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Proposed clinical application for tuning fuzzy logic controller of artificial pancreas utilizing a personalization factor

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Journal of Diabetes science and Technology 2010年第4期4卷 913-922页

作者： Mauseth, Richard Wang, Youqing Dassau, Eyal Kircher Jr., Robert Matheson, Donald Zisser, Howard Jovanovič, Lois Doyle III, Francis J. Division of Pediatric Endocrinology Department of Pediatrics University of Washington Seattle WA United States Seattle Collaborative Group Seattle WA United States Department of Chemical Engineering University of California Santa Barbara CA United States Biomolecular Science and Engineering Program University of California Santa Barbara CA United States Sansum Diabetes Research Institute Santa Barbara CA United States

Background: Physicians tailor insulin dosing based on blood glucose goals, response to insulin, compliance, lifestyle, eating habits, daily schedule, and fear of and ability to detect hypoglycemia. Method: We introduce a method that allows a physician to tune a fuzzy logic controller (FLC) artificial pancreas (AP) for a particular patient. It utilizes the physician's judgment and weighing of various factors. The personalization factor (PF) is a scaling of the dose produced by the FLC and is used to customize the dosing. The PF has discrete values of 1 through 5. The proposed method was developed using a database of results from 30 University of Virginia/Padova Metabolic Simulator in silico subjects (10 adults, 10 adolescents, and 10 children). Various meal sizes and timing were used to provide the physician information on which to base an initial dosing regimen and PF. Future decisions on dosing aggressiveness using the PF would be based on the patient's data at follow-up. Results: Three examples of a wide variation in diabetes situations are given to illustrate the physician's thought process when initially configuring the AP system for a specific patient. Conclusions: Fuzzy logic controllers are developed by encoding human expertise into the design of the controller. The FLC methodology allows for the real-time scaling of doses without compromising the integrity of the dosing rules matrix. The use of the PF to individualize the AP system is enabled by the fuzzy logic development methodology. © Diabetes Technology Society.

关键词： Artificial pancreas Diabetes Fuzzy logic Personalization Physician method

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Urchin‐Shaped Manganese Oxide Nanoparticles as pH‐Responsive ActivatableT1Contrast Agents for Magnetic Resonance Imaging†

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Angewandte Chemie 2011年第45期123卷

作者： Taekhoon Kim Eun‐Jin Cho Youngjoo Chae Minsik Kim Aram Oh Juhong Jin Eun‐Sook Lee Hionsuck Baik Seungjoo Haam Jin‐Suck Suh Yong‐Min Huh Kwangyeol Lee Department of Chemistry Korea University Seoul 136‐701 (Korea) Program for Nanomedical Science and Technology Yonsei University (Korea) Department of Radiology & Department of Biochemistry and Molecular Biology Yonsei University (Korea) YUHS‐KRIBB Medical Convergence Research Institute Yonsei University Seoul 120‐752 (Korea) Korea Basic Science Institute (KBSI) Seoul 136‐713 (Korea) Department of Chemical and Biomolecular Engineering Yonsei University Seoul 120‐749 (Korea) Severance Biomedical Science Institute Yonsei University (Korea)

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Contribution of space charges to the polarization of ferroelectric superlattices and its effect on dielectric properties

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Physical Review B 2010年第9期82卷 094115-094115页

作者： M. B. Okatan I. B. Misirlioglu S. P. Alpay Materials Science and Engineering Program Department of Chemical Materials and Biomolecular Engineering University of Connecticut Storrs Connecticut 06269 USA Faculty of Engineering and Natural Sciences Sabancı University Tuzla-Orhanlı 34956 Istanbul Turkey Department of Physics University of Connecticut Storrs Connecticut 06269 USA

A theoretical model is developed for ferroelectric bilayers and multilayer heterostructures that employs a nonlinear Landau-Devonshire formalism coupled with a detailed analysis of the depolarizing fields arising from the polarization mismatch across interlayer interfaces and the electrical fields of localized space charges at such interfaces. We first present how space charges alter the free-energy curves of ferroelectrics and then proceed with a numerical analysis for heteroepitaxial (001) PbTiO3-SrTiO3 (PTO-STO) bilayers and (001) superlattice structures on (001) STO substrates. The switchable (ferroelectric) and nonswitchable (built-in) polarizations and the dielectric properties of PTO-STO bilayers and superlattices are calculated as a function of the planar space-charge density and the volume fraction of the PTO layer. Similar to the temperature dependence of a monolithic ferroelectric, there exists a critical volume fraction PTO below which the bilayer or the superlattice is in the paraelectric state. This critical volume fraction is strongly dependent on the density of trapped charges at the interlayer interfaces. For charge-free (001) PTO-STO heteroepitaxial bilayer and superlattices, the critical fraction is 0.40 for both constructs but increases to 0.6 and 0.72, for the bilayer and the superlattice, respectively, for a planar space-charge density of 0.05 C/m2. Furthermore, our results show that close to the vicinity of ferroelectric-paraelectric phase transition, there is a recovery in ferroelectric polarization. The dielectric-response calculations verify that there is sharp ferroelectric phase transformation for charge-free bilayers and superlattices whereas it is progressively smeared out with an increase in the charge density. Furthermore, our analysis shows that the dielectric constant of these multilayers at a given volume fraction of PTO decreases significantly in the presence of space charges.

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Guest Editorial

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Integrated Ferroelectrics 2010年第1期111卷 1-2页

作者： Cole, M.W. Alpay, S.P. Fuentes Cobas, L. Ivill, M. U.S. Army Research Laboratory WMRD Rodman Materials Research Laboratory Aberdeen Proving Ground MD United States Materials Science and Engineering Program Department of Chemical Materials and Biomolecular Engineering University of Connecticut Storrs CT United States Complejo Industrial Chihuahua Chihuahua Mexico

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Back Cover: Enhancement of Donor–Acceptor Polymer Bulk Heterojunction Solar Cell Power Conversion Efficiencies by Addition of Au Nanoparticles (Angew. Chem. Int. Ed. 24/2011)

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Angewandte Chemie International Edition 2011年第24期50卷

作者： Dong Hwan Wang Do Youb Kim Kyeong Woo Choi Dr. Jung Hwa Seo Dr. Sang Hyuk Im Prof. Jong Hyeok Park Prof. O Ok Park Prof. Alan J. Heeger Center for Polymers and Organic Solids University of California at Santa Barbara Santa Barbara CA 93106 (USA) Fax: (+1) 805-893-4755 Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (BK 21 Graduate Program) 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 (Republic of Korea) Fax: (+82) 42-350-3910 KRICT-RPFL Global Research Laboratory Advanced Materials Division Korea Research Institute of Chemical Technology Daejeon (Republic of Korea) School of Chemical Engineering and SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon 440-746 (Republic of Korea) Fax: (+82) 31-290-7272 Jong Hyeok Park School of Chemical Engineering and SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon 440-746 (Republic of Korea) Fax: (+82) 31-290-7272 O Ok Park Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (BK 21 Graduate Program) 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 (Republic of Korea) Fax: (+82) 42-350-3910 Alan J. Heeger Center for Polymers and Organic Solids University of California at Santa Barbara Santa Barbara CA 93106 (USA) Fax: (+1) 805-893-4755

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Enhancement of Donor–Acceptor Polymer Bulk Heterojunction Solar Cell Power Conversion Efficiencies by Addition of Au Nanoparticles†

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Angewandte Chemie 2011年第24期123卷

作者： Dong Hwan Wang Do Youb Kim Kyeong Woo Choi Jung Hwa Seo Sang Hyuk Im Jong Hyeok Park O Ok Park Alan J. Heeger Center for Polymers and Organic Solids University of California at Santa Barbara Santa Barbara CA 93106 (USA) Fax: (+1) 805‐893‐4755 Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (BK 21 Graduate Program) 373‐1 Guseong‐dong Yuseong‐gu Daejeon 305‐701 (Republic of Korea) Fax: (+82) 42‐350‐3910 KRICT‐RPFL Global Research Laboratory Advanced Materials Division Korea Research Institute of Chemical Technology Daejeon (Republic of Korea) School of Chemical Engineering and SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon 440‐746 (Republic of Korea) Fax: (+82) 31‐290‐7272

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Rücktitelbild: Enhancement of Donor–Acceptor Polymer Bulk Heterojunction Solar Cell Power Conversion Efficiencies by Addition of Au Nanoparticles (Angew. Chem. 24/2011)

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Angewandte Chemie 2011年第24期123卷

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Adaptive Control Algorithm for a Rapid and Slow Acting Insulin Therapy Following Run-to-run Methodology

Adaptive Control Algorithm for a Rapid and Slow Acting Insul...

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American Control Conference

作者： F. Campos-Cornejo D.U. Campos-Delgado Eyal Dassau Howard Zisser Lois Jovanovic F. J. Doyle Facultad de Ingenieria CIEP UASLP S.L.P. Mexico Facultad de Ciencias UASLP S.L.P. Mexico Department of Chemical Engineering and Biomolecular Science & Engineering Program University of California Santa Barbara and Sansum Diabetes Research Institute Santa Barbara Department of Chemical Engineering University of California Santa Barbara and Sansum Diabetes Research Institute Santa Barbara

ISBN: (纸本)9781424474264

An adaptive scheme is developed to automatically adjust the insulin dosing protocol for a person with type 1 diabetes mellitus. The adaptive strategy follows the run-to-run philosophy with a multiple-daily injections (MDI) therapy. Insulin lispro (rapid acting) and insulin glargine (slow acting) are employed in the protocol which uses pre and postprandial glucose concentrations. The key information for the synthesis of the control algorithm is the subject's insulin sensitivity that is calculated considering that there is no previous information about the subject's response to the insulin protocol. Therefore, the sensitivity information is estimated recursively using online data in a time scale of days. After the sensitivity is recalculated, the run-to-run correction scheme is updated, obtaining an adaptive MDI therapy. The advisory algorithm is evaluated in silico by constant random parameters variations and superimposing sinusoidal oscillations on glucose-insulin model parameters to implement intra-individual variability of the glucoregulatory system. For this purpose, the glucose-insulin model developed by Dalla Man et al. (2007) and subcutaneous insulin absorption description by Tarin et al. (2005) were employed. The results show that the algorithm is successful in achieving an euglycemic control despite variable meals (+-15percent variation in carbohydrate content and timing +-15 min) and time-varying parametric variations in the glucose-insulin model. No severe hypoglycemic (< 50 mg/dL) or hyperglycemic (> 180 mg/dL) events were observed in average for 30 virtual patients.

关键词： Computer algorithms time scales insulin replacement therapy parameter variation Insulin Glargine Type 1 Diabetes Mellitus adaptive control Insulin Insulins Self tuning

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Defining the syntax for self-assembling RNA tertiary architectures.

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Nucleic acids symposium series (2004) 2009年第53期53卷 83-84页

作者： Jaeger, Luc Chemistry and Biochemistry Department Biomolecular Science and Engineering Program University of California Santa Barbara 93106-9510 CA United States

Stable RNAs are modular and hierarchical three-dimensional (3D) architectures taking advantage of recurrent structural motifs to form extensive non-covalent tertiary interactions (1, 2). Using comparative sequence and structural analysis of known X-ray structures of RNAs, folding and assembly principles of RNA can presently be gathered to generate the syntax of a proto-language for rational design and prediction of RNA 3D shapes. RNA architectonics refers to the deciphering of this proto-language and to its use to build new functional RNA shapes with self-assembly properties (3-5). This approach can therefore contribute to the prediction and rational design of RNA tertiary structures for potential applications in nanotechnology, synthetic biology and medicine.

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Synthesis of an AIE-active fluorogen and its application in cell imaging

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science China Chemistry 2009年第1期52卷 15-19页

作者： LAM Jacky Wing Yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian Department of Chemistry The Hong Kong University of Science & Technology (HKUST) Clear Water Bay Department of Chemical and Biomolecular Engineering HKUST Clear Water Bay Bioengineering Graduate Program HKUST Clear Water Bay

A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.

关键词： aggregation-induced emission biosensor cell imaging

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