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Left Atrial Appendage Occlusion: Current Stroke Prevention Strategies and a Shift Toward Data-Driven, Patient-Specific Approaches

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Journal of the Society for Cardiovascular Angiography and Interventions 2022年第5期1卷 100405-100405页

作者： Mendez, Keegan Kennedy, Darragh G. Wang, Dee Dee Roche, Ellen T. Harvard/MIT Health Sciences and Technology Program Massachusetts Institute of Technology Cambridge MA United States Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA United States Department of Biomedical Engineering Columbia University New York NY United States Henry Ford Health Detroit MI United States Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA United States

The left atrial appendage (LAA) is a complex structure with unknown physiologic function protruding from the main body of the left atrium. In patients with atrial fibrillation, the left atrium does not contract effectively. Insufficient atrial and LAA contractility predisposes the LAA morphology to hemostasis and thrombus formation, leading to an increased risk of cardioembolic events. Oral anticoagulation therapies are the mainstay of stroke prevention options for patients;however, not all patients are candidates for long-term oral anticoagulation. Percutaneous occlusion devices are an attractive alternative to long-term anticoagulation therapy, although they are not without limitations, such as peri-implant leakage and device-related thrombosis. Although efforts have been made to reduce these risks, significant interpatient heterogeneity inevitably yields some degree of device-anatomy mismatch that is difficult to resolve using current devices and can ultimately lead to insufficient occlusion and poor patient outcomes. In this state-of-the-art review, we evaluated the anatomy of the LAA as well as the current pathophysiologic understanding and stroke prevention strategies used in the management of the risk of stroke associated with atrial fibrillation. We highlighted recent advances in computed tomography imaging, preprocedural planning, computational modeling, and novel additive manufacturing techniques, which represent the tools needed for a paradigm shift toward patient-centric LAA occlusion. Together, we envisage that these techniques will facilitate a pipeline from the imaging of patient anatomy to patient-specific computational and bench-top models that enable customized, data-driven approaches for LAA occlusion that are engineered specifically to meet each patient's unique needs. © 2022 The Authors

关键词： computed tomography imaging left atrial appendage left atrial appendage occlusion stroke

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CCL5 Protects Cortical Neuron Function by Regulating M2 Microglia Activation After Mild Traumatic Brain Injury

SSRN

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SSRN 2022年

作者： Tsai, Yih-Jeng Ho, Man-Hau Yen, Chia-Hung Wang, Jia-Yi Burnouf, Thierry Chen, Chia-Yen Wang, Yun Chiang, Yung-Hsiao Hoffer, Barry J. Chou, Szu-Yi Department of Otolaryngology Head and Neck Surgery Shin Kong Wu HoSu Memorial Hospital Taipei Taiwan School of Medicine Fu Jen Catholic University New Taipei City Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University National Health Research Institute Taiwan Graduate Institute of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Biological Science and Technology National Pingtung University of Science and Technology Neipu Pingtung91201 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Neurosurgery Taipei Medical University Hospital Taipei11031 Taiwan Neuroscience Research Center Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan NeuroTMULille International Laboratory Taipei Medical University Taipei Taiwan International PhD Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Brain and Consciousness Research Centre TMU Shuang Ho Hospital New Taipei City Taiwan Center for Neuropsychiatric Research National Health Research Institutes Zhunan Miaoli County Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University 11031 Taiwan Department of Neurosurgery Case Western Reserve University School of Medicine ClevelandOH United States Scientist Emeritus National Institutes of Health United States International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Cytokines and chemokines play important roles in inflammation and repair following brain injury. M1 microglia are pro-inflammatory which produce cytokines and lead to neural injury;in contrast, M2 microglia are anti-inflammatory, release neurotrophic factors, and promote neural repair processes. Chemokine CCL5, increased after TBI, shows a neuroprotective function by reducing oxidative stress. CCL5 may contribute to the balance between oxidative stress and immune responses after brain injury. Herein, we investigated the role of CCL5 in microglial polarization after mild traumatic brain injury, focusing on the cerebral cortex.C57BL/6 and CCL5 knockout (CCL5-KO) mice were given a mild traumatic brain injury (TBI) using weight-drop. Neurological parameters such as motor and sensory functions were analyzed by mNSS score, accelerating rotarod, beam walking, and adhesive removal tests. Oxidative stress and neuron damage were measured by NADPH oxidase activity, hypoxyloprobe staining and FJC. Performance of motor and sensory functions in both WT and CCL5-KO mice were impaired after brain injury which recovered after 7 days-post-injury (dpi) in the WT group but only after 14 days in the CCL5-KO mouse group. RT-qPCR analysis revealed that pro-inflammation cytokines - IL-1β, TNF-α, and IL-6 were higher in CCL5-KO mice compared to WT mice at 4 and 14 dpi. In contrast, M2-like microglia markers - IL-10 and Agr-1 were increased in WT mouse cortical tissue at 4 dpi. Oxidative stress increased both M1 and M2- related cytokine expression in BV2 cells treated with H 2 O 2;CCL5 treatment increased M2- but suppressed M1- related cytokine gene activation. Intranasal delivery of CCL5 reduced neuronal oxidative stress, increased IL-10 expression and improved motor and sensory functions in CCL5-KO mice after brain *** summary, CCL5, which alters immune responses and protects neurons from TBI damage, has an important function in regulating M2-like microglial polarization during post-

关键词： Polarization

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Qualitative comparison of stuttering experiences in Chinese and Japanese higher education

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Journal of Fluency Disorders 2025年

作者： Chengqi He Kazunori Takeda Yu-an Chen Xinyi Yang Jinfeng Huang Mizuki Aoki Shoko Miyamoto Graduate School of Human Comprehensive Science University of Tsukuba Tsukuba Japan Faculty of Human Sciences University of Tsukuba Tsukuba Japan Graduate School of Humanities and Social Sciences International Education Development Program Hiroshima University Hiroshima Japan Health Science Center School of Biomedical Engineering Shenzhen University

Purpose This qualitative study explored students’ stuttering experiences in Chinese and Japanese universities, highlighting and comparing the unique challenges faced by Chinese and Japanese students who stutter (SWS) in higher education settings. Method A total of 11 Chinese and 11 Japanese undergraduate SWS participants were involved in this study. Data were collected through semi-structured interviews grounded in the ICF model, focusing on the functional aspects of stuttering, personal and environmental factors, and student activities and participation in university life. Interviews were analyzed using reflexive thematic analysis with NVivo software to identify overarching themes and subthemes. Results Reflexive thematic analysis revealed five overarching themes: communication barriers, psychological experiences and coping strategies, public attitudes on campus, limitations of university support services, and expectations regarding university support. Both groups faced communication barriers across academic, social, and career development contexts. Regarding personal factors, both groups expressed negative emotional reactions, particularly challenges in accepting their stuttering. Both groups reported limited university support, with Chinese SWS seeking more specialized counseling, and Japanese SWS expressing a desire for increased awareness of stuttering. Conclusion This study highlights how cultural and societal norms shape the stuttering experiences of university students in China and Japan, which were often described in negative terms. These findings underscore the need for culturally responsive, individualized interventions that move beyond the simplistic 'individualism–collectivism' dichotomy and more effectively address the complex needs of SWS in East Asian contexts.

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Hospital Admission Risks and Excess Costs for Neurological Symptoms Attributable to Long-Term Exposure to Fine Particulate Matter in New York State, USA

SSRN

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SSRN 2023年

作者： Min, Jieun Lee, Whanhee Bell, Michelle L. Kim, Yijun Heo, Seulkee Kim, Ga Eun Kim, Jee Hyun Yun, Ji Young Kim, Soo In Schwartz, Joel Ha, Eunhee Department of Environmental Medicine School of Medicine Ewha Womans University Seoul Korea Republic of Graduate Program in System Health Science and Engineering College of Medicine Ewha Womans University Seoul Korea Republic of Ewha Womans University College of Medicine Seoul Korea Republic of School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan Korea Republic of Yale School of the Environment Yale University New HavenCT United States Department of Psychiatry Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine Seoul Korea Republic of Department of Neurology Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine Seoul Korea Republic of Department of Environmental Health Harvard T H Chan School of Public Health BostonMA United States Department of Medical Science Ewha Womans University School of Medicine Ewha Medical Research Institute Seoul Korea Republic of

Background: Although emerging evidence suggests that PM2.5 is linked to neurological symptoms (NSs) via neuroinflammation, relevant studies are scarce. This study aimed to investigate the risks and excess costs of hospital admission for five NSs—fatigue, headache, dizziness, convulsion, and paralysis—attributable to long-term exposure to PM2.5 in New York State, ***: We analyzed the New York Statewide Planning and Research Cooperative System (SPARCS) from 2010 to 2016. A Bayesian hierarchical model with integrated nested Laplace approximations was performed to estimate the risks and excess costs of hospital admission for NSs due to long-term exposure to PM2.5 at the county ***: A 1 µg/m3 increase in lag 0–1 years PM2.5 was associated with an increased risk of headache and convulsion by 1.06 (1.01, 1.11) and 1.04 (1.01, 1.06), respectively. The excess hospital admission cost for five NSs attributable to lag 0–1 years PM2.5 above the new World Health Organization guideline (annual standard: 5 µg/m3) was $200.24 (95% CI: 6.00, 376.96) million during 2011–2016, recording the highest for convulsion ($153.73 [95% CI: 63.61, 244.19] million).Conclusions: This study provides quantitative estimates of risks and excess costs for NSs attributable to long-term PM2.5 and suggests that policies that reduce long-term PM2.5 concentration in accordance with the new WHO air quality guidelines can yield substantial health and economic benefits related to NSs in the New York State population. © 2023, The Authors. All rights reserved.

关键词： Hierarchical systems

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Synthesis of auricular prosthesis based on nanoparticle silicone/TiO2 for microtia case

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AIP Conference Proceedings 2023年第1期2720卷

作者： Prihartini Widiyanti Elia Abraham Matualaga Jan Ady Biomedical Engineering Program Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia Institute of Tropical Disease Universitas Airlangga Surabaya 60115 Indonesia Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia

Microtia occurs in about 1 to 10 cases per 10,000 birth rates, affects person’s physical appearance which lead to increased depression and individual anxiety. Solution of microtia is ear prostheses. Silicone rubber (SR) or polydimethylsiloxane (PDMS) is as chosen material for ear prosthesis due to its durability, is inert, easy to manipulate, and biocompatibility. SR has disadvantages, such as low tear and tensile strength, inadequate elasticity and degradation of physical, and colour properties over time. The aim of this study is to synthesize and characterize SR / nanoparticles composite TiO2 auricular prosthesis. Composites were obtained by mixing SR with TiO2 nanoparticles with a percentage of 1%, 2%, and 3% (w / w), the casting method was used to obtain ear prostheses and test specimens. The compressive modulus values for the percentage of 0%, 1%, 2%, and 3% respectively were 0.47 MPa; 0.29 MPa; 0.42 MPa; 0.35 MPa and the tensile modulus, respectively were 0.33 MPa; 0.35 MPa; 0.34 MPa; 0.31 MPa. SEM test results showed that the addition of TiO2 nanoparticles at a all percentage experienced agglomeration on a micrometric scale. FTIR test revealed that the occurrence of crosslinks in wave number 1384.71 cm−1 and 1384.54 cm-1. The occurrence of peak shifts in wave numbers containing OH groups indicated some interaction between the polymer matrix and the filler. It can be concluded that there was no percentage addition of TiO2 nanoparticles in mechanical test results that showed the closest value to the control value due to agglomeration.

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High-temperature strain-mediated oxidation of 2D MoS2

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Materials and Design 2023年 236卷

作者： Rouhan, Mehdi Hobley, Jonathan Lin, Kuang-I Hofmann, Mario Yao, Yu-Chi Chang, Yung-Huang Carpick, Robert William Schall, J. David Jeng, Yeau-Ren Department of Biomedical Engineering National Cheng Kung University 1 University Road Tainan City70101 Taiwan Core Facility Center National Cheng Kung University 1 University Road Tainan City70101 Taiwan Department of Physics National Taiwan University Taipei106 Taiwan Bachelor Program in Interdisciplinary Studies National Yunlin University of Science and Technology 123 University Road Yunlin64002 Taiwan Department of Mechanical Engineering and Applied Mechanics University of Pennsylvania 220 S. 33rd St. PhiladelphiaPA19104-6315 United States Department of Mechanical Engineering North Carolina Agricultural and Technical State University GreensboroNC27411 United States Tainan70101 Taiwan

MoS2 is 2D material applicable for electronics, photo-detectors, light-emitting diodes, and solar cells. Since these applications operate at elevated temperatures, determining and controlling the environmental stability of MoS2 is essential. This study uses Raman spectroscopic experiments at elevated temperatures to observe reversible and irreversible changes in 2D MoS2 films with varying thickness, morphology, and substrate to explore the limits of its thermal stability. Molecular dynamics simulations and in-situ X-ray diffraction confirm that thermal expansion causes the Raman reversible spectral shifts. Further analysis reveals irreversible spectral shifts associated with oxidation and strain effects caused by oxidation with two distinct modes. The former is due to the general homogenous thinning of layers from the top layer down through randomly spaced sulfur vacancies. The latter is due to inhomogeneous oxidation, which known to occur as localized pitting at grain boundaries, void formation from nucleation centers, or stress corrosion cracking starting from edges under strain. Segregation of doping and strain contributions confirms higher strain in the edges. Annealing increases the spread of the strain distribution. These results highlight the critical role of strain, resulting from thermal expansion coefficient mismatch between substrates and 2D MoS2 films, on their environmental stability. © 2023 The Authors

关键词： Raman spectroscopy

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Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

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International journal of nanomedicine 2024年 19卷 2395-2407页

作者： Jui-Jen Chang Yi-Chen Wang Shu-Hui Yang Ju-Yu Wu Ming-Wei Chang Hui-Min David Wang Department of Medical Research China Medical University Hospital China Medical University Taichung 40447 Taiwan. Graduate Institute of Integrated Medicine China Medical University Taichung 40447 Taiwan. Division of Cardiology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung City 802 Taiwan. Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 807 Taiwan. Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung 402 Taiwan. Bachelor Program of Biotechnology National Chung Hsing University Taichung 402 Taiwan. Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung 402 Taiwan. Nanotechnology and Integrated Bioengineering Centre University of Ulster Belfast BT15 1AB Northern Ireland UK. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung 404 Taiwan. Center of Applied Nanomedicine National Cheng Kung University Tainan 701 Taiwan.

Background:Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell membrane secretion properties to encapsulate target substances to enhance the therapeutic effect of cancer. Methods:Astaxanthin was selected as an anticancer drug due to our previous research finding that astaxanthin has extremely high antioxidant, anti-ultraviolet damage, and anti-tumor properties. The manufacturing method of the astaxanthin nanovesicle carrier is to mix melanoma cells and astaxanthin in an appropriate ratio and then remove the genetic material and inflammatory factors of cancer cells by extrusion. Results:In terms of results, after the co-culture of astaxanthin nanovesicles and melanoma cancer cells, it was confirmed that the ability of astaxanthin nanovesicles to inhibit the growth and metastasis of melanoma cancer cells was significantly better than the same amount of astaxanthin alone, and it had no effect on normal Human cells are also effective. There was no apparent harm on normal cells, indicating the ability of the vesicles to be selectively transported. Conclusion:Our findings illustrated the potential of astaxanthin nanovesicles as an anticancer drug.

关键词： astaxanthin melanoma nanoparticle

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Crevice Corrosion Degrades Metaphyseal Sleeves Following Total Knee Arthroplasty: A Retrieval Study

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The Journal of arthroplasty 2025年

作者： Shabnam Aslani Michael A Kurtz Christopher E Pelt Joshua P Rainey Michael J Archibeck Jeremy M Gililland William A Sutton James A Smith Jeremy L Gilbert Steven M Kurtz Implant Research Core School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia PA USA. Implant Research Core School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia PA USA. Electronic address: michael.kurtz@drexel.edu. Department of Orthopaedic Surgery University of Utah Salt Lake City UT USA. Clemson-MUSC Bioengineering Program Clemson University Charleston SC USA.

BACKGROUND:Surgeons use metaphyseal sleeves in revision total knee arthroplasty (TKA) to compensate for bone loss and improve stability. However, a clinical case series documented corrosion on these devices and associated the subsequent metal release with adverse local tissue reactions. In this study, we investigated corrosion at the mixed-alloy, metaphyseal sleeve-implant interface. We asked: (1) How common is corrosion? (2) Does more damage occur at the femoral cobalt chrome alloy (CoCrMo) taper? (3) What damage modes occur? METHODS:We analyzed 17 femoral and 15 tibial implant-sleeve components following revision surgery. First, corrosion was classified using the Goldberg score and quantified using the axial corrosion (ΔC) on CoCrMo implants. Then, moderately and severely corroded devices were imaged using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). Differences in corrosion on CoCrMo tibial and femoral implants were assessed using nonparametric statistics. RESULTS:We observed corrosion on 82% of femoral adapters, 100% of femoral sleeves, 73% of tibial trays, and 86% of tibial sleeves. On CoCrMo femoral adapters, we measured more axial corrosion than on CoCrMo tibial trays (P = 0.04). The predominant damage modes on femoral adapters included pitting, etching, and oxide debris. On titanium alloy femoral sleeves, we documented a burnishing effect, revealing the underlying microstructure. CONCLUSION:Our findings indicate that mechanically assisted crevice corrosion (MACC) promotes metaphyseal implant degradation. Should surgeons encounter patients who have metaphyseal sleeves and unexplained pain or suspected metal release, consider measuring metal concentrations after rigorous rule out of competing diagnoses.

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State of the art in vivo reactive oxygen species measurements in skeletal muscle using fluorescent proteins

Redox Biochemistry and Chemistry

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Redox Biochemistry and Chemistry 2025年 13卷

作者： Ryotaro Kano Hideki Shirakawa David C. Poole Daisuke Hoshino Yutaka Kano Department of Engineering Science Bioscience and Technology Program University of Electro-Communications Chofu Tokyo Japan Research Fellowship for Young Scientists Japan Society for the Promotion of Science Chiyoda Tokyo Japan Departments of Anatomy & Physiology and Kinesiology Kansas State University Manhattan KS USA Center for Neuroscience and Biomedical Engineering (CNBE) University of Electro-Communications Chofu Tokyo Japan

Evaluation of the effects of muscle contractions on reactive oxygen species (ROS) concentrations and their intracellular and intraorganelle dynamics is important for understanding protection against cellular damage and resolving the mechanistic bases for muscle plasticity after training, with aging and in disease. Because of the highly reactive nature of ROS, measurement methods have typically been limited to a few established approaches. In this review, we discuss the advantages and limitations of the typical methods for detecting ROS in skeletal muscle to date. In particular, we focus on the importance of in vivo imaging using ROS-sensitive genetically encoded fluorescent proteins. The pressing need for quantitative analysis of each organelle, such as mitochondria, to advance our comprehensive biological understanding of ROS dynamics during muscle contractions is stressed. These considerations provide a direction for more fully understanding exercise-induced redox signaling.

关键词： Muscle contractions Muscle adaptation Hydrogen peroxide Mitochondria Imaging Interorganelle heterogeneity

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Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells

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Bioactive Materials 2021年第9期6卷 2742-2751页

作者： Myung Chul Lee Hoon Seonwoo Kyoung Je Jang Shambhavi Pandey Jaewoon Lim Sangbae Park Jae Eun Kim Yun-Hoon Choung Pankaj Garg Jong Hoon Chung Department of Biosystems&Biomaterials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Biosystems Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Industrial Machinery Engineering Sunchon National University315 Maegok-dongSunchon57922Republic of Korea Interdisciplinary Program in IT-Bio Convergence System Sunchon National UniversitySuncheon57922Republic of Korea Division of Agro-system Engineering Gyeongsang National University501 Jinju-daeroJinju52828Republic of Korea Institute of Agriculture&Life Science Gyeongsang National UniversityJinju52828Republic of Korea Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea Department of Otolaryngology Ajou University School of MedicineSuwon16499Republic of Korea Ajou University Graduate School of Medicine Bk21 Plus Research Center for Biomedical SciencesSuwon16499Republic of Korea BK21 Global Smart Farm Educational Research Center Seoul National UniversitySeoul08826Republic of Korea

Hydroxyapatite(HA)is a representative substance that induces bone *** research team extracted nanohydroxyapatite(EH)from natural resources,especially equine bones,and developed it as a molecular biological ***(PEI)was used to coat the EH to develop a gene *** verify that PEI is well coated in the EH,we first observed the morphology and dispersity of PEI-coated EH(pEH)by electron *** pEH particles were well distributed,while only the EH particles were not distributed and ***,the existence of nitrogen elements of PEI on the surface of the pEH was confirmed by EDS,calcium concentration measurement and fourier transform infrared spectroscopy(FT-IR).Additionally,the pEH was confirmed to have a more positive charge than the 25 kD PEI by comparing the zeta *** a result of pGL3 transfection,pEH was better able to transport genes to cells than 25 kD *** verification as a gene carrier for pEH,we induced osteogenic differentiation of DPSCs by loading the BMP-2 gene in pEH(BMP-2/pEH)and delivering it to the *** a result,it was confirmed that osteogenic differentiation was promoted by showing that the expression of osteopontin(OPN),osteocalcin(OCN),and runt-related transcription factor 2(RUNX2)was significantly increased in the group treated with BMP-2/*** conclusion,we have not only developed a novel nonviral gene carrier that is better performing and less toxic than 25 kD PEI by modifying natural HA(the agricultural byproduct)but also proved that bone differentiation can be effectively promoted by delivering BMP-2 with pEH to stem cells.

关键词： Nanocomposites biomedical applications Hydroxyapatite Polyethyleneimine Gene carrier Osteogenic differentiation

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