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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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Clinical and Genetic Relevance of Somatic Mutations in Core Binding Factor (CBF) Acute Myeloid Leukemia (AML) Patients Using Serial Sequencing

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BLOOD 2017年 130卷 3955-3955页

作者： Kim, Taehyung Moon, Joon Ho Ahn, Jae-Sook Tyndel, Marc S. Kim, Yeo-Kyeoung Lee, Seung-Shin Ahn, Seo-Yeon Jung, Sung-Hoon Yang, Deok-Hwan Lee, Je-Jung Choi, Seunghyun Lee, Yoojin Sohn, Sang Kyun Min, Yoo Hong Cheong, June-Won Kim, Hyeoung-Joon Zhang, Zhaolei Kim, Dennis (Dong-Hwong) Donnelly Centre for Cellular and Biomolecular Research University of Toronto Toronto Canada Department of Computer Science University of Toronto Toronto Canada Kyungpook National University Hospital Daegu Korea Republic of (South) Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun-Gun Korea Republic of (South) The Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto Toronto Canada Genome Research Center for Hematopoietic Disease Chonnam National University Hwasun Hospital Hwasun Korea Republic of (South) Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Korea Republic of (South) Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun-gun Korea Republic of (South) Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Korea Republic of (South) Hematopoietic Genomics Research Centre Chonnam National University Hwasun Hospital Hwasun-gun Korea Republic of (South) Hematology/Oncology Kyungpook National University Hospital Daegu Korea Republic of (South) Yonsei Univ. College of Med. Seoul KOR Yonsei University College of Medicine Seoul KOR Department of Molecular Genetics University of Toronto Toronto Canada Blood and Marrow Transplant Program Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University Health Network Toronto Canada

3955

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Macromol. Rapid Commun. 22/2016

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Macromolecular Rapid Communications 2016年第22期37卷

作者： Syamal S. Tallury Behnam Pourdeyhimi Melissa A. Pasquinelli Richard J. Spontak Fiber & Polymer Science Program North Carolina State University Raleigh NC 27695 USA Department of Materials Science & Engineering North Carolina State University Raleigh NC 27695 USA The Nonwovens Institute North Carolina State University Raleigh NC 27695 USA Department of Chemical & Biomolecular Engineering North Carolina State University Raleigh NC 27695 USA

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Fluorescence quenching kinetics of Py excimer in PS films

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Earth and Environmental science Transactions of the Royal Society of Edinburgh 2014年第1期1629卷 1-7页

作者： Jang, Hyun-Sook Lei, Yu Nieh, Mu-Ping Institute of Materials Science Polymer Program University of Connecticut United States Chemical and Biomolecular Engineering University of Connecticut United States

Excimer fluorescence of two-component thin films made of pyrene (Py) and polystyrene (PS) can be quenched by the vapor of nitro-aromatic and nitro-ester explosives with a high selectivity and sensitivity. Normally, an electrospun film can be quenched in minutes by the vapor of the explosives. In order to understand the origin of the mechanism, we have investigated the fluorescence quenching rate of the binary thin films as functions of the molecular weights (MW) of the polystyrene (from 2,500 to 900,000 g/mol) and film thicknesses (110nm and 610 nm) in presence of the vapor of 2,4-dinitrotoluene (2,4-DNT, a type of nitro-explosives). The diffusion coefficients of 2, 4-DNT in the solid films are found nearly independent of MW but have strong dependence on the film thicknesses. © 2014 Materials Research Society.

关键词： diffusion polymer sensor

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Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study

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The Lancet HIV 2021年第6期8卷 e363-e375页

作者： Sartorius, Benn VanderHeide, John D. Yang, Mingyou Goosmann, Erik A. Hon, Julia Haeuser, Emily Cork, Michael A. Perkins, Samantha Jahagirdar, Deepa Schaeffer, Lauren E. Serfes, Audrey L. LeGrand, Kate E. Abbastabar, Hedayat Abebo, Zeleke Hailemariam Abosetugn, Akine Eshete Abu-Gharbieh, Eman Accrombessi, Manfred Mario Kokou Adebayo, Oladimeji M. Adegbosin, Adeyinka Emmanuel Adekanmbi, Victor Adetokunboh, Olatunji O. Adeyinka, Daniel Adedayo Ahinkorah, Bright Opoku Ahmadi, Keivan Ahmed, Muktar Beshir Akalu, Yonas Akinyemi, Oluwaseun Oladapo Akinyemi, Rufus Olusola Aklilu, Addis Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Noore Alamneh, Alehegn Aderaw Alanzi, Turki M. Alemu, Biresaw Wassihun Alhassan, Robert Kaba Ali, Tilahun Alipour, Vahid Amini, Saeed Ancuceanu, Robert Ansari, Fereshteh Anteneh, Zelalem Alamrew Anvari, Davood Anwer, Razique Appiah, Seth Christopher Yaw Arabloo, Jalal Asemahagn, Mulusew A. Asghari Jafarabadi, Mohammad Asmare, Wondwossen Niguse Atnafu, Desta Debalkie Atout, Maha Moh'd Wahbi Atreya, Alok Ausloos, Marcel Awedew, Atalel Fentahun Ayala Quintanilla, Beatriz Paulina Ayanore, Martin Amogre Aynalem, Yared Asmare Ayza, Muluken Altaye Azari, Samad Azene, Zelalem Nigussie Babar, Zaheer-Ud-Din Baig, Atif Amin Balakrishnan, Senthilkumar Banach, Maciej Bärnighausen, Till Winfried Basu, Sanjay Bayati, Mohsen Bedi, Neeraj Bekuma, Tariku Tesfaye Bezabhe, Woldesellassie M. Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bibi, Sadia Bikbov, Boris Birhan, Tsegaye Adane Bitew, Zebenay Workneh Bockarie, Moses John Boloor, Archith Brady, Oliver J. Bragazzi, Nicola Luigi Briko, Andrey Nikolaevich Briko, Nikolay Ivanovich Burugina Nagaraja, Sharath Butt, Zahid A. Cárdenas, Rosario Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Cook, Aubrey J. Cormier, Natalie Maria Cowden, Richard G. Culquichicon, Carlos Dagnew, Baye Dahlawi, Saad M.A. D Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford United Kingdom Malaria Atlas Project University of Oxford Oxford United Kingdom The George Institute for Global Health University of Oxford Oxford United Kingdom Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Insights Program Bill and Melinda Gates Foundation Seattle WA United States Global Programs Medical Teams International Seattle WA United States Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston MA United States Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Pediatric Chronic Kidney Disease Research Center Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Arba Minch University Arba Minch Ethiopia Department of Medical Laboratory Sciences Arba Minch University Arba Minch Ethiopia College of Medicine and Health Science Arba Minch University Arba Minch Ethiopia Department of Nursing Arba Minch University Arba Minch Ethiopia Department of Biomedical Sciences Arba Minch University Arba Minch Ethiopia Department of Public Health Debre Berhan University Debre Brehan

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique,

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A Biomimetic Phosphatidylcholine‐Terminated Monolayer Greatly Improves the In Vivo Performance of Electrochemical Aptamer‐Based Sensors

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Angewandte Chemie 2017年第26期129卷

作者： Hui Li Philippe Dauphin‐Ducharme Netzahualcóyotl Arroyo‐Currás Claire H. Tran Philip A. Vieira Shaoguang Li Christina Shin Jacob Somerson Tod E. Kippin Kevin W. Plaxco Department of Chemistry and Biochemistry University of California Santa Barbara Santa Barbara CA 93106 USA Department of Psychology California State University Dominguez Hills 1000 E. Victoria Ave. Carson CA 90747 USA Department of Psychological and Brain Sciences University of California Santa Barbara Santa Barbara CA 93106 USA The Neuroscience Research Institute and Department of Molecular Cellular and Developmental Biology University of California Santa Barbara Santa Barbara CA 93106 USA Interdepartmental Program Biomolecular Science and Engineering University of California Santa Barbara Santa Barbara CA 93106 USA Center for Bioengineering University of California Santa Barbara Santa Barbara CA 93106 USA

The real‐time monitoring of specific analytes in situ in the living body would greatly advance our understanding of physiology and the development of personalized medicine. Because they are continuous (wash‐free and reagentless) and are able to work in complex media (e.g., undiluted serum), electrochemical aptamer‐based (E‐AB) sensors are promising candidates to fill this role. E‐AB sensors suffer, however, from often‐severe baseline drift when deployed in undiluted whole blood either in vitro or in vivo. We demonstrate that cell‐membrane‐mimicking phosphatidylcholine (PC)‐terminated monolayers improve the performance of E‐AB sensors, reducing the baseline drift from around 70 % to just a few percent after several hours in flowing whole blood in vitro. With this improvement comes the ability to deploy E‐AB sensors directly in situ in the veins of live animals, achieving micromolar precision over many hours without the use of physical barriers or active drift‐correction algorithms.

关键词： Aptamere Biomimetische Oberflächen Elektrochemische Sensoren In-vivo-Messungen Membranmonoschichten

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Next Generation Sequencing (NGS)-Based Post-Transplant Monitoring in Acute Myeloid Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation (HCT)

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BLOOD 2017年 130卷 271-271页

作者： Kim, Taehyung Moon, Joon Ho Ahn, Jae-Sook Tyndel, Marc S. Kim, Yeo-Kyeoung Lee, Seung-Shin Ahn, Seo-Yeon Jung, Sung-Hoon Yang, Deok-Hwan Lee, Je-Jung Choi, Seunghyun Shin, Myung-Geun Kook, Hoon Kim, Sun-Hee Park, Seong Kyu Kim, Hyeoung-Joon Zhang, Zhaolei Kim, Dennis (Dong-Hwong) Donnelly Centre for Cellular and Biomolecular Research University of Toronto Toronto Canada Department of Computer Science University of Toronto Toronto Canada Kyungpook National University Hospital Daegu Korea Republic of (South) Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun-Gun Korea Republic of (South) The Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto Toronto Canada Genome Research Center for Hematopoietic Disease Chonnam National University Hwasun Hospital Hwasun Korea Republic of (South) Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Korea Republic of (South) Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun-gun Korea Republic of (South) Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Korea Republic of (South) Hematopoietic Genomics Research Centre Chonnam National University Hwasun Hospital Hwasun-gun Korea Republic of (South) Departments of Laboratory Medicine Chonnam National Univ. Hwasun Hosp. Hwasun-gun South Korea Chonnam National Univ. Hwasun Hospital Hwasun-Gun KOR Samsung Medical Center Seoul KOR Soonchunhyang University Bucheon Hospital Bucheon Korea Republic of (South) Department of Molecular Genetics University of Toronto Toronto Canada Blood and Marrow Transplant Program Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University Health Network Toronto Canada

271

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Fluorescence quenching kinetics of Py excimer in PS films

Fluorescence quenching kinetics of Py excimer in PS films

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2013 MRS Fall Meeting

关键词： Explosives

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Fine control of carbon-polyelectrolyte thin film sensors sensitivity for human motion monitoring

Fine control of carbon-polyelectrolyte thin film sensors sen...

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Fifth Asia International Symposium on Mechatronics (AISM 2015)

作者： S. Seo J. J. Park Y. T. Park Myongji University Seodaemun-gu Seoul KR Department of Chemical and Biomolecular Engineering (BK21+Graduate Program) Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 305-701 Republic of Korea Department of Mechanical Engineering Myongji University 116 Myongji-ro Cheoin-gu Youngin Gyeonggi-do 449-728 Republic of Korea

Carbon nanomaterials have emerged as highly promising nanomaterials for recent thirty years. There have been numerous researches regarding potential applications of carbon nanomaterials due to their outstanding properties which originate from the network of sp2-hybridized carbon atoms. In this regard, it is also reported that a variety of functional composites or hybrid materials with carbon nanomaterials result in novel applications as well as synergistic enhancements in target properties. In this study, multi-functional polymer/graphene nanoplatelet multilayer composite films were fabricated by layer-by-layer assembly. Graphene nanoplatelets (GNPs), two-dimensional carbon nanomaterials provide not only excellent electrical conductivity but barrier property for gas molecules. Layer-by-layer assembly is a simple, inexpensive bottom-up techniques for multilayer film deposition with easy control of inner structures. In this study, transparent conductor for next generation flexible electronics was considered as a potential application of layer-by-layer assembled polymer/GNP multilayer composites films. GNP coating on thin polymer substrates was expected to be applicable to flexible display applications, while metal oxides such as indium tin oxide have a limitation due to its mechanical fragility. Thus, electrically conductive layer-by-layer assembled GNP films which shows gas barrier property as well as mechanical flexibility could be fabricated with low material and processing cost. Though thermal annealing and acid treatment on GNP films effectively lowered the sheet resistance of the films, their transmittance and sheet resistance still need to improve further to be used as transparent conductors for flexible display applications. Meanwhile, further efforts must be focused on the possibility of other applications.

关键词： Carbon nanotube Conductive electrode Graphene Layer-by-layer (LbL) self-assembly Strain sensor Surface resistance fine control graphene Carbon Nanotubes BARRIER PROPERTIES economic indicators flexible displays Carbon Nanomaterials strain sensors thin film sensors functional composite material assemblies multilayers Composite films

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The studies of short-chain phosphatidylcholine effect on the spontaneous lipid transfer in phospholipid-based vesicles using differential scanning calorimetry

The studies of short-chain phosphatidylcholine effect on the...

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Student Poster Sessions 2014 - Core programming Area at the 2014 AIChE Annual Meeting

作者： Charubin, Kamil Xia, Yan Nieh, Mu-Ping Department of Chemical and Biomolecular Engineering University of Connecticut StorrsCT United States Polymer Program Institute of Material Science University of Connecticut CT United States Department of Biomedical Engineering University of Connecticut CT United States

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