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Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Nature communications 2025年第1期16卷 4235-4235页

作者： Cecilia Anza-Ramirez J. Jaime Miranda Benedetta Armocida Jorge César Correia Harriette Gillian Christine Van Spall David Beran Amirali Aali Kalkidan Hassen Abate Semagn Mekonnen Abate Cristiana Abbafati Mohsen Abbasi-Kangevari Zeinab Abbasi-Kangevari Zahra Aryan Sina Azadnajafabad Mohammadreza Azangou-Khyavy Seyyed-Hadi Ghamari Mohammad Keykhaei Javad Khanali Sara Momtazmanesh Fateme Montazeri Shayan Rahmani Mohammad-Mahdi Rashidi Nazila Rezaei Negar Rezaei Sahar Saeedi Moghaddam Hossein Hassanian-Moghaddam Ali-Asghar Kolahi Ali Nikoobar Hedayat Abbastabar Ahmed M. Abdel-Azeem Michael Abdelmasseh Juan Sanabria Sherief Abd-Elsalam Ahmed Abdelwahab Gholamreza Abdoli Mohammad Abdollahi Meriem Abdoun Deldar Morad Abdulah Abu Yousuf Md Abdullah Ame Mehadi Abdurehman Getachew Abebe Aidin Abedi Chirag P. Doshi Vida Abedi Hassan Abidi Richard Gyan Aboagye Hassan Abolhassani Nima Rezaei Lucas Guimarães Abreu Michael R. M. Abrigo Yonas Derso Abtew Hiwa Abubaker Ali Eman Abu-Gharbieh Hiba Jawdat Barqawi Rabih Halwani Maha Mohamed Saber-Ayad Iman M. Talaat Ahmed Abu-Zaid Manfred Mario Kokou Accrombessi Juan Manuel Acuna Denberu Eshetie Adane Tigist Demssew Adane Isaac Yeboah Addo Giovanni Addolorato Oluwafemi Atanda Adeagbo Victor Adekanmbi Miracle Ayomikun Adesina Isaac Iyinoluwa Olufadewa Olatunji O. Adetokunboh Daniel Adedayo Adeyinka Qorinah Estiningtyas Sakilah Adnani Aanuoluwapo Adeyimika Afolabi Olayinka Stephen Ilesanmi Muhammad Sohail Afzal Saira Afzal Gina Agarwal Prerna Agarwal Pradyumna Agasthi Anurag Agrawal Marcela Agudelo-Botero Adolfo Martinez-Valle Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Sohail Ahmad Tauseef Ahmad Ali Ahmadi Siamak Sabour Keivan Ahmadi Sanjay Basu Sepideh Ahmadi Ali Ahmed Shaun Wen Huey Lee Ayman Ahmed Haroon Ahmed Jivan Qasim Ahmed Gahin Abdulraheem Tayib Yahya Yahya Luai A. Ahmed Iffat Elbarazi Syed Mahboob Shah Janardhana P. Aithala Marjan Ajami Budi Aji Hossein Akbarialiabad Yibeltal Akelew Meisam Akhlaghdoust Elham Jamshidi Addis Aklilu Azene Tesfaye Melat Woldemariam Maxwell Ak CRONICAS Center of Excellence in Chronic Diseases Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Peruana Cayetano Heredia Lima Peru Sydney School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine London UK Division of Tropical and Humanitarian Medicine University of Geneva Geneva Switzerland Department of Cardiovascular Endocrine-metabolic Diseases and Aging Istituto Superiore di Sanità Rome Italy Division of Endocrinology Diabetology Nutrition and Therapeutic Patient Education Department of Medicine Geneva University Hospitals Geneva Switzerland Department of Medicine and Department of Health Research Evidence and Impact McMaster University Hamilton ON Canada Research Institute of St. Joe’s Hamilton ON Canada Population Health Research Institute Hamilton Canada Geneva University Hospitals Geneva Switzerland Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Nutrition and Dietetics Jimma University Jimma Ethiopia Anesthesiology Department Dilla University Addis Ababa Ethiopia Department of Juridical and Economic Studies La Sapienza University Rome Italy Non-Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Brigham and Women’s Hospital Harvard University Boston MA USA Students’ Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Institute Tehran University of Medical Sciences Tehran Iran Chapter of Addiction Medicine University of Sydney Sydney NSW Australia Advanced Diagnostic and Intervent

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © 2025. The Author(s).

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Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

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EMBO Molecular Medicine 2018年第9期10卷 e8552-e8552页

作者： Kondelin, Johanna Salokas, Kari Saarinen, Lilli Ovaska, Kristian Rauanheimo, Heli Plaketti, Roosa-Maria Hamberg, Jiri Liu, Xiaonan Yadav, Leena Gylfe, Alexandra E Cajuso, Tatiana Hänninen, Ulrika A Palin, Kimmo Ristolainen, Heikki Katainen, Riku Kaasinen, Eevi Tanskanen, Tomas Aavikko, Mervi Taipale, Minna Taipale, Jussi Renkonen-Sinisalo, Laura Lepistö, Anna Koskensalo, Selja Böhm, Jan Mecklin, Jukka-Pekka Ongen, Halit Dermitzakis, Emmanouil T Kilpivaara, Outi Vahteristo, Pia Turunen, Mikko Hautaniemi, Sampsa Tuupanen, Sari Karhu, Auli Välimäki, Niko Varjosalo, Markku Pitkänen, Esa Aaltonen, Lauri A Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland Institute of Biotechnology University of Helsinki Helsinki Finland Helsinki Institute of Life Science University of Helsinki Helsinki Finland Division of Functional Genomics Department of Medical Biochemistry and Biophysics (MBB) Karolinska Institutet Stockholm Sweden Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden Science for Life Center Huddinge Sweden Department of Surgery Helsinki University Central Hospital Hospital District of Helsinki and Uusimaa Helsinki Finland The HUCH Gastrointestinal Clinic Helsinki University Central Hospital Helsinki Finland Department of Pathology Jyväskylä Central Hospital Jyväskylä Finland Department of Surgery Jyväskylä Central Hospital University of Eastern Finland Jyväskylä Finland Department Sport and Health Sciences University of Jyväskylä Jyväskylä Finland Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Institute for Genetics and Genomics in Geneva (iGE3) University of Geneva Geneva Switzerland Swiss Institute of Bioinformatics Geneva Switzerland

Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS) tumors, yet they have not been as comprehensively studied. To identify candidate driver genes affected by point mutations in MSI CRC, we ranked genes based on mutation significance while correcting for replication timing and gene expression utilizing an algorithm, MutSigCV. Somatic point mutation data from the exome kit-targeted area from 24 exome-sequenced sporadic MSI CRCs and respective normals, and 12 whole-genome-sequenced sporadic MSI CRCs and respective normals were utilized. The top 73 genes were validated in 93 additional MSI CRCs. The MutSigCV ranking identified several well-established MSI CRC driver genes and provided additional evidence for previously proposed CRC candidate genes as well as shortlisted genes that have to our knowledge not been linked to CRC before. Two genes, SMARCB1 and STK38L, were also functionally scrutinized, providing evidence of a tumorigenic role, for SMARCB1 mutations in particular. © 2018 The Authors. Published under the terms of the CC BY 4.0 license

关键词： cancer genetics colorectal cancer microsatellite instability

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Author Correction: The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis

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Scientific reports 2020年第1期10卷 9350页

作者： Che-Chang Chang Yen-Sung Huang Ying-Mei Lin Chia-Ju Lin Jen-Chong Jeng Shin-Mei Liu Tsai-Ling Ho Ruei-Ting Chang Chun A Changou Chun-Chen Ho Hsiu-Ming Shih Graduate Institute of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. ccchang168@tmu.edu.tw. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. ccchang168@tmu.edu.tw. Ph.D Program in Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. ccchang168@tmu.edu.tw. Traditional Herbal Medicine Research Center of Taipei Medical University Hospital Taipei 11031 Taiwan. ccchang168@tmu.edu.tw. Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan. Graduate Institute of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. The Ph.D. Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. Graduate Institute of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. hmshih@nhri.org.tw. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. hmshih@nhri.org.tw. Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan. hmshih@nhri.org.tw. Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli County 35053 Taiwan. hmshih@nhri.org.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Corrigendum to 'Beta-propiolactone inactivated bivalent bluetongue virus vaccine containing montanide ISA-71VG adjuvant induces long-term immune response in sheep against serotypes 4 and 16 even after 3 years of controlled vaccine storage' [Vet. Microbiol. 226 (2018) 23-30]

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Veterinary microbiology 2019年 230卷 291页

作者： Kuandyk Zhugunissov Yerbol Bulatov Dmitriy Taranov Zakir Yershebulov Zhumagali Koshemetov Asankadyr Zhunushov Gourapura J Renukaradhya Kaissar Tabynov Yergali Abduraimov Laboratory of Technology for Microbial Cultivation Gvardeiskiy Kazakhstan. Electronic address: kuandyk_83@mail.ru. Laboratory of Technology for Microbial Cultivation Gvardeiskiy Kazakhstan. Department of Biologics Quality Assuarance Gvardeiskiy Kazakhstan. Laboratory of Infectious Disease Diagnosis Research Institute for Biological Safety Problems Gvardeiskiy Kazakhstan. Biotechnology Research Institute Bishkek Kyrgyzstan. Food Animal Health Research Program Ohio Agricultural Research and Development Center Department of Veterinary Preventive Medicine The Ohio State University (OSU) Wooster OH 44691 USA. Laboratory of Infectious Disease Prevention Gvardeiskiy Kazakhstan. Microbial Collection Laboratory Research Institute for Biological Safety Problems Gvardeiskiy Kazakhstan.

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Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

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Archives of virology 2021年第12期166卷 3567-3579页

作者： Jens H Kuhn Scott Adkins Bernard R Agwanda Rim Al Kubrusli Sergey V Alkhovsky Gaya K Amarasinghe Tatjana Avšič-Županc María A Ayllón Justin Bahl Anne Balkema-Buschmann Matthew J Ballinger Christopher F Basler Sina Bavari Martin Beer Nicolas Bejerman Andrew J Bennett Dennis A Bente Éric Bergeron Brian H Bird Carol D Blair Kim R Blasdell Dag-Ragnar Blystad Jamie Bojko Wayne B Borth Steven Bradfute Rachel Breyta Thomas Briese Paul A Brown Judith K Brown Ursula J Buchholz Michael J Buchmeier Alexander Bukreyev Felicity Burt Carmen Büttner Charles H Calisher Mengji Cao Inmaculada Casas Kartik Chandran Rémi N Charrel Qi Cheng Yuya Chiaki Marco Chiapello Il-Ryong Choi Marina Ciuffo J Christopher S Clegg Ian Crozier Elena Dal Bó Juan Carlos de la Torre Xavier de Lamballerie Rik L de Swart Humberto Debat Nolwenn M Dheilly Emiliano Di Cicco Nicholas Di Paola Francesco Di Serio Ralf G Dietzgen Michele Digiaro Olga Dolnik Michael A Drebot J Felix Drexler William G Dundon W Paul Duprex Ralf Dürrwald John M Dye Andrew J Easton Hideki Ebihara Toufic Elbeaino Koray Ergünay Hugh W Ferguson Anthony R Fooks Marco Forgia Pierre B H Formenty Jana Fránová Juliana Freitas-Astúa Jingjing Fu Stephanie Fürl Selma Gago-Zachert George Fú Gāo María Laura García Adolfo García-Sastre Aura R Garrison Thomas Gaskin Jean-Paul J Gonzalez Anthony Griffiths Tony L Goldberg Martin H Groschup Stephan Günther Roy A Hall John Hammond Tong Han Jussi Hepojoki Roger Hewson Jiang Hong Ni Hong Seiji Hongo Masayuki Horie John S Hu Tao Hu Holly R Hughes Florian Hüttner Timothy H Hyndman M Ilyas Risto Jalkanen Dàohóng Jiāng Gilda B Jonson Sandra Junglen Fujio Kadono Karia H Kaukinen Michael Kawate Boris Klempa Jonas Klingström Gary Kobinger Igor Koloniuk Hideki Kondō Eugene V Koonin Mart Krupovic Kenji Kubota Gael Kurath Lies Laenen Amy J Lambert Stanley L Langevin Benhur Lee Elliot J Lefkowitz Eric M Leroy Shaorong Li Longhui Li Jiànróng Lǐ Huazhen Liu Igor S Lukashevich Piet Maes William Marciel de Souza Marco Marklewitz Sergio H Marshall Shin-Yi L Marzano Se Integrated Research Facility at Fort Detrick National Institute of Allergy and Infectious Diseases National Institutes of Health Frederick MD USA. kuhnjens@mail.nih.gov. United States Department of Agriculture Agricultural Research Service US Horticultural Research Laboratory Fort Pierce FL USA. Zoology Department National Museums of Kenya Nairobi Kenya. Jomo Kenyatta University of Agriculture & Technology Nairobi Kenya. Division Phytomedicine Faculty of Life Sciences Humboldt-Universität zu Berlin Berlin Germany. D.I. Ivanovsky Institute of Virology of N.F. Gamaleya National Center on Epidemiology and Microbiology of Ministry of Health of Russian Federation Moscow Russia. Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA. Faculty of Medicine University of Ljubljana Ljubljana Slovenia. Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Campus de Montegancedo Pozuelo de Alarcón Madrid Spain. Departamento de Biotecnología-Biología Vegetal Escuela Técnica Superior de Ingeniería Agronómica Alimentaria y de Biosistemas Universidad Politécnica de Madrid Madrid Spain. Center for Ecology of Infectious Diseases Department of Infectious Diseases Department of Epidemiology and Biostatistics Insitute of Bioinformatics University of Georgia Athens GA USA. Institute of Novel and Emerging Infectious Diseases Friedrich-Loeffler-Institut Federal Research Institute for Animal Health Greifswald-Insel Riems Germany. Department of Biological Sciences Mississippi State University Mississippi State MS USA. Center for Microbial Pathogenesis Institute for Biomedical Sciences Georgia State University Atlanta GA USA. Edge BioInnovation Consulting and Mgt Frederick MD USA. Institute of Diagnostic Virology Friedrich-Loeffler-Institut Greifswald-Insel Riems Germany. UFyMA INTA-CONICET Cordoba Argentina. Genomics and Bioinformatics D

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Corrigendum to: TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis "Toxicol Appl Pharmacol. 2016;305:194-202"

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Toxicology and applied pharmacology 2020年 387卷 114858页

作者： Chao-Feng Lin Han-Li Huang Chieh-Yu Peng Yu-Ching Lee Hui-Po Wang Che-Ming Teng Shiow-Lin Pan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taiwan Department of Medicine MacKay Medical College New Taipei City Taiwan Division of Cardiology Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan Division of Cardiology Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taiwan. Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404 Taiwan School of Pharmacy College of Pharmacy China Medical University Taichung 404 Taiwan. The Center of Translational Medicine Taipei Medical University Taipei Taiwan Program for Biotechnology in Medicine Taipei Medical University Taipei Taiwan. College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Pharmacological Institute College of Medicine National Taiwan University Taipei 100 Taiwan. Department of Pharmacology College of Medicine Taipei Medical University Taipei 10031 Taiwan. Electronic address: slpan@tmu.edu.tw.

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A synthetic biological secondary metabolite,Lycogen^TM,produced and extracted from Rhodobacter sphaeroides WL-APD911 in an optimizatioal scale-up strategy

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Food Science and Human Wellness 2017年第4期6卷 195-201页

作者： Cheng-Chin Wang Shi-Ying Huang Shu-Hung Huang Zhi-Hong Wen Jyun-Ying Huang Wen-Sheng Liu Hui-Min David Wang Research and Development Department Chia-Yi SteelTainan 717TaiwanChina College of Oceanology and Food Science Quanzhou Normal UniversityQuanzhou 362000China Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae Quanzhou 362000China Division of Plastic Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807TaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 807TaiwanChina Center for Stem Cell Research Kaohsiung Medical UniversityKaohsiung 807TaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung 807TaiwanChina Orthopaedic Research Center Kaohsiung Medical UniversityKaohsiung 807TaiwanChina Doctoral Degree Program in Marine Biotechnology National Sun Yat-sen University and Academia SinicaKaohsiung 804TaiwanChina Marine Biomedical Laboratory and Center for Translational Biopharmaceuticals Department of Marine Biotechnology and ResourcesNational Sun Yat-sen UniversityKaohsiung 804TaiwanChina Graduate Institute of Biomedical Engineering National Chung Hsing UniversityTaichung 402TaiwanChina Department and Graduate Institute of Aquaculture National Kaohsiung Marine UniversityKaohsiung 811TaiwanChina Asia-Pacific Biotech Developing Inc.Kaohsiung 803TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 404TaiwanChina

The optimization of fermentation medium is important for synthetic biological secondary metabolite *** effect of rotation speed,inoculum amount,and medium supplements on the cell growth and Lycogen^TM secretion of photobacterium Rhodobacter sphaeroides WL-APD911 was *** results reveal that a higher rotational speed exhibit a higher cell density,and the increasing in the amount of inoculum amount show a slight augment on the growth of *** *** the case of nitrogen sources adding,Lycogen^TM production was achieved with a 0.5 mM l-lysine ***,the attention of Tween 80 presented a tremendous increase in the secondary *** surface methodology(RSM)exhibited the optimization of medium supplements for Lycogen^TM invention is accomplished at molasses concentration of 10 g/L,yeast extract concentration of 40 g/L,0.3%Tween 80 and NaCl concentration of 5 g/L,***,the batch fermentation is carried out in both 5 L and 20 L fermentors to study the scale-up process factors to be *** a 20 L fermentor,Lycogen^TM yields under the optimal culture condition are over 2 times than in the shake *** present results provide the Lycogen^TM optimal culture mediums,scale-up procedures and efficient extractions from *** WL-APD911.

关键词： Rhodobacter sphaeroides WL-APD911 Lycogen^TM Response surface methodology(RSM) Ferementation

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Genetic variation of somaclonal mutants from the 8th generation of Pekalongan accession rodent tuber (typhonium flagelliforme lodd.) based on RAPD-PCR analysis

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IOP Conference Series: Earth and Environmental Science 2018年第1期195卷

作者： Ragapadmi Purnamaningsih Nesti Fronika Sianipar Khoirunnisa Assidqi Harco Leslie Hendric Spits Warnars Indonesia Center for Agricultural Biotechnology and Genetic Resources Research and Development (BB-Biogen) Bogor 16111 Indonesia Food Technology Department Faculty of Engineering Bina Nusantara University Jakarta Indonesia 11480 Research Interest Group Food Biotechnology Bina Nusantara University Jakarta 11480 Indonesia Computer Science Department BINUS Graduate Program – Doctor of Computer Science Bina Nusantara University Jakarta 11480 Indonesia

Rodent tuber is a potential plant which can be developed as an anticancer drug. The rodent tuber plant has a low anticancer compound which does not have an economic value to be utilized on an industrial scale, particularly to explore as an anticancer drug. The material plant was used 30 clones of Rodent Tuber Pekalongan to increase its bioactive compounds using a combination of in vitro culture with gamma-ray irradiation. The selection process has been done until the 8th generation and obtained 14 somaclonal mutants that have higher bioactive compounds than control plant (non-mutant). This study aimed to analyze the genetic variation of 14 somaclonal mutants of rodent tuber using RAPD with 14 primers. The results were produced 513 total bands with the size of 200-5000 bp and 380 polymorphic bands between somaclonal mutants. OPB-18 primer produced the most polymorphic bands and five specific polymorphic bands of 1336 bp, 1070 bp, 901 bp, 861 bp and 728 bp in the somaclonal mutant M23 (20-4-2-1-1-1). OPD-20 primer produced seven specific polymorphic bands of 1574 bp, 1557 bp, 1501 bp, 1496 bp, 1234 bp, 1229 bp and 1086 bp in the M23 somaclonal mutant. The phylogenetic analysis showed that there were two main groups with the coefficient similarity between 0.77 and 0.83. The highest genetic variation obtained was found in the M23 somaclonal mutant with a genetic difference of 23% compared with control. There are five somaclonal mutants (M24, M22, M21, M16, M14) that have a genetic variation of up to 22% over the control. This study shows that OPB-18 and OPD-20 primers were efficient in detecting somaclonal mutant variants.

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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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Author Correction: Nrf2 contributes to the weight gain of mice during space travel

Communications biology

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Communications biology 2020年第1期3卷 566页

作者： Takafumi Suzuki Akira Uruno Akane Yumoto Keiko Taguchi Mikiko Suzuki Nobuhiko Harada Rie Ryoke Eriko Naganuma Nanae Osanai Aya Goto Hiromi Suda Ryan Browne Akihito Otsuki Fumiki Katsuoka Michael Zorzi Takahiro Yamazaki Daisuke Saigusa Seizo Koshiba Takashi Nakamura Satoshi Fukumoto Hironobu Ikehata Keizo Nishikawa Norio Suzuki Ikuo Hirano Ritsuko Shimizu Tetsuya Oishi Hozumi Motohashi Hirona Tsubouchi Risa Okada Takashi Kudo Michihiko Shimomura Thomas W Kensler Hiroyasu Mizuno Masaki Shirakawa Satoru Takahashi Dai Shiba Masayuki Yamamoto Department of Medical Biochemistry Tohoku University Graduate School of Medicine Sendai Japan. Department of Integrative Genomics Tohoku Medical Megabank Organization Tohoku University Sendai Japan. JEM Utilization Center Human Spaceflight Technology Directorate JAXA Tsukuba Japan. The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM) Tohoku University Sendai Japan. Center for Radioisotope Sciences Tohoku University Graduate School of Medicine Sendai Japan. Institute for Animal Experimentation Tohoku University Graduate School of Medicine Sendai Japan. Department of Functional Brain Imaging Institute of Development Aging and Cancer Tohoku University Sendai Japan. Department of Molecular Hematology Tohoku University Graduate School of Medicine Sendai Japan. Department of Molecular Biotechnology and Health Sciences University of Turin 10125 Torino Italy. Division of Molecular Pharmacology & Cell Biophysics Tohoku University Graduate School of Dentistry Sendai Japan. Division of Pediatric Dentistry Tohoku University Graduate School of Dentistry Sendai Japan. Immunology Frontier Research Center Osaka University Suita Japan. Division of Oxygen Biology Tohoku University Graduate School of Medicine Sendai Japan. Department of Gene Expression Regulation Institute of Development Aging and Cancer Tohoku University Sendai Japan. Laboratory Animal Resource Center in Transborder Medical Research Center and Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Tsukuba Japan. Translational Research Program Fred Hutchinson Cancer Research Center Seattle WA USA. JEM Utilization Center Human Spaceflight Technology Directorate JAXA Tsukuba Japan. shiba.dai@jaxa.jp. Department of Medical Biochemistry Tohoku University Graduate School of Medicine Sendai Japan. masiyamamoto@med.tohoku.ac.jp. Department of Integrative Genomics Tohoku Medical Megabank Organization Tohoku University Sendai Japan. masiyamamoto@med.toho

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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