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Spatiotemporal Control of Morphogen Delivery to Pattern Stem Cell Differentiation in Three-Dimensional Hydrogels

Current Protocols in Stem Cell Biology 2019年第1期51卷 e97页

作者： Balikov, Daniel A. Lippmann, Ethan S. Bellan, Leon M. Department of Mechanical Engineering Vanderbilt University Nashville TN United States Interdisciplinary Materials Science Program Vanderbilt University Nashville TN United States Department of Biomedical Engineering Vanderbilt University Nashville TN United States Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville TN United States

Morphogens are biological molecules that alter cellular identity and behavior across both space and time. During embryonic development, morphogen spatial localization can be confined to small volumes in a single tissue or permeate throughout an entire organism, and the temporal effects of morphogens can range from fractions of a second to several days. In most cases, morphogens are presented as a gradient to adjacent cells within tissues to pattern cell fate. As such, to appropriately model development and build representative multicellular architectures in vitro, it is vital to recapitulate these gradients during stem cell differentiation. However, the ability to control morphogen presentation within in vitro systems remains challenging. Here, we describe an innovative platform using channels patterned within thick, three-dimensional hydrogels that deliver multiple morphogens to embedded cells, thereby demonstrating exquisite control over both spatial and temporal variations in morphogen presentation. This generalizable approach should have broad utility for researchers interested in patterning in vitro tissue structures. © 2019 by John Wiley & Sons, Inc. © 2019 John Wiley & Sons, Inc.

关键词： differentiation gradient hydrogel morphogen stem cell tissue engineering

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Gas-Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

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Angewandte Chemie 2023年第27期135卷

作者： Junjie Cheng Yang Zhu Yi Dai Li Li Miya Zhang Duo Jin Manman Liu Jiaji Yu Wenxin Yu Dan Su Jianhua Zou Xiaoyuan Chen Yangzhong Liu Department of Pharmacy The First Affiliated Hospital of USTC Division of Life Sciences and Medicine Department of Chemistry University of Science and Technology of China 230026 Hefei China Contribution: Conceptualization (lead) Investigation (lead) Writing - original draft (lead) Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore 119074 Singapore Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore 117599 Singapore Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore 117597 Singapore Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos 138673 Singapore Singapore Contribution: Investigation (supporting) College of Pharmaceutical Sciences Anhui Xinhua University 230088 Hefei China Contribution: Supervision (supporting) Writing - review & editing (lead) Contribution: Funding acquisition (lead) Supervision (supporting)

The metabolic reprogramming of tumors requires high levels of adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads to severe side effects. Therefore, improving the therapeutic response and promoting healing are critical considerations in the development of PTT. Here, we proposed a gas-mediated energy remodeling strategy to improve mild PTT efficacy while minimizing side effects. In the proof-of-concept study, a Food and Drug Administration (FDA)-approved drug-based hydrogen sulfide (H 2 S) donor was developed to provide a sustained supply of H 2 S to tumor sites, serving as an adjuvant to PTT. This approach proved to be highly effective in disrupting the mitochondrial respiratory chain, inhibiting ATP generation, and reducing the overexpression of heat shock protein 90 (HSP90), which ultimately amplified the therapeutic outcome. With the ability to reverse tumor thermotolerance, this strategy delivered a greatly potent antitumor response, achieving complete tumor ablation in a single treatment while minimizing harm to healthy tissues. Thus, it holds great promise to be a universal solution for overcoming the limitations of PTT and may serve as a valuable paradigm for the future clinical translation of photothermal nanoagents.

关键词： Heat Shock Proteins Nanoagents Near-Infrared-II Window Photothermal Therapy Tumor Therapy

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Low-frequency electronic noise in superlattice and random-packed thin films of colloidal quantum dots

arXiv

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arXiv 2019年

作者： Geremew, Adane Qian, Caroline Abelson, Alex Rumyantsev, Sergey Kargar, Fariborz Law, Matt Balandin, Alexander A. Department of Electrical and Computer Engineering University of California RiversideCA92521 United States Department of Chemical and Biomolecular Engineering University of California IrvineCA92627 United States Department of Materials Science and Engineering University of California IrvineCA92697 United States CENTERA Laboratories Institute of High-Pressure Physics Polish Academy of Sciences Warsaw01-142 Poland Department of Chemistry University of California IrvineCA92697 United States Center Materials Science and Engineering Program University of California RiversideCA92521 United States

We report measurements of low-frequency electronic noise in ordered superlattice, weakly-ordered and random-packed thin films of 6.5 nm PbSe quantum dots prepared using several different ligand chemistries. For all samples, the normalized noise spectral density of the dark current revealed a Lorentzian component, reminiscent of the generation-recombination noise, superimposed on the 1/f background (f is the frequency). An activation energy of ~0.3 eV was extracted from the temperature dependence of the noise spectra. The noise level in the ordered films was lower than that in the weakly-ordered and random-packed films. A large variation in the magnitude of the noise spectral density was also observed in samples with different ligand treatments. The obtained results are important for application of colloidal quantum dot films in photodetectors. Copyright © 2019, The Authors. All rights reserved.

关键词： Thin films

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Highly Efficient and Stable Perovskite Solar Cells Enabled by Low-Cost Industrial Organic Pigment Coating

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Angewandte Chemie 2020年第5期133卷

作者： Dr. Qingquan He Michael Worku He Liu Dr. Eric Lochner Alex J. Robb Sandrine Lteif Dr. J. S. Raaj Vellore Winfred Dr. Kenneth Hanson Dr. Joseph B. Schlenoff Dr. Bumjoon J. Kim Dr. Biwu Ma Department of Chemistry and Biochemistry Florida State University Tallahassee FL 32306 USA Materials Science and Engineering Program Florida State University Tallahassee FL 32306 USA Department of Physics Florida State University Tallahassee FL 32306 USA Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

Surface passivation of perovskite solar cells (PSCs) using a low-cost industrial organic pigment quinacridone (QA) is presented. The procedure involves solution processing a soluble derivative of QA, N , N -bis(tert-butyloxycarbonyl)-quinacridone (TBOC-QA), followed by thermal annealing to convert TBOC-QA into insoluble QA. With halide perovskite thin films coated by QA, PSCs based on methylammonium lead iodide (MAPbI 3 ) showed significantly improved performance with remarkable stability. A PCE of 21.1 % was achieved, which is much higher than 18.9 % recorded for the unmodified devices. The QA coating with exceptional insolubility and hydrophobicity also led to greatly enhanced contact angle from 35.6° for the pristine MAPbI 3 thin films to 77.2° for QA coated MAPbI 3 thin films. The stability of QA passivated MAPbI 3 perovskite thin films and PSCs were significantly enhanced, retaining about 90 % of the initial efficiencies after more than 1000 hours storage under ambient conditions.

关键词： hydrophobicity perovskite solar cells quinacridone stability surface passivation

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Front Cover: Photosystem I Multilayers within Porous Indium Tin Oxide Cathodes Enhance Mediated Electron Transfer (ChemElectroChem 3/2020)

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ChemElectroChem 2020年第3期7卷 581-581页

作者： Kody D. Wolfe Dilek Dervishogullari Christopher D. Stachurski Joshua M. Passantino Dr. G. Kane Jennings Dr. David E. Cliffel Interdisciplinary Materials Science Program Vanderbilt University Nashville Tennessee 37235-1822 United States Department of Chemistry Vanderbilt University Nashville Tennessee 37235-1822 United States Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville Tennessee 37235-1822 United States

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Singlet Oxygen Generation in Dark-Hypoxia by Catalytic Microenvironment-Tailored Nanoreactors for NIR-II Fluorescence-Monitored Chemodynamic Therapy

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Angewandte Chemie 2021年第27期133卷

作者： Tao Chen Peidong Hou Yafei Zhang Rujiang Ao Lichao Su Yifan Jiang Yuanli Zhang Huilan Cai Jun Wang Prof. Qiushui Chen Prof. Jibin Song Prof. Lisen Lin Prof. Huanghao Yang Prof. Xiaoyuan Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 China Departments of Diagnostic Radiology Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 117597 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Singlet oxygen ( 1 O 2 ) has a potent anticancer effect, but photosensitized generation of 1 O 2 is inhibited by tumor hypoxia and limited light penetration depth. Despite the potential of chemodynamic therapy (CDT) to circumvent these issues by exploration of 1 O 2 -producing catalysts, engineering efficient CDT agents is still a formidable challenge since most catalysts require specific pH to function and become inactivated upon chelation by glutathione (GSH). Herein, we present a catalytic microenvironment-tailored nanoreactor (CMTN), constructed by encapsulating MoO 4 2− catalyst and alkaline sodium carbonate within liposomes, which offers a favorable pH condition for MoO 4 2− -catalyzed generation of 1 O 2 from H 2 O 2 and protects MoO 4 2− from GSH chelation owing to the impermeability of liposomal lipid membrane to ions and GSH. H 2 O 2 and 1 O 2 can freely cross the liposomal membrane, allowing CMTN with a built-in NIR-II ratiometric fluorescent 1 O 2 sensor to achieve monitored tumor CDT.

关键词： catalytic microenvironment chemodynamic therapy nanoreactors NIR-II ratiometric fluorescence singlet oxygen

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AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets

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Immunoinformatics (Amsterdam, Netherlands) 2023年 10卷 100025页

作者： William D Lees Scott Christley Ayelet Peres Justin T Kos Brian Corrie Duncan Ralph Felix Breden Lindsay G Cowell Gur Yaari Martin Corcoran Gunilla B Karlsson Hedestam Mats Ohlin Andrew M Collins Corey T Watson Christian E Busse Institute of Structural and Molecular Biology Birkbeck College London England. Human-Centered Computing and Information Science Institute for Systems and Computer Engineering Technology and Science Porto Portugal. Peter O'Donnell Jr. School of Public Health UT Southwestern Medical Center Dallas TX USA. Bioengineering Program Faculty of Engineering Bar-Ilan University Ramat Gan Israel. Department of Biochemistry and Molecular Genetics School of Medicine University of Louisville KY USA. Department of Biological Sciences Simon Fraser University Burnaby BC Canada. Fred Hutchinson Cancer Research Center Seattle WA USA. Peter O'Donnell Jr. School of Public Health Department of Immunology School of Biomedical Sciences UT Southwestern Medical Center Dallas TX USA. Department of Microbiology Tumor and Cell Biology Karolinska Institutet Stockholm Swede. Department of Immunotechnology and SciLifeLab Lund University Lund Sweden. School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney NSW Australia. Division of B Cell Immunology German Cancer Research Center Heidelberg Germany.

Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes and alleles require specific evidence and data types, but the discovery landscape is rapidly changing. To exploit the potential of emerging data, and to provide the field with improved state-of-the-art germline sets, an intermediate approach is needed that will allow the rapid publication of consolidated sets derived from these emerging sources. These sets must use a consistent naming scheme and allow refinement and consolidation into genes as new information emerges. Name changes should be minimised, but, where changes occur, the naming history of a sequence must be traceable. Here we outline the current issues and opportunities for the curation of germline IG/TR genes and present a forward-looking data model for building out more robust germline sets that can dovetail with current established processes. We describe interoperability standards for germline sets, and an approach to transparency based on principles of findability, accessibility, interoperability, and reusability.

关键词： AIRR-seq Immune receptor Immune receptor germline Immune receptor repertoire Rep-seq

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Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

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Angewandte Chemie 2021年第32期133卷

作者： Dr. Kuikun Yang Dr. Guocan Yu Zhiqing Yang Ludan Yue Dr. Xiangjun Zhang Chen Sun Jianwen Wei Dr. Lang Rao Prof. Xiaoyuan Chen Prof. Ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Science University of Macau Avenida da Universidade Taipa Macau China MoE Frontiers Science Center for Precision Oncology University of Macau Avenida da Universidade Taipa Macau China Key Lab of Organic Optoelectronics & Molecular Engineering Department of Chemistry Tsinghua University Beijing China Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory Shenzhen China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H 2 O 2 level in tumor tissues. Herein, we developed a supramolecular nanoparticle via a simple one-step supramolecular polymerization-induced self-assembly process using platinum (IV) complex-modified β-cyclodextrin-ferrocene conjugates as supramolecular monomers. The supramolecular nanoparticles could dissociate rapidly upon exposure to endogenous H 2 O 2 in the tumor and release hydroxyl radicals as well as platinum (IV) prodrugs in situ, which is reduced into cisplatin to significantly promote the generation of H 2 O 2 in the tumor tissue. Thus, the supramolecular nanomedicine overcomes the limitation of conventional chemodynamic therapy via the self-augmented cascade radical generation and drug release. In addition, dissociated supramolecular nanoparticles could be readily excreted from the body via renal clearance to effectively avoid systemic toxicity and ensure long term biocompatibility of the nanomedicine. This work may provide new insights on the design and development of novel supramolecular nanoassemblies for cascade chemo/chemodynamic therapy.

关键词： drug delivery self-amplified dissociation self-assembly supramolecular polymerization synergistic chemo/chemodynamic therapy

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Sustainability insights from Late Pleistocene climate change and horse migration patterns

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science (New York, N.Y.) 2025年第6748期388卷 748-755页

作者： Running Horse Collin, Yvette Bataille, Clément P Hershauer, Samantha Hunska Tašunke Icu, Mila Nujipi, Akil Justin, Wilson Stelkia, Jane Stelkia, James Aaron Topkok, Sean Asikłuk Leonard, Beth Ginondidoy Soop, Beatle Gonzalez, Mario Luta Wiƞ, Anpetu Wiƞ, Wakiƞyala Omniya, Tanka Dull Knife, Barbara Means, Bill Tecumseh Collin, Cruz Koskey, Michael Kapp, Joshua D. Landry, Zoe Fraser, Danielle Southon, John Lindroos, Eve E. Hassler, Auguste Chauvey, Lorelei Tressières, Gaetan Tonasso-Calvière, Laure Schiavinato, Stéphanie Seguin-Orlando, Andaine Perdereau, Aude Oliveira, Pedro H. Aury, Jean-Marc Wincker, Patrick Kirillova, Irina V. Vasiliev, Sergey K. Kusliy, Mariya A. Graphodatsky, Alexander S. Tishkin, Alexey A. Barnes, Ian Druckenmiller, Pat Jass, Christopher N. MacPhee, Ross D E Barrón-Ortiz, Christina I. Groves, Pam Mann, Dan Froese, Duane G. Wooller, Matthew Miller, Joshua H. Crowley, Brooke Zazula, Grant Hall, Elizabeth Hewitson, Susan Shapiro, Beth Orlando, Ludovic Centre for Anthropobiology and Genomics of Toulouse CNRS UMR 5288 Université de Toulouse Toulouse France Taku Skan Skan Wasakliyapi: Global Institute for Traditional Sciences Keystone SD United States Pine Ridge Reservation SD United States Department of Earth and Environmental Sciences University of Ottawa Ottawa ON Canada Department of Forestry and Natural Resources Purdue University West Lafayette IN United States Department of Biomolecular Engineering University of California Santa Cruz Santa Cruz CA USA Mt. Sanford Tribal Health Corporation Hq Chistochina AK United States ANCSA Regional Corporation Slana AK United States Cheesh'Na Tribal Council Gakona AK United States sqilxʷ/suknaqin or Okanagan Nation Oliver BC Canada sqilxʷ/suknaqin or Okanagan Nation BC Canada Center for Cross-Cultural Studies University of Alaska Fairbanks Fairbanks AK United States Shageluk AK United States Institute of Culture and Environment Alaska Pacific University Anchorage AK United States McLean SK Canada Department of Ecology and Evolutionary Biology University of California Santa Cruz Santa Cruz CA USA Palaeobiology Canadian Museum of Nature Gatineau QC Canada Department of Earth Sciences and Biology Carleton University Ottawa ON Canada Smithsonian National Museum of Natural History WA United States Department of Earth System Science University of California Irvine Irvine CA United States Department of Archaeology School of Geosciences University of Aberdeen Aberdeen United Kingdom Genoscope Institut de Biologie François Jacob CEA CNRS Université d'Évry Université Paris-Saclay Évry France Génomique Métabolique Genoscope Institut François Jacob CEA CNRS Université d'Évry Université Paris-Saclay Évry France Ice Age Museum Shidlovskiy National Alliance "Ice Age Moscow Russian Federation ArchaeoZOOlogy in Siberia and Central Asia - ZooSCAn CNRS-IAET SB RAS International Research Laboratory Institute of Archaeology and Ethnography SB RAS Novos

Climate affects habitat, food availability, and the movement and sustainability of all life. In this work, we apply Indigenous and Western scientific methods, including genomics and isotope profiling, on fossils from across Beringia to explore the effect of climate change on horses. We find that Late Pleistocene horses from Alaska and northern Yukon are related to populations from Eurasia and crossed the Bering land bridge multiple times during the last glacial interval. We also find deeply divergent lineages north and south of the American ice sheets that genetically influenced populations across Beringia and into Eurasia. As climate warmed and horses entered the ice-free corridor connecting Beringia and midcontinental America, restricted mobility and food availability impeded population growth. Our combined Western and Indigenous framework offers critical guidance for wildlife conservation amid ongoing climate change.

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A LRET Nanoplatform Consisting of Lanthanide and Amorphous Manganese Oxide for NIR-II Luminescence Lifetime Imaging of Tumor Redox Status

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Angewandte Chemie 2022年第47期134卷

作者： Dr. Mengyao Zhao Dr. Hongjun Zhuang Dr. Hongxin Zhang Dr. Benhao Li Jiang Ming Prof. Xiaoyuan Chen Prof. Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macau 999078 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Contribution: Conceptualization (lead) Investigation (lead) Writing - original draft (lead) Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Fudan University Shanghai 200433 China Contribution: Investigation (supporting) Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore 138673 Singapore Contribution: Funding acquisition (lead) Supervision (lead)

Designing luminescence lifetime sensors in the second near-infrared (NIR-II) window is a great challenge due to the difficult structural construction. Here, we report a tumor redox responsive and easily synthesized material, amorphous manganese oxide (MnO x ) with indirect band gap of 1.02 eV, as an energy acceptor to build a luminescence resonance energy transfer (LRET) toolbox for universally regulating NIR-I to NIR-II luminescence lifetimes of lanthanide nanoparticles, in which energy transfer is based on matched energy gap instead of conventional overlapped spectra. We further utilize ytterbium (Yb 3+ )-doped YbNP@MnO x as an NIR-II luminescence lifetime sensor to realize in vitro quantitative redox visualization with relative errors under 5 % in samples covered with mouse skin. Furthermore, HepG2 cells and tumors with high redox state have been accurately distinguished by NIR-II luminescence lifetime imaging. The quantified intracellular and intratumor glutathione (GSH) levels are highly consistent with the commercial kit results, illustrating the reliable redox visualization ability in biological tissue.

关键词： Amorphous Manganese Oxide Lanthanide Luminescence Lifetime Imaging NIR-II LRET Quantitative Redox Visualization

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