Self-assembly or bottom-up techniques based on molecular recognition are attracting a great deal of interest for nanofabrication. One such technology is based on the use of self-assembling tecto-RNA that has been show...
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There is a significant push to develop closed-loop control systems to deliver insulin for type 1 diabetic subjects. As part of this process, mathematical models are required to test and validate the proposed algorithm...
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A dual-rate Kalman filter is developed for realtime continuous glucose monitoring. Frequent (5 minute) sampling of a noisy, continuous glucose sensor is used for estimation of glucose and its rate-of-change. Infrequen...
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A dual-rate Kalman filter is developed for realtime continuous glucose monitoring. Frequent (5 minute) sampling of a noisy, continuous glucose sensor is used for estimation of glucose and its rate-of-change. Infrequent (8 hour intervals) reference glucose meter samples enable the sensor gain and its rate-of-change to be updated. The dual-rate Kalman filter formulation accounts for uncertainty in both the continuous glucose sensor and the reference glucose meter. The method is tested on simulated and experimental data, confirming its superiority to simple one-point calibration
There is a significant push to develop closed-loop control systems to deliver insulin for type 1 diabetic subjects. As part of this process, mathematical models are required to test and validate the proposed algorithm...
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There is a significant push to develop closed-loop control systems to deliver insulin for type 1 diabetic subjects. As part of this process, mathematical models are required to test and validate the proposed algorithms. There are several published physiology-based models of glucose and insulin dynamics in the literature, however, all of them were derived using data from subjects without diabetes. For this particular study we have selected one of the recently published models, by Hovorka et al., replacing the subcutaneous insulin infusion model with the one described by Wilinska et al., Five subjects with type 1 diabetes underwent a hyperinsulinemic-euglycemic clamp with a meal challenge and corresponding subcutaneous insulin bolus. The data collected were used to fit the model parameters using global optimization methods. Our results show that the model is capable of describing the observed dynamics for type 1 subjects under the experimental conditions, and as such can be used to simulate subject behavior under the experimental conditions
A versatile molecular system based on RNA allows construction of a large library of programmable, self-assembling jigsaw pieces called tectosquares, which are square in shape and that are designed with a variety of st...
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作者：
Lu SunLei ZhuLixia RongBenjamin S. HsiaoPolymer Program
Institute of Materials Science and Department of Chemical Materials and Biomolecular Engineering University of Connecticut Storrs CT 06269‐3136 USA Fax: (+1) 860‐486‐4745 http://www.ims.uconn.edu/∼lzhu Department of Chemistry
State University of New York at Stony Brook Stony Brook NY 11794‐3400 USA
We analyze the interaction of two conducting, charged polymer chains in solution using a minimal model for their electronic degrees of freedom. We show that a crossing of the two chains in which the polymers pass with...
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We analyze the interaction of two conducting, charged polymer chains in solution using a minimal model for their electronic degrees of freedom. We show that a crossing of the two chains in which the polymers pass within angstroms of each other leads to a decrease of the electronic energy of the combined system that is significantly larger than the thermal energy and thus promotes interchain aggregation. We consider the competition of this attractive interaction with the screened electrostatic repulsion and thereby propose a phase diagram for such polymers in solution; depending on the charge density and persistence length of the chains, the polymers may be unbound, bound in loose, braidlike structures, or tightly bound in a parallel configuration.
Through investigation of transient phase characteristics, a methodology is developed to optimize the phase resetting properties of robust nonlinear biological oscillators;in particular, those of the circadian rhythm. ...
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