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Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract

Nanomedicine 2014年第3期9卷 457-468页

作者： Pan-In, Porntip Tachapruetinun, Amornset Chaichanawongsaroj, Nuntaree Banlunara, Wijit Suksamrarn, Sunit Wanichwecharungruang, Supason Program in Biotechnology Faculty of Science Chulalongkorn University Bangkok Thailand Department of Chemistry Faculty of Science Chulalongkorn University Bangkok Thailand Department of Transfusion Medicine Innovation Center for Research and Development of Medical Diagnostic Technology Project Chulalongkorn University Bangkok Thailand Department of Pathology Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand Department of Chemistry Faculty of Science Srinakharinwirot University Bangkok Thailand

Aim: To combat the resistance of Helicobacter pylori to antibiotics through the use of Garcinia mangostana extract (GME) in the form that can be localized at stomach mucosa. Materials & methods: GME and its major active component, α-mangostin, are encapsulated into the moderately acid stable mucoadhesive nanocarriers, and tested for anti-H. pylori and antiadhesion activities in vitro and their ability to eradicate H. pylori in infected mice. Results: The two in vitro activities are observed and are enhanced when the materials are encapsulated into nanocarriers. Preliminary in vivo tests revealed the ability to combat H. pylori in mice following oral administration of the encapsulated GME, but not the unencapsulated GME. Conclusion: Nanoencapsulated GME is a potential anti-H. pylori agent. Original submitted 10 August 2012;Revised submitted 9 December 2012;Published online 3 June 201. © 2014 Future Medicine Ltd.

关键词： Antiadhesion Garcinia mangostana Helicobacter pylori Mucoadhesion Nanocarrier α-mangostin

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31st Annual Meeting and Associated programs of the Society for Immunotherapy of Cancer (SITC 2016): part two Abstracts

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JOURNAL FOR IMMUNOTHERAPY OF CANCER 2016年第SUPPL 1期4卷 107-221页

作者： [Anonymous] Department of Immunology University of Texas MD Anderson Cancer Center Houston TX USA Department of Cancer Medicine University of Texas MD Anderson Cancer Center Houston TX USA Immune Design Seattle WA USA Innate Pharma Marseille Provence-Alpes-Cote d’Azur France MedImmune Cambridge England UK Georgetown-Lombardi Comprehensive Cancer Center Washington DC USA Westmead and Blacktown Hospitals Melanoma Institute Australia and the University of Sydney Westmead New South Wales Australia University of California Los Angeles CA USA University of Washington Seattle WA USA Dana-Farber Cancer Institute/Brigham and Women’s Hospital Harvard University Boston MA USA University of Texas MD Anderson Cancer Center Houston TX USA Beth Israel Deaconess Medical Center Boston MA USA Gallipoli Medical Research Foundation Greenslopes Private Hospital and the University of Queensland Greenslopes Queensland Australia Olivia Newton-John Cancer Research Institute Heidelberg Victoria Australia Canterbury District Health Board Christchurch Hospital Christchurch New Zealand Waikato Hospital Regional Cancer Centre Hamilton New Zealand Royal Prince Alfred Hospital Melanoma Institute Australia the University of Sydney and Chris O’Brien Lifehouse Camperdown New South Wales Australia Tasman Oncology Research Southport Gold Coast Queensland Australia Merck & Co. Inc. Kenilworth NJ USA Quantitative Solutions A Certara Company Oss Netherlands Melanoma Institute Australia the University of Sydney Mater Hospital and Royal North Shore Hospital Wollstonecraft New South Wales Australia Columbia University Medical Center New York NY USA Institut d’Investigacions Biomediques August Pi i Sunyer Barcelona Catalonia Spain Icahn School of Medicine at Mount Sinai New York NY USA New York Presbyterian/Columbia University Medical Center New York NY USA Memorial Sloan Kettering Cancer Center New York NY USA Peregrine Pharmaceuticals Inc. Tustin CA USA Regeneron Tarrytown NY USA University of

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World Congress Integrative Medicine & Health 2017: Part one: Berlin, Germany. 3-5 May 2017

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BMC Complement Altern Med 2017年第SUPPL 1期17卷 322-322页

作者： Benno Brinkhaus Torkel Falkenberg Aviad Haramati Stefan N. Willich Josephine P. Briggs Merlin Willcox Klaus Linde Töres Theorell Lisa M. Wong Jeffrey Dusek Darong Wu David Eisenberg Bettina Berger Kathi Kemper Beate Stock-Schröer Hedda Sützl-Klein Rosaria Ferreri Gary Kaplan Harald Matthes Gabriele Rotter Elad Schiff Zahi Arnon Eckhard Hahn Christina M. Luberto David Martin Silke Schwarz Diethard Tauschel Andrew Flower Harsha Gramminger Hedwig H. Gupta S. N. Gupta Annette Kerckhoff Christian S. Kessler Andreas Michalsen Eun S. Kim Eun H. Jang Rana Kim Sae B. Jan Martin Mittwede Wiebke Mohme Eran Ben-Arye Massimo Bonucci Bashar Saad Thomas Breitkreuz Elio Rossi Rejin Kebudi Michel Daher Samaher Razaq Nahla Gafer Omar Nimri Mohamed Hablas Gunver Sophia Kienle Noah Samuels Michael Silbermann Lena Bandelin Anna-Lena Lang Eva Wartner Christoph Holtermann Maxwell Binstock Robert Riebau Edin Mujkanovic Holger Cramer Romy Lauche Andres Michalsen Lesley Ward Dominik Irnich Wolfram Stör Geoffrey Burnstock Hans-Georg Schaible Thomas Ots Jost Langhorst Tobias Sundberg Catherina Amarell Melanie Anheyer Marion Eckert Mercedes Ogal Annette Schönauer Birgit Reisenberger Bernhard Brand Dennis Anheyer Gustav Dobos Matthias Kroez Aldo Ammendola Jun J. Mao Claudia Witt Yufei Yang Miriam Oritz Markus Horneber Petra Voiß Alexandra von Rosenstiel Catharina Amarell Friedemann Schad Marc Schläppi Matthias Kröz Arndt Büssing Gil Bar-Sela David Avshalomov Samuel Attias Sian Cotton Miek Jong Mats Jong Christian Scheffer Friedrich Edelhäuser Abdullah AlBedah Myeong Soo Lee Mohamed Khalil Keiko Ogawa Yoshiharu Motoo Junsuke Arimitsu Masao Ogawa Genki Shimizu Rainer Stange Karin Kraft Kenny Kuchta Kenji Watanabe D Bonin Harald Gruber Sabine Koch Urs Pohlmann Christine Caldwell Barbara Krantz Ria Kortum Lily Martin Lisa S. Wieland Ben Kligler Susan Gould-Fogerite Yuqing Zhang John J. Riva Michael Lumpkin Emily Ratner Liu Ping Pei Jian Gesa-Meyer Hamme Xiaosong Mao Han Chouping Sven Schröder Josef Hummelsberger Michael Wullinger Marc Brodzky Chr Institute for Social Medicine Epidemiology and Health Economics Charité – Universitätsmedizin Berlin Berlin Germany Department of Neurobiology Care Sciences and Society Division of Nursing Research Group Integrative Care Karolinska Institutet Stockholm Sweden I C – The Integrative Care Science Center Järna Sweden Department of Biochemistry Molecular and Cellular Biology Georgetown University Medical Center Washington DC USA Department of Medicine Georgetown University Medical Center Washington DC USA NCCIH NIH Bethesda MD USA Department of Primary Care and Population Sciences University of Southampton Aldermoor Health Centre Coxford Rd Southampton 2016 5ST UK Institute of General Practice Technical University Munich Munich Germany Department of Neuroscience Karolinska Institute Stockholm Sweden Stress Research Institute Stockholm University Stockholm Sweden Arts and Humanities Initiative Harvard Medical School Boston MA 02115 USA Psychosomatic medicine Neuropsychology Allina Health Minneapolis MN USA nd Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China Department of Nutrition Harvard University T H Chan School of Public Health Boston MA 02115 USA Department of Health University of Witten/Herdecke Witten/Herdecke Germany OSU Blacklick OH USA Carstens-Foundation and FORUM D-45276 Essen Germany ESIHR (European Society for Integrative Health Care) A-1070 Vienna Austria Hospital Centre of Integrated Medicine Hospital of Pitiglian o ASL SudEst Toscana Grosseto Italy The Kaplan Center for Integrative Medicine Georgetown University McLean VA USA Hospital Havelhöhe Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité University Hospital Berlin Germany Internal medicine and Complementary medicine service Bnai Zion Medical Center Haifa Israel Complementary-Integrative Surgery Service Bnai Zion Medical Center Haifa Israel The Emek Yezreel Academic College Yezreel Valley Israel Medicine

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Erratum to: Aquaculture genomics, genetics and breeding in the United States: current status, challenges, and priorities for future research

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BMC genomics 2017年第1期18卷 235页

作者： Hisham Abdelrahman Mohamed ElHady Acacia Alcivar-Warren Standish Allen Rafet Al-Tobasei Lisui Bao Ben Beck Harvey Blackburn Brian Bosworth John Buchanan Jesse Chappell William Daniels Sheng Dong Rex Dunham Evan Durland Ahmed Elaswad Marta Gomez-Chiarri Kamal Gosh Ximing Guo Perry Hackett Terry Hanson Dennis Hedgecock Tiffany Howard Leigh Holland Molly Jackson Yulin Jin Karim Khalil Thomas Kocher Tim Leeds Ning Li Lauren Lindsey Shikai Liu Zhanjiang Liu Kyle Martin Romi Novriadi Ramjie Odin Yniv Palti Eric Peatman Dina Proestou Guyu Qin Benjamin Reading Caird Rexroad Steven Roberts Mohamed Salem Andrew Severin Huitong Shi Craig Shoemaker Sheila Stiles Suxu Tan Kathy F J Tang Wilawan Thongda Terrence Tiersch Joseph Tomasso Wendy Tri Prabowo Roger Vallejo Hein van der Steen Khoi Vo Geoff Waldbieser Hanping Wang Xiaozhu Wang Jianhai Xiang Yujia Yang Roger Yant Zihao Yuan Qifan Zeng Tao Zhou School of Fisheries Aquaculture and Aquatic Sciences Auburn University Auburn AL 36849 USA. Department of Biological Sciences Auburn University Auburn AL 36849 USA. Environmental Genomics Inc. P. O. Box 196 Southborough MA 01772-1801 USA. Aquaculture Genetics & Breeding Technology Center Virginia Institute of Marine Science Gloucester Point VA 23062 USA. Department of Biology Middle Tennessee State University Murfreesboro TN 37132 USA. Aquatic Animal Health Research Unit USDA-ARS 990 Wire Road Auburn AL 36832 USA. USDA-ARS-NL Wheat & Corn Collections at a Glance GRP National Animal Germplasm Program 1111 S. Mason St. Fort Collins CO 80521-4500 USA. USDA-ARS/CGRU 141 Experimental Station Road Stoneville MS 38701 USA. Center for Aquaculture Technologies 8395 Camino Santa Fe Suite E San Diego CA 92121 USA. Department of Fisheries and Wildlife Oregon State University Corvallis OR 97331 USA. Department of Fisheries Animal & Veterinary Science 134 Woodward Hall 9 East Alumni Avenue Kingston RI 02881 USA. Haskin Shellfish Research Laboratory Department of Marine and Coastal Sciences Rutgers University 6959 Miller Avenue Port Norris NJ 08349 USA. Department of Genetics Cell Biology and Development 5-108 MCB 420 Washington Avenue SE Minneapolis MN 55455 USA. Department of Biological Sciences University of Southern California Los Angeles CA 90089-0371 USA. Taylor Shellfish Farms 130 SE Lynch RD Shelton WA 98584 USA. Department of Biology University of Maryland 2132 Biosciences Research Building College Park MD 20742 USA. National Center for Cool and Cold Water Aquaculture Agricultural Research Service United States Department of Agriculture Kearneysville WV 25430 USA. School of Fisheries Aquaculture and Aquatic Sciences Auburn University Auburn AL 36849 USA. liuzhan@auburn.edu. Troutlodge 27090 Us Highway 12 Naches WA 98937 USA. USDA ARS NEA NCWMAC Shellfish Genetics at the University Rhode Island 469 CBLS 120 Flagg

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Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015: Yogyakarta, Indonesia. 4-6 June 2015

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BMC Proc 2016年第SUPPL 1期10卷 1-1页

作者： IB Tan Ellen T. Chang Chien-Jen Chen Wan-Lun Hsu Yin-Chu Chien Allan Hildesheim James D. McKay Valerie Gaborieau Mohamed Arifin Bin Kaderi Dewajani Purnomosari Catherine Voegele Florence LeCalvez-Kelm Graham Byrnes Paul Brennan Beena Devi L. Li Y. Zhang Y. Fan K. Sun Z. Du H. Sun A. T. Chan S. W. Tsao Y. X. Zeng Q. Tao Pierre Busson Claire Lhuillier Olivier Morales Dhafer Mrizak Aurore Gelin Nikiforos Kapetanakis Nadira Delhem Sheila Mansouri Jennifer Cao Anup Vaidya Lori Frappier Lo Kwok Wai Sui-Hong Chen Jin-lin Du Ming-Fang Ji Qi-Hong Huang Qing Liu Su-Mei Cao Denise L. Doolan Anna Coghill Jason Mulvenna Carla Proietti Lea Lekieffre Jeffrey Bethony and Allan Hildesheim Renske Fles Sagung Rai Indrasari Camelia Herdini Santi Martini Atoillah Isfandiari Achmad Rhomdoni Marlinda Adham Ika Mayangsari Erik van Werkhoven Maarten Wildeman Bambang Hariwiyanto Bambang Hermani Widodo Ario Kentjono Sofia Mubarika Haryana Marjanka Schmidt Brian O’Sullivan Enis Ozyar Anne W. M. Lee Mu-Sheng Zeng Xiaojiang Gao Minzhong Tang Pat Martin Yi Zeng Mary Carrington Anna E. Coghill Wei Bu Hanh Nguyen Kelly J. Yu Pei-Jen Lou Cheng-Ping Wang Jeffrey I. Cohen Ann D. King Tseng-Cheng Chen Ching-Yuan Lin Yung-An Tsou Yi-Shing Leu Li-Jen Laio Yen-Liang Chang Chun-Hun Hua Ming-Shiang Wu Chu-Hsing Kate Hsiao Jehn-Chuan Lee Ming-Hsui Tsai Skye Hung-Chun Cheng Li-Jen Liao Tsung-Lin Yang Jenq-Yuh Ko Josephine Mun Yee Ko Wei Dai Dora Kwong Wai Tong Ng Anne Lee Roger Kai Cheong Ngan Chun Chung Yau Stewart Tung Maria Li Lung Mingfang Ji Wei Sheng Mun Hon Ng Weimin Cheng Xia Yu Biaohua Wu Kuangrong Wei Jun Zhan Yi Xin Zeng Su Mei Cao Ningshao Xia Yong Yuan Qian Cui Miao Xu Jin-Xin Bei Yi-Xin Zeng B Şahin A Dizman M Esassolak A Saran İkizler HC Yıldırım M Çaloğlu B Atalar F Akman C Demiroz BM Atasoy E Canyilmaz S Igdem G Ugurluer T Kütük M Akmansoy E Ozyar Kiattisa Sommat Fu Qiang Wang Li-Lian Kwok Terence Tan Kam Weng Fong Yoke Lim Soong Shie Lee Cheah Joseph Wee M Casanova E Özyar C Patte D Orbach A Ferrari VF Cristine H Errihani J Pan L Zhang S The Netherlands Cancer Institute Amsterdam The Netherlands Faculty of Medicine Universitas Gadjah Mada/Dr Sardjito General Hospital Yogyakarta Indonesia Health Sciences Practice Exponent Inc. ᅟ ᅟ Division of Epidemiology Department of Health Research and Policy Stanford University School of Medicine ᅟ CA USA Genomics Research Center Academia Sinica Taipei Taiwan Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan Infections & Immunoepidemiology Branch DCEG NCI ᅟ USA International Agency for Research on Cancer Lyon France International Islamic University Malaysia Kuantan Pahang Malaysia Faculty of Medicine Universitas Gadjah Mada Yogyakarta Indonesia Umum Hospital Sarawak Sarawak Malaysia Cancer Epigenetics Laboratory Department of Clinical Oncology State Key Laboratory of Oncology in South China Sir YK Pao Center for Cancer Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong ᅟ ᅟ Department of Anatomy The University of Hong Kong ᅟ Hong Kong Université Paris-sud CNRS UMR8126 and Gustave Roussy Villejuif France Université de Lille CNRS UMR 8161 and Institut Pasteur de Lille Lille France Department of Molecular Genetics University of Toronto Toronto Ontario Canada The Chinese University of Hong Kong ᅟ Hong Kong Department of Cancer Prevention Research Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in Southern China Guangzhou 510060 Guangdong P.R. China Infectious Diseases Program QIMR Berghofer Institute of Medical Research Brisbane QLD Australia Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Microbiology and Tropical Medicine George Washington University Washington DC USA Department of Head and Neck Surgery Netherlands Cancer Institute Amsterdam The Netherlands Department of Otorhinolaryngology Head and Neck Surgery Faculty of Medicine Universitas Gadjah Mada/Dr Sardjito Gen

A1 Hope and despair in the current treatment of nasopharyngeal cancerIB TanI1 NPC international incidence and risk factorsEllen T ChangI2 Familial nasopharyngeal carcinoma and the use of biomarkersChien-Jen Chen, Wan-... 详细信息

A1 Hope and despair in the current treatment of nasopharyngeal cancer

IB Tan

I1 NPC international incidence and risk factors

Ellen T Chang

I2 Familial nasopharyngeal carcinoma and the use of biomarkers

Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien

I3 Genetic susceptibility risk factors for sporadic and familial NPC: recent findings

Allan Hildesheim

I5 Genetic and environmental risk factors for nasopharyngeal cancer in Southeast Asia

James D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena Devi

I6 Characterization of the NPC methylome identifies aberrant epigenetic disruption of key signaling pathways and EBV-induced gene methylation

Li L, Zhang Y, Fan Y, Sun K, Du Z, Sun H, Chan AT, Tsao SW, Zeng YX, Tao Q

I7 Tumor exosomes and translational research in NPC

Pierre Busson, Claire Lhuillier, Olivier Morales, Dhafer Mrizak, Aurore Gelin, Nikiforos Kapetanakis, Nadira Delhem

I8 Host manipulations of the Epstein-Barr virus EBNA1 protein

Sheila Mansouri, Jennifer Cao, Anup Vaidya, and Lori Frappier

I9 Somatic genetic changes in EBV-associated nasopharyngeal carcinoma

Lo Kwok Wai

I10 Preliminary screening results for nasopharyngeal carcinoma with ELISA-based EBV antibodies in Southern China

Sui-Hong Chen, Jin-lin Du, Ming-Fang Ji, Qi-Hong Huang, Qing Liu, Su-Mei Cao

I11 EBV array platform to screen for EBV antibodies associated with NPC and other EBV-associated disorders

Denise L. Doolan, Anna Coghill, Jason Mulvenna, Carla Proietti, Lea Lekieffre, Jeffrey Bethony, and Allan Hildesheim

I12 The nasopharyngeal carcinoma awareness program in Indonesia

Renske Fles, Sagung Rai Indrasari, Camelia Herdini, Santi Martini, Atoillah Isfandiari, Achmad Rhomdoni, Marlinda Adham, Ika Mayangsari, Erik van Werkhoven, Maarten Wi

关键词： Apparent Diffusion Coefficient Epstein Barr Virus Nasopharyngeal Carcinoma Intensity Modulate Radiation Therapy Epstein Barr Virus Infection

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Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

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BMC genomics 2016年第6期17 Suppl 6卷 487页

作者： Jerry W. Shay Noriko Homma Ruyun Zhou Muhammad Imran Naseer Adeel G. Chaudhary Mohammed Al-Qahtani Nobutaka Hirokawa Maryam Goudarzi Albert J. Fornace Saleh Baeesa Deema Hussain Mohammed Bangash Fahad Alghamdi Hans-Juergen Schulten Angel Carracedo Ishaq Khan Hanadi Qashqari Nawal Madkhali Mohamad Saka Kulvinder S. Saini Awatif Jamal Jaudah Al-Maghrabi Adel Abuzenadah Adeel Chaudhary Mohammed Al Qahtani Ghazi Damanhouri Heba Alkhatabi Anne Goodeve Laura Crookes Nikolas Niksic Nicholas Beauchamp Adel M. Abuzenadah Jim Vaught Bruce Budowle Mourad Assidi Abdelbaset Buhmeida Leena Merdad Sudhir Kumar Sayaka Miura Karen Gomez Mahmood Rasool Ahmed Rebai Sajjad Karim Hend F. Nour Eldin Heba Abusamra Elham M. Alhathli Nada Salem Mohammed H. Al-Qahtani Hossam Faheem Ashok Agarwa Eberhard Nieschlag Joachim Wistuba Oliver S. Damm Mohd A. Beg Taha A. Abdel-Meguid Hisham A. Mosli Osama S. Bajouh Serdar Coskun Muhammad Abu-Elmagd Ashraf Dallol Sahar Hakamy Wejdan Al-Qahtani Asia Al-Harbi Shireen Hussain Burak Ozkosem Rick DuBois Safia S. Messaoudi Maryam T. Dandana Touhami Mahjoub Wassim Y. Almawi S. Abdalla M. Nabil Al-Aama Asmaa Elzawahry Tsuyoshi Takahashi Sachiyo Mimaki Eisaku Furukawa Rie Nakatsuka Isao Kurosaka Takahiko Nishigaki Hiromi Nakamura Satoshi Serada Tetsuji Naka Seiichi Hirota Tatsuhiro Shibata Katsuya Tsuchihara Toshirou Nishida Mamoru Kato Sajid Mehmood Naeem Mahmood Ashraf Awais Asif Muhammad Bilal Malik Siddique Mehmood Aadil Hussain Qazi Mohammad Sajid Jamal Mughees Uddin Siddiqui Mohammad A. Alzohairy Mohammad A. Al Karaawi Taoufik Nedjadi Heba Al-Khattabi Adel Al-Ammari Ahmed Al-Sayyad Hédia Zitouni Nozha Raguema Marwa Ben Ali Wided Malah Raja Lfalah Wassim Almawi Mohammed Elanbari Andrey Ptitsyn Sana Mahjoub Rabeb El Ghali Bechir Achour Nidhal Ben Amor Brahim N’siri Hamid Morjani Esam Azhar Vera Chayeb Maryam Dendena Hedia Zitouni Khedija Zouari-Limayem Bassem Refaat Ahmed M. Ashshi Sarah A. Batwa Hazem Ramadan Amal Awad Ahmed Ateya Adel Galal Ahmed El-Shemi Ahmad Ashshi Mohammed Basalamah Youjin Na Cha University of Texas Southwestern Medical Center Dallas USA Department of Cell Biology and Anatomy Graduate School of Medicine the University of Tokyo Tokyo Japan Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Department of Biochemistry and Molecular & Cellular Biology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Radiation Medicine Lombardi Comprehensive Cancer Center Georgetown University Washington USA Center of Excellence in Genomic Medicine Research (CEGMR) King Abdulaziz University Jeddah Kingdom of Saudi Arabia King Fahd Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia Centre of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Sheffield Diagnostic Genetic Service Sheffield Children’s NHS Foundation Trust Western Bank Sheffield UK Center of Innovations in Personalized Medicine King Abdulaziz University Jeddah Saudi Arabia President ISBER Editor-in-Chief Biopreservation & Biobanking ᅟ USA Institute of Applied Genetics Department of Molecular and Medical Genetics University of North Texas Health Science Center Fort Worth USA Department of Dental Public Health Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia Institute for Genomics and Evolutionary Medicine Temple University Philadelphia USA Center of Excellence in Genomic Medicine King Abdulaziz University Jeddah Kingdom of Saudi Arabia Laboratory of Molecular and Cellular Screening Processes (Bioinformatics Group) Centre of Biotechnology of Sfax Sfax Tunisia Fujitsu Technology Solutions International ᅟ ᅟ Case Western Reserve University School of Medicine and Lerner College of Medicine Cleveland Clinic Foundation Cleveland USA American Center for Reproductive Medicine Andrology Center Cleveland USA Center for Reproductive Medicine and

O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me

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Biohydrogen production by Thermoanaerobacterium thermosaccharolyticum KKU-ED1: Culture conditions optimization using xylan as the substrate

Biohydrogen production by Thermoanaerobacterium thermosaccha...

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作者： Saripan, Arunsri Fangkum Reungsang, Alissara Program of Environmental Science Faculty of Science and Technology Thepsatri Rajabhat University Lopburi 15000 Thailand Department of Biotechnology Faculty of Technology Khon Kaen University Khon Kaen 40002 Thailand Research Group for Development of Microbial Hydrogen Production Processes from Biomass Khon Kaen University Khon Kaen 40002 Thailand

Thermophilic hydrogen production from xylan by Thermoanaerobacterium thermosaccharolyticum KKU-ED1 isolated from elephant dung was investigated using batch fermentation. The optimum conditions for hydrogen production from xylan by the strain KKU-ED1 were an initial pH of 7.0, temperature of 55 °C and xylan concentration of 15 g/L. Under the optimum conditions, the hydrogen yield (HY), hydrogen production rate (HPR) and xylanase activity were 120.05 ± 15.07 mL H2/g xylan, 11.53 ± 0.19 mL H2/L h and 0.41 units/mL, respectively. The optimum conditions were then used to produce hydrogen from 62.5 g/L sugarcane bagasse (SCB) (equivalent to 15 g/L xylan) in which the HY and HPR of 1.39 ± 0.10 mL H2/g SCB (5.77 ± 0.41 mL H2/g xylan) and 0.66 ± 0.04 mL H2/L h, respectively, were achieved. In comparison to the other strains, the HY of the strain KKU-ED1 (120.05 ± 15.07 mL H2/g xylan) was close to that of Clostridium sp. strain X53 (125.40 mL H2/g xylan) and Clostridium butyricum CGS5 (90.70 mL H2/g xylan hydrolysate). Copyright © 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

关键词： Hydrogen production

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Screening of Gold Biomineralization Mechanism in Cyanobacteria

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Procedia Computer Science 2013年 23卷 129-136页

作者： Sivamoke Dissook Krittima Anekthanakul Weerayuth Kittichotirat Bioinformatics and System biology program School of bioresources and technology King Mongkut's University of Technology Thonburi Bangkhunthian Bangkok 10150 Thailand Biotechnology program School of bioresources and technology King Mongkut's University of Technology Thonburi Bangkok 10150 Thailand Systems biology and bioinformatics research group Pilot Plant Development and Training Institute King Mongkut's University of Technology Thonburi Bangkhuntien Bangkok 10150 Thailand

The metal-uptake ability known as biomineralization of microorganisms including fungi, yeasts and bacteria has been known for a long time. This process caused by metal ion stress response from microorganisms offering an efficient way to extract metal in solid state from environment, thus it can be applied in heavy metals bioremediation and precious metal recovery. Since metal biomineralization is the matter of ion stress response from microorganisms and cyanobacteria is one of the most successful organisms on the planet, therefore in this study we try to evaluate the biomineralization potential of cyanobacteria based on their genomes using gold biomineralization as a case study. According to our method we found that there are six cyanobacteria strains which have high potential for gold biomineralization.

关键词： screening tools biomineralization cyanobacteria

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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Transcriptional Regulatory Network of Arabidopsis Starch Metabolism under Extensive Light Condition: A Potential Model of Transcription-modulated Starch Metabolism in Roots of Starchy Crops

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Procedia Computer Science 2013年 23卷 113-121页

作者： Somkid Bumee Papapit Ingkasuwan Saowalak Kalapanulak Asawin Meechai Supapon Cheevadhanarak Treenut Saithong Systems Biology and Bioinformatics Research Laboratory Pilot Plant Development and Training Institute King Mongkut's University of Technology Thonburi Bangkhuntien campus Bangkok Thailand 10150 Bioinformatics and Systems Biology Program School of Bioresources and Technology King Mongkut's University of Technology Thonburi Bangkhuntien campus Bangkok Thailand 10150 Department of Chemical Engineering Faculty of Engineering King Mongkut's University of Technology Thonburi Bangkok Thailand 10140 Division of Biotechnology School of Bioresources and Technology King Mongkut's University of Technology Thonburi Bangkhuntien campus Bangkok Thailand 10150

Starchy root crops are a major carbohydrates source for being both human food and animal feed. The increasing demand of such crops has been a driving force of studies and research in biology of the crops. However, the related-knowledge as well as the existing information is still very few in comparison with the Arabidopsis model plant. Accordingly, the aims of this work are (1) to attempt to exploit the enormous data of Arabidopsis model plant to infer the regulation in the starchy root crops, and (2) to investigate the possibility and plausibility of the inference. Here, the transcriptional regulatory network of starch metabolism of Arabidopsis under extensive light condition was performed through the modified graphical Gaussian model (GGM) to infer the regulation of the similar process in root crops. The resulting correlation network of the significant genes includes 70 transcription factors and two starch-related genes, alpha-Glucosidase-like3 ( AGL3:At3g45940 ) and beta-Amylase 5 ( BAM5:At4g15210 ). Though the results provided the potential transcription factors of starch-related genes, which could be useful for further investigation, it is more likely that the selected condition of data is not appropriate to represent the starch metabolism in root crops. The results showed that greater than 70% of the significant genes were related to the starch degradation process which might reflect that the plants were under stress. This observation was supported by the Gene Ontology (GO) enrichment analysis that found many enriched GO terms relevant to the stress response. In conclusion, we believe that the data of the model plant are useful for gaining more understanding into the regulation in other plants, including root crops, but the suitable condition of data measurement in use need to be well defined.

关键词： transcriptional regulatory network graphical Gaussian model starch metabolism

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