcatheter through a vascular phantom to deliver fluid payloads to target sites suggest the presented strategy holds promise for TACE as well as additional endovascular interventions and minimally invasive surgeries.

关键词： Liver cancer Actuators Navigation Deformation Phantoms Liver Soft robotics Bending Three-dimensional printing Payloads

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No winners: Performance of lung cancer prediction models depends on screening-detected, incidental, and biopsied pulmonary nodule use cases.

arXiv

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arXiv 2024年

作者： Li, Thomas Z. Xu, Kaiwen Krishnan, Aravind Gao, Riqiang Kammer, Michael N. Antic, Sanja Xiao, David Knight, Michael Martinez, Yency Paez, Rafael Lentz, Robert J. Deppen, Stephen Grogan, Eric L. Lasko, Thomas A. Sandler, Kim L. Maldonado, Fabien Landman, Bennett A. Medical Scientist Training Program Vanderbilt University NashvilleTN37235 United States Biomedical Engineering Vanderbilt University NashvilleTN37235 United States Computer Science Vanderbilt University NashvilleTN37235 United States Electrical and Computer Engineering Vanderbilt University NashvilleTN37235 United States Digital Technology and Innovation Siemens Healthineers PrincetonNJ08540 United States Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Medical Center NashvilleTN37232 United States Department of Thoracic Surgery Vanderbilt University Medical Center NashvilleTN37232 United States Biomedical Informatics Vanderbilt University Medical Center NashvilleTN37232 United States Radiology and Radiological Sciences Vanderbilt University Medical Center NashvilleTN37232 United States

Purpose: Statistical models for predicting lung cancer have the potential to facilitate earlier diagnosis of malignancy and avoid invasive workup of benign disease. Many models have been published, but comparative studies of their utility in different clinical settings in which patients would arguably most benefit are scarce. Materials and Methods: This study retrospectively evaluated promising predictive models for lung cancer prediction in three clinical settings: lung cancer screening with low-dose computed tomography, incidentally detected pulmonary nodules, and nodules deemed suspicious enough to warrant a biopsy. We leveraged 9 cohorts (n=898, 896, 882, 219, 364, 117, 131, 115, 373) from multiple institutions to assess the area under the receiver operating characteristic curve (AUC) of validated models including logistic regressions on clinical variables and radiologist nodule characterizations, artificial intelligence on chest CTs, longitudinal imaging AI, and multi-modal approaches. We implemented each model from their published literature, re-training the models if necessary, and curated each cohort from primary data sources. Results: We observed that model performance varied greatly across clinical use cases. No single predictive model emerged as a clear winner across all cohorts, but certain models excelled in specific clinical contexts. Single timepoint chest CT AI performed well in lung screening, but struggled to generalize to other clinical settings. Longitudinal imaging and multimodal models demonstrated comparatively promising performance on incidentally-detected nodules. However, when applied to nodules that underwent biopsy, all models underperformed. Conclusion: These results underscore the strengths and limitations of 8 validated predictive models and highlight promising directions towards personalized, noninvasive lung cancer diagnosis. © 2024, CC BY-NC-SA.

关键词： Biopsy

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Whole-body phase plane analysis for standard maximum vertical jump assessment

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Gait & Posture 2021年 90卷 203-204页

作者： Rodrigues, C. Correia, M. Abrantes, J. Rodrigues, B. Nadal, J. INESC TEC - Institute for Systems and Computer Engineering- Technology and Science C-BER - Centre for Biomedical Engineering Research Porto Portugal University of Porto Faculty of Engineering Porto Portugal Lusófona University CICANT Centre for Research in Applied Communication Culture and New Technologies - MovLab Laboratory of Technologies for Interactions and Interfaces Lisbon Portugal Federal University of Pernambuco Department of Electronic and Systems Recife Brazil Federal University of Rio de Janeiro Biomedical Engineering Program Rio de Janeiro Brazil

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Synthesis of Gadolinium-Doped Molybdenum Diselenide Nanospheres for Ultrasensitive Electrochemical Determination of Essential Amino Acid in Human Serum and Milk Samples

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Journal of the Electrochemical Society 2023年第5期170卷 057501-057501页

作者： Jeromiyas, Nithiya Govindasamy, Mani Alothman, Asma A. Ouladsmane, Mohamed Huang, Chi-Hsien National Kaohsiung University of science and Technology Kaohsiung City81157 Taiwan Department of Chemistry Korea University Seongbuk-gu Seoul Korea Republic of Faculty International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam Chennai602105 India Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Biochemical Technology R&D Center Ming Chi University of Technology New Taipei City243303 Taiwan

The electrocatalytic activity and electronic conductivity of 2D transition metal chalcogenides are usually enhanced by as follows the ideal strategy such as doping or substitution heterogeneous atoms. Here, a rare Earth metal ion of gadolinium (Gd3+) was doped with MoSe2 and synthesized through the hydrothermal method. The morphology and nanostructure of Gd3+ with MoSe2 spheres were analyzed under X-ray diffraction, Fourier-transform infrared spectroscopy, X-ray photoelectron, High-resolution transmission electron microscopy analysis, Field emission scanning electron microscopy, and energy-dispersive spectroscopy. Furthermore, the Gd3+ doped MoSe2 sphere modified glassy carbon electrode (Gd@MoSe2/GCE) was used for the sensing of tryptophan. The Gd@MoSe2 modified GCE shows remarkable sensing performance of tryptophan resulting in a linear range (20 nM-220 μM) with a low detection limit (6.7 nM). Under the optimal condition, the developed electrochemical sensor was successfully used to determine tryptophan (TRP) in blood serum and milk samples. The electrochemical biosensing results suggest that the doping of the Gd3+ doped MoSe2 sensor is a promising electrocatalyst in biological and food samples. © 2023 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

关键词： Amino acids

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Breaking Mechanical Holography in Combinatorial Metamaterials

arXiv

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arXiv 2024年

作者： Sirote-Katz, Chaviva Palti, Ofri Spiro, Naomi Kálmán, Tamás Shokef, Yair Department of Biomedical Engineering Tel Aviv University Tel Aviv69978 Israel The Future Scientists Center Alpha Program Tel Aviv Youth University Tel Aviv69978 Israel University of Illinois at Urbana-Champaign UrbanaIL61801 United States Department of Mathematics Institute of Science Tokyo H-214 2-12-1 Ookayama Tokyo Meguro-ku152-8551 Japan Hiroshima University Higashi-Hiroshima Hiroshima739-8526 Japan School of Mechanical Engineering Tel Aviv University Tel Aviv69978 Israel Center for Computational Molecular and Materials Science Tel Aviv University Tel Aviv69978 Israel Center for Physics and Chemistry of Living Systems Tel Aviv University Tel Aviv69978 Israel

Combinatorial mechanical metamaterials are made of anisotropic, flexible blocks, such that multiple metamaterials may be constructed using a single block type, and the system’s response strongly depends on the mutual orientations of the blocks within the lattice. We study a family of possible block types for the square, honeycomb, and cubic lattices. Blocks that are centrally symmetric induce holographic order, such that mechanical compatibility (meaning that blocks do not impede each other’s motion) implies bulk-boundary coupling. With them, one can design a compatible metamaterial that will deform in any desired texture only on part of its boundary. With blocks that break holographic order, we demonstrate how to design the deformation texture on the entire boundary. Correspondingly, the number of compatible holographic metamaterials scales exponentially with the boundary, while in non-holographic cases we show that it scales exponentially with the bulk. © 2024, CC BY.

关键词： Holography

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Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures

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Angewandte Chemie 2023年第48期135卷

作者： Dr. Yunqi Yang Dr. Qinyi Lu Yu Chen Marcello DeLuca Prof. Dr. Gaurav Arya Prof. Dr. Yonggang Ke Prof. Dr. Stefan Zauscher Department of Mechanical Engineering and Materials Science Department of Biomedical Engineering Duke University Durham NC 27708 USA Department of Chemistry Emory University Atlanta GA 30322 USA University Program in Materials Science and Engineering Duke University Durham NC 27708 USA Department of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA 30322 USA

DNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological milieu due to their fast degradation by nucleases. Recently, we showed how enzymatic polymerization could be harnessed to grow polynucleotide brushes of tunable length and location on the surface of DNA origami nanostructures, which greatly enhances their nuclease stability. Here, we report on strategies that allow for both spatial and temporal control over polymerization through activatable initiation, cleavage, and regeneration of polynucleotide brushes using restriction enzymes. The ability to site-specifically decorate DNA origami nanostructures with polynucleotide brushes in a spatiotemporally controlled way provides access to “smart” functionalized DNA architectures with potential applications in drug delivery and supramolecular assembly.

关键词： DNA Nanostructures Restriction Enzymes Sequential Brush Growth Surface-Initiated Polymerization Terminal Deoxynucleotidyl Transferase

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Graphene Acid Quantum Dots: A Highly Active Multifunctional Carbon Nano Material that Intervene in the Trajectory Towards Neurodegeneration

SSRN

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SSRN 2024年

作者： ElMorsy, Sherin M. Gutierrez, Denisse A. Valdez, Salvador Kumar, Jyotish Aguilera, Renato J. Noufal Sanad, Mohamed Sarma, Hemen Chinnam, Sampath Narayan, Mahesh The Environmental Science & Engineering Program The University of Texas at El Paso El PasoTX79968 United States Cellular Characterization and Biorepository Core Facility Border Biomedical Research Center Department of Biological Sciences College of Science The University of Texas at El Paso 500 West University Avenue El PasoTX79968-0519 United States Department of Chemistry and Biochemistry The University of Texas at El Paso 500 West University Avenue El PasoTexas79968 United States Department of Chemical Engineering Hampton University HamptonVA23668 United States Assam Kokrajhar783370 India Department of Chemistry M.S. Ramaiah Institute of Technology Karnataka Bengaluru560054 India Autonoumous Institution Affiliated to Visvesvaraya Technological University Belgaum India

Carbon dots (CDs) are carbon nano materials (CNMs) that find use across several biological applications because of their water solubility, biocompatible nature, eco-friendliness, and ease of synthesis. Additionally, their physiochemical properties can be chemically tuned for further optimization towards specific applications. Here, we investigate the efficacy of C70-derived Graphene Acid Quantum Dots (GAQDs) in mitigating the transformation of soluble, monomeric Hen Egg-White Lysozyme (HEWL) to mature fibrils during its amyloidogenic trajectory. Our findings reveal that GAQDs exhibit dose-dependent inhibition of HEWL fibril formation (up to 70% at 5 mg/mL) without affecting mitochondrial membrane potential or inducing apoptosis at the same density. Furthermore, GAQDs scavenged reactive oxygen species (ROS);achieving a 50% reduction in ROS levels at a mere 100 µg/mL when exposed to a standard free radical generator. GAQDs were not only found to be biocompatible with a human neuroblastoma-derived SHSY-5Y cell line but also rescued the cells from rotenone-induced apoptosis. The GAQD-tolerance of SHSY-5Y cells coupled with their ability to restitute cells from rotenone-dependent apoptosis, when taken in conjunction with the biocompatibility data, indicate that GAQDs possess neuroprotective potential. The data position this class of CNMs as promising candidates for resolving aberrant cellular outputs that associate with the advent and progress of multifactorial neurodegenerative disorders including Parkinson's (PD) and Alzheimer’s diseases (AD) wherein environmental causes are implicated (95% etiology). The data suggest that GAQDs are a multifunctional carbon-based sustainable nano-platform at the intersection of nanotechnology and neuroprotection for advancing green chemistry-derived, sustainable healthcare solutions. © 2024, The Authors. All rights reserved.

关键词： Graphene

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