检索结果-内蒙古大学图书馆

SSRN 2025年

作者： Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T. Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei110301 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei110301 Taiwan Graduate Institute of Healthy Industry Technology Research Center for Chinese Herbal Medicine College of Human Ecology Chang Gung University of Science and Technology Taoyuan333324 Taiwan Faculty of Pharmacy Lac Hong University Dongnai Bien Hoa Viet Nam Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Viet Nam National Museum of Marine Biology and Aquarium Pingtung944401 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University Organization of African Unity Street Abassia Cairo11566 Egypt Center for Reproductive Medicine and Sciences Taipei Medical University Hospital Taipei110301 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei110301 Taiwan

Marine invertebrates are well-established as prolific sources of secondary metabolites, renowned for their remarkable chemical diversity and extensive spectrum of biological activities. Among these, Zoanthus Kuroshio (ZK) has gained significant attention due to its abundant chemical constituents, particularly alkaloids, which exhibit promising bioactivities against osteoporosis. To investigate its therapeutic potential, the extracts of cultured ZK exhibited significant anti-osteoporotic activity in vitro with MG-63 cells, leading to the integration of Global Natural Products Social Molecular Networking (GNPS) to identify fractions containing the highest amounts of alkaloids. Subsequent isolation efforts resulted in the discovery of five novel zoanthamine-type alkaloids: norzoabenzaldehyde (1), norzoazepanol (2), 11-keto-3-acetoxynorzoanthamine (3), 11-hydroxynorzoanthamide B (4), and 11-hydroxyzoanthamide B (5), alongside four previously identified compounds, including norzoanthaminone (6), 3-acetoxynorzoanthamine (7), 3-acetoxyzoanthamine (8), and 3-hydroxynorzoanthamine (9). Structural elucidation of compounds 1, 3, 4, and 5 was achieved using comprehensive spectroscopic analyses, whereas compound 2 required advanced techniques, including time-dependent density functional theory nuclear magnetic resonance (TDDFT-NMR) calculations and comparative analysis of theoretical and experimental electronic circular dichroism (ECD) data, to ascertain its absolute configuration. Bioassays evaluating alkaline phosphatase activity and mineralization demonstrated that compound 9 exhibited significant activity, with an IC50 value of 20 µM. The mechanism by which this compound operates was elucidated through network pharmacology, molecular docking and dynamics simulations, further confirming the stability of interactions between compound 9 and key protein targets, thereby emphasizing its potential as a promising lead compound for osteoporosis therapeutics. © 2025, The Authors. All

关键词： Spectroscopic analysis

来源：评论

学校读者我要写书评

暂无评论

Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Scientific World Journal

引用

Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

来源：评论

学校读者我要写书评

暂无评论

Comparative Genome Analysis of ThreeHalobacillusStrains Isolated From Saline Environments Reveal Potential Salt Tolerance and Algicidal Mechanisms

引用

Environmental Microbiology Reports 2025年第3期17卷 e70121页

作者： Saru Gurung Chang-Muk Lee Hang-Yeon Weon So-Ra Han Tae-Jin Oh Department of Life Science and Biochemical Engineering SunMoon University Asan Republic of Korea Bio Big Data-Based Chungnam Smart Clean Research Leader Training Program SunMoon University Asan Republic of Korea Agricultural Microbiology Division National Institute of Agricultural Sciences Rural Development Administration Jeonju Republic of Korea Technology Services Division National Institute of Agricultural Sciences Rural Development Administration Jeonju Republic of Korea Genome-Based BioIT Convergence Institute Asan Republic of Korea Department of Pharmaceutical Engineering and Biotechnology SunMoon University Asan Republic of Korea

Harmful algal blooms (HABs) pose a significant global threat to water ecosystems, prompting extensive research into their inhibition and control strategies. This study presents genomic and bioinformatic analyses to investigate the algicidal potential and elucidate the survival mechanisms in harsh conditions of newly identified Halobacillus species three strains (SSTM10-2 T , SSBR10-3 T , and SSHM10-5 T ) isolated from saline environments. Moreover, genomic and bioinformatic analyses were conducted to elucidate their survival mechanisms in harsh conditions. Moreover, comparative genomic analysis revealed a diverse set of orthologous genes, with a core genome primarily associated with metabolism and information processing. Pangenome analysis highlighted accessory and unique genes potentially involved in environmental adaptation and stress response. Functional annotation using KEGG pathways identified genes linked to xenobiotic compound degradation, stress tolerance, and salt adaptation. Additionally, the study elucidated potential mechanisms underlying algicidal activity, implicating Carbohydrate-Active enZYmes (CAZymes), cytochrome P450 oxidases (CYP), and quorum sensing (QS) systems. Finally, analysis of KEGG pathways related to microcystin degradation suggested the strains' capacity to mitigate HABs. Thus, this research enhances understanding of the genomic diversity, phylogeny, and functional characteristics of Halobacillus species, offering insights into their ecological roles and potential applications in biotechnology and environmental management.

关键词： algicidal activity comparative genome analysis Halobacillus sp. halotolerance stress response

来源：评论

学校读者我要写书评

暂无评论

Multiple strain analysis of Streptomyces species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities (vol 11, 17544, 2021)

引用

SCIENTIFIC REPORTS 2021年第1期11卷 1-14页

作者： Tenebro, Chuckcris P. Trono, Dana Joanne Von L. Vicera, Carmela Vannette B. Sabido, Edna M. Ysulat, Jovito A., Jr. Macaspac, Aaron Joseph M. Tampus, Kimberly A. Fabrigar, Trisha Alexis P. Saludes, Jonel P. Dalisay, Doralyn S. Center for Chemical Biology and Biotechnology (C2B2) University of San Agustin 5000 Iloilo City Philippines Department of Biology College of Liberal Arts Sciences and Education University of San Agustin 5000 Iloilo City Philippines Balik Scientist Program Department of Science and Technology Philippine Council for Health Research and Development (PCHRD) 1631 Bicutan Taguig City Philippines Center for Natural Drug Discovery and Development (CND3) University of San Agustin 5000 Iloilo City Philippines Department of Chemistry College of Liberal Arts Sciences and Education University of San Agustin 5000 Iloilo City Philippines

The marine ecosystem has become the hotspot for finding antibiotic-producing actinomycetes across the globe. Although marine-derived actinomycetes display strain-level genomic and chemodiversity, it is unclear whether functional traits,i.e., antibiotic activity, vary in near-identicalStreptomycesspecies. Here, we report culture-dependent isolation, antibiotic activity, phylogeny, biodiversity, abundance, and distribution ofStreptomycesisolated from marine sediments across the west-central Philippines. Out of 2212 marine sediment-derived actinomycete strains isolated from 11 geographical sites, 92 strains exhibited antibacterial activities against multidrug-resistantStaphylococcus aureus,Pseudomonas aeruginosa, andEscherichia coli. The 16S rRNA andrpoBgene sequence analyses confirmed that antibiotic-producing strains belong to the genusStreptomyces, highlightingStreptomyces parvulusas the most dominant species and three possible new species. Antibiotic-producingStreptomycesstrains were highly diverse in Southern Antique, and species diversity increase with marine sediment depth. Multiple strains with near-identical 16S rRNA andrpoBgene sequences displayed varying strength of antibiotic activities. The genotyping of PKS and NRPS genes revealed that closely related antibiotic-producing strains have similar BGC domains supported by their close phylogenetic proximity. These findings collectively suggestStreptomyces' intraspecies adaptive characteristics in distinct ecological niches that resulted in outcompeting other bacteria through differential antibiotic production.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Green synthesis of silver and copper nanoparticles and their composites usingOcimum sanctumleaf extract displayed enhanced antibacterial, antioxidant and anticancer potentials

引用

Artificial Cells, Blood Substitutes, and biotechnology 2024年第1期52卷

作者： M. Ashokkumar K. Palanisamy A. Ganesh Kumar C. Muthusamy K. J. Senthil Kumar a Department of Physics Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences Saveetha University Thandalam India b Department of Chemistry Srinivasan College of Arts and Science(Affiliated to Bharathidasan University Tiruchirappalli) Perambalur India c Department of Microbiology Centre for Research and Development Hindustan College of Arts & Science Kelambakkam India d Department of Biotechnology Srinivasan College of Arts and Science (Affiliated to Bharathidasan University Tiruchirappalli) Perambalur India e Center for General Education National Chung Hsing University Taichung Taiwanf Bachelor Program of Biotechnology National Chung Hsing University Taichung Taiwan

Green-synthesized silver and copper nanoparticles (NPs), along with their composites, exhibit various biological *** sanctum(Holy basil), traditionally used as medicine in South Asia, treats respiratory disorders, digestive issues, skin diseases and inflammatory conditions. Modern scientific studies support these bioactivities; however, no studies have investigated their bioactivity in combination with NPs. In this study, silver and copper NPs were synthesized using AgNO3and CuSO4·5H2O solutions, respectively, withOcimum sanctumleaf extract, and their antibacterial, antioxidant and anticancer properties were examined. Spectroscopic analyses, including Fourier transform infra-red (FTIR), transmission electron microscopy (TEM) and X-ray diffraction (XRD), elucidated the physicochemical characteristics of the green-synthesized nanoparticles (Os-AgNPs andOs-CuNPs), revealing sizes of 11.7 and 13.1 nm, respectively. TheOs-AgNPs:Os-CuNPs nano-composite with a 1:2 ratio exhibited a zone of inhibition ranging from 8 to 12 mm against tested bacterial pathogens. Additionally, the NPs and their composites demonstrated potent antioxidant activity, with notable 2-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity observed in composites with ratios of 2:1 and 1:2. Furthermore, they displayed potential anticancer activity against human leukaemia (Jurkat) cancer cells. Although no distinct difference in anticancer property was observed among the NPs and their composites, our study highlights their well-defined nanostructure and significant biological activity, suggesting their potential as therapeutic agents in the pharmaceutical *** AbstractDisplay full size

关键词： Silver nanoparticles copper nanoparticles nano-composites antioxidant antibacterial anticancer

来源：评论

学校读者我要写书评

暂无评论

Gelatin-guar gum hydrogel for topical application: cytotoxicity, antibacterial activity against MRSA, and non-irritant characteristics

引用

European Polymer Journal 2025年

作者： Francisca Vanessa C. Canafístula Matheus X. Oliveira Ana Jérsia Araújo José Delano B. Marinho Filho Rodrigo Elísio de Sá Alyne R. Araujo-Nobre Sansara Sanny M. Araújo Fábio Oliveira S. Ribeiro Roberta Jeane B. Jorge Ana Celeste X. Oliveira Fpelipe Rhaynan S. Andrade Jeanny S. Maciel Regina Celia M. de Paula Judith Pessoa A. Feitosa Department of Organic and Inorganic Chemistry Polymer Laboratory Federal University of Ceará UFC Fortaleza CE Brazil Cell Culture Laboratory of the Delta LCCDelta Parnaiba Delta Federal University UFDPar Parnaíba PI Brazil Research Center on Biodiversity and Biotechnology BIOTEC Parnaiba Delta Federal University UFDPar Parnaíba PI Brazil Drug Research and Development Center (NPDM) Federal University of Ceará UFC Fortaleza CE Brazil Program in Morphological Science Department of Morphology School of Medicine Federal University of Ceará UFC Fortaleza CE Brazil

Hydrogels based on oxidized guar gum (OxGG) and gelatin (Gel) were synthesized via Schiff base crosslinking using three different gelatin proportions (60–80 wt%). The hydrogels were characterized by rheology, FT-IR, GPC, SEM, swelling behavior, and degradation analyses. Variations in gelatin content led to hydrogels with distinct physicochemical properties; higher gelatin concentrations resulted in shorter gelation times, increased crosslinking density, lower swelling capacity, smaller interconnected porous structures, and faster degradation in PBS. All three hydrogels exhibited strong intrinsic antibacterial activity, inhibiting methicillin/oxacillin-resistant Staphylococcus aureus (MRSA) by >98 % and Staphylococcus epidermidis and Staphylococcus aureus by >95 %. The performance of these hydrogels was compared with that of other recently reported gels exhibiting high MRSA inhibition as well as with gelatin-containing hydrogels. Notably, OxGG:Gel hydrogels stood out because of their high antibacterial activity, which was achieved without the addition of antibiotic agents or the need for additional treatments such as photothermal therapy. Furthermore, all hydrogels demonstrated good cell viability and did not induce significant changes in the CAM blood vessels, such as vascular lysis, hemorrhage, or coagulation, confirming their non-irritating nature. The OxGG:Gel70 hydrogel exhibited superior cell viability, intermediate degradation rate, and strong efficacy against MRSA. In addition to being nonirritating, it exhibited a protective effect against vascular events. Moreover, this hydrogel exhibited key functional properties, including injectability, self-healing, and adhesiveness. Given these characteristics, OxGG:Gel70 stands out among MRSA-active hydrogels and has great potential for topical applications, including dermatitis, skin inflammation, ophthalmic formulations, and wound healing.

关键词：

来源：评论

学校读者我要写书评

暂无评论

The effect of Murashige and Skoog (MS) and Growmore fertilizer media composition on growth of Ambon banana plants in vitro

引用

IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： A R Utomo Nandariyah A Yunus Undergraduate Program in Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Indonesia Lecturer staff of the Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Indonesia Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University Indonesia

Efforts to propagate banana seeds with good quality on a large scale can be pursued through tissue culture techniques. In tissue culture often uses Murashige and Skoog (MS) media but these media are difficult to obtain. Growmore is a leaf fertilizer that has the potential to replace MS media because it has a complete nutrient content. This study aims to obtain the most effective composition of MS media and Growmore fertilizer for the growth of ambon banana shoots in vitro. The study was conducted at the Plant Physiology and biotechnology Laboratory, Sebelas Maret University using a completely randomized design pattern (CRD) with a single factor divided into 5 levels with 6 replications. Variables observed include the time of buds, number of shoots, plant height, time of leaves, number of leaves, time of roots, number of roots, root length. The results showed the composition of 25% MS + 75% Growmore gave the highest results on the number of shoots, the composition of 50% MS + 50% gave the best results on plantlet height, number of leaves, and number of roots.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice

引用

Heliyon 2024年第2期10卷

作者： Chu, Pei-Yi Hsu, Chang-Lu Lin, Yen-An Pan, Yi-Cheng Dai, Yun-Hao Yu, Ying-Chun Yang, Juan-Cheng Ma, Wen-Lung Chen, Yi-Jinn Lillian Lee, Chia-Lin Wu, Yang-Chang Chinese Medicine Research and Development Center China Medical University Hospital Taichung Taiwan Department of Business Administration National Chiayi University Chiayi Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan .Ph.D. Program for Cancer Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan Department of Medical Research and Organ Transplantation Center China Medical University Hospital Taichung Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung Taiwan Department of Physics National Kaohsiung Normal University Kaohsiung Taiwan Department of Cosmeceutics China Medical University Taichung 40604 Taiwan Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology College of Medical and Health Science Asia University Taichung Taiwan

The present study investigated the potential anti-obesity properties of Citrus depressa Hayata (CDH) juice in HBV transgenic mice, as well as the impact of fermentation on the effectiveness of the juice. The results revealed that fermentation increased the levels of polyphenols and hesperidin in CDH juice. The animal study demonstrated that both juices were effective in mitigating the weight gain induced by a high-fat diet by correcting metabolic parameter imbalances, reducing hepatic lipid accumulation, and reversing hepatic immune suppression. Furthermore, fermented juice exhibited superior efficacy in managing body weight and inhibiting the expansion of white adipose tissue (WAT). Fermented juice significantly enhanced adiponectin production and PPARγ expression in WAT, while also reducing hypertrophy. This study offers valuable insights into the potential role of CDH juices in combating obesity associated with high fat consumption and underscores the promise of CDH juice as a functional beverage. © 2024 The Authors

关键词： Citrus depressa hayata fermentation HBV Hesperidin High-fat diet-induced obesity Juice Mice Polyphenol

来源：评论

学校读者我要写书评

暂无评论

Mechanisms and therapeutic actions of edible fruits in inflammatory bowel disease: A review of pre-clinical studies

Food Chemistry Advances

引用

Food Chemistry Advances 2023年 3卷

作者： Arunachalam, Karuppusamy Sreeja, Puthanpura Sasidharan Yang, Xuefei Center for Studies in Stem Cells Cell Therapy and Toxicological Genetics (CeTroGen) Faculty of Medicine (FAMED) Federal University of Mato Grosso do Sul (UFMS) Mato Grosso do Sul Campo Grande Brazil Postgraduate Program in Health and Development of the Midwest Region Faculty of Medicine (FAMED) Federal University of Mato Grosso do Sul (UFMS) Mato Grosso do Sul Campo Grande Brazil Department of Botany NSS College Palakkad India Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Kunming China Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences Nay Pyi Taw Myanmar

The review highlights the significance of traditional knowledge in using edible fruits to address health issues, specifically focusing on inflammatory bowel disease (IBD). Edible fruits are rich in beneficial components like dietary fiber, vitamins, minerals, polyphenols, bioactive peptides, and antioxidants which contribute to overall health and show potential in managing gastrointestinal disorders. The objective of the review is to provide strong evidence supporting the effectiveness of edible fruits in preventing and treating IBD. The study conducted an extensive review of research published from 2001 to 2022, gathering data from reputable sources and evaluating the utilization of edible fruits in IBD treatment. This review identified 36 species of edible fruits across 10 families historically used in traditional medicine. Various bioactive molecules like tannins, flavonoids, saponins, terpenoids, alkaloids, and ascorbic acid have been isolated from these fruits. Recent studies have shown that compounds from edible fruits can counteract intestinal inflammation in animal models by influencing key signaling pathways and exhibiting immunomodulatory, anti-inflammatory, and antioxidant properties. The review suggests that extracts from edible fruits could offer potential alternative or supplementary treatments for individuals with IBD. However, the review also acknowledges limitations in some prior studies, including inadequate dosages, insufficient standards, and an incomplete understanding of mechanisms. Further research is needed to fully elucidate the mechanisms underlying the effects of these extracts and compounds. © 2023 The Author(s)

关键词： Edible fruits Inflammasome-signaling pathway Inflammatory bowel disease Polyphenols Pre-clinical studies

来源：评论

学校读者我要写书评

暂无评论

Enhanced exopolysaccharide production of Cordyceps militaris via mycelial cell immobilization on plastic composite support in repeated-batch fermentation

引用

International Journal of Biological Macromolecules 2023年第1期250卷 126267页

作者： Lin, Shin-Ping Sung, Ting-Hsuan Angkawijaya, Artik Elisa Go, Alchris Woo Hsieh, Chang-Wei Hsu, Hsien-Yi Santoso, Shella Permatasari Cheng, Kuan-Chen School of Food Safety Taipei Medical University #250 Wuxing Street Xinyi Dist. Taipei11042 Taiwan Research Center of Biomedical Device Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Nutrition and Health Sciences Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Center for Sustainable Resource Science RIKEN Yokohama230-0045 Japan Department of Chemical Engineering National Taiwan University of Science and Technology #43 Sec. 4 Keelung Rd Taipei10607 Taiwan Department of Food Science and Biotechnology National Chung Hsing University South Dist. Taichung City40227 Taiwan Department of Medical Research China Medical University Hospital North Dist. Taichung City404333 Taiwan Taiwan Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Energy and Environment Department of Materials Science and Engineering City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Jl. Kalijudan 37 East Java Surabaya60114 Indonesia Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung40

Repeated-batch fermentation with fungal mycelia immobilized in plastic composite support (PCS) eliminates the lag phase during fermentation and improves metabolite productivity. The strategy is implemented herein, and a novel modified PCS is developed to enhance exopolysaccharide (EPS) production from the medicinal fungus Cordyceps militaris. A modified PCS (SYE + PCS) was made by compositing polypropylene (PP) with a nutrient mixture containing soybean hull, peptone, yeast extract, and minerals (SYE+). The use of SYE + PCS has consistent cell productivity throughout the multiple fermentation cycles, which resulted in a more higher cell productivity after second batch compared to unmodified PCS. The cell grown on SYE + PCS also generates a higher yield of EPS (3.36, 6.93, and 5.72 g/L in the first, second, and third fermentation cycles, respectively) up to three-fold higher than the cell immobilized on unmodified PCS. It is also worth noting that the EPS from mycelium grown on SYE + PCS contains up to 2.3-fold higher cordycepin than those on unmodified PCS. The presence of nutrients in SYE + PCS also affects the hydrophobicity and surface roughness of the PC, improving mycelial cell adhesion. This study also provides a preliminary antioxidant activity assessment of EPS from immobilized C. militaris grown with SYE + PCS. © 2023

关键词： Mycelium

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：