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A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs

BIOCELL 2024年第4期48卷 541-557页

作者： JHILAM PRAMANIK AKASH KUMAR SARVESH RUSTAGI MEHAK KATYAL SHEETAL THAKUR JUTISHNA BORA SUMIRA MALIK ANCHAL TREHAN NAYAN TALUKDAR PETR SLAMA Department of Food Technology ITM UniversityGwaliorIndia Department of Food Technology SRM UniversitySonipatIndia Department of Food Technology Uttaranchal UniversityDehradunIndia Department of Nutrition and Dietetics Manav Rachna International Institute of Research&Studies(MRIIRS)FaridabadIndia University Centre for Research and Development UIBTChandigarh UniversityMohaliIndia Amity institute of Biotechnology Amity UniversityJharkhandRanchiIndia Department of Biotechnology University Center for Research&Development(UCRD)Chandigarh UniversityMohaliPunjabIndia Department of Science Guru Nanak College of Pharmaceutical SciencesDehradunIndia Program of Biotechnology Faculty of ScienceAssam down town UniversityGuwahatiIndia Department of Animal Morphology Physiology and GeneticsMendel University in BrnoBrnoCzech Republic

Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods,pharmaceutical products as well as in the environmental and medicalﬁ***,these secondary metabolites obtained from plants are in low amounts,and it is difﬁcult to synthesize them at the industrial *** these challenges,they may be utilized for a variety of medicinal products that are either available in the market or are being researched and *** metabolites are complex compounds that exhibit ***,under controlled conditions with elicitors,desired secondary metabolites may be produced from plant cell *** review emphasizes the various aspects of secondary metabolites including their types,synthesis,and applications as medicinal *** article aims to promote the use of plant secondary metabolites in the management and treatment of various diseases.

关键词： Secondary metabolites Medicinal plant Synthesis Health benefits

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7S,8R-Dihydroxydeepoxysarcophytoxide: A natural dihydrofuranocembranoid from the octocoral Sarcophyton stellatum

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Phytochemistry Letters 2024年 63卷 14-17页

作者： Sheu, Jyh-Horng Zheng, Li-Guo Chen, You-Ying Chien, Su-Ying Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Chinese Medicine Research and Development Center China Medical University Hospital National Museum of Marine Biology and Aquarium Instrumentation Center National Taiwan University Graduate Institute of Natural Products Kaohsiung Medical University Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University

Chemical screening of the octocoral Sarcophyton stellatum led to the isolation of a natural dihydrofuranocembranoid, 7S,8R-dihydroxydeepoxysarcophytoxide (1). Single-crystal X-ray diffraction analysis was conducted to determine the absolute configuration of 1, and its structure was confirm using two-dimensional NMR experiments and a literature review. Dihydrofuranocembranoid 1 actively enhanced alkaline phosphatase activity. © 2024 Phytochemical Society of Europe

关键词： Absolute configuration Alkaline phosphatase Dihydrofuranocembranoid Sarcophytoxide

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Genome-wide identification and characterization of ACBP gene family in Populus reveal salinity alkali-responsive profiles

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Journal of Forestry research 2023年第2期34卷 481-496页

作者： Yu Chang Xinru Xu Hongxia Zheng Hao Xie Bo Li Sixue Chen Ying Li Shaojun Dai Key Laboratory of Saline-Alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationCollege of Life SciencesNortheast Forestry UniversityHarbin 150040People’s Republic of China Development Center of Plant Germplasm Resources College of Life SciencesShanghai Normal UniversityShanghai 200234People’s Republic of China Department of Biology Genetics InstitutePlant Molecular and Cellular Biology ProgramInterdisciplinary Center for Biotechnology ResearchUniversity of FloridaGainesvilleFloridaUSA

Acyl-CoA-binding proteins(ACBPs)are important for the transport of acyl groups for macro molecular biosynthesis involved in plant growth,development,and diverse stress(e.g.,cold,drought,salinity,and heavy metals)***,we report the phylogeny and characteristics of the ACBP family in the woody plant Populus *** genes encoding ACBP proteins were identified,and they are distributed on eight chromosomes in *** PtACBP genes were divided into four subgroups according to gene structure,conserved motifs and phylogenetic *** analysis revealed that cis-elements were related to stress response,phytohormone response,and physical and reproductive growth *** levels of PtACBP genes varied among different organs,with the highest expression in leaves and the lowest in *** real-time PCR(qRT-PCR)analysis showed that under salinity-alkali stresses(i.e.,200 mM NaCl,75 mM Na2CO3,and 100 mM NaHCO3),four(PtACBP1,PtACBP3,PtACBP4 and PtACBP8)of eight PtACBP genes were significantly induced in roots and *** data provide a comprehensive analysis of the ACBPs family in ***,which could be useful for gene function analyses.

关键词： Acyl-CoA-binding proteins(ACBPs) Gene structure Expression pattern Stress response Populus trichocarpa

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Potato protein hydrolysate inhibits RANKL-induced osteoclast development by inhibiting osteoclastogenic genes via the NF-κB/MAPKs signaling pathways

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Environmental Toxicology 2024年第7期39卷 3991-4003页

作者： Chen, Yi-Ju He, Yen-Hua Lo, Yun-Hsin Yang, Hong-Siang Abomughaid, Mosleh Mohammad Kumar, K. J. Senthil Lin, Wan-Teng Department of Surgery Taichung Veterans General Hospital Taichung Taiwan Department of Animal Science and Biotechnology College of Agriculture and Health Tunghai University Taichung Taiwan Department of Food Science College of Agriculture and Health Tunghai University Taichung Taiwan Department of Hospitality Management College of Agriculture and Health Tunghai University Taichung Taiwan Department of Medical Laboratory Sciences College of Applied Medical Sciences University of Bisha Bisha Saudi Arabia Bachelor Program of Biotechnology and Center for General Education National Chung Hsing University Taichung Taiwan Research and Development Division Utopia Holiday Hotel Corporation Taichung Taiwan

In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti-osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor-κB ligand (RANKL), and PP902 was examined for its inhibitory effect. Initially, treatment with PP902 was found to significantly prevent RANKL-induced morphological changes in macrophage cells, as determined by tartrate-resistant acid phosphatase (TRAP) staining analysis. This notion was further supported by F-actin analysis using a confocal microscope. Furthermore, PP902 treatment effectively and dose-dependently down-regulated the expression of RANKL-induced osteoclastogenic marker genes, including TRAP, CTR, RANK, NFATc1, OC-STAMP, and c-Fos. These inhibitory effects were associated with suppressing NF-κB transcriptional activation and subsequent reduced nuclear translocation. The decrease in NF-κB activity resulted from reduced activation of its upstream kinases, including I-κBα and IKKα. Moreover, PP902 significantly inhibited RANKL-induced p38MAPK and ERK1/2 activities. Nevertheless, PP902 treatment prevents RANKL-induced intracellular reactive oxygen species generation via increased HO-1 activity. The combined antioxidant and anti-inflammatory effects of PP902 resulted in significant suppression of osteoclastogenesis, suggesting its potential as an adjuvant therapy for osteoclast-related diseases. © 2024 Wiley Periodicals LLC.

关键词： Genes

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Characterization of a new triaxial nanofiber membrane and osteogenic differentiation capacity of human bone marrow mesenchymal stem cells for bone repair

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Journal of Materials research 2025年第7期40卷 1117-1134页

作者： Altundag-Erdogan, Özlem Çetinkaya, Hayrullah Çelebi-Saltik, Betül Altun, Belgin Şahin, Mehtap Mağden, Gamze Kara Öteyaka, Mustafa Özgür Department of Stem Cell Sciences Graduate School of Health Sciences and Center for Stem Cell Research and Development Hacettepe University Sihhiye Ankara06100 Turkey Department of Chemical Engineering Eskisehir Osmangazi University Eskişehir26040 Turkey Vocational School Health Services Hacettepe University Sihhiye Ankara06100 Turkey BUGAMED Biotechnology Industry and Trade Inc Eskişehir26380 Turkey Eskişehir Vocational School Electronics and Automation Eskisehir Osmangazi University Mechatronic Program Eskişehir26250 Turkey

A triaxial nanofiber membrane was developed using a custom triaxial nozzle during electrospinning. The membrane consisted of three layers (outer middle (PVA-Collagen Type I-BMP-2), and inner (PVA-nHAP)). TEM revealed the diameters of the outer, middle, and inner layers as 167.5, 142.6, and 119.3 nm, respectively. The triaxial nanofiber membrane exhibited superior tensile strength (36 MPa) and elastic modulus (2.5 GPa), along with a roughness of 359 nm and hydrophilic properties. In addition, it demonstrated a 200% swelling ratio and reduced bacterial colonization by 10.8-fold. Both Calcium deposition and ALP activity were significantly higher and increased expression of BSP (eightfold), OCN (13-fold), and OPN (488-fold) genes were observed in membrane + OST groups (p © The Author(s), under exclusive licence to The Materials research Society 2025.

关键词： Bone

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Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis

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RSC Advances 2024年第24期14卷 17195-17201页

作者： Do, Hai Nhat Chen, Yu-Ta Chien, Su-Ying Chen, You-Ying Zhang, Mingzi M. Tsou, Lun Kelvin Chen, Jih-Jung Wen, Zhi-Hong Lo, Yi-Hao Zheng, Li-Guo Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan National Museum of Marine Biology & Aquarium Pingtung944401 Taiwan Department of Family Medicine Zuoying Armed Forces General Hospital Kaohsiung813204 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli350401 Taiwan Department of Pharmacy School of Pharmaceutical Sciences National Yang Ming Chia Tung University Taipei112304 Taiwan Shu-Zen Junior College of Medicine and Management Kaohsiung821004 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung804201 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University Kaohsiung804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807378 Taiwan PhD Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City242062 Taiwan

The chemical screening of an octocoral identifed as Junceella fragilis has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin (5). Single-crystal X-ray diffraction analysis was carried out to determine the absolute configurations of 1 and 2, while the structures of new compounds 4 and 5 were ascertained with 2D NMR experiments. Briaranes 1 and 3-5 were active in enhancing alkaline phosphatase (ALP) activity. © 2024 The Royal Society of Chemistry.

关键词： Metabolites

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In silico analysis of Phlogacanthus thyrsiflorus Nees. and its protective effects against cardiomyopathic stress induced by alloxan in mice model

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Vegetos 2025年 1-10页

作者： Bora, Jutishna Malik, Sumira Lata, Smita Baruah, Taranga Jyoti Rustagi, Sarvesh Ranjan, Himanshu Deshwal, Ravi K. Ramniwas, Seema Talukdar, Nayan Amity Institute of Biotechnology Amity University Jharkhand Ranchi India University Center for Research & Development (UCRD) Chandigarh University NH-05 Chandigarh-Ludhiana Highway Punjab Mohali India Department of Biochemistry Assam Royal Global University Assam Guwahati 781035 India School of Applied and Life Sciences Uttaranchal University Uttarakhand Dehradun 248007 India Shri Ramswaroop Memorial University Deva Road Uttar Pradesh Lucknow 225003 India Marwadi University Research Center Faculty of Sciences Marwadi University Gujarat Rajkot India Program of Biotechnology Faculty of Science Assam down town University Assam Guwahati India

This study aims to evaluate the protective role of Phlogacanthus thyrsiflorus (P. thyrsiflorus) on hyperglycemia induced oxidative stress and apoptosis in the hearts of diabetic mice. Acute toxicity testing and preliminary phytochemical screens were performed on methanolic flower extract (MFE) after it had been prepared. Thereafter, molecular docking was performed. The results identified active compounds which demonstrated strong binding affinity with the selected target proteins involved in oxidative stress under diabetic conditions. Moreover, the oxidative damage in the tissues of the Normal control mice (NCM), Diabetic control mice (DCM), Ascorbic acid-treated Diabetic mice (D + AA), and MFE-treated Diabetic mice (D + MFE) groups were assessed using lipid peroxidation and the protein carbonyl test. The diabetic mice treated with MFE showed a significant reduction in protein carbonyl levels and malondialdehyde (MDA). The effect of MFE on apoptosis was demonstrated by TUNEL enzyme where a few apoptotic cells were shown by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay. Therefore, in diabetic mice, the MFE of P. thyrsiflorus has cardiomyopathy benefits via controlling hyperglycemia-induced oxidative stress and apoptosis. © The Author(s) under exclusive licence to Society for Plant research 2025.

关键词： Alloxan Apoptosis Hyperglycemia Methanolic flower extract Oxidative stress Phlogacanthus thyrsiflorus

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Natural products from the culture broth of an actinobacteria Streptomyces sp. M5205 and evaluation of their antifungal activity

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Phytochemistry Letters 2024年 59卷 59-63页

作者： Chen, Jih-Jung Cheng, Ming-Jen Tseng, Min Wu, Ming-Der Weng, Jing-Ru Department of Pharmacy School of Pharmaceutical Sciences National Yang Ming Chiao Tung University (NYCU) Taipei 112304 Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung 404333 Taiwan Department of Life Science Fu Jen Catholic University New Taipei City 24205 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu 300193 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 80424 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University Kaohsiung 80424 Taiwan

One previously undescribed trinorditerpene analog, M5205 (1), together with four known triterpenes, betulinic acid (2), betulin (3), messagenic acid D (4), and betulonic acid (5), were isolated from the EtOAc extract of the culture broth of the actinomycete Streptomyces sp. M5205. One previously undescribed sesquiterpene analog, M5205 (1), together with four known analogs, betulinic acid (2), betulin (3), messagenic acid D (4), and betulonic acid (5), were isolated from the EtOAc extract of the culture broth of the actinomycete Streptomyces sp. M5205. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that 4 constituents (Compounds 1 & 335) possessed mild antifungal activity against Fusarium sp. LC8, Neopestalotiopsis sp. BCRC 35002, and Colletotrichum gloeosporioides BCRC 35178. It is worth mentioning that the chemical composition of the type strain Streptomyces sp. M5205 has never been studied. © 2023

关键词： Actinobacteria Antifungal Secondary metabolites Sesquiterpene Streptomyces sp. M5205

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Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria

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Computational and Structural biotechnology Journal 2024年 23卷 1477-1488页

作者： Su, Han-Li Lai, Shu-Jung Tsai, Keng-Chang Fung, Kit-Man Lung, Tse-Lin Hsu, Hsing-Mien Wu, Yi-Chen Liu, Ching-Hui Lai, Hui-Xiang Lin, Jiun-Han Tseng, Tien-Sheng Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi City600 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Research Center for Cancer Biology China Medical University Taichung Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Academia Sinica Taipei11529 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung Taiwan Department of Industrial Technology Ministry of Economic Affairs Taipei Taiwan Food Industry Research and Development Institute Hsinchu City Taiwan

Mycobacteria are causative agents of tuberculosis (TB), which is a global health concern. Drug-resistant TB strains are rapidly emerging, thereby necessitating the urgent development of new drugs. Two-component signal transduction systems (TCSs) are signaling pathways involved in the regulation of various bacterial behaviors and responses to environmental stimuli. Applying specific inhibitors of TCSs can disrupt bacterial signaling, growth, and virulence, and can help combat drug-resistant TB. We conducted a comprehensive pharmacophore-based inhibitor screening and biochemical and biophysical examinations to identify, characterize, and validate potential inhibitors targeting the response regulators PhoP and MtrA of mycobacteria. The constructed pharmacophore model Phar-PR-n4 identified effective inhibitors of formation of the PhoP–DNA complex: ST132 (IC50 = 29 ± 1.6 µM) and ST166 (IC50 = 18 ± 1.3 µM). ST166 (KD = 18.4 ± 4.3 μM) and ST132 (KD = 14.5 ± 0.1 μM) strongly targeted PhoP in a slow-on, slow-off manner. The inhibitory potency and binding affinity of ST166 and ST132 for MtrAC were comparable to those of PhoP. Structural analyses and molecular dynamics simulations revealed that ST166 and ST132 mainly interact with the α8-helix and C-terminal β-hairpin of PhoP, with functionally essential residue hotspots for structure-based inhibitor optimization. Moreover, ST166 has in vitro antibacterial activity against Macrobacterium marinum. Thus, ST166, with its characteristic 1,2,5,6-tetrathiocane and terminal sulphonic groups, has excellent potential as a candidate for the development of novel antimicrobial agents to combat pathogenic mycobacteria. © 2024 The Authors

关键词： Antimicrobial agents

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Use of corncob and pineapple peel as associated substrates for biosurfactant production

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Environmental Science and Pollution research 2024年第47期31卷 57973-57988页

作者： Santos, Brenda Lohanny Passos Vieira, Isabela Maria Monteiro Santos, Pablo Omar Lubarino Menezes, Millena Souza de Souza, Roberto Rodrigues Ruzene, Denise Santos Silva, Daniel Pereira Northeastern Biotechnology Network Federal University of Sergipe SE São Cristóvão49100-000 Brazil Center for Exact Sciences and Technology Federal University of Sergipe SE São Cristóvão49100-000 Brazil Graduate Program in Biotechnology Federal University of Sergipe SE São Cristóvão49100-000 Brazil Graduate Program in Intellectual Property Science Federal University of Sergipe SE São Cristóvão49100-000 Brazil CISAS – Center for Research and Development in Agrifood Systems and Sustainability Instituto Politécnico de Viana Do Castelo Viana Do Castelo4900-347 Portugal Department of Production Engineering Federal University of Sergipe Rodovia Marechal Rondon S/N Jardim Rosa Elze Sergipe São Cristóvão49100-000 Brazil

Biosurfactants are amphiphilic biomolecules with promising tensoative and emulsifying properties that find application in the most varied industrial sectors: environment, food, agriculture, petroleum, cosmetics, and hygiene. In the current work, a 23 full-factorial design was performed to evaluate the effect and interactions of pineapple peel and corncob as substrates for biosurfactant production by Bacillus subtilis LMA-ICF-PC 001. In a previous stage, an alkaline pretreatment was applied to corncob samples to extract the xylose-rich hydrolysate. The results indicated that pineapple peel extract and xylose-rich hydrolysate acted as partial glucose substitutes, minimizing production costs with exogenous substrates. Biosurfactant I (obtained at 8.11% pineapple peel extract, 8.11% xylose-rich hydrolysate from corncob, and 2.8109 g/L glucose) exhibited a significant surface tension reduction (52.37%) and a promising bioremediation potential (87.36%). On the other hand, biosurfactant III (obtained at 8.11% pineapple peel extract, 31.89% xylose-rich hydrolysate from corncob, and 2.8109 g/L glucose) exhibited the maximum emulsification index in engine oil (69.60%), the lowest critical micellar concentration (68 mg/L), and the highest biosurfactant production (5.59 g/L). These findings demonstrated that using pineapple peel extract and xylose-rich hydrolysate from corncob effectively supports biosurfactant synthesis by B. subtilis, reinforcing how agro-industrial wastes can substitute traditional carbon sources, contributing to cost reduction and environmental sustainability. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Ananas comosus Bacillus subtilis Zea mays Agro-industrial waste Bioremediation potential Emulsification index Surface tension

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