检索结果-内蒙古大学图书馆

arXiv 2024年

作者： Ohta, Kazuhiro Ono, Satoshi Information Science and Biomedical Engineering Program Kagoshima University Korimoto 1-21-40 Kagoshima890-0065 Japan

Neural Radiance Field (NeRF), capable of synthesizing high-quality novel viewpoint images, suffers from issues like artifact occurrence due to its fixed sampling points during rendering. This study proposes a method t... 详细信息

关键词： Deep neural networks

来源：评论

学校读者我要写书评

暂无评论

Injectable Platelet Lysate–Thai Silk Fibroin Hydrogel for Canine Intervertebral Disc Repair: A Minimally Invasive Strategy for Sustained Growth Factor Release

SSRN

引用

SSRN 2025年

作者： Ratanavaraporn, Juthamas Chayatup, Kannika Boonkruephan, Sarinthorn Keeratihattayakorn, Saran Wangdee, Chalika Interdisciplinary Program of Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Biomedical Engineering Research Center Faculty of Engineering Chulalongkorn University Bangkok Thailand Research Unit Chulalongkorn University Bangkok10330 Thailand Department of Veterinary Surgery Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand

Canine intervertebral disc degeneration (IVDD) is a progressive spinal disorder that compromises mobility, induces chronic pain, and reduces quality of life. Existing treatments provide only symptomatic relief and do not halt disease progression or restore disc integrity. This study aims to develop and characterize an injectable platelet lysate–Thai silk fibroin (PL–TSF) hydrogel as a minimally invasive platform for localized and sustained growth factor delivery in canine IVDD treatment. The hydrogel was formulated using PL from expired canine platelet concentrates and TSF extracted from cocoons of Thai-bred Bombyx mori silkworms. Fabricated via sonication-induced gelation, it exhibited tunable gelation kinetics and injectability through a 27-gauge spinal needle, supporting clinical feasibility for minimally invasive delivery. PL incorporation enhanced the hydrogel’s elasticity and mechanical resilience without compromising scaffold integrity. The system demonstrated biphasic degradation over 35 days. TGF-β1 release kinetics exhibited an initial burst followed by sustained release over 28 days, consistent with diffusion-controlled delivery suitable for IVD repair. Cytotoxicity testing confirmed good biocompatibility and supported the viability of canine chondrocytes. By combining mechanical support with prolonged growth factor availability, PL–TSF hydrogels address key limitations of conventional platelet-based therapies and represent a promising strategy for early-stage IVDD intervention. Further in vivo studies are warranted to confirm long-term regenerative efficacy and facilitate clinical translation in veterinary medicine. © 2025, The Authors. All rights reserved.

关键词： Gelation

来源：评论

学校读者我要写书评

暂无评论

Measurement of peripheral nerve magnetostimulation thresholds of a head solenoid coil between 200 Hz and 88.1 kHz

引用

IEEE Journal of Translational engineering in Health and Medicine 2025年 13卷 275-285页

作者： Barksdale, Alex C. Ferris, Natalie G. Mattingly, Eli Sliwiak, Monika Guerin, Bastien Wald, Lawrence L. Davids, Mathias Klein, Valerie MIT Department of Electrical Engineering and Computer Science CambridgeMA United States Martinos Center for Biomedical Imaging CharlestownMA United States Harvard University Harvard Graduate Program in Biophysics CambridgeMA United States Harvard-MIT Division of Health Sciences and Technology BostonMA United States Harvard Medical School BostonMA United States

Objective: Magnetic fields switching at kilohertz frequencies induce electric fields in the body, which can cause peripheral nerve stimulation (PNS). Although magnetostimulation has been extensively studied below 10 kHz, the behavior of PNS at higher frequencies remains poorly understood. This study aims to investigate PNS thresholds at frequencies up to 88.1 kHz and to explore deviations from the widely accepted hyperbolic strength-duration curve (SDC). Methods and procedures: PNS thresholds were measured in the head of 8 human volunteers using a solenoidal coil at 16 distinct frequencies, ranging from 200 Hz to 88.1 kHz. A hyperbolic SDC was used as a reference to compare the frequency-dependent behavior of PNS thresholds. Results: Contrary to the predictions of the hyperbolic SDC, PNS thresholds did not decrease monotonically with frequency. Instead, thresholds reached a minimum near 25 kHz, after which they increased by an average of 39% from 25 kHz to 88.1 kHz across subjects. This pattern indicates a significant deviation from previously observed behavior at lower frequencies. Conclusion: Our results suggest that PNS thresholds exhibit a non-monotonic frequency dependence at higher frequencies, diverging from the traditional hyperbolic SDC. These findings offer critical data for refining neurodynamic models and provide insights for setting PNS safety limits in applications like MRI gradient coils and magnetic particle imaging (MPI). Further investigation is needed to understand the biological mechanisms driving these deviations beyond 25 kHz. Clinical impact: These findings call for further basic research into biological mechanisms underlying high frequency PNS threshold trends, and supports refinement of safety guidelines for MRI and MPI systems for clinical implementation. © 2013 IEEE.

关键词： Neuroimaging

来源：评论

学校读者我要写书评

暂无评论

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

引用

National science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling Tang Yuhao Wang Wenhao Zhang Heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu Hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of Hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

来源：评论

学校读者我要写书评

暂无评论

Design and Feasibility Test of In-House Indirect Perfusion Bioreactor for 3-D Cell Culture 15

Design and Feasibility Test of In-House Indirect Perfusion B...

引用

15th biomedical engineering International Conference, BMEiCON 2023

作者： Suwannaphan, T. Tharasanit, T. Wongpakham, T. Pimpin, A. Chessadangkul, K. King Mongkut's University of Technology North Bangkok Department of Mechanical Engineering Technology Bangkok Thailand Faculty of Veterinary Science Chulalongkorn University Department of Obstetrics Gynaecology and Reproduction Bangkok Thailand Chulalongkorn University Faculty of Engineering Department of Mechanical Engineering Bangkok Thailand Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand

ISBN: (纸本)9798350345247

Selection of bioreactor system depends on many factors such as type of products, process of culture, and product density. No standard for development methodology is available nowadays. This work demonstrated the development of multi mini-chamber indirect perfusion bioreactor to support 3-D cell culture. The systems consisted of scaffolds, cell/scaffold retainers, culture tanks with a single peristaltic pump. Flow simulation was conducted to investigate the effects of flow rate and inlets/outlets' position on the distribution of shear stresses on the cell/scaffold cassettes installed inside the bioreactor. The prototype with 4 culture tanks connected in series was tested for long period operation. Lastly, preliminary experiments to culture and differentiate pig muscle stem cells were conducted. The results showed that muscle cells were successfully differentiated both on glass slides and aloe vera scaffolds inside the developed bioreactor. © 2023 IEEE.

关键词： Flow simulation

来源：评论

学校读者我要写书评

暂无评论

Towards a Healthy AI Tradition: Lessons from Biology and biomedical science

arXiv

引用

arXiv 2024年

作者： Kasif, Simon Department of Biomedical Engineering Bioinformatics Graduate Program Department of Computer Science Boston University United States Department of Computer Science Tel Aviv University

AI is a magnificent field that directly and profoundly touches on numerous disciplines ranging from philosophy, computer science, engineering, mathematics, decision and data science and economics, to cognitive science, neuroscience and more. The number of applications and impact of AI is second to none and the potential of AI to broadly impact future science developments is particularly thrilling. While attempts to understand knowledge, reasoning, cognition and learning go back centuries, AI remains a relatively new field. In part due to the fact it has so many wide-ranging overlaps with other disparate fields it appears to have trouble developing a robust identity and culture. Here we suggest that contrasting the fast-moving AI culture to biological and biomedical sciences is both insightful and useful way to inaugurate a healthy tradition needed to envision and manage our ascent to AGI and beyond (independent of the AI Platforms used). After all, the human brain is a biological organ produced by evolution and human intelligence is a remarkable bi-product of nature and nurture and their complex interaction. In this perspective, we focus on traditions and culture, namely the commonly observed practices of evaluating, recognizing applauding, critiquing, debating and managing all progress including useful advances and discovery of challenging limitations. We are not discussing specific scientific exchanges between AI and Biology that include interdisciplinary cross fertilization of scientific methods, technology, ideas and applications that have been amply demonstrated and will continue to be transformative in the future. In a previous perspective, we suggested that biomedical laboratories or centers can usefully embrace logistic traditions in AI labs that will allow them to be highly collaborative, improve the reproducibility of research, reduce risk aversion and produce faster mentorship pathways for PhDs and fellows. This perspective focuses on the benefits of AI a

关键词： Biological organs

来源：评论

学校读者我要写书评

暂无评论

Effect of exposure to a light-emitting diode (LED) on the physicochemical characteristics of natural latex biomembranes used to treat diabetic ulcers

引用

Research on biomedical engineering 2022年第3期38卷 901-911页

作者： Santana, Thamis Fernandes Oliveira, Rebeca Hannah de Melo dos Santos, Ludmila Evangelista Lima, Eunice Paloma Nascimento Faria, Sylvia de Sousa Fonseca, Marcos Augusto Moutinho da Silva, Jaqueline Rodrigues Tatmatsu-Rocha, José Carlos Gomes, Marília Miranda Forte Fleury Rosa, Mário Fabrício Fleury Rosa, Suélia de Siqueira Rodrigues Carneiro, Marcella Lemos Brettas Postgraduate Program in Biomedical Engineering University of Brasilia Federal District Brasilia Brazil Postgraduate Program in Materials Science and Engineering Federal University of Campina Grande Paraiba Campina Grande Brazil Department of Electrical Engineering University of Brasilia Federal District Brasilia Brazil Postgraduate Program in Biology Animal University of Brasilia Federal District Brasilia Brazil Medicine Faculty Physical Therapy Department Federal University of Ceara Ceara Fortaleza Brazil Postgraduate Technology and Health Program University of Brasília Federal District Brasília Brazil

Purpose: Natural latex biomembrane has shown high therapeutic potential for the treatment of diabetic ulcers when associated with phototherapy. In this study, physical and chemical alterations in the latex biomembranes were evaluated after exposure to light-emitting diode (LED) irradiation and after contact with NaCl solution. Methods: There were three experimental groups: natural latex biomembranes (1) in natura;(2) after 35 min of LED light irradiation;and (3) after immersion in NaCl 0.9 g% solution. The samples were analyzed by tensile strength test, thermogravimetry, contact angle wettability, and Fourier-transform infrared spectroscopy. Results: The biomembranes that were submitted to contact with NaCl aqueous solution or exposure to LED did not undergo impairment of mechanical resistance. The thermogravimetry analysis indicated that increasing temperature led to mass loss in all samples, referring to their decomposition temperatures. In the wettability test, biomembranes exposed to LED showed a significant reduction in the contact angle between 0 and 10 min, indicating an increase in hydrophilicity, suggesting water storage capacity. The Fourier-transform infrared spectrometry assay showed that there was a more significant reduction in vibration intensity after immersion in NaCl solution compared to untreated biomembranes. An increase in the intensity of the entire spectrum of biomembranes exposed to LED was observed in comparison with the other samples, which may be related to photodegradation caused by LED light irradiation. Conclusion: The biomembranes underwent significant changes in its chemical structure after being subjected to different types of exposure and maintained its elasticity and tensile strength properties, in addition to showing good water retention capacity after exposure to LED. Thus, it maintains many of its properties for application as a tissue-regenerating biomaterial, even when subjected to LED irradiation and a humid environment. © 20

关键词： Tissue regeneration

来源：评论

学校读者我要写书评

暂无评论

Deep learning model for pleural effusion detection via active learning and pseudo-labeling: a multisite study

引用

BMC Medical Imaging 2024年第1期24卷 92页

作者： Chang, Joseph Lin, Bo-Ru Wang, Ti-Hao Chen, Chung-Ming Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University No. 1 Sec. 1 Jen-Ai Road Taipei 100 Taipei 100 Taiwan EverFortune.AI Co. Ltd Taichung Taiwan The Data Science Degree Program College of Electrical Engineering and Computer Science National Taiwan University and Academia Sinica Taipei Taiwan Department of Radiation Oncology China Medical University Hospital Taichung Taiwan Department of Medicine China Medical University Taichung Taiwan

Background: The study aimed to develop and validate a deep learning-based Computer Aided Triage (CADt) algorithm for detecting pleural effusion in chest radiographs using an active learning (AL) framework. This is aimed at addressing the critical need for a clinical grade algorithm that can timely diagnose pleural effusion, which affects approximately 1.5 million people annually in the United States. Methods: In this multisite study, 10,599 chest radiographs from 2006 to 2018 were retrospectively collected from an institution in Taiwan to train the deep learning algorithm. The AL framework utilized significantly reduced the need for expert annotations. For external validation, the algorithm was tested on a multisite dataset of 600 chest radiographs from 22 clinical sites in the United States and Taiwan, which were annotated by three U.S. board-certified radiologists. Results: The CADt algorithm demonstrated high effectiveness in identifying pleural effusion, achieving a sensitivity of 0.95 (95% CI: [0.92, 0.97]) and a specificity of 0.97 (95% CI: [0.95, 0.99]). The area under the receiver operating characteristic curve (AUC) was 0.97 (95% DeLong’s CI: [0.95, 0.99]). Subgroup analyses showed that the algorithm maintained robust performance across various demographics and clinical settings. Conclusion: This study presents a novel approach in developing clinical grade CADt solutions for the diagnosis of pleural effusion. The AL-based CADt algorithm not only achieved high accuracy in detecting pleural effusion but also significantly reduced the workload required for clinical experts in annotating medical data. This method enhances the feasibility of employing advanced technological solutions for prompt and accurate diagnosis in medical settings. © The Author(s) 2024.

关键词： Active learning Chest radiographs Deep learning Pleural effusion X-rays

来源：评论

学校读者我要写书评

暂无评论

Understanding ADC variation by fat content effect using a dual-function MRI phantom

引用

European Radiology Experimental 2024年第1期8卷 19页

作者： Liu, Yi-Jui Tsai, Tung-Sheng Li, Ya-Hui Peng, Jo-Hua Chang, Hing-Chiu Peng, Hsu-Hsia Lee, Ying-Chieh Lee, Tung-Yang Liou, Chang-Hsien Lin, Tz-Feng Chew, Fatt-Yang Chou, Ruey-Hwang Juan, Chun-Jung Department of Automatic Control Engineering Feng Chia University Taichung Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital 199 Sec. 1 Xinglong Rd. Hsinchu County Zhubei City 302 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Biomedical Engineering Chinese University of Hong Kong Hong Kong Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Institute of Nuclear Engineering and Science National Tsing Hua University Hsinchu Taiwan Department of Fiber and Composite Materials Feng Chia University Taichung Taiwan Department of Medical Imaging China Medical University Hospital Taichung Taiwan Department of Radiology School of Medicine China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 406 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung Taiwan Department of Medical Laboratory and Biotechnology Asia University Taichung Taiwan

Background: A dual-function phantom designed to quantify the apparent diffusion coefficient (ADC) in different fat contents (FCs) and glass bead densities (GBDs) to simulate the human tissues has not been documented yet. We propose a dual-function phantom to quantify the FC and to measure the ADC at different FCs and different GBDs. Methods: A fat-containing diffusion phantom comprised by 30 glass-bead-containing fat-water emulsions consisting of six different FCs (0, 10, 20, 30, 40, and 50%) multiplied by five different GBDs (0, 0.1, 0.25, 0.5, and 1.0 g/50 mL). The FC and ADC were measured by the “iterative decomposition of water and fat with echo asymmetry and least squares estimation-IQ,” IDEAL-IQ, and single-shot echo-planar diffusion-weighted imaging, SS-EP-DWI, sequences, respectively. Linear regression analysis was used to evaluate the relationship among the fat fraction (FF) measured by IDEAL-IQ, GBD, and ADC. Results: The ADC was significantly, negatively, and linearly associated with the FF (the linear slope ranged from -0.005 to -0.017, R² = 0.925 to 0.986, all p < 0.001). The slope of the linear relationship between the ADC and the FF, however, varied among different GBDs (the higher the GBD, the lower the slope). ADCs among emulsions across different GBDs and FFs were overlapped. Emulsions with low GBDs plus high FFs shared a same lower ADC range with those with median or high GBDs plus median or lower FFs. Conclusions: A novel dual-function phantom simulating the human tissues allowed to quantify the influence of FC and GBD on ADC. Relevance statement: The study developed an innovative dual-function MRI phantom to explore the impact of FC on ADC variation that can affect clinical results. The results revealed the superimposed effect on FF and GBD density on ADC measurements. Key points: • A dual-function phantom made of glass bead density (GBD) and fat fraction (FF) emulsion has been developed. • Apparent diffusion coefficient (ADC) values

关键词： Adipose tissue Diffusion magnetic resonance imaging Phantoms (imaging) Quality assurance (healthcare) Quality control

来源：评论

学校读者我要写书评

暂无评论

Cytometry in the Short-Wave Infrared

引用

ACS Nano 2024年第28期18卷 18534-18547页

作者： Liu, Te-I Wang, Jhih-Shan Nguyen, Ai-Phuong Raabe, Marco Quiroz Reyes, Carlos Jose Lin, Chih-Hsin Lin, Ching-Wei Institute of Atomic and Molecular Sciences Academia Sinica Taipei City106319 Taiwan Department of Materials Science and Engineering National Taiwan University Taipei City106319 Taiwan Department of Physics University of Stuttgart Stuttgart70174 Germany Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Ph.D. Program in Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University New Taipei City235603 Taiwan

Cytometry plays a crucial role in characterizing cell properties, but its restricted optical window (400-850 nm) limits the number of stained fluorophores that can be detected simultaneously and hampers the study and utilization of short-wave infrared (SWIR;900-1700 nm) fluorophores in cells. Here we introduce two SWIR-based methods to address these limitations: SWIR flow cytometry and SWIR image cytometry. We develop a quantification protocol for deducing cellular fluorophore mass. Both systems achieve a limit of detection of ∼0.1 fg cell-1 within a 30 min experimental time frame, using individualized, high-purity (6,5) single-wall carbon nanotubes as a model fluorophore and macrophage-like RAW264.7 as a model cell line. This high-sensitivity feature reveals that low-dose (6,5) serves as an antioxidant, and cell morphology and oxidative stress dose-dependently correlate with (6,5) uptake. Our SWIR cytometry holds immediate applicability for existing SWIR fluorophores and offers a solution to the issue of spectral overlapping in conventional cytometry. © 2024 The Authors. Published by American Chemical Society.

关键词： Oxygen

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：