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Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity

iScience 2024年第6期27卷 110129页

作者： Sidibé, Adama Mykuliak, Vasyl V. Zhang, Pingfeng Hytönen, Vesa P. Wu, Jinhua Wehrle-Haller, Bernhard Department of Cell Physiology and Metabolism University of Geneva Centre Médical Universitaire Rue Michel-Servet 1 Geneva CH-1211 Switzerland Faculty of Medicine and Health Technology Tampere University Arvo Ylpön katu 34 Tampere FI-33520 Finland Cancer Signaling and Microenvironment Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia 19111 PA United States Fimlab Laboratories Biokatu 4 Tampere FI-33520 Finland

Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood. Here, we investigated how acetylation of the distal NPKY-motif of Integrin-β1 influences endothelial cell physiology and barrier function. Expression of an acetylation-mimetic β1-K794Q-GFP mutant led to the accumulation of immature cell-matrix adhesions accompanied by a transcriptomic reprograming of endothelial cells, involving genes associated with cell adhesion, proliferation, polarity, and barrier function. β1-K794Q-GFP induced constitutive MAPK signaling, junctional impairment, proliferation, and reduced contact inhibition at confluence. Structural analysis of Integrin-β1 interaction with KINDLIN2, biochemical pulldown assay, and binding energy determination by using molecular dynamics simulation showed that acetylation of K794 and the K794Q-mutant increased KINDLIN2 binding affinity to the Integrin-β1. Thus, enhanced recruitment of KINDLIN2 to Lysine-acetylated Integrin-β1 and resulting modulation of barrier function, offers new therapeutic possibilities for controlling vascular permeability and disease conditions. © 2024 The Author(s)

关键词： Cell Cell biology Structural biology

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Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers containing tertiary lymphoid structures

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iScience 2025年

作者： Richard H. Mebane Teia Noel Nathan Ing Kenneth Gouin Aagam Shah David Zitser Andrew Martinez Gaorav Gupta Sandra Demaria Lorenzo Galluzzi Alice Ho Heather McArthur Stephen S. Shiao Simon.R.V. Knott Department of Biomedical Sciences Cedars-Sinai Medical Center Los Angeles CA USA Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles CA USA Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel hill NC USA Radiation Oncology Weill Cornell Medicine New York NY USA Cancer Signaling and Microenvironment Program Fox Chase Cancer Center Philadelphia PA USA Breast Cancer Clinical Research Unit Duke University Medical Center Raleigh NC USA Department of Internal Medicine Division of Hematology-Oncology University of Texas

Tertiary lymphoid structures (TLSs) are associated with improved cancer immunotherapy responses. However, TLSs vary in their ability to elicit anticancer immune activity, so it is important to develop databases that allow study of variables that regulate their function. We applied single RNA molecule resolution imaging to longitudinal biopsies taken from women with TLS-enriched triple negative breast cancers prior to therapy, after pembrolizumab and after pembrolizumab plus radiation therapy. We developed a computational framework to align and analyze spatial trajectories between TLSs and tumor beds. Tumors with higher T cell infiltration rates were eradicated after pembrolizumab. In contrast, those with lower malignant cell and T cell interaction rates at baseline showed CXCL9 + macrophage infiltration after pembrolizumab, and infiltration of T cells expressing CXCL9-associated programs prior to cancer cell removal after radiation therapy. This manuscript describes single RNA molecule resolution profiling of breast tumors bearing tertiary lymphoid structures throughout an immunotherapy response.

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Correction: Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing

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BMC genomics 2023年第1期24卷 388页

作者： Elena V Demidova Ilya G Serebriiskii Ramilia Vlasenkova Simon Kelow Mark D Andrake Tiffiney R Hartman Tatiana Kent James Virtucio Gail L Rosen Richard T Pomerantz Roland L Dunbrack Erica A Golemis Michael J Hall David Y T Chen Mary B Daly Sanjeevani Arora Cancer Prevention and Control Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA. Kazan Federal University Kazan 420008 Russia. Program in Cancer Signaling and Microenvironment Fox Chase Cancer Center Philadelphia PA 19111 USA. Department of Biochemistry and Molecular Biophysics University of Pennsylvania Philadelphia PA 19104 USA. Arcadia University Glenside PA USA. Department of Biochemistry & Molecular Biology Sidney Kimmel Cancer Center Thomas Jeferson University Philadelphia PA 19107 USA. Ecological and Evolutionary Signal-Processing and Informatics Laboratory Department of Electrical and Computer Engineering College of Engineering Drexel University Philadelphia PA 19104 USA. Department of Cancer and Cellular Biology Lewis Katz School of Medicine Philadelphia PA 19140 USA. Department of Clinical Genetics Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA. Department of Surgical Oncology Fox Chase Cancer Center Philadelphia PA 19111 USA. Cancer Prevention and Control Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA. Mary.Daly@fccc.edu. Department of Clinical Genetics Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA. Mary.Daly@fccc.edu. Cancer Prevention and Control Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA. Sanjeevani.Arora@fccc.edu. Department of Radiation Oncology Fox Chase Cancer Center Philadelphia PA 19111 USA. Sanjeevani.Arora@fccc.edu.

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Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

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cancer Cell 2025年第3期43卷 361-379.e10页

作者： Chen, Jianzhou Levy, Antonin Tian, Ai-Ling Huang, Xuehan Cai, Guoxin Fidelle, Marine Rauber, Conrad Ly, Pierre Pizzato, Eugénie Sitterle, Lisa Piccinno, Gianmarco Liu, Peng Durand, Sylvère Mao, Misha Zhao, Liwei Iebba, Valerio Felchle, Hannah Mallard de La Varende, Anne-Laure Fischer, Julius Clemens Thomas, Simon Greten, Tim F. Jones, Jennifer C. Monge, Cecilia Demaria, Sandra Formenti, Silvia Belluomini, Lorenzo Dionisi, Valeria Massard, Christophe Blanchard, Pierre Robert, Charlotte Quevrin, Clément Lopes, Eloise Clémenson, Céline Mondini, Michele Meziani, Lydia Zhan, Yizhou Zeng, Chengbing Cai, Qingxin Morel, Daphne Sun, Roger Laurent, Pierre-Antoine Mangoni, Monica Di Cataldo, Vanessa Arilli, Chiara Trommer, Maike Wegen, Simone Neppl, Sebastian Riechelmann, Rachel P. Camandaroba, Marcos P. Neto, Elson Santos Fournier, Pierre-Edouard Segata, Nicola Holicek, Peter Galluzzi, Lorenzo Buqué, Aitziber Alves Costa Silva, Carolina Derosa, Lisa Kroemer, Guido Chen, Chuangzhen Zitvogel, Laurence Deutsch, Eric Gustave Roussy Cancer Campus (GRCC) Clinicobiome Villejuif Cedex 94805 France Faculté de Médecine Université Paris-Saclay Kremlin-Bicêtre 94270 France Institut National de la Santé Et de la Recherche Médicale (INSERM) UMR 1015 Equipe Labellisée—Ligue Nationale contre le Cancer Villejuif 94805 France CICBT1428 Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France Department of Radiation Oncology Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France INSERM U1030 Radiothérapie Moléculaire et Innovations Thérapeutiques Gustave Roussy Cancer Campus (GRCC) Villejuif 94805 France Metabolomics and Cell Biology Platforms UMS AMMICa Gustave Roussy Cancer Campus Villejuif 94805 France Centre de Recherche des Cordeliers INSERM U1138 Équipe Labellisée – Ligue Nationale contre le Cancer Université Paris Cité Sorbonne Université Paris 75006 France Institut du Cancer Paris CARPEM Department of Biology Hôpital Européen Georges Pompidou AP-HP Paris 75015 France Department of Radiation Oncology Cancer Hospital of Shantou University Medical College Shantou 515031 China Department of Gastroenterology and Infectious Diseases University Hospital Heidelberg Heidelberg 69120 Germany Department of Computational Cellular and Integrative Biology University of Trento Trento 38123 Italy Department of Radiation Oncology Weill Cornell Medicine New York 10065 NY United States Drug Development Department (DITEP) Gustave Roussy Cancer Campus Villejuif 94805 France Department of Radiation Oncology Cyberknife and Radiotherapy Faculty of Medicine and University Hospital Cologne Cologne 50937 Germany Center for Integrated Oncology (CIO) Faculty of Medicine and University Hospital Cologne University of Cologne Cologne 50937 Germany Center for Molecular Medicine Cologne University of Cologne Cologne 50931 Germany Olivia Newton-John Cancer Wellness & Research Centre Austin Health Department of Radiation Oncology Heidelberg Melbourne 3084 VIC Australia Departme

The mechanisms governing the abscopal effects of local radiotherapy in cancer patients remain an open conundrum. Here, we show that off-target intestinal low-dose irradiation (ILDR) increases the clinical benefits of immune checkpoint inhibitors or chemotherapy in eight retrospective cohorts of cancer patients and in tumor-bearing mice. The abscopal effects of ILDR depend on dosimetry (≥1 and ≤3 Gy) and on the metabolic and immune host-microbiota interaction at baseline allowing CD8⁺ T cell activation without exhaustion. Various strains of Christensenella minuta selectively boost the anti-cancer efficacy of ILDR and PD-L1 blockade, allowing emigration of intestinal PD-L1-expressing dendritic cells to tumor-draining lymph nodes. An interventional phase 2 study provides the proof-of-concept that ILDR can circumvent resistance to first- or second-line immunotherapy in cancer patients. Prospective clinical trials are warranted to define optimal dosimetry and indications for ILDR to maximize its therapeutic potential. © 2025 The Author(s)

关键词： bile acids cancer Christensenella minuta dendritic cells gut microbiota metabolomics radiotherapy tumor immunosurveillance

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A retinoic acid:YAP1 signaling axis controls atrial lineage commitment

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Cell Reports 2025年第5期44卷 115687页

作者： Abraham, Elizabeth Kostina, Aleksandra Volmert, Brett Roule, Thomas Huang, Ling Yu, Jingting Williams, April E. Megill, Emily Douglas, Aidan Pericak, Olivia M. Morris, Alex Stronati, Eleonora Larrinaga-Zamanillo, Arantza Fueyo, Raquel Zubillaga, Mikel Andrake, Mark D. Akizu, Naiara Aguirre, Aitor Estaras, Conchi Department of Cardiovascular Sciences Aging + Cardiovascular Discovery Center Lewis Katz School of Medicine Temple University Philadelphia 19140 PA United States Institute for Quantitative Health Science and Engineering Division of Developmental and Stem Cell Biology Michigan State University East Lansing 48824 MI United States Department of Biomedical Engineering College of Engineering Michigan State University East Lansing 48824 MI United States Raymond G. Perelman Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Philadelphia 19104 PA United States Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies La Jolla 92037 CA United States Department of Child and Adolescence Psychiatry The Children's Hospital of Philadelphia Philadelphia 19104 PA United States Department of Chemical and Systems Biology Stanford University School of Medicine Stanford 94305 CA United States Cancer Epigenetics Institute Fox Chase Cancer Center Philadelphia 19111 PA United States Molecular Modeling Facility Program in Cancer Signaling and Microenvironment Fox Chase Cancer Center Philadelphia 19111 PA United States

In cardiac progenitor cells (CPCs), retinoic acid (RA) signaling induces atrial lineage gene expression and acquisition of an atrial cell fate. To achieve this, RA coordinates a complex regulatory network of downstream effectors that is not fully identified. To address this gap, we applied a functional genomics approach (i.e., scRNA-seq and snATAC-seq) to untreated and RA-treated human embryonic stem cell (hESC)-derived CPCs. Unbiased analysis revealed that the Hippo effectors YAP1 and TEAD4 are integrated with the atrial transcription factor enhancer network and that YAP1 activates RA enhancers in CPCs. Furthermore, Yap1 deletion in mouse embryos compromises the expression of RA-induced genes, such as Nr2f2, in the CPCs of the second heart field. Accordingly, in hESC-derived patterned heart organoids, YAP1 regulates the formation of an atrial chamber but is dispensable for the formation of a ventricle. Overall, our findings revealed that YAP1 cooperates with RA signaling to induce atrial lineages during cardiogenesis. © 2025 The Author(s)

关键词： atrial differentiation cardiac enhancers cardiac progenitors chamber development CP: Developmental biology heart organoids NR2F2 retinoic acid signaling SHF TEAD4 YAP1

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Author Correction: Disrupting cellular memory to overcome drug resistance

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Nature communications 2024年第1期15卷 4264页

作者： Guillaume Harmange Raúl A Reyes Hueros Dylan L Schaff Benjamin Emert Michael Saint-Antoine Laura C Kim Zijian Niu Shivani Nellore Mitchell E Fane Gretchen M Alicea Ashani T Weeraratna M Celeste Simon Abhyudai Singh Sydney M Shaffer Cellular and Molecular Biology Graduate Group Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Biochemistry and Molecular Biophysics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Bioengineering School of Engineering and Applied Sciences University of Pennsylvania Philadelphia PA USA. Division of Biology and Biological Engineering California Institute of Technology Pasadena CA 91125 USA. Department of Electrical and Computer Engineering University of Delaware Newark DE 19716 USA. Abramson Family Cancer Research Institute Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Chemistry College of the Arts and Sciences University of Pennsylvania Philadelphia PA USA. Department of Physics College of the Arts and Sciences University of Pennsylvania Philadelphia PA USA. Department of Biology College of the Arts and Sciences University of Pennsylvania Philadelphia PA USA. The Wharton School University of Pennsylvania Philadelphia PA USA. Cancer Signaling and Microenvironment Research Program Fox Chase Cancer Center Philadelphia PA USA. Department of Biochemistry and Molecular Biology Johns Hopkins School of Public Health Baltimore MD USA. Sidney Kimmel Cancer Center Johns Hopkins School of Medicine Baltimore MD USA. Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Bioengineering School of Engineering and Applied Sciences University of Pennsylvania Philadelphia PA USA. sydshaffer@***. Department of Pathology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. sydshaffer@***.

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Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference

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Oncoimmunology 2025年第1期14卷 2507856页

作者： Fereshteh Talebi Fabiana Gregucci Jalal Ahmed Nir Ben Chetrit Brian D Brown Timothy A Chan Dhan Chand Julie Constanzo Sandra Demaria Dmitry I Gabrilovich Encouse Golden Andrew Godkin Chandan Guha Gaorav P Gupta Aisha Hasan Fernanda G Herrera Howard Kaufman Donna Li Alan A Melcher Sierra McDonald Taha Merghoub Arta M Monjazeb Sébastien Paris Sean Pitroda Anguraj Sadanandam Dörthe Schaue Laura Santambrogio Phillippe Szapary Julien Sage James W Welsh Anna Wilkins Kristina H Young Eric Wennerberg Laurence Zitvogel Lorenzo Galluzzi Eric Deutsch Silvia C Formenti Department of Radiation Oncology Weill Cornell Medicine New York NY USA. Icahn Genomics Institute Department of Immunology and Immunotherapy Icahn School of Medicine at Mount Sinai New York NY USA. Department of Cancer Sciences Global Center for Immunotherapy and Precision Immuno-Oncology Cleveland Clinic Cleveland OH USA. Case Western University School of Medicine Cleveland OH USA. Agenus Inc Lexingston MA USA. Institut de Recherche en Cancérologie de Montpellier (IRCM) INSERM U1194 Université de Montpellier Institut régional du Cancer de Montpellier (ICM) Montpellier France. AstraZeneca Gaithersburg MD USA. Division of Infection and Immunity/Systems Immunity University Research Institute School of Medicine Cardiff University Cardiff UK. Departments of Radiation Oncology and Pathology Albert Einstein College of Medicine New York NY USA. Department of Radiation Oncology Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC USA. Johnson & Johnson New Brunswick NJ USA. AGORA Cancer Research Center Swiss Cancer Center Leman Lausanne Switzerland. Services of Radiation Oncology and Immuno-Oncology Centre Hospitalier Universitaire Vaudois Lausanne Switzerland. Department of Oncology Ludwig Institute of Cancer Research University of Lausanne Lausanne Switzerland. Ankyra Therapeutics Cambridge MA USA. University of Wisconsin Madison WI USA. Division of Radiotherapy and Imaging The Institute of Cancer Research London UK. UNC Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC USA. Swim Across America and Ludwig Collaborative Laboratory Department of Pharmacology Weill Cornell Medicine New York NY USA. Sandra and Edward Meyer Cancer Center and Parker Institute for Cancer Immunotherapy Weill Cornell Medicine New York NY USA. Department of Radiation Oncology University of California San Diego CA USA. Nanobiotix Paris France. Department of Radiation and Cellular Oncology

The annual ImmunoRad Conference has established itself as a recurrent occasion to explore the possibility of combining radiation therapy (RT) and immunotherapy (IT) for clinical cancer management. Bringing together a number of preclinical and clinical leaders in the fields of radiation oncology, immuno-oncology and IT, this annual event fosters indeed essential conversations and fruitful exchanges on how to address existing challenges to expand the therapeutic value of RT-IT combinations. The 8th edition of the ImmunoRad Conference, which has been held in October 2024 at the Weill Cornell Medical College of New York City, highlighted exciting preclinical and clinical advances at the interface between RT and IT, setting the stage for extra progress toward extended benefits for patients with an increasing variety of tumor types. Here, we critically summarize the lines of investigation that have been discussed at the occasion of the 8th Annual ImmunoRad Conference.

关键词： Abscopal effect CAR T cells CD8+ cytotoxic T lymphocytes TREG cells low-dose radiation therapy tumor-associated macrophages

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Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors (vol 19, pg 302, 2018)

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NATURE IMMUNOLOGY 2018年第6期19卷 645-645页

作者： Patin, Etienne Hasan, Milena Bergstedt, Jacob Rouilly, Vincent Libri, Valentina Urrutia, Alejandra Alanio, Cecile Scepanovic, Petar Hammer, Christian Joensson, Friederike Beitz, Benoit Quach, Helene Lim, Yoong Wearn Hunkapiller, Julie Zepeda, Magge Green, Cherie Piasecka, Barbara Leloup, Claire Rogge, Lars Huetz, Francois Peguillet, Isabelle Lantz, Olivier Fontes, Magnus Di Santo, James P. Thomas, Stephanie Fellay, Jacques Duffy, Darragh Quintana-Murci, Lluis Albert, Matthew L. Unit of Human Evolutionary Genetics Department of Genomes & Genetics Institut Pasteur Paris France CNRS UMR 2000 Paris France Center of Bioinformatics Biostatistics and Integrative Biology Institut Pasteur Paris France Center for Translation Research Institut Pasteur Paris France Department of Automatic Control Lund University Lund Sweden International Group for Data Analysis Institut Pasteur Paris France Laboratory of Dendritic Cell Immunobiology Department of Immunology Institut Pasteur Paris France INSERM U1223 Paris France Department of Cancer Immunology Genentech South San Francisco CA USA School of Life Sciences École Polytechnique Fédérale de Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland Antibodies in Therapy and Pathology Department of Immunology Institut Pasteur Paris France INSERM U760 Paris France Department of Human Genetics Genentech South San Francisco CA USA Employee Donation Program Genentech South San Francisco CA USA Department of Development Sciences Genentech South San Francisco CA USA Immunoregulation Unit Department of Immunology Institut Pasteur Paris France INSERM U783 Faculté de Médecine Site Necker-Enfants Malades Université Paris Descartes Paris France Lymphocyte Population Biology CNRS URA 1961 Institut Pasteur Paris France Center of Clinical Investigations CIC-BT1428 IGR/Curie Paris France Department of Biopathology Institut Curie Paris France Equipe Labellisée de la Ligue de Lutte Contre le Cancer Institut Curie Paris France INSERM/Institut Curie U932 Paris France Centre for Mathematical Sciences Lund University Lund Sweden Innate Immunity Unit Institut Pasteur Paris France St. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Paris Descartes University Imagine Insti

The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases.

关键词： Activated Lymphocyte Genetic factors Immunity Nonspecific Immune Cell Variation

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Erratum to: Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity

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BMC Biochemistry 2011年第1期12卷 1-2页

作者： Kozlowski, Eliene O Lima, Paula C Vicente, Cristina P Lotufo, Tito Bao, Xingfeng Sugahara, Kazuyuki Pavão, Mauro SG Laboratório de Bioquímica e Biologia Celular de Glicoconjugados Hospital Universitário Clementino Fraga Filho and Programa de Glicobiologia Instituto de Bioquímica Médica Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Department of Anatomy Cellular Biology Physiology and Biophysics Instituto de Biologia Universidade Estadual de Campinas São Paulo Brasil Laboratório de Ecologia Animal Instituto de Ciências do Mar Universidade Federal do Ceará Fortaleza Brasil Department of Biochemistry Kobe Pharmaceutical University Kobe Japan Glycobiology Unit Tumor Microenvironment Program Cancer Research Center Sanford-Burnham Institute for Medical Research La Jolla USA Laboratory of Proteoglycan Signaling and Therapeutics Hokkaido University Graduate School of Life Science Frontier Research Center for Post-Genomic Science and Technology Graduate Sapporo Japan

After the publication of the work entitled "Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity", by Kozlowski et al., BMC Biochemistry 2011, 12: 29, we found that the legends to Figures 2 to 5 contain serious mistakes that compromise the comprehension of the work. This correction article contains the correct text of the legends to Figures 2 to 5.

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