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Transdermal nanolipoplex simultaneously inhibits subcutaneous melanoma growth and suppresses systemically metastatic melanoma by activating host immunity

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Nanomedicine: Nanotechnology, Biology, and Medicine 2023年 47卷 102628-102628页

作者： Chen, Chia-Hung Weng, Tzu-Han Chuang, Cheng-Hsun Huang, Kai-Yao Huang, Sih-Cheng Chen, Pin-Rong Huang, Hsiao-Hsuan Huang, Ling-Ya Shen, Pei-Chun Chuang, Po-Ya Huang, Hsiao-Yen Wu, Yi-Syuan Chang, Hao-Chiun Weng, Shun-Long Liao, Kuang-Wen Department of Medical Research Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan Dependent of Medical Education MacKay Memorial Hospital Taipei10449 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Industrial Development Graduate Program of College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Medicine MacKay Medical College New Taipei City25245 Taiwan Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan MacKay Junior College of Medicine Nursing and Management Taipei City11260 Taiwan Drug Development and Value Creation Research Center College of Dental Medicine Kaohsiung Medical University School of Dentistry Graduate Institute of Medicine College of Medicine Center for Cancer Research Kaohsiung Medical University Kaohsiung City80708 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan City70101 Taiwan Ph.D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan

Benefit for clinical melanoma treatments, the transdermal neoadjuvant therapy could reduce surgery region and increase immunotherapy efficacy. Using lipoplex (Lipo-PEG-PEI-complex, LPPC) encapsulated doxorubicin (DOX) and carrying CpG oligodeoxynucleotide;the transdermally administered nano-liposomal drug complex (LPPC-DOX-CpG) would have high cytotoxicity and immunostimulatory activity to suppress systemic metastasis of melanoma. LPPC-DOX-CpG dramatically suppressed subcutaneous melanoma growth by inducing tumor cell apoptosis and recruiting immune cells into the tumor area. Animal studies further showed that the colonization and growth of spontaneously metastatic melanoma cells in the liver and lung were suppressed by transdermal LPPC-DOX-CpG. Furthermore, NGS analysis revealed IFN-γ and NF-κB pathways were triggered to recruit and activate the antigen-presenting-cells and effecter cells, which could activate the anti-tumor responses as the major mechanism responsible for the therapeutic effect of LPPC-DOX-CpG. Finally, we have successfully proved transdermal LPPC-DOX-CpG as a promising penetrative carrier to activate systemic anti-tumor immunity against subcutaneous and metastatic tumor. © 2022

关键词： Tumors

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Endoplasmic Reticulum Stress in Aquaculture Species

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Reviews in Aquaculture 2025年第3期17卷

作者： Esmaeili, Noah Martyniuk, Christopher J. Kadri, Sunil Ma, Hongyu Guangdong Provincial Key Laboratory of Marine Biotechnology Shantou University Shantou China International Joint Research Center for the Development and Utilization of Important Mariculture Varieties Surrounding the South China Sea Region Shantou University Shantou China STU-UMT Joint Shellfish Research Laboratory Shantou University Shantou China Center for Environmental and Human Toxicology Department of Physiological Sciences College of Veterinary Medicine University of Florida Gainesville FL United States UF Genetics Institute Interdisciplinary Program in Biomedical Sciences Neuroscience University of Florida Gainesville FL United States RINA Research Institute for Environment and Livelihoods Charles Darwin University Brinkin NT Australia

Fundamental metabolic functions depend upon the endoplasmic reticulum (ER), as this organelle plays a central role in maintaining cellular homeostasis. Different physiological and pathological conditions can result in the accumulation of misfolded/unfolded proteins, which this accumulation causes ER stress. These pathological conditions can lead to disease and are concerning for species used for aquaculture. In this comprehensive article, we review studies in cultured species that demonstrate the presence of ER stress to understand conditions and events that may underlie this toxicological outcome. Literature indicates that ER stress can be induced by exposure to pollution, environmental factors (salinity, ammonia, nitrate, hypoxia, and temperature), nutritional changes (quality and quantity of protein, lipid, carbohydrate, vitamins, and minerals), and pathogens. ER stress in aquatic species has been demonstrated through tissue histology and microscopy, gene expression analysis, and other omics approaches. In terms of cell signaling for ER stress, the most common gene indicators identified in aquaculture species include grp78, ire1, perk, chop, erol, atf4, atf6, xbp1, and eif2. The ER stress should be minimized in order to divert more energy for individual growth and achieve sustainable and profitable aquaculture. Here, we provide an overview of ER stress in aquatic species and suggest future directions for research. © 2025 John Wiley & Sons Australia, Ltd.

关键词： crustacean fish nutrition physiology protein folding

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Selection of M5 short-stemmed mutants from 200 gray gamma ray irradiation in Mentik Wangi rice

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： S A Qoni'ah Parjanto A Yunus Undergraduate Program in Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Indonesia. Lecturer staff of the Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Indonesia. Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University Indonesia.

Mentik Wangi rice is native to Indonesia, it has an oval round shape of rice, yellow brown rice, and fragrant aroma. Mentik Wangi has a weakness that is relatively long harvest time, the plant is too high so it easily fell. This research aims to determine the performance of M5 generation of mutant rice and to select M5 generation of mutant plants resulted from 200 gray gamma irradiation which has short stems with high productivity. The research was carried out by planting 36 genotypes, namely 35 M4 lines of 200 gray gamma ray irradiation and control plant (without irradiation). Observation data were analyzed descriptively and t test to determine differences in M5 generation of Mentik Wangi rice from 200 gray gamma ray irradiation with control plants (without irradiation). Based on the research results that Mentik Wangi rice plants with gamma ray irradiation 200 Gray have better performance compared to control plants (without irradiation) and there are 28 individuals M5 Mentik Wangi rice mutants selected by short-stemmed plants and have high productivity.

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Assessing the growth-promoting traits of actinobacteria spp. isolated from Cleome africana: Implications on growth and root enhancement of Medicago sativa

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Journal of King Saud University - Science 2023年第6期35卷

作者： Raklami, Anas Quintas-Nunes, Francisco Nascimento, Francisco X. Jemo, Martin Oufdou, Khalid Syed, Asad Bahkali, Ali H. Verma, Meenakshi Nafis, Ahmed AgroBiosciences Program College for Sustainable Agriculture and Environmental Sciences University Mohammed VI Polytechnic (UM6P) Benguerir Morocco iBET Instituto de Biologia Experimental e Tecnológica Oeiras 2781-901 Portugal Laboratory of Microbial Biotechnologies Agrosciences and Environment (BioMAgE) Labeled Research Unit-CNRST N°4 Faculty of Sciences Semlalia Cadi Ayyad University Marrakech Morocco Department of Botany and Microbiology College of Science King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia University Centre for Research & Development Department of Chemistry Chandigarh University Mohali Gharuan India Microbiology and antimicrobial agents team Laboratory of Plant Biotechnology Ecology and Valorization of Ecosystems (LB2VE/URL-CNRST n°10) Faculty of Sciences Chouaïb Doukkali University El Jadida 24000 Morocco

Objective: Endophytes actinobacteria isolated from the Cleome africana shoot and root tissues were compared for their growth promotion (PGP) traits and their beneficial effects on shoot and root enhancement evaluated using Medicago sativa as test crop. Methods: Healthy plants of C. africana evolved for long periods on heavy metal mining sites were sampled and the resident endophytes actinobacteria communities in root and leaves tissues isolated and characterized based on their 16 s rRNA regions and a culture dependent approach. The growth-promoting traits in terms of phosphate solubilization activity, siderophore production, indole acetic acid synthesis and ACC deaminase activity, resistance to drought and salt stresses were studied for the selected endophytes. The beneficial effect of the two selected actinobacteria and their consortium in promoting growth of M. sativa plants from an inoculation assay that comprised four treatments: [a control (Con), inoculation with Streptomyces sp. (A3), inoculation with Amycolatopsis sp. (A4), and a consortium of A3+A4]. Sixty days after sowing, plants were harvested, and the biomass production was measured. Results: The six isolated actinobacteria strains were identified as members of the Streptomyces, Amycolatopsis and Nocardia genus. Isolates of A2 and A4 presented increased identity to A. endophytica (99.10%) and A. nivea (99.44%) respectively, isolates A1 were in the Nocardia genus, with high affinity to the N.m exicana (98.7% 16S rRNA similarity). Isolates A3 was a non-cultured and not yet identified, while the isolates A5 and A6 all from the Streptomyces genus. Isolates A6 showed high affinity S. xishensis, strain YIM M 10378, and the isolates A5 were closely related to S. nogalater (100%). Cultures of isolates A3 and A4 and their consortium was used to inoculate M. sativa and the shoot, root dry weight and total biomass (shoot+root) was higher in the inoculated plants than uninoculated ones. Conclusion: The significant i

关键词： Biochemical properties Indole acetic acid contents Inorganic phosphate (Pi) solubilization

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Diversity induction with gamma ray irradiation on Dendrobium odoardi orchid

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： T S Fathin S Hartati A Yunus Undergraduate Student of Agrotechnology Study Program Faculty of Agriculuture Sebelas Maret University Indonesia Lecturer of Agrotechnology Study Program Faculty of Agriculuture Sebelas Maret University Indonesia Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University Indonesia

Orchid is an ornamental plant commodity that has potential to be developed. One species of orchid that is in demand is Dendrobium odoardi. The aims of this research is to determine the characteristics and morphological diversity of Dendrobium odoardi orchid irradiated gamma ray results and without gamma ray irradiation. This research was conducted in two places, the implementation of gamma ray irradiation at the PATIR-BATAN Laboratory and subculture in Plant Physiology and biotechnology Laboratory of Agriculture Faculty, UNS. The research was conducted start from March 2019 – January 2020. The research used a simple design of one factor, the doses of gamma ray irradiation with 5 levels, 0 Gy (control), 10 Gy, 15 Gy, 20 Gy, and 25 Gy. Each level of treatment was planted and observed 50 plantlets. Observational data were analyzed descriptively by comparing observational data from Dendrobium odoardi orchids irradiated with control plants. The results showed that the induction of gamma ray irradiation resulted changes in morphological characters in Dendrobium odoardi orchid such as, increasing plant height, increasing leaf width, decreasing number of roots, decreasing root length, change in leaf shape and change in leaf color. Changes in the morphological character of Dendrobium odoardi orchids produce plant diversity.

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Selection of M3 genotype short stem results of ray gamma 250 gray in Mentik Wangi rice

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： B S Putranto Parjanto A Yunus Student of Agrotechnology Study Program Agriculture Faculty Universitas Sebelas Maret Surakarta Indonesia Lecturer of Agrotechnology Study Program Agriculture Faculty Universitas Sebelas Maret Surakarta Indonesia Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University

This study aims to determine the performance of Mentik Wangi rice at M3 generation mutant rice and select the M3 generation mutant plants as a result of 250 gray gamma irradiation which has short stems with high productivity. The research was carried out by planting 70 M2 lines of 250 gray gamma irradiation and control plants. The variables observed were plant height, total number of tillers, number of productive tillers, flowering age, harvest age, panicle length, number of seeds per panicle, panicle bush thickness index, weight of 100 seeds, weight of seeds per clump. Following observation, data were analyzed descriptively and statistically compared using t-test to determine the difference of M3 generation of fragrant Mentik rice from 250 gray gamma irradiation with control plants (without irradiation). There are 24 individual selected lines of M3 generation of fragrant Mentik Wangi mutants from 250 Gy gamma ray radiation which have a short stem character and have higher productivity than control plants.

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Yield quality and performance of three strains black rice from gamma ray irradiation

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IOP Conference Series: Earth and Environmental Science 2021年第1期905卷

作者： Nandariyah M Rahayu B Pujiasmanto V P Luxrensa Lecturer of Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Surakarta 57126 Central Java Indonesia Research and Development Center for Biotechnology and Biodiversity Research and Community Service Institute Universitas Sebelas Maret Indonesia Undergraduate Program in Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University Surakarta 57126 Central Java Indonesia

Black rice is one of the local Indonesian rice varieties contains high anthocyanins. This research used the treatment of three different strains resulting from gamma ray irradiation (strain 8, 44 and 51) and control (without irradiation). The data was analyzed descriptively and qualitatively to compare three strains of black rice irradiated by gamma ray with control (without irradiation). The result showed that the three strains of black rice 'Cempo Ireng' irradiated by gamma ray had better yield quality and performance compare to control (without irradiation). Strain 44 was the strain with the highest anthocyanin content of 75.11 ppm and the best performing strain (organoleptic score of 3.53 and seed pericarp color of 4). Strain 51 had the best amylose content (8.43%), the highest protein content (7.48%), the highest fat content (1.59%), the best vigor (80%) and seed viability (64%).

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Selection of mutant short stem M5 from 200 Gy gamma ray irradiation on Mentik Susu rice

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： F Nugroho E Purwanto A Yunus Student of Agrotechnology Study Program Agriculture Faculty Universitas Sebelas Maret Surakarta Indonesia Lecturer of Agrotechnology Study Program Agriculture Faculty Universitas Sebelas Maret Surakarta Indonesia Center of Biotechnology and Biodiversity Research and Development Universitas Sebelas Maret Surakarta Indonesia

Mentik Susu rice is one of Indonesian local rice variety that is less attractive to farmers because of its high stems and low yield. One method of using physical mutagen is gamma ray radiation. The purpose of this research is observing the performance of mutated M5 generation of mentik susu rice which already irradiated with 200 Gy gamma ray and selecting the short-stemmed ones which have high productivity. The research was conducted in Novermber 2018-April 2019 on Palur Village, Mojolaban, Sukoharjo Regency. The experiment was done by planting 35 individual M5 and control seeds. The variables observed were plant height, harvest age, number of productive tillers, panicle intensity index, seed yield per plant. Data were analyzed descriptively and compared the performance of mentik susu rice M5 with control via T test analysis. The results showed that there was a difference in the performance of the M5 mutants of mentik susu rice as result of 200 Gy gamma ray irradiation compared to control mentik susu rice. There are 22 selected mutant plant individuals in the M-MS2-G15T3-5-2(18,25,16,8)strains; M-MS2-G15T3-4-15(10)strains; M-MS2-G15T3-2-5(56,18,9)strains; M-MS2-G18T7-4-4(11)strains; M-MS2-G18T7-4-12(15,13,18)strains; M-MS2-G17T17-13-9(23,21,29)strains; M-MS2-G18T7-4-9(17,12)strains; M-MS2-G15T3-2-18(35)strains; M-MS2-G15T3-2-14(28,61,36)strains; and M-MS2-G18T3-6-13(35)strains.

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Cashew : Contribution to the household economy and carbon stock (Case study in Wonogiri regency)

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IOP Conference Series: Earth and Environmental Science 2021年第1期637卷

作者： B Pujiasmanto E S Rahayu E Murniyanto Agrotechnology Study Program Faculty of Agriculture Sebelas Maret University ID Center of Biotechnology and Biodiversity Research and Development Sebelas Maret University ID Agribusiness Study Program Faculty of Agriculture Sebelas Maret University ID Natural Resources Management Study Program Faculty of Agriculture Trunojoyo University ID

Wonogiri Regency is a cashew crop center in Central Java. Cashew is planting in dryland at an elevation of 100 to 400 m above sea level with a monoculture and multicultural pattern. Cashew plants are cultivated as people plantations, planted regularly on each plot or as a fence on the ownership limits of dry land, plots, and mounds. Cashew plants are evergreen, have a tight canopy with sympodial branching patterns, flowering all the time so they can cover the surface of the soil. Such plant patterns provide acceptance for households and protect the environment. research to reveal the contribution of household income, land cover rates, and carbon stocks has been carried out by survey methods. Data collection techniques were carried out by interviewing the head of the household and the measurement of cashew land. The results showed that the B / C ratio > 1 and increased with the age of the plant, it contributed to the acceptance of household income. Canopy cover and carbon stock increase every year so that it is beneficial to maintain soil fertility.

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Ten decadal advances in fungal biology leading towards human well‑being

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Fungal Diversity 2022年第5期116卷 547-614页

作者： Ausana Mapook·Kevin DHyde Kevin D.Hyde Khadija Hassan Blondelle Matio Kemkuignou Adela Cmokova Frank Surup Eric Kuhnert Pathompong Paomephan Tian Cheng Sybren de Hoog Yinggai Song Ruvishika S.Jayawardena Abdullah M.S.Al‑Hatmi Tokameh Mahmoudi Nadia Ponts Lena Studt‑Reinhold Florence Richard‑Forget K.W.Thilini Chethana Dulanjalee L.Harishchandra Peter E.Mortimer Huili Li Saisamorm Lumyong Worawoot Aiduang Jaturong Kumla Nakarin Suwannarach Chitrabhanu S.Bhunjun Feng‑Ming Yu Qi Zhao Doug Schaefer Marc Stadler Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department Microbial Drugs Helmholtz Centre for Infection Research(HZI)and German Centre for Infection Research(DZIF)Partner Site Hannover‑BraunschweigInhoffenstrasse 738124 BrunswickGermany Institute of Microbiology Technische Universitat BraunschweigSpielmannstrase 738106 BrunswickGermany Laboratory of Fungal Genetics and Metabolism Institute of MicrobiologyCzech Academy of SciencesPragueCzech Republic Centre of Biomolecular Drug Research(BMWZ) Institute for Organic ChemistryLeibniz University HannoverSchneiderberg 3830167 HannoverGermany Department of Biotechnology Faculty of ScienceMahidol University272 Rama VI RoadRatchathewiBangkok 10400Thailand Center of Expertise in Mycology Radboud University Medical Center/Canisius Wilhelmina HospitalNijmegenThe Netherlands Key Laboratory of Environmental Pollution Monitoring and Disease Control Guizhou Medical UniversityGuiyangChina Microbiology Parasitology and Pathology Graduate ProgramFederal University of ParanaCuritibaBrazil Department of Dermatology Peking University First HospitalPeking UniversityBeijingChina Natural and Medical Sciences Research Center University of NizwaNizwaOman Department of Biochemistry Erasmus University Medical CenterRotterdamThe Netherlands INRAE UR1264 Mycology and Food Safety(MycSA)33882 Villenave d’OrnonFrance Department of Applied Genetics and Cell Biology Institute of Microbial GeneticsUniversity of Natural Resources and Life SciencesVienna(BOKU)Tulln an der DonauAustria Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Centre for Mountai

Fungi are an understudied resource possessing huge potential for developing products that can greatly improve human *** the current paper,we highlight some important discoveries and developments in applied mycology and interdisciplinary Life Science *** examples concern recently introduced drugs for the treatment of infections and neurological diseases;application of–OMICS techniques and genetic tools in medical mycology and the regulation of mycotoxin production;as well as some highlights of mushroom cultivaton in *** for new diagnostic tools in medical mycology and the exploitation of new candidates for therapeutic drugs,are also *** addition,two entries illustrating the latest developments in the use of fungi for biodegradation and fungal biomaterial production are *** other areas where there have been and/or will be significant developments are also *** is our hope that this paper will help realise the importance of fungi as a potential industrial resource and see the next two decades bring forward many new fungal and fungus-derived products.

关键词： Biomaterial CRISPR Drug development Morel cultivation Mushroom cultivation Mycotoxin biosynthesis Plastic degradation

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