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An insight into leaf secretions of Asian palmyra palm: A wound healing material from nature

Materials Today: Proceedings 2021年 47卷 733-738页

作者： R. Mariselvam S. Ignacimuthu A.J.A. Ranjitsingh Selvakumar P. Mosae Xavier Research Foundation St Xavier’s College Palayamkottai Tirunelveli Tamil Nadu 627 002 India Saraswathi Institute of Lifescience Terkkumadathur Tirunelveli Tamil Nadu 627 423 India Department of Biotechnology Prathyusha Engineering College Tiruvallur Tamil Nadu 602025 India Science and Math Program Asian University for Women Chittagong 4000 Bangladesh Panaiyaanmai-Centre for Self Reliance and Sustainable Development Munnetram Green Industry Kadayam Tenkasi Tamil Nadu 627415 India

The external anatomy of the tree leaves of the monocotyledon plant, Asian palmyra palm ( Borassus flabellifer ), differs from that of other plants in the scaly secretions on their surfaces. These secretions are used by traditional palmyra tree climbers to treat cuts or wounds inflicted by their tools during palm juice tapping. We performed a study to scientifically validate this traditional application and determine the pharmacological significance of palmyra secretion. Light microscopy, ultraviolet (UV) and Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) were performed to characterize the scaly secretions of palmyra palm. Phytochemical investigation and biological properties like antimicrobial and wound healing studies were conducted using standard procedures. Phytochemical investigation confirmed the presence of tannins, carbohydrates, protein, terpenoids, and reducing sugar. SEM results revealed the presence of hair-like structure on the leaf secretions. Leaf secretions also exhibited enhanced antibacterial and wound healing property.

关键词： Asian palmyra palm Borassus flabellifer Leaf secretion Palmyra warriors Traditional medicine Wound healing material

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1039P Discovery of a novel inhibitor of PD-L1 maturation that overcomes adaptive resistance to cancer immunotherapy

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Annals of Oncology 2024年 35卷 S697-S697页

作者： E. Teixidor Vilà S. Verdura J.A. Encinar À. Llop Hernández È. Sais A. Hernandez Martinez A. Romera J.M. Brunet Vidal B. Martin-Castillo E. Lopez-Bonet J. Bosch-Barrera E. Cuyàs J.A. Menendez Medical Oncology Catalan Institute of Oncology Girona Spain Metabolism and Cancer Research Group Girona Biomedical Research Institute (IDIBGI-CERCA) Girona Spain Institute of Research Development and Innovation in Health Biotechnology of Elche (IDiBE) Miguel Hernández University (UMH) Elche Spain Unit of Clinical Research Catalan Institute of Oncology Girona Spain Department of Anatomical Pathology Dr. Josep Trueta Hospital of Girona Girona Spain Program Against Cancer Therapeutic Resistance (ProCURE) Catalan Institute of Oncology Girona Spain

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Creatine and l-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish

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Scientific Reports 2024年第1期14卷 1-19页

作者： Pan, Shao-Wei Wang, Horng-Dar Hsiao, He-Yun Hsu, Po-Jui Tseng, Yung-Che Liang, Wen-Chen Jong, Yuh-Jyh Yuh, Chiou-Hwa Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Zhunan Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu Taiwan Department of Laboratory Medicine Mackay Memorial Hospital Taipei Taiwan Department of Medical Laboratory Science and Biotechnology Yuanpei University of Medical Technology Hsinchu Taiwan Department of Nursing MacKay Medical College Taipei Taiwan Marine Research Station Institute of Cellular and Organism Biology Academia Sinica I-Lan Taiwan Department of Pediatrics School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Translational Research Center of Neuromuscular Diseases Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu Taiwan Ph.D. Program in Environmental and Occupational Medicine Kaohsiung Medical University Kaohsiung Taiwan

Lamin A/C gene (LMNA) mutations contribute to severe striated muscle laminopathies, affecting cardiac and skeletal muscles, with limited treatment options. In this study, we delve into the investigations of five distinct LMNA mutations, including three novel variants and two pathogenic variants identified in patients with muscular laminopathy. Our approach employs zebrafish models to comprehensively study these variants. Transgenic zebrafish expressing wild-type LMNA and each mutation undergo extensive morphological profiling, swimming behavior assessments, muscle endurance evaluations, heartbeat measurement, and histopathological analysis of skeletal muscles. Additionally, these models serve as platform for focused drug screening. We explore the transcriptomic landscape through qPCR and RNAseq to unveil altered gene expression profiles in muscle tissues. Larvae of LMNA(L35P), LMNA(E358K), and LMNA(R453W) transgenic fish exhibit reduced swim speed compared to LMNA(WT) measured by DanioVision. All LMNA transgenic adult fish exhibit reduced swim speed compared to LMNA(WT) in T-maze. Moreover, all LMNA transgenic adult fish, except LMNA(E358K), display weaker muscle endurance than LMNA(WT) measured by swimming tunnel. Histochemical staining reveals decreased fiber size in all LMNA mutations transgenic fish, excluding LMNA(WT) fish. Interestingly, LMNA(A539V) and LMNA(E358K) exhibited elevated heartbeats. We recognize potential limitations with transgene overexpression and conducted association calculations to explore its effects on zebrafish phenotypes. Our results suggest lamin A/C overexpression may not directly impact mutant phenotypes, such as impaired swim speed, increased heart rates, or decreased muscle fiber diameter. Utilizing LMNA zebrafish models for drug screening, we identify l-carnitine treatment rescuing muscle endurance in LMNA(L35P) and creatine treatment reversing muscle endurance in LMNA(R453W) zebrafish models. Creatine activates AMPK and mTOR pathw

关键词： Creatine l-Carnitine LMNA Striated muscle laminopathy Zebrafish

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Co-production of hydrogen and ethanol by Thermoanaerobacterium thermosaccharolyticum KKU-ED1 from alpha-cellulose and cellulose fraction of sugarcane bagasse

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Bioresource Technology Reports 2021年 15卷

作者： Saripan, Khamanitjaree Reungsang, Alissara Sittijunda, Sureewan Environmental Science Program Faculty of Science and Technology Thepsatri Rajabhat University Lopburi15000 Thailand Department of Biotechnology Faculty of Technology Khon Kaen University Khon Kaen40002 Thailand Research Group for Development of Microbial Hydrogen Production Process from Biomass Khon Kaen University Khon Kaen40002 Thailand Academy of Science Royal Society of Thailand Bangkok10300 Thailand Faculty of Environment and Resource Studies Mahidol University Nakhon Pathom73170 Thailand

This research aims to evaluate the co-production of hydrogen and ethanol from lignocellulosic materials by Thermoanaerobacterium thermosaccharolyticum KKU-ED1. The optimum conditions for co-production of hydrogen and ethanol in batch fermentation was determined using alpha-cellulose as a basic model substrate to mimic the natural cellulose part of a lignocellulosic material. The optimal conditions attained were an initial pH of 7.0, a temperature of 55 °C, and a cellulose content of 20 g/L, which resulted in the maximum hydrogen production and ethanol (EtOH) yield of 6113 mL H2/L and 1.71 mmol EtOH/g-celluloseconsumed, respectively. The potential of the KKU-ED1 strain to produce hydrogen and ethanol from natural cellulose in sugarcane bagasse was further evaluated under the optimum conditions. Hydrogen production and ethanol yield of 218 mL H2/L, and 0.26 mmol EtOH/g-celluloseconsumed were obtained. Results indicated that the strain KKU-ED1 is a thermophilic cellulolytic bacterium capable of co-producing hydrogen and ethanol from lignocellulosic materials. © 2021 Elsevier Ltd

关键词： Ethanol

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Integrating Bioprinted Oral Epithelium with Millifluidics for Fluorouracil Perfusion and Fusobacterium Infection to Bioengineer Oral Mucositis-on-A-Chip

SSRN

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SSRN 2024年

作者： Truong, Tien T.T. Phan, Toan V. Oo, Yamin Sariya, Ladawan Chaisuparat, Risa Scaglione, Silvia Souza, Glauco R. Yodmuang, Supansa Hong, Catherine H.L. Tan, Kai Soo Phoolcharoen, Waranyoo Matangkasombut, Oranart Ferreira, João N. Center of Excellence Innovation for Oral Health and Healthy Longevity Faculty of Dentistry Chulalongkorn University Bangkok10330 Thailand International Graduate Program in Oral Biology Faculty of Dentistry Chulalongkorn University Bangkok10330 Thailand The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals Faculty of Veterinary Science Mahidol University Nakhon Pathom73170 Thailand Department of Oral Pathology Faculty of Dentistry Chulalongkorn University Bangkok10330 Thailand National Research Council of Italy Genova16149 Italy React4life S.p.A. Genova16152 Italy ChemoSen3D HoustonTX77054 United States Global Business Development and Innovation Greiner Bio-one N.A. CharlotteNC28110 United States Department of Research Affairs Faculty of Medicine Chulalongkorn University Bangkok10330 Thailand Faculty of Dentistry National University of Singapore Singapore119085 Singapore Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok10330 Thailand Department of Microbiology Center of Excellence on Oral Microbiology and Immunology Faculty of Dentistry Chulalongkorn University Bangkok10330 Thailand Research Laboratory of Biotechnology Chulabhorn Research Institute Bangkok10210 Thailand

Oral mucositis (OM) remains a painful complication of anticancer chemotherapy (CT), tending to progress in severity in the presence of Fusobacterium nucleatum (Fn). Yet, no effective therapy exists to suppress OM since in vitro models mimicking CT-induced OM are lacking, halting the discovery of new drugs. Here, we developed an integrated millifluidic in vitro tissue culture system for OM disease modeling. This bioengineered system integrates magnetically bioassembled oral epithelium sheets with millifluidics for CT-based 5-fluorouracil perfusion and Fn infection to model CT-induced OM. After modeling OM with all pro-inflammatory hallmarks, we were able to suppress OM with our in-house plant-produced epidermal growth factor (P-EGF), a well-known re-epithelialization cue. Thus, this the first instance where a milifluidic system enabled OM modeling in the presence of CT drug perfusion and Fn infection. This bioengineered system is a novel tool for drug discovery as it propelled P-EGF as a promising therapy for OM. © 2024, The Authors. All rights reserved.

关键词： Chemotherapy

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Agar-altered foaming bacterial cellulose with carvacrol for active food packaging applications

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Food Packaging and Shelf Life 2024年 42卷

作者： Kusuma, Anita Chandra Chou, Yu-Chieh Hsieh, Chen-Che Santoso, Shella Permatasari Go, Alchris Woo Lin, Hong-Ting Victor Hsiao, I.-Lun Lin, Shin-Ping Master Program in Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Section 4 Taipei 10617 Taiwan Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya 60114 Indonesia Department of Chemical Engineering National Taiwan University of Science and Technology 43 Keelung Road Section 4 Taipei 10607 Taiwan Department of Food Science National Taiwan Ocean University No. 2 Pei-Ning Road Keelung 20224 Taiwan School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan

Bacterial cellulose (BC) is a biodegradable nanoscale film produced by microorganisms, which possesses great mechanical properties and biocompatibility. In this study, we produced foaming BC (FBC) utilizing foam medium with different concentrations of agar. In addition, carvacrol was loaded into the agar/FBC to establish active packaging material. Evaluation by characterization tests indicated that agar/FBC provided lower crystallinity (59.8%∼71.4%) and a high swelling ability (94.7%∼97.9%) compared to BC (92.2% and 96.1%). The 1.5% agar/FBC with carvacrol group exhibited the significantly highest antimicrobial properties against Escherichia coli and Staphylococcus aureus. Moreover, release measurements showed that greater agar addition contributed to higher protein and carvacrol release extents out of the film. Finally, a sea bass packaging test indicated that carvacrol with 1.5% agar/FBC presented a higher antimicrobial ability against Shewanella putrefaciens, great inhibition of lipid oxidation (67.5%), and a slower spoilage degree (49.8%) which suggested that agar/FBC with carvacrol has potential for active food packaging. © 2024 Elsevier Ltd

关键词： Agar Bacterial cellulose Carvacrol Foaming bacterial cellulose Food packaging Sea bass

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An insight into leaf secretions of Asian palmyra palm: A wound healing material from nature 1

An insight into leaf secretions of Asian palmyra palm: A wou...

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1st International Conference on Frontiers in Chemical Sciences, ICFCS 2020

作者： Mariselvam, R. Ignacimuthu, S. Ranjitsingh, A.J.A. Mosae, Selvakumar P. Xavier Research Foundation St Xavier's College Palayamkottai Tamil Nadu Tirunelveli627 002 India Saraswathi Institute of Lifescience Terkkumadathur Tamil Nadu Tirunelveli627 423 India Department of Biotechnology Prathyusha Engineering College Tamil Nadu Tiruvallur602025 India Science and Math Program Asian University for Women Chittagong4000 Bangladesh Panaiyaanmai-Centre for Self Reliance and Sustainable Development Munnetram Green Industry Kadayam Tamil Nadu Tenkasi627415 India

The external anatomy of the tree leaves of the monocotyledon plant, Asian palmyra palm (Borassus flabellifer), differs from that of other plants in the scaly secretions on their surfaces. These secretions are used by traditional palmyra tree climbers to treat cuts or wounds inflicted by their tools during palm juice tapping. We performed a study to scientifically validate this traditional application and determine the pharmacological significance of palmyra secretion. Light microscopy, ultraviolet (UV) and Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) were performed to characterize the scaly secretions of palmyra palm. Phytochemical investigation and biological properties like antimicrobial and wound healing studies were conducted using standard procedures. Phytochemical investigation confirmed the presence of tannins, carbohydrates, protein, terpenoids, and reducing sugar. SEM results revealed the presence of hair-like structure on the leaf secretions. Leaf secretions also exhibited enhanced antibacterial and wound healing property. © 2020 Elsevier Ltd. All rights reserved.

关键词： Scanning electron microscopy

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Combination of MS medium and Gandasil D on banana shoots growth in vitro

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： A N A Damayanti Nandariyah A Yunus Undergraduate Program in Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Lecturer staff of the Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University.

Cavendish banana has a high economic for food export commodities. High export opportunities need to be balanced with increased productivity by selecting superior seedlings through in vitro seed propagation. The tissue fruitfulness depends on the media used. The media used substitution between MS media and Gandasil D leaf fertilizer with different concentrations. The researcher also used a completely randomized design (CRD) of one factor with five treatment combinations and six repetition. The treatment used is MS 100% as a control; 75% MS + 25% Gandasil D; 50% MS + 50% Gandasil D; 25% MS + 75% Gandasil D; 100% D. the variables observed include time of buds, number of shoots, plantlet height, time of leaves, number of leaves, time of roots, number of roots, and root length. The data analysis used is the physical analysis method based on the F test of 5% level. The results of the research showed that 100% Gandasil D and 25% MS + 75% Gandasil D treatment had the highest influence on the number of leaves, number of shoots, plant height, and number of roots. The mixture of MS media and leaf fertilizer can be used as an alternative medium for multiplication of Cavendish bananas.

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Symbiotic Bacteroides and Clostridium-rich methanogenic consortium enhanced biogas production of high-solid anaerobic digestion systems

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Bioresource Technology Reports 2021年 14卷

作者： Tukanghan, Wisarut Hupfauf, Sebastian Gómez-Brandón, María Insam, Heribert Salvenmoser, Willi Prasertsan, Poonsuk Cheirsilp, Benjamas O-Thong, Sompong Biotechnology Program Department of Biology Faculty of Science Thaksin University Phatthalung93210 Thailand Department of Microbiology University of Innsbruck Technikerstraße 25d Innsbruck6020 Austria Universidade de Vigo VigoE-36310 Spain Department of Zoology University of Innsbruck Technikerstraße 25d Innsbruck6020 Austria Research and Development Office Prince of Songkla University Hat YaiSongkhla90112 Thailand Center of Excellence in Innovative Biotechnology for Sustainable Utilization of Bioresources Faculty of Agro-Industry Prince of Songkhla University Hat YaiSongkhla90112 Thailand International College Thaksin University Songkhla90000 Thailand

The high-solid anaerobic digestion (AD) for anaerobic co-digestion of palm oil mill effluent (POME) and oil palm empty fruit bunches (EFB) has low degradation efficiency. The enhancement of biogas production and EFB degradation efficiency by Bacteroides and Clostridium-rich methanogenic consortium was investigated. A Bacteroides and Clostridium-rich methanogenic consortium have xylanase, FPase, endo-glucanase, and exo-glucanase activity of 9.2, 1.3, 2.1, and 1.5 IU·mL−1, respectively with EFB degradation efficiency of 57.5%. Methane production (79 m3-CH4·tonne−1-EFB) by Bacteroides and Clostridium-rich methanogenic consortium augmentation was increased by 67.2%. The real application of bioaugmentation in the feedstock mixing tank before a feed to the AD reactor significantly increased methane yield (376.7 mL-CH4·g-1-VS−) by 85.5%. Bioaugmentation of Bacteroides and Clostridium-rich methanogenic consortium increased the number of hydrolytic bacteria and strengthened symbiotic relationships with indigenous microorganisms resulting in high biogas production, accelerated hydrolysis, and reduced solids accumulation of the high-solid AD process. © 2021 Elsevier Ltd

关键词： Fruits

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Perfomance selection of Mentik Wangi M5 generation rice resulting from 100 gray gamma-ray irradiation

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： O P Sutanto Nandariyah A Yunus Undergraduate Program in Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Lecturer staff of the Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University.

Mentik Wangi rice is local rice originating from Yogyakarta Indonesia, which has distinctive fragrant and fluffier texture. The problems that occur in Mentik Wangi rice cultivation are that the harvest time is longer, and the plants are too high so that it gives a potential lower production impact because it is easy to collapse. One way to overcome this problem is through plant breeding with gamma-ray irradiation. The aim of this research is to select Mentik Wangi M5 irradiated by 100 Gy gamma-ray, which has a short stem and has high productivity. Observation data were analyzed descriptively, followed by a T-test to compare the performance of Mentik Wangi M5 rice plants from 100 gray gamma irradiation with control plants (without irradiation). The shortest plant height is in the M-MW1-G12-01-18–05 of 96cm with a height range of 96–110 cm. The highest number of productive tillers was found in the M-MW1-G80-11-08-15 with a range of 15–25 tillers. The highest panicle density index range was found in the M-MW1-G35-02-06-19 of 4.6-6.77. The highest level of plant productivity was found in the M-MW1-G12-01-18-01 which was 5.95 tons/ha. The results of the selection there are 21 individual plant mutans.

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