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CLEO: QELS_Fundamental science, QELS 2022

作者： Jerome, Bryant Prasad, Ciril S. Doumani, Jacques Dewey, Oliver S. Baydin, Andrey Pasquali, Matteo Kono, Junichiro Gao, Weilu Alabastri, Alessandro Naik, Gururaj V. Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Chemical and Biomolecular Engineering Rice University HoustonTX77005 United States Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Chemistry Rice University HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Electrical and Computer Engineering University of Utah Salt Lake CityUT84112 United States

Aligned carbon nanotube films make an excellent hyperbolic material platform in the infrared. Here, we experimentally demonstrate the presence of high-k modes in aligned carbon nanotube films and outcouple them to fre... 详细信息

ISBN: (纸本)9781557528209

关键词： Carbon films

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E-DNA scaffold sensors and the reagentless, single- step, measurement of HIV-diagnostic antibodies in human serum

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Microsystems & Nanoengineering 2020年第1期6卷 1141-1148页

作者： Claudio Parolo Ava S.Greenwood Nathan E.Ogden Di Kang Chase Hawes Gabriel Ortega Netzahualcoyotl Arroyo-Curras Kevin W.Plaxco Department of Chemistry and Biochemistry University of CaliforniaSanta BarbaraSanta BarbaraCAUSA Department of Materials University of CaliforniaSanta BarbaraSanta BarbaraCAUSA Department of Pharmacology and Molecular Sciences Johns Hopkins School of MedicineBaltimoreMD 21205USA Interdepartmental Program in Biomolecular Science and Engineering University of CaliforniaSanta BarbaraSanta BarbaraCA 93106USA

The multiplexed,point-of-care measurement of specific antibodies could improve the speed with which diseases are diagnosed and their treatment *** this end,we are developing E-DNA scaffold sensors,which consist of a rigid,nucleic acid“scaffold”attached on one end to an electrode and presenting both a redox reporter and an epitope on the *** the absence of antibody,the reporter efficiently transfers electrons when interrogated ***-induced steric hindrance limits movement,reducing electron transfer in a manner that is both easily measured and quantitatively related to target *** we have used monoclonal antibodies to explore the analytical performance of E-DNA sensors,showing that they support the rapid,single-step,quantitative detection of multiple antibodies in small volume ***,in contrast,we employ authentic human samples to better explore the platform’s clinical ***,we developed E-DNA sensors targeting three HIV-specific antibodies and then compared the analytical and clinical performance of these against those of gold standard serological *** so we find that,although the multistep amplification of an ELISA leads to a lower detection limits,the clinical sensitivity of ELISAs,E-DNA sensors and lateral-flow dipsticks are indistinguishable across our test *** thus appears that,by merging the quantitation and multiplexing of ELISAs with the convenience and speed of dipsticks,E-DNA scaffold sensors could significantly improve on current serological practice.

关键词： antibodies attached initiated

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Spatiotemporal multi-omics:exploring molecular landscapes in aging and regenerative medicine

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Military Medical Research 2025年第4期12卷 528-566页

作者： Liu-Xi Chu Wen-Jia Wang Xin-Pei Gu Ping Wu Chen Gao Quan Zhang Jia Wu Da-Wei Jiang Jun-Qing Huang Xin-Wang Ying Jia-Men Shen Yi Jiang Li-Hua Luo Jun-Peng Xu Yi-Bo Ying Hao-Man Chen Ao Fang Zun-Yong Feng Shu-Hong An Xiao-Kun Li Zhou-Guang Wang Affiliated Cixi Hospital Wenzhou Medical UniversityNingbo 315300ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina National Key Laboratory of Macromolecular Drug Development and Manufacturing School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina State Key Laboratory of Bioelectronics School of Biological Science&Medical EngineeringSoutheast UniversityNanjing 210096China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510515China Department of Human Anatomy Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000ShandongChina Integrative Muscle Biology Laboratory Division of Regenerative and Rehabilitative SciencesUniversity of Tennessee Health Science CenterMemphisTN 38163United States Key Laboratory for Laboratory Medicine Ministry of EducationZhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui Hospital of Zhejiang UniversityLishui 323000ZhejiangChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 324025ZhejiangChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program NUS Center for Nanom

Aging and regeneration represent complex biological phenomena that have long captivated the scientific *** fully comprehend these processes,it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal *** omics methodologies,such as genomics and transcriptomics,have been instrumental in identifying critical molecular facets of aging and ***,these methods are somewhat limited,constrained by their spatial resolution and their lack of capacity to dynamically represent tissue *** advent of emerging spatiotemporal multi-omics approaches,encompassing transcriptomics,proteomics,metabolomics,and epigenomics,furnishes comprehensive insights into these intricate molecular *** sophisticated techniques facilitate accurate delineation of molecular patterns across an array of cells,tissues,and organs,thereby offering an in-depth understanding of the fundamental mechanisms at *** review meticulously examines the significance of spatiotemporal multi-omics in the realms of aging and regeneration *** underscores how these methodologies augment our comprehension of molecular dynamics,cellular interactions,and signaling ***,the review delineates the foundational principles underpinning these methods,followed by an evaluation of their recent applications within the *** review ultimately concludes by addressing the prevailing challenges and projecting future advancements in the ***,spatiotemporal multi-omics are instrumental in deciphering the complexities inherent in aging and regeneration,thus charting a course toward potential therapeutic innovations.

关键词： Spatiotemporal multi-omics Aging and regeneration Cellular interactions Innovative therapeutic strategies

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Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei Guo Weizhi Xu Xin Xue Guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

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Giant Deep-Ultraviolet Circular Dichroism in Synthetic Architectures of Ordered Carbon Nanotubes

Giant Deep-Ultraviolet Circular Dichroism in Synthetic Archi...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Doumani, Jacques Lou, Minhan Dewey, Oliver Hong, Nina Fan, Jichao Baydin, Andrey Pasquali, Matteo Yomogida, Yohei Yanagi, Kazuhiro Saito, Riichiro Kono, Junichiro Gao, Weilu Department of Electrical and Computer Engineering Rice University HoustonTX United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX United States Department of Electrical and Computer Engineering The University of Utah Salt Lake CityUT United States Carbon Hub Rice University HoustonTX United States Department of Chemical and Biomolecular Engineering Rice University HoustonTX United States J.A. Woollam Co. LincolnNE United States The Smalley-Curl Institute Rice University HoustonTX United States Department of Chemistry Rice University HoustonTX United States Department of Materials Science and NanoEngineering Rice University HoustonTX United States Department of Physics and Astronomy Tokyo Metropolitan University Tokyo Japan Department Physics Tohoku University Sendai Japan Department Physics and Astronomy Rice University HoustonTX United States

We demonstrate tunable, giant, and structure-induced deep-ultraviolet circular dichroism in macroscopically chiral assemblies of racemic carbon nanotubes prepared using two approaches: mechanical-rotation-assisted vac... 详细信息

ISBN: (纸本)9781957171258

关键词： Dichroism

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Controlling assembly and oscillations of elastic membranes with an active fluid

arXiv

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arXiv 2024年

作者： Berezney, John Ray, Sattvic Kolvin, Itamar Bowick, Mark Fraden, Seth Dogic, Zvonimir Department of Physics Brandeis University WalthamMA02454 United States Department of Physics University of California at Santa Barbara Santa BarbaraCA93106 United States School of Physics Georgia Institute of Technology 837 State St NW AtlantaGA30332 United States Kavli Institute of Theoretical Physics University of California at Santa Barbara Santa BarbaraCA93106 United States Biomolecular Science and Engineering Program University of California at Santa Barbara Santa BarbaraCA93106 United States

We use the chaotic flows generated by a microtubule-based active fluid to assemble self-binding actin filaments into a thin elastic sheets. Starting from a uniformly dispersed state, active flows drive the motion of actin filaments, inducing their bundling and formation of bundle-bundle connections that ultimately generate an elastic network. The emerging network separates from the active fluid to form a thin elastic sheets suspended at the sample midplane. At intermediate times, the active fluid drives large in-plane and out-of-plane deformations of the elastic sheet which are driven by low-energy bending modes. Self-organized sheets eventually exhibit centimeter-sized global spontaneous oscillations and traveling waves, despite being isotropically driven on micron lengths by the active fluid. The active assembly generates diverse network structures which are not easily realizable with conventional paradigms of equilibrium self-assembly and materials processing. Self-organized mechanical sheets pose a challenge for understanding of how a hierarchy of structure, mechanics, and dynamics emerges from a largely structureless initial suspension of active and passive microscopic components. © 2024, CC BY.

关键词： Self assembly

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Machine Learning Prediction on the Fractional Free Volume of Polymer Membranes

SSRN

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SSRN 2022年

作者： Tao, Lei He, Jinlong Arbaugh, Tom McCutcheon, Jeffrey R. Li, Ying Department of Mechanical Engineering University of Connecticut StorrsCT06269 United States Department of Physics Wesleyan University MiddletownCT06459 United States Department of Chemical & Biomolecular Engineering Center for Environmental Sciences and Engineering University of Connecticut StorrsCT06269 United States Polymer Program Institute of Materials Science University of Connecticut StorrsCT06269 United States Department of Mechanical Engineering University of Wisconsin-Madison MadisonWI53706 United States

Fractional free volume (FFV) characterizes the microstructural level features of polymers and affects their properties including thermal, mechanical, and separation performance. Experimental measurements and theoretical analyses have been used to quantify the FFV of polymers, but challenges remain because of their limitations. Experimental measurements are laborious and based on semi-empirical equations, while Bondi’s group contribution theory involves ambiguities like the determination of van der Waals volume and the choice of factor values in the theoretical equation. To efficiently evaluate the FFV of polymers, this study utilizes high-throughput molecular dynamics (MD) simulations to build a large dataset regarding polymer’s FFV. Based on this large dataset, we further build machine learning (ML) models to establish the composition-structure relation. Inspired by group contribution theory which correlates polymer’s functional groups to FFV, our ML models correlate polymer’s sub-structures or physico-chemical indexes to FFV. Our study first benchmarks the MD simulation protocol to obtain reliable FFV of polymers and then carries out high-throughput MD simulations for more than 6,500 homopolymers and 1,400 polyamides. Such a large and diverse dataset makes the well-trained ML models more generalizable, compared with the group contribution theory. The efficiency of a feed-forward neural network model is further demonstrated by applying it to a hypothetical polyimide dataset of more than 8 million chemical structures. The predicted FFVs of hypothetical polyimides are further validated by MD simulations. The obtained FFVs of the 8 million polymers, plus their previously reported gas separation performances, demonstrate the promising capability of ML virtual screening for the discovery of polymer membranes with exceptional permeability/selectivity. © 2022, The Authors. All rights reserved.

关键词： Molecular dynamics

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Polyether Sulfone Membrane Surface Modification by Electrospun Polysulfone Hybrid Nanocomposite Fibers for Separating Oil/Water Emulsion

SSRN

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SSRN 2022年

作者： Ponnamma, Deepalekshmi Elgawady, Yara Hassan, Mohamed K. Adham, Samer Al-Maas, Mashael Alamgir, Karim Al-Maadeed, Mariam Al Ali Center for Advanced Materials Qatar University P. O. Box 2713 Doha Qatar ConocoPhilips Global Water Sustainability Center Qatar Science and Technology Park Doha Qatar Department of Chemical & Biomolecular Engineering University of Houston S222 Engineering Bldg 1 4726 Calhoun Rd HoustonTX77204 United States Materials Science and Technology Program Qatar University P. O. Box 2713 Doha Qatar

Electrospun fibers of polysulfone (PSf)/iron oxide (FeO)/halloysite nanotubes (HNT) nanocomposite was applied to modify the polyether sulfone (PES) standard membrane support surface for developing highly efficient oil/water emulsion separating membranes. This facile and simple spinning process for shorter periods ensured nanocomposite coatings on the standard PES membranes and allows better oil/water separation process. Moderate hydrophilicity of the membranes results in the higher permeate flux and quicker separation performance. Good regeneration ability and separation performance were achieved for the mechanically stronger membranes as proved from the ultrafiltration and mechanical testing methods. The surface contact angle values are investigated for the hydrophilic nature of the membranes and the under oil angle values show promising results. © 2022, The Authors. All rights reserved.

关键词： Emulsification

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Controlling the size and adhesion of DNA droplets using surface-active DNA molecules

arXiv

引用

arXiv 2023年

作者： Gao, Daqian Wilken, Sam Nguyen, Anna Abraham, Gabrielle R. Liedl, Tim Saleh, Omar A. Physics Department University of California Santa BarbaraCA93106 United States Institute of Collaborative Biotechnologies University of California Santa BarbaraCA93106 United States Biomolecular Science & Engineering Program University of California Santa BarbaraCA93106 United States Department für Physik Ludwig-Maximilians-Universität München80539 Germany Materials Department University of California Santa BarbaraCA93106 United States

Liquid droplets of biomolecules serve as organizers of the cellular interior and are of interest in biosensing and biomaterials applications. Here, we investigate means to tune the interfacial properties of a model biomolecular liquid consisting of multi-armed DNA'nanostar' particles. We find that long DNA molecules that have binding affinity for the nanostars are preferentially enriched on the interface of nanostar droplets, thus acting as surfactants. Fluorescent measurements indicate that, in certain conditions, the interfacial density of the surfactant is around 20 per square micron, indicative of a sparse brush-like structure of the long, polymeric DNA. Increasing surfactant concentration leads to decreased droplet size, down to the sub-micron scale, consistent with arrest of droplet coalescence by the disjoining pressure created by the brush-like surfactant layer. Added DNA surfactant also keeps droplets from adhering to both hydrophobic and hydrophilic solid surfaces, apparently due to this same disjoining effect of the surfactant layer. We thus demonstrate control of the size and adhesive properties of droplets of a biomolecular liquid, with implications for basic biophysical understanding of such droplets, as well as for their applied use. Copyright © 2023, The Authors. All rights reserved.

关键词： DNA

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Deterministic synthesis of phase pure 2D perovskites via progressive transformation of layer thickness

arXiv

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arXiv 2022年

作者： Hou, Jin Li, Wenbin Zhang, Hao Sidhik, Siraj Blancon, Jean-Christophe Even, Jacky Kanatzidis, Mercouri G. Mohite, Aditya D. Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Department of Chemical and Biomolecular Engineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley‐Curl Institute Rice University HoustonTX77005 United States INSA de Rennes CNRS UMR 6082 Rennes35708 France Department of Chemistry Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States

Two-dimensional (2D) halide perovskites have emerged as semiconductor platforms for realizing efficient and durable optoelectronic devices. However, the reproducible synthesis of 2D perovskite crystals with desired layer thickness (or n value) greater than 2, has been an enduring challenge due to the lack of kinetic control (temperature, time, stoichiometry) for each layer thickness. Here, we demonstrate a novel method term as the kinetically controlled space confinement (KCSC) for the deterministic growth of phase pure Ruddlesden-Popper (RP) and Dion-Jacobson (DJ) 2D perovskites. The phase-pure growth was achieved by progressively increasing the temperature (fixed time) or the crystallization time (fixed temperature), which allowed for an acute control of the crystallization kinetics. We also observe a systematic transformation from a lower n-value to n=3, 4, 5, 6 in 2D perovskites. In-situ photoluminescence spectroscopy and imaging suggest that the progressive transformation from lower to higher n-value occurs via intercalation of excess precursor ions. These experiments enabled the development of a machine learning assisted multi-parameter phase diagram, which predicts the growth of 2D phase with a specific n-value. © 2022, CC BY.

关键词： Perovskite

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