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检索条件"机构=Program in Cancer Signaling and Microenvironment"
17 条 记 录,以下是1-10 订阅
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Impact of radiation therapy on the immunological tumor microenvironment
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Cell Chemical Biology 2025年 第5期32卷 678-693页
作者: Guilbaud, Emma Naulin, Flavie Meziani, Lydia Deutsch, Eric Galluzzi, Lorenzo Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA United States Department of Radiotherapy Gustave Roussy Cancer Campus Villejuif France INSERM RAMO-IT U1030 Villejuif France Faculty of Medicine University of Paris-Saclay Bicêtre Le Kremlin France
External beam radiation therapy (RT) is a cornerstone of modern cancer management, being utilized in both curative and palliative settings due to its safety, efficacy, and widespread availability. A primary biological... 详细信息
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A macrophage-neutrophil program drives mammary carcinogenesis
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Trends in cancer 2025年 第5期11卷 427-429页
作者: Lukas Bolini Simon R V Knott Lorenzo Galluzzi Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Department of Biomedical Sciences Cedars-Sinai Medical Center Los Angeles CA USA. Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Electronic address: deadoc80@***.
The molecular and cellular pathways through which breast cancer evades immunosurveillance remain poorly understood. Recent data from Camargo et al. demonstrate that - on recruitment to the tumor microenvironment by du... 详细信息
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Novel metabolic routes to cancer immune evasion
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Trends in cancer 2025年
作者: Ayoub Jaa Aitziber Buque Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Electronic address: abuquemartinez@***.
The tumor microenvironment (TME) comprises heterogeneous cell types that closely interact with each other. Crosstalk among the TME components determines antitumor immune responses and their sensitivity to therapies su... 详细信息
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DACIT: Device for Axon - cancer Cell Interaction Testing in 2D & 3D
SSRN
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SSRN 2025年
作者: Velazquez-Quesada, Ines Alizadeh, Vahid Allison, Kara Belova, Elizaveta Kallogjerovic, Svetllana Hesketh, Natasha Zhang, Xiaotian Thomas, Gareth Tuzel, Erkan Gligorijevic, Bojana Temple University Hospital United States Bioengineering Department Temple University PhiladelphiaPA19122 United States Lewis Katz School of Medicine Temple University PhiladelphiaPA19140 United States Cancer Signaling and Microenvironment Program Fox Chase Cancer Center PhiladelphiaPA19111 United States Fels Cancer Institute for Personalized Medicine Lewis Katz School of Medicine Temple University PhiladelphiaPA19140 United States
There is increasing interest in studying the role of peripheral innervation in tumor growth and metastasis. However, in vitro studies of interactions between cancer cells and axonal projections are technically challen... 详细信息
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Defeating kinases that promote tumorigenesis through non-catalytic functions with PROTACs - PIM kinase as an example
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Emerging Therapeutic Targets 2025年 第4-5期29卷
作者: Pedro Torres-Ayuso John Brognard a Department of Cancer and Cellular Biology Lewis Katz School of Medicine Temple University Philadelphia PA USAb Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA c Laboratory of Cell and Developmental Signaling National Cancer Institute National Institutes of Health Frederick MD USA
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The role of RAC1 in resistance to targeted therapies in cancer
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Small GTPases 2024年 第1期15卷 1-14页
作者: Cristina Uribe-Alvarez Jonathan Chernoff Cancer Signaling & Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA.
RAC1 is a small 21 kDa RHO GTPase that plays a pivotal role in regulating actin cytoskeletal dynamics and cell growth. Alterations in the activity of RAC1 are implicated in a range of diseases, including cancer. Incre... 详细信息
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Challenges and Opportunities Modeling the Dynamic Tumor Matrisome
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Biomedical Engineering Frontiers 2023年 第1期4卷 239-246页
作者: Shelly R.Peyton Manu O.Platt Edna Cukierman Department of Chemical Engineering University of Massachusetts AmherstAmherstMAUSA Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGAUSA Cancer Signaling&Microenvironment Program Marvin and Concetta Greenberg Pancreatic Cancer Institute.Fox Chase Cancer CenterTemple HealthPhiladelphiaPAUSA
We need novel strategies to target the complexity of cancer and,particularly,of metastatic *** an example of this complexity,certain tissues are particularly hospitable environments for metastases,whereas others do no... 详细信息
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A retinoic acid:YAP1 signaling axis controls atrial lineage commitment
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Cell Reports 2025年 第5期44卷 115687页
作者: Abraham, Elizabeth Kostina, Aleksandra Volmert, Brett Roule, Thomas Huang, Ling Yu, Jingting Williams, April E. Megill, Emily Douglas, Aidan Pericak, Olivia M. Morris, Alex Stronati, Eleonora Larrinaga-Zamanillo, Arantza Fueyo, Raquel Zubillaga, Mikel Andrake, Mark D. Akizu, Naiara Aguirre, Aitor Estaras, Conchi Department of Cardiovascular Sciences Aging + Cardiovascular Discovery Center Lewis Katz School of Medicine Temple University Philadelphia 19140 PA United States Institute for Quantitative Health Science and Engineering Division of Developmental and Stem Cell Biology Michigan State University East Lansing 48824 MI United States Department of Biomedical Engineering College of Engineering Michigan State University East Lansing 48824 MI United States Raymond G. Perelman Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Philadelphia 19104 PA United States Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies La Jolla 92037 CA United States Department of Child and Adolescence Psychiatry The Children's Hospital of Philadelphia Philadelphia 19104 PA United States Department of Chemical and Systems Biology Stanford University School of Medicine Stanford 94305 CA United States Cancer Epigenetics Institute Fox Chase Cancer Center Philadelphia 19111 PA United States Molecular Modeling Facility Program in Cancer Signaling and Microenvironment Fox Chase Cancer Center Philadelphia 19111 PA United States
In cardiac progenitor cells (CPCs), retinoic acid (RA) signaling induces atrial lineage gene expression and acquisition of an atrial cell fate. To achieve this, RA coordinates a complex regulatory network of downstrea... 详细信息
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Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients
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cancer Cell 2025年 第3期43卷 361-379.e10页
作者: Chen, Jianzhou Levy, Antonin Tian, Ai-Ling Huang, Xuehan Cai, Guoxin Fidelle, Marine Rauber, Conrad Ly, Pierre Pizzato, Eugénie Sitterle, Lisa Piccinno, Gianmarco Liu, Peng Durand, Sylvère Mao, Misha Zhao, Liwei Iebba, Valerio Felchle, Hannah Mallard de La Varende, Anne-Laure Fischer, Julius Clemens Thomas, Simon Greten, Tim F. Jones, Jennifer C. Monge, Cecilia Demaria, Sandra Formenti, Silvia Belluomini, Lorenzo Dionisi, Valeria Massard, Christophe Blanchard, Pierre Robert, Charlotte Quevrin, Clément Lopes, Eloise Clémenson, Céline Mondini, Michele Meziani, Lydia Zhan, Yizhou Zeng, Chengbing Cai, Qingxin Morel, Daphne Sun, Roger Laurent, Pierre-Antoine Mangoni, Monica Di Cataldo, Vanessa Arilli, Chiara Trommer, Maike Wegen, Simone Neppl, Sebastian Riechelmann, Rachel P. Camandaroba, Marcos P. Neto, Elson Santos Fournier, Pierre-Edouard Segata, Nicola Holicek, Peter Galluzzi, Lorenzo Buqué, Aitziber Alves Costa Silva, Carolina Derosa, Lisa Kroemer, Guido Chen, Chuangzhen Zitvogel, Laurence Deutsch, Eric Gustave Roussy Cancer Campus (GRCC) Clinicobiome Villejuif Cedex 94805 France Faculté de Médecine Université Paris-Saclay Kremlin-Bicêtre 94270 France Institut National de la Santé Et de la Recherche Médicale (INSERM) UMR 1015 Equipe Labellisée—Ligue Nationale contre le Cancer Villejuif 94805 France CICBT1428 Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France Department of Radiation Oncology Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France INSERM U1030 Radiothérapie Moléculaire et Innovations Thérapeutiques Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France Metabolomics and Cell Biology Platforms UMS AMMICa Gustave Roussy Cancer Campus Villejuif 94805 France Centre de Recherche des Cordeliers INSERM U1138 Équipe Labellisée – Ligue Nationale contre le Cancer Université Paris Cité Sorbonne Université Paris 75006 France Institut du Cancer Paris CARPEM Department of Biology Hôpital Européen Georges Pompidou AP-HP Paris 75015 France Department of Radiation Oncology Cancer Hospital of Shantou University Medical College Shantou 515031 China Department of Gastroenterology and Infectious Diseases University Hospital Heidelberg Heidelberg 69120 Germany Department of Computational Cellular and Integrative Biology University of Trento Trento 38123 Italy Department of Radiation Oncology Weill Cornell Medicine New York 10065 NY United States Drug Development Department (DITEP) Gustave Roussy Cancer Campus Villejuif 94805 France Department of Radiation Oncology Cyberknife and Radiotherapy Faculty of Medicine and University Hospital Cologne Cologne 50937 Germany Center for Integrated Oncology (CIO) Faculty of Medicine and University Hospital Cologne University of Cologne Cologne 50937 Germany Center for Molecular Medicine Cologne University of Cologne Cologne 50931 Germany Olivia Newton-John Cancer Wellness & Research Centre Austin Health Department of Radiation Oncology Heidelberg Melbourne 3084 VIC Australia Departme
The mechanisms governing the abscopal effects of local radiotherapy in cancer patients remain an open conundrum. Here, we show that off-target intestinal low-dose irradiation (ILDR) increases the clinical benefits of ... 详细信息
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A novel anti-FGFR1 monoclonal antibody OM-RCA-01 exhibits potent antitumor activity and enhances the efficacy of immune checkpoint inhibitors in lung cancer models
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Immuno-Oncology and Technology 2024年 23卷 100725-100725页
作者: Tsimafeyeu, I. Makhov, P. Ovcharenko, D. Smith, J. Khochenkova, Y. Olshanskaya, A. Khochenkov, D. Bureau for Cancer Research - BUCARE New York Program in Cancer Signaling and Microenvironment Fox Chase Cancer Center Philadelphia Altogen Labs Austin United States N.N. Blokhin National Medical Research Center of Oncology Moscow Clinical Oncology Hospital No. 1 Moscow Center for Medicinal Chemistry Togliatti State University Togliatti Russian Federation
Background: Fibroblast growth factor receptor 1 (FGFR1) plays a crucial role in carcinogenesis. Exploring the combination of the novel humanized monoclonal anti-FGFR1 antibody OM-RCA-01 and immunotherapy was intriguin... 详细信息
来源: 评论