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Acute Oral Toxicity Test of Nicotiana tabacum L. Bio-Oil Against Female Winstar Rats

IOP Conference Series: Earth and Environmental Science 2019年第1期353卷

作者： H N Andjani Y Sentosa K Yati A Fauzantoro M Gozan Y J Yoo Chemical Engineering Department Faculty of Engineering Universitas Indonesia Kampus Baru UI Depok 16424 Indonesia Faculty of Pharmacy and Science Universitas Muhammadiyah Prof. DR. HAMKA Jakarta 13460 Indonesia Development and Pharmaceutical Technology Laboratory Faculty of Pharmacy Universitas Indonesia Kampus Baru UI Depok 16424 Indonesia Laboratory for Biotechnology Agency for the Assessment and Application of Technology (BPPT) 630 Bld. Kawasan Puspitek Serpong Tangerang Selatan Banten 15314 Indonesia Research Center for Biomedical Engineering (RCBE) Universitas Indonesia Kampus UI Depok 16424 Indonesia Program of Bioengineering Seoul National University I Gwanak-gu Seoul 08826 Republic of Korea

Tobacco plants are notably known for its pesticidal properties, particularly due to its nicotine content. In this study, Nicotiana tabacum L. bio-oil was obtained using pyrolysis technique. The safety of the bio-oil to be used as bioinsecticide was analyzed through acute oral toxicity test by administering 5000 mg bio-oil/kg body weight of female winstar rats that were analogous to humans. It was concluded that the bio-oil was not toxic due to absence of mortality and no significant change in the body weight and behavior of the rats.

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H Dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

关键词： Lung adenocarcinoma Lung cancer Mendelian randomization Pathway analysis Tuberculosis

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Bio-polymer chitosan and corn starch with extract of hibiscus rosa-sinensis (hibiscus) as PH indicator for visually-smart food packaging

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AIP Conference Proceedings 2018年第1期1985卷

作者： Maizatulnisa Othman Afiqah Athirah Yusup Nazarudin Zakaria Khalisanni Khalid 1Department of Manufacturing and Materials Engineering International Islamic University Malaysia (IIUM) Jalan Gombak 53100 Kuala Lumpur Malaysia 2Faculty of Biocomposite Technology UniversitiTeknologi MARA 40450 Shah Alam Selangor Malaysia 3Agri-Nanotechnology Program (BT04) Biotechnology and Nanotechnology Research Center (BT) Malaysian Agricultural Research and Development Institute (MARDI) MARDI Headquarters Persiaran MARDI-UPM 43400 Serdang Selangor Malaysia

This study is focusing on the presence of pigments called anthocyanin in hibiscus, can be used as pH indicator as the pigments react with OH− ions before changing its color depending on the acidity or alkalinity of the surroundings. Hence, a system for pH monitoring based on chitosan, corn starch and phytochemical extract from Hibiscus rosa-sinensis (hibiscus), all inexpensively obtained from renewable sources is developed. Chitosan, corn starch and hibiscus extract were used to produce biopolymer pH indicator for smart food packaging. The system is then characterized by using FT-IR, as well as light microscopy. In order to validate the use of this system as a meat spoilage detection sensor, application tests were conducted with chicken breasts. The results show that the system has good optical and morphological properties and is very sensitive to pH variations. During the application test, the s ystem visually indicated pH changes. This shows a clear response to pH variation of the samples. Therefore, it has potential to be used as a visual indicator of the storage and consumption conditions of food.

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Effect of Extraction Time and Na2CO3 Concentration on The Characteristics of Alginate Extracted from Sargassum sp.

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IOP Conference Series: Earth and Environmental Science 2018年第1期209卷

作者： Erliza Hambali Satya Chandra Wibawa Sakti Mochamad Zakki Fahmi Febri Eko Wahyudianto Nuryono P Yessi Mohamad Yani Ellya Sinurat Borneo Satria Pratama Departement of Agroindustrial Technology Institut Pertanian Bogor Indonesia Department of Chemistry Faculty of Science and Technology Universitas Airlangga Campus C Mulyorejo Surabaya Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada Sekip Utara Yogyakarta Indonesia Inorganic and Physical Chemistry Research Division Institut Teknologi Bandung Jl. Ganesha 10 Bandung 40132 Indonesia Research and Development Center for Marine and Fisheries Product Processing and Biotechnology Jakarta Indonesia Master Program of Agroindustrial Technology Faculty of Agricultural Technology Institut Pertanian Bogor Indonesia Environmental Science and Technology Study Program Department of Biology Faculty of Science and Technology Universitas Airlangga Campus C Mulyorejo Surabaya Indonesia Surfactant and Bioenergy Research Centre IPB Baranangsiang Bogor Indonesia

Alginate is a polysaccharide extracted from cell walls and intracellular matrix of brown seaweed, and has been widely used for industrial purpose due to gelling capabilities in the presence of divalent cations. However, the characteristics of alginate extracted are depend on alginate gel strength and viscosity. The objective of this research was to investigate the effect of extraction time and Na2CO3 concentration on the characteristics of alginates extracted from Sargassum sp. by acid method. Alginate extractions were conducted by varying the extraction time for 1.5, 2.0 and 2.5 hours; and varying the Na2CO3 concentration of 1, 2 and 3 %. The characteristics observed are alginate yield, viscosity, pH, and water content. The alginates extracted using various Na2CO3 concentration and extraction time resulted alginates with low, medium and high viscosity. Furthermore, the yield, pH and water content of alginates extracted in this research had fulfilled the standard of Food Chemical Codex.

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Getting Undergraduates Ready for China’s Belt and Road Initiative (BRI) Through an Overseas Experiential Learning Project

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China and the World 2021年第3期4卷

作者： Andrew Min Han Chin Thomas Menkhoff Hans-Dieter Evers Hoong Hui Daniel Gn Kevin Koh Chester Wey Lee Patrick H. M. Loh Linda Low Sebastian Tan Teng Seng Teo Natalie Yap Lee Kong Chian School of Business Singapore Management University (SMU) 81 Victoria Street Singapore 188065 Singapore Andrew Chin Min Han graduated from Tsinghua University in Beijing China with a Tsinghua–MIT Sloan International Master of Business Administration degree under the Singapore Government’s Asian Business Fellowship (ABF) scholarship program. He is the Program Director of Singapore Management University (SMU) Executive Certificate in China Business and of the SMU Internationalisation Series. He teaches as an Adjunct Faculty of Strategy and Organisation at the SMU Lee Kong Chian School of Business since January 2017. He teaches effectively in English and Chinese. With over 23 years of experience in education and publishing industry in Asia Andrew Chin’s multi-sector career has enabled him to experience the full spectrum of the education industry in his roles as the Singapore EDB Officer handling the World-Class University portfolio and the Specialist Information and Publishing Industry portfolio Chief Representative and Country Manager (China) at Thomson Learning (Fortune 500 company) and Co-founder and CEO for an early childhood education business. Andrew was a Business Development Director (Universities) at Sodexo Group (Fortune 500 company) for the Asia-Pacific region. After working 10 years in Beijing China Andrew returned to Singapore in 2012 to work closely with the top leadership at Singapore Management University on the SMU China & East Asia Initiatives. Thomas Menkhoff is the Professor of Organisational Behaviour & Human Resources (Education) at the Lee Kong Chian School of Business Singapore Management University (SMU). Two of his recent publications include: (i) Menkhoff Thomas Ning Kan Siew Evers Hans-Dieter and Chay Yue Wah eds. Living in Smart Cities: Innovation and Sustainability (New Jersey: World Scientific Publishing 2018) and (ii) Chay Yue Wah Menkhoff Thomas and Low Linda eds. China’s Belt and Road Initiative — Understanding the Dynamics of a Global Transfor

In this paper, we explain how an experiential learning course and study tour to Gansu Province (People’s Republic of China) enabled undergraduates at the Singapore Management University (SMU) to acquire 21st-century competencies and higher-order thinking skills by analyzing and evaluating specific aspects of China’s Belt and Road Initiative (BRI) and China–Singapore (Chongqing) Connectivity Initiative — New International Land–Sea Trade Corridor (CCI-ILSTC) with emphasis on developing viable Go-To-Market (GTM) strategies aimed at selling Gansu produce in four Southeast Asian markets. We share how the course was designed to support the attainment of key learning goals and discuss how we turned pedagogical aspirations into concrete learning outcomes. We introduce key aspects of the so-called “SMU-XO” project that the students conducted in partnership with an industry partner, Pacific International Lines (PIL), and discuss how the project work helped learners to gain global competency by (i) examining critical issues related to BRI such as multi-modal infrastructure connectivity, (ii) appreciating the local perspectives of project stakeholders in Lanzhou and Shanghai and (iii) successfully interacting with people from different cultures, namely China, Indonesia, Vietnam, Malaysia and Thailand.

关键词： Experiential learning Singapore China Belt and Road Initiative (BRI)

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Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

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Nature communications 2021年第1期12卷 995页

作者： Vasiliki Lagou Reedik Mägi Jouke- Jan Hottenga Harald Grallert John R B Perry Nabila Bouatia-Naji Letizia Marullo Denis Rybin Rick Jansen Josine L Min Antigone S Dimas Anna Ulrich Liudmila Zudina Jesper R Gådin Longda Jiang Alessia Faggian Amélie Bonnefond Joao Fadista Maria G Stathopoulou Aaron Isaacs Sara M Willems Pau Navarro Toshiko Tanaka Anne U Jackson May E Montasser Jeff R O'Connell Lawrence F Bielak Rebecca J Webster Richa Saxena Jeanette M Stafford Beate St Pourcain Nicholas J Timpson Perttu Salo So-Youn Shin Najaf Amin Albert V Smith Guo Li Niek Verweij Anuj Goel Ian Ford Paul C D Johnson Toby Johnson Karen Kapur Gudmar Thorleifsson Rona J Strawbridge Laura J Rasmussen-Torvik Tõnu Esko Evelin Mihailov Tove Fall Ross M Fraser Anubha Mahajan Stavroula Kanoni Vilmantas Giedraitis Marcus E Kleber Günther Silbernagel Julia Meyer Martina Müller-Nurasyid Andrea Ganna Antti-Pekka Sarin Loic Yengo Dmitry Shungin Jian'an Luan Momoko Horikoshi Ping An Serena Sanna Yvonne Boettcher N William Rayner Ilja M Nolte Tatijana Zemunik Erik van Iperen Peter Kovacs Nicholas D Hastie Sarah H Wild Stela McLachlan Susan Campbell Ozren Polasek Olga Carlson Josephine Egan Wieland Kiess Gonneke Willemsen Johanna Kuusisto Markku Laakso Maria Dimitriou Andrew A Hicks Rainer Rauramaa Stefania Bandinelli Barbara Thorand Yongmei Liu Iva Miljkovic Lars Lind Alex Doney Markus Perola Aroon Hingorani Mika Kivimaki Meena Kumari Amanda J Bennett Christopher J Groves Christian Herder Heikki A Koistinen Leena Kinnunen Ulf de Faire Stephan J L Bakker Matti Uusitupa Colin N A Palmer J Wouter Jukema Naveed Sattar Anneli Pouta Harold Snieder Eric Boerwinkle James S Pankow Patrik K Magnusson Ulrika Krus Chiara Scapoli Eco J C N de Geus Matthias Blüher Bruce H R Wolffenbuttel Michael A Province Goncalo R Abecasis James B Meigs G Kees Hovingh Jaana Lindström James F Wilson Alan F Wright George V Dedoussis Stefan R Bornstein Peter E H Schwarz Anke Tönjes Bernhard R Winkelmann Bernhard O Boehm Winfried März Andres Metspalu Jackie F Price Panos Delouk Wellcome Centre for Human Genetics University of Oxford Oxford UK. Department of Microbiology and Immunology Laboratory of Adaptive Immunity KU Leuven Leuven Belgium. VIB-KU Leuven Center for Brain and Disease Research Leuven Belgium. Estonian Genome Centre Institute of Genomics University of Tartu Tartu Estonia. Department of Biological Psychology Vrije Universiteit Amsterdam The Netherlands. Amsterdam Public Health Research Institute VU University medical center Amsterdam The Netherlands. Research Unit of Molecular Epidemiology Institute of Epidemiology Helmholtz Zentrum München Research Center for Environmental Health Neuherberg Germany. German Center for Diabetes Research (DZD München-Neuherberg Germany. MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge UK. University of Lille Nord de France Lille France. CNRS UMR8199 Institut Pasteur de Lille Lille France. INSERM U970 Paris Cardiovascular Research Center PARCC 75006 Paris France. Department of Life Sciences and Biotechnology University of Ferrara Ferrara Italy. Boston University Data Coordinating Center Boston MA USA. Department of Psychiatry VU University Medical Center Amsterdam The Netherlands. MRC Integrative Epidemiology Unit University of Bristol Bristol UK. Bristol Medical School University of Bristol Bristol UK. Institute for Bioinnovation Biomedical Sciences Research Center Al. Fleming Vari Greece. Department of Medicine Imperial College London London UK. Cardiovascular Medicine Unit Center for Molecular Medicine Department of Medicine Karolinska Institutet Stockholm Karolinska University Hospital Solna Sweden. Institute for Molecular Bioscience The University of Queensland Brisbane QLD 4072 Australia. Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark. Université de Lorraine IGE-PCV F-54000 Nancy France. Genetic Epidemiology Unit Department of Epidemiology Erasmus Medical Center Rotterdam the Netherlands. CAR

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Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts

Communications Biology

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Communications Biology 2019年第1期2卷 1-2页

作者： Bret A. Moore Brian C. Leonard Lionel Sebbag Sydney G. Edwards Ann Cooper Denise M. Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M. Griffey Lynette Bower David Clary Jeremy Mason Michel J. Roux Hamid Meziane Yann Herault Colin McKerlie Ann M. Flenniken Lauryl M. J. Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J. Gallegos John R. Seavitt Jason D. Heaney Arthur L. Beaudet Mary E. Dickinson Monica J. Justice Vivek Philip Vivek Kumar Karen L. Svenson Robert E. Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J. K. Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K. White Martin Hrabe de Angelis Wolfgang Wurst Sara M. Thomasy Paul Flicek Helen Parkinson Steve D. M. Brown Terrence F. Meehan Patsy M. Nishina Stephen A. Murray Mark P. Krebs Ann-Marie Mallon K. C. Kent Lloyd Christopher J. Murphy Ala Moshiri William R. Pritchard Veterinary Medical Teaching Hospital School of Veterinary Medicine University of California-Davis Davis USA Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California-Davis Davis USA Comparative Pathology Laboratory School of Veterinary Medicine University of California-Davis Davis USA Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center) Harwell Oxfordshire UK Mouse Biology Program and Department of Surgery School of Medicine University of California-Davis Davis USA European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge UK Institut de Génétique et de Biologie Moléculaire et Cellulaire Université de Strasbourg Illkirch France Centre National de la Recherche Scientifique Illkirch France Institut National de la Santé et de la Recherche Médicale Illkirch France Université de Strasbourg Illkirch France CELPHEDIA PHENOMIN Institut Clinique de la Souris (ICS) CNRS INSERM University of Strasbourg Illkirch-Graffenstaden France The Centre for Phenogenomics Toronto Canada The Hospital for Sick Children Toronto Canada Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital Toronto Canada Department of Molecular Physiology and Biophysics Baylor College of Medicine Houston USA Department of Molecular and Human Genetics Baylor College of Medicine Houston USA The Jackson Laboratory Bar Harbor USA SKL of Pharmaceutical Biotechnology and Model Animal Research Center Collaborative Innovation Center for Genetics and Development Nanjing Biomedical Research Institute Nanjing University Nanjing China RIKEN BioResource Center Tsukuba Japan Clinical Pharmacology Charterhouse Square Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK Korea Mouse Phenotyping Consortium (KMPC) and BK21 Program for Veterinary Science Research Institute for Veterinary Science College of

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Molecular analysis of Toxoplasma gondii Surface Antigen 1 (SAG1) gene cloned from Toxoplasma gondii DNA isolated from Javanese acute toxoplasmosis

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Journal of Physics: Conference Series 2018年第1期1022卷

作者： Sri Haryati Afiono Agung Prasetyo Yulia Sari Ruben Dharmawan A-IGIC (A-Infection Genomics Immunology & Cancer) Research Group Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Department of Parasitology Faculty of Medicine Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Center of Biotechnology and Biodiversity Research and Development Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Division of Virology Department of Microbiology Faculty of Medicine Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Doctoral Program of Medical Sciences Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia.

Toxoplasma gondii Surface Antigen 1 (SAG1) is often used as a diagnostic tool due to its immunodominant-specific as antigen. However, data of the Toxoplasma gondii SAG1 protein from Indonesian isolate is limited. To study the protein, genomic DNA was isolated from a Javanese acute toxoplasmosis blood samples patient. A complete coding sequence of Toxoplasma gondii SAG1 was cloned and inserted into an Escherichia coli expression plasmid and sequenced. The sequencing results were subjected to bioinformatics analysis. The Toxoplasma gondii SAG1 complete coding sequences were successfully cloned. Physicochemical analysis revealed the 336 aa of SAG1 had 34.7 kDa of weight. The isoelectric point and aliphatic index were 8.4 and 78.4, respectively. The N-terminal methionine half-life in Escherichia coli was more than 10 hours. The antigenicity, secondary structure, and identification of the HLA binding motifs also had been discussed. The results of this study would contribute information about Toxoplasma gondii SAG1 and benefits for further works willing to develop diagnostic and therapeutic strategies against the parasite.

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Human T-lymphotropic Virus-1/2 detected in drug abused men who have sex with men infected with HIV in Surakarta, Indonesia

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Journal of Physics: Conference Series 2018年第1期1022卷

作者： Afiono Agung Prasetyo Yulia Sari A-IGIC (A-Infection Genomics Immunology & Cancer) Research Group Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Center of Biotechnology and Biodiversity Research and Development Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Division of Virology Department of Microbiology Faculty of Medicine Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Department of Parasitology Faculty of Medicine Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57126 Indonesia. Doctoral Program of Medical Sciences Faculty of Medicine Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta Indonesia.

Human T-lymphotropic virus types 1 and 2 (HTLV-1/2) share similar routes of transmission with human immunodeficiency virus (HIV), and the HTLV-1/2 co-infection may affect the clinical course of HIV infection. The HIV/HTLV-1/2 co-infection risk higher if the patient performing the high-risk activities. This study evaluated the presentation of HTLV-1 and 2 in HIV-infected men who have sex with men with drug abused history in Surakarta Indonesia. Blood samples collected from HIV-infected men who have sex with men with drug abused history in Surakarta were tested using HTLV-1/2 enzyme-linked immunosorbent assays and confirmed by RT-PCR nested addressed the part of HTLV-1 LTR and HTLV-2 LTR region, respectively. The specificity of the molecular assays was confirmed by sequencing the amplicons. The anti HTLV-1/2 positive rate was 17.4% (8/46). All positive serological samples were confirmed by nested RT-PCR. Of these, three was HTLV-1 positive and five was HTLV-2 positive. Molecular analysis of positive PCR products revealed that all HTLV-1 isolates had a close relationship with HTLV-1 isolated in Japan while all HTLV-2 isolates with that of isolated in the USA. HTLV-1 and HTLV-2 were detected in drug abused men who have sex with men infected with HIV in Surakarta.

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Comparison of Pretreatment Methods on Vetiver Leaves for Efficient Processes of Simultaneous Saccharification and Fermentation by Neurospora sp.

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Journal of Physics: Conference Series 2017年第1期877卷 012048-012048页

作者： Restiawaty, E Dewi, A Study Program of Bioenergy and Chemurgy Engineering Research Group of Chemical Engineering Process Design and Development Faculty of Industrial Technology Institut Teknologi Bandung Jln. Let. Jen. Purn. Dr. (HC) Mashudi No. 1 Sumedang West Java 45363 Indonesia Biosciences and Biotechnology Research Centre Institut Teknologi Bandung Jln. Ganesha 10 Bandung 40132 Indonesia Biosciences and Biotechnology Research Centre Institut Teknologi Bandung Jln. Ganesha 10 Bandung 40132 Indonesia

Lignocellulosic biomass is a potential raw material for bioethanol production. Neurospora sp. can be used to convert lignocellulosic biomass into bioethanol because of its ability to perform simultaneous saccharification and fermentation. However, lignin content, degree of polymerization, and crystallinity of cellulose contained in lignocellulosic biomass can inhibit cellulosic-biomass digestion by Neurospora sp, so that a suitable pretreatment method of lignocellulosic biomass is needed. The focus of this research was to investigate the suitable pretreatment method for vetiver leaves (Vetiveria zizanioides L. Nash) used as a raw material producing bioethanol in the process of simultaneous saccharification and fermentation (SSF) by Neurospora sp.. Vetiver plants obtained from Garut are deliberately cultivated to produce essential oils extracted from the roots of this plant. Since the vetiver leaves do not contain oil, some of harvested leaves are usually used for crafts and cattle feed, and the rest are burned. This study intended to look at other potential of vetiver leaves as a source of renewable energy. Pretreatments of the vetiver leaves were conducted using hot water, dilute acid, alkaline & dilute acid, and alkaline peroxide, in which each method was accompanied by thermal treatment. The results showed that the alkaline peroxide treatment is a suitable for vetiver leaves as indicated by the increase of cellulose content up to 65.1%, while the contents of hot water soluble, hemicellulose, lignin, and ash are 8.7%, 18.3%, 6.8%, and 1.1%, respectively. Using this pretreatment method, the vetiver leaves can be converted into bioethanol by SSF process using Neurospora sp. with a concentration of bioethanol of 6.7 g/L operated at room temperature.

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