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检索条件"机构=Program in Cancer Signaling and Microenvironment"
17 条 记 录,以下是1-10 订阅
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The role of RAC1 in resistance to targeted therapies in cancer
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Small GTPases 2024年 第1期15卷 1-14页
作者: Cristina Uribe-Alvarez Jonathan Chernoff Cancer Signaling & Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA.
RAC1 is a small 21 kDa RHO GTPase that plays a pivotal role in regulating actin cytoskeletal dynamics and cell growth. Alterations in the activity of RAC1 are implicated in a range of diseases, including cancer. Incre... 详细信息
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Impact of radiation therapy on the immunological tumor microenvironment
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Cell Chemical Biology 2025年 第5期32卷 678-693页
作者: Guilbaud, Emma Naulin, Flavie Meziani, Lydia Deutsch, Eric Galluzzi, Lorenzo Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA United States Department of Radiotherapy Gustave Roussy Cancer Campus Villejuif France INSERM RAMO-IT U1030 Villejuif France Faculty of Medicine University of Paris-Saclay Bicêtre Le Kremlin France
External beam radiation therapy (RT) is a cornerstone of modern cancer management, being utilized in both curative and palliative settings due to its safety, efficacy, and widespread availability. A primary biological... 详细信息
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A macrophage-neutrophil program drives mammary carcinogenesis
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Trends in cancer 2025年 第5期11卷 427-429页
作者: Lukas Bolini Simon R V Knott Lorenzo Galluzzi Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Department of Biomedical Sciences Cedars-Sinai Medical Center Los Angeles CA USA. Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Electronic address: deadoc80@***.
The molecular and cellular pathways through which breast cancer evades immunosurveillance remain poorly understood. Recent data from Camargo et al. demonstrate that - on recruitment to the tumor microenvironment by du... 详细信息
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Challenges and Opportunities Modeling the Dynamic Tumor Matrisome
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Biomedical Engineering Frontiers 2023年 第1期4卷 239-246页
作者: Shelly R.Peyton Manu O.Platt Edna Cukierman Department of Chemical Engineering University of Massachusetts AmherstAmherstMAUSA Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGAUSA Cancer Signaling&Microenvironment Program Marvin and Concetta Greenberg Pancreatic Cancer Institute.Fox Chase Cancer CenterTemple HealthPhiladelphiaPAUSA
We need novel strategies to target the complexity of cancer and,particularly,of metastatic *** an example of this complexity,certain tissues are particularly hospitable environments for metastases,whereas others do no... 详细信息
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Novel metabolic routes to cancer immune evasion
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Trends in cancer 2025年
作者: Ayoub Jaa Aitziber Buque Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Electronic address: abuquemartinez@***.
The tumor microenvironment (TME) comprises heterogeneous cell types that closely interact with each other. Crosstalk among the TME components determines antitumor immune responses and their sensitivity to therapies su... 详细信息
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A novel anti-FGFR1 monoclonal antibody OM-RCA-01 exhibits potent antitumor activity and enhances the efficacy of immune checkpoint inhibitors in lung cancer models
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Immuno-Oncology and Technology 2024年 23卷 100725-100725页
作者: Tsimafeyeu, I. Makhov, P. Ovcharenko, D. Smith, J. Khochenkova, Y. Olshanskaya, A. Khochenkov, D. Bureau for Cancer Research - BUCARE New York Program in Cancer Signaling and Microenvironment Fox Chase Cancer Center Philadelphia Altogen Labs Austin United States N.N. Blokhin National Medical Research Center of Oncology Moscow Clinical Oncology Hospital No. 1 Moscow Center for Medicinal Chemistry Togliatti State University Togliatti Russian Federation
Background: Fibroblast growth factor receptor 1 (FGFR1) plays a crucial role in carcinogenesis. Exploring the combination of the novel humanized monoclonal anti-FGFR1 antibody OM-RCA-01 and immunotherapy was intriguin... 详细信息
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DACIT: Device for Axon - cancer Cell Interaction Testing in 2D & 3D
SSRN
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SSRN 2025年
作者: Velazquez-Quesada, Ines Alizadeh, Vahid Allison, Kara Belova, Elizaveta Kallogjerovic, Svetllana Hesketh, Natasha Zhang, Xiaotian Thomas, Gareth Tuzel, Erkan Gligorijevic, Bojana Temple University Hospital United States Bioengineering Department Temple University PhiladelphiaPA19122 United States Lewis Katz School of Medicine Temple University PhiladelphiaPA19140 United States Cancer Signaling and Microenvironment Program Fox Chase Cancer Center PhiladelphiaPA19111 United States Fels Cancer Institute for Personalized Medicine Lewis Katz School of Medicine Temple University PhiladelphiaPA19140 United States
There is increasing interest in studying the role of peripheral innervation in tumor growth and metastasis. However, in vitro studies of interactions between cancer cells and axonal projections are technically challen... 详细信息
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Targeting CDK2 to circumvent treatment resistance in HR+ breast cancer
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Trends in molecular medicine 2024年
作者: Leire Arrizabalaga Esmeralda García-Torralba Lorenzo Galluzzi Aitziber Buqué Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA Program of Immunology and Immunotherapy Cima Universidad de Navarra Pamplona Spain Navarra Institute for Health Research (IDISNA) Pamplona Spain. Department of Medical Oncology Hospital Universitario Morales Meseguer Murcia Spain Department of Medicine Medical School University of Murcia Murcia Spain IMIB-Arrixaca Murcia Spain. Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Electronic address: deadoc80@***. Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA. Electronic address: abuquemartinez@***.
Genetic and epigenetic defects of the p53 system have previously been associated with resistance to CDK4/6 inhibitors in women with HR breast cancer. Recent data from Kudo et al. demonstrate that CDK2-targeting agents... 详细信息
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Defeating kinases that promote tumorigenesis through non-catalytic functions with PROTACs - PIM kinase as an example
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Emerging Therapeutic Targets 2025年 第4-5期29卷
作者: Pedro Torres-Ayuso John Brognard a Department of Cancer and Cellular Biology Lewis Katz School of Medicine Temple University Philadelphia PA USAb Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA c Laboratory of Cell and Developmental Signaling National Cancer Institute National Institutes of Health Frederick MD USA
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Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity
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iScience 2024年 第6期27卷 110129页
作者: Sidibé, Adama Mykuliak, Vasyl V. Zhang, Pingfeng Hytönen, Vesa P. Wu, Jinhua Wehrle-Haller, Bernhard Department of Cell Physiology and Metabolism University of Geneva Centre Médical Universitaire Rue Michel-Servet 1 Geneva CH-1211 Switzerland Faculty of Medicine and Health Technology Tampere University Arvo Ylpön katu 34 Tampere FI-33520 Finland Cancer Signaling and Microenvironment Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia 19111 PA United States Fimlab Laboratories Biokatu 4 Tampere FI-33520 Finland
Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understo... 详细信息
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