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computer science and Information Engineering, CSIE, WRI World Congress on FLAGGED

作者： Shaozhi Wu Peng Xu Shadnaz Asgari Marvin Bergsneider Xiao Hu Biomedical Engineering Graduate Program Henry Samueli School of Engineering and Applied Science University of California Los Angeles USA Neural Systems and Dynamics Laboratory Department of Neurosurgery the David Geffen School of Medicine University of California Los Angeles USA School of Computer Science and Engineering University of Electronic Science and Technology Chengdu China

A data mining framework has been proposed to estimate intracranial pressure (ICP) non-invasively in our previous work. In the corresponding approach, the feature vector extracted from arterial blood pressure (ABP) and flow velocity (FV) is translated to the estimated errors by the mapping function for each entry in the database. In this paper, three different mapping function solutions, linear least squares (LLS), truncated singular value decomposition (TSVD) and standard Tikhonov regularization (STR) are systemically tested to compare the possible effects of different solutions on the non-invasive ICP estimation. The conducted comparison demonstrated that the selection of mapping function solution actually influences the estimation. Among the tested three solutions for mapping function, TSVD and STR show better ICP estimation performance with smaller ICP errors than LLS.

关键词： Cranial pressure Data mining Biomedical engineering Data engineering Spatial databases computer science Feature extraction Arterial blood pressure Biomedical measurements Laboratories

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Executive Summary of Dagstuhl Seminar on Structured Decompositions and Efficient Algorithms (08492)

Executive Summary of Dagstuhl Seminar on Structured Decompos...

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Structured Decompositions and Efficient Algorithms 2008

作者： Dahlke, Stephan Daubechies, Ingrid Elad, M. Kutyniok, Gitta Teschke, Gerd Philipps-Universität Marburg FB12 Mathematik und Informatik Hans-Meerwein Straße Lahnberge Marburg35032 Germany Princeton University Program in Applied and Computational Mathematics Fine Hall Washington Road PrincetonNJ08544-1000 United States Technion Computer Science Department Haifa Technion City32000 Israel Universität Osnabrück Institute of Mathematics Osnabrück49069 Germany Hochschule Neubrandenburg University of Applied Sciences Institute for Computational Mathematics in Science and Technology Brodaer Str. 2 Neubrandenburg17033 Germany

New emerging technologies such as high-precision sensors or new MRI machines drive us towards a challenging quest for new, more effective, and more daring mathematical models and algorithms. Therefore, in the last few years researchers have started to investigate different methods to efficiently represent or extract relevant information from complex, high dimensional and/or multimodal data. Efficiently in this context means a representation that is linked to the features or characteristics of interest, thereby typically providing a sparse expansion of such. Besides the construction of new and advanced ansatz systems the central question is how to design algorithms that are able to treat complex and high dimensional data and that efficiently perform a suitable approximation of the signal. One of the main challenges is to design new sparse approximation algorithms that would ideally combine, with an adjustable tradeoff, two properties: a provably good 'quality' of the resulting decomposition under mild assumptions on the analyzed sparse signal, and numerically efficient design. The topic is driven by applications as well as by theoretical questions. Therefore, the aim of this seminar was to bring together a good mixture of scientists with different backgrounds in order to discuss recent progress as well as new challenging perspectives. In particular, it was intended to strengthen the interaction of mathematicians and computer scientists. © 2009 Dagstuhl Seminar Proceedings. All Rights Reserved.

关键词： Clustering algorithms

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Multiscale modeling in rodent ventricular myocytes

Multiscale modeling in rodent ventricular myocytes

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作者： Lu, Shaoying Michailova, Anushka Saucerman, Jeffrey Cheng, Yuhui Yu, Zeyun Kaiser, Timothy Li, Wilfred Bank, Randolph Holst, Michael McCammon, J. Hayashi, Takeharu Hoshijima, Masahiko Arzberger, Peter McCulloch, Andrew Bioengineering Department University of Illinois United States Bioengineering Department UCSD United States Department of Biomedical Engineering University of Virginia United States Department of Mathematics UCSD United States UCSD United States College of Computer Science and Technology Jilin University China Department of Mathematics Center for Computational Mathematics and the Computational Science Mathematics and Engineering Doctoral Program at UCSD Department of Pharmacology UCSD United States Center for Research in Biological Systems UCSD United States Department of Bioengineering UCSD United States Department of Bioengineering PFBH 241 University of California San Diego 9500 Gilman Drive San Diego CA 92093-0412 United States

There is a growing body of experimental evidence suggesting that the Ca2+ signaling in ventricular myocytes is characterized by a high gradient near the cell membrane and a more uniform Ca2+ distribution in the cell interior [1]--[7]. An important reason for this phenomenon might be that in these cells the t-tubular system forms a network of extracellular space, extending deep into the cell interior. This allows the electrical signal, that propagates rapidly along the cell membrane, to reach the vicinity of the sarcoplasmic reticulum (SR), where intracellular Ca2+ required for myofilament activation is stored [1], [8]--[11]. Early studies of cardiac muscle showed that the t-tubules are found at intervals of about 2 lm along the longitudinal cell axis in close proximity to the Z-disks of the sarcomeres [12]. Subsequent studies have demonstrated that the t-tubular system has also longitudinal extensions [9]--[11], [13].

关键词： Cells

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Identification of cell cycle-related regulatory motifs using a kernel canonical correlation analysis

Identification of cell cycle-related regulatory motifs using...

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8th International Conference on Bioinformatics: Computational Biology, InCoB 2009

作者： Rhee, Je-Keun Joung, Je-Gun Chang, Jeong-Ho Fei, Zhangjun Zhang, Byoung-Tak Graduate Program in Bioinformatics Seoul National University Seoul 151-744 Korea Republic of Seoul National University Seoul 151-744 Korea Republic of Boyce Thompson Institute for Plant Research Cornell University Ithaca NY 14853 United States Konan Technology Inc. Seoul 135-080 Korea Republic of USDA Robert W. Holley Center for Agriculture and Health Ithaca NY 14853 United States School of Computer Science and Engineering Seoul National University Seoul 151-744 Korea Republic of

Background: Gene regulation is a key mechanism in higher eukaryotic cellular processes. One of the major challenges in gene regulation studies is to identify regulators affecting the expression of their target genes in specific biological processes. Despite their importance, regulators involved in diverse biological processes still remain largely unrevealed. In the present study, we propose a kernel-based approach to efficiently identify core regulatory elements involved in specific biological processes using gene expression profiles. Results: We developed a framework that can detect correlations between gene expression profiles and the upstream sequences on the basis of the kernel canonical correlation analysis (kernel CCA). Using a yeast cell cycle dataset, we demonstrated that upstream sequence patterns were closely related to gene expression profiles based on the canonical correlation scores obtained by measuring the correlation between them. Our results showed that the cell cycle-specific regulatory motifs could be found successfully based on the motif weights derived through kernel CCA. Furthermore, we identified co-regulatory motif pairs using the same framework. Conclusion: Given expression profiles, our method was able to identify regulatory motifs involved in specific biological processes. The method could be applied to the elucidation of the unknown regulatory mechanisms associated with complex gene regulatory processes. © 2012 BioMed Central Ltd .

关键词： Gene expression

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Expanding the plausible solution space for robustness in an intelligent tutoring system

Expanding the plausible solution space for robustness in an ...

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9th International Conference on Intelligent Tutoring Systems

作者： Kazi, Hameedullah Haddawy, Peter Suebnukarn, Siriwan Computer Science and Information Management Program Asian Institute of Technology Thailand School of Dentistry Thammasat University Thailand Department of Computer Science Isra University Pakistan

ISBN: (纸本)9783540691303

The knowledge acquisition bottleneck is a problem pertinent to the authoring of any intelligent tutoring system. Allowing students a broad scope of reasoning and solution representation whereby a wide range of plausible student solutions are accepted by the system, places additional burden on knowledge acquisition. In this paper we present a strategy to alleviate the burden of knowledge acquisition for building a tutoring system for medical problem-based learning (PBL). The Unified Medical Language System (UMLS) is deployed as domain ontology and information structure in the ontology is exploited to make intelligent inferences and expand the domain model. Using these inferences and expanded domain model, the tutoring system is able to accept a broader range of plausible student solutions that lie beyond the scope of explicitly encoded solutions. We describe the development of a tutoring system prototype and report the evaluation of system correctness in accepting such plausible solutions. The system evaluation indicates an average accuracy of 94.59% when compared against human domain experts, who agreed among themselves with a statistical agreement based on Pearson Correlation Coefficient of 0.48 and p < 0.05.

关键词： robustness intelligent tutoring systems medical problem-based learning UMLS knowledge acquisition bottleneck.

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Teaching Abstraction to Novices: Pattern-Based and ADT-Based Problem-Solving Processes

Teaching Abstraction to Novices: Pattern-Based and ADT-Based...

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IEEE Frontiers in Education Conference 2008

作者： Haberman, Bruria Muller, Orna Computer Science Department Holon Institute of Technology Israel CS Academia and Industry Program Israel Science Education Department Computer Science Group Tel-Aviv University Israel Software Engineering Department Ort Braude College of Engineering Israel

ISBN: (纸本)9781424419692

is taught to computer-science students as part of a comprehensive curriculum. The students encounter the concept of abstraction in various contexts while learning the different modules, each of which emphasizes some specific aspects of the concept. In this paper we present two instructional approaches, both related to utilizing abstraction in problem-solving processes: (1) pattern-oriented instruction (POI), and (2) abstract data type (ADT)-oriented instruction. We present these methods with respect to their employment in teaching problem solving to novices, and elaborate on abstraction processes.

关键词： Abstraction algorithmic patterns abstract data types problem solving

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Meeting Report from the Second "Minimum Information for Biological and Biomedical Investigations" (MIBBI) workshop

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Standards in genomic sciences 2010年第3期3卷 259-66页

作者： Carsten Kettner Dawn Field Susanna-Assunta Sansone Chris Taylor Jan Aerts Nigel Binns Andrew Blake Cedrik M Britten Ario de Marco Jennifer Fostel Pascale Gaudet Alejandra González-Beltrán Nigel Hardy Jan Hellemans Henning Hermjakob Nick Juty Jim Leebens-Mack Eamonn Maguire Steffen Neumann Sandra Orchard Helen Parkinson William Piel Shoba Ranganathan Philippe Rocca-Serra Annapaola Santarsiero David Shotton Peter Sterk Andreas Untergasser Patricia L Whetzel Beilstein-Institut Frankfurt am Main Germany Centre for Ecology & Hydrology UK Oxford e-Research Centre University of Oxford UK The European Bioinformatics Institute (EBI) UK Faculty of Engineering - ESAT/SCD Leuven University Leuven-Heverlee Belgium Division of Pathway Medicine University of Edinburgh Medical School Edinburgh UK MRC Harwell UK Medical Department University Medical Center Johannes Gutenberg University-Mainz Mainz Germany Consortium for Genomic Technology Milano Italy University of Nova Gorica Nova Gorica Slovenia NIEHS NIH US National Toxicology Program USA Swiss Institute of Bioinformatics Geneva Switzerland Computational and Systems Medicine and Department of Computer Science University College London London UK Department of Computer Science Aberystwyth University Aberystwyth UK Center for Medical Genetics Ghent University Ghent Belgium Department of Plant Biology University of Georgia Athens USA Department of Stress- and Developmental Biology Institute for Plant Biochemistry Halle Germany Peabody Museum of Natural History Yale University New Haven USA Macquarie University Sydney Australia National University of Singapore Singapore Cancer Pharmacology The Mario Negri Institute for Pharmacological Research Milan Italy Image Bioinformatics Research Group Department of Zoology University of Oxford Oxford UK Wellcome Trust Sanger Institute UK Zentrum für Molekulare Biologie der Universität Heidelberg Heidelberg Germany The National Center for Biomedical Ontology / Stanford Center for Biomedical Informatics Research Stanford University Stanford USA

This report summarizes the proceedings of the second workshop of the 'Minimum Information for Biological and Biomedical Investigations' (MIBBI) consortium held on Dec 1-2, 2010 in Rüdesheim, Germany through the sponsorship of the Beilstein-Institute. MIBBI is an umbrella organization uniting communities developing Minimum Information (MI) checklists to standardize the description of data sets, the workflows by which they were generated and the scientific context for the work. This workshop brought together representatives of more than twenty communities to present the status of their MI checklists and plans for future development. Shared challenges and solutions were identified and the role of MIBBI in MI checklist development was discussed. The meeting featured some thirty presentations, wide-ranging discussions and breakout groups. The top outcomes of the two-day workshop as defined by the participants were: 1) the chance to share best practices and to identify areas of synergy; 2) defining a series of tasks for updating the MIBBI Portal; 3) reemphasizing the need to maintain independent MI checklists for various communities while leveraging common terms and workflow elements contained in multiple checklists; and 4) revision of the concept of the MIBBI Foundry to focus on the creation of a core set of MIBBI modules intended for reuse by individual MI checklist projects while maintaining the integrity of each MI project. Further information about MIBBI and its range of activities can be found at http://***/.

关键词： Minimum Information European Bioinformatics Institute Biomedical Ontology Stable Link Breakout Group

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Efficient color feature extraction and matching for motion estimation and mapping

Efficient color feature extraction and matching for motion e...

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2008 IEEE/RSJ International Conference on Intelligent Robots and Systems, IROS

作者： Hwang, Hyoseok Kweon, In-So Robotics Program Korea Advanced Institute of Science and Technology Daejon Korea Republic of Faculty of Electrical Engineering and Computer Science Korea Advanced Institute of Science and Technology Daejon Korea Republic of

ISBN: (纸本)9781424420582

Feature extraction and matching is one of the most significant research areas in robot vision. In this paper, we present a new method for motion estimation and mapping using color feature extraction and matching. The proposed method reduces computational cost and has good performance. The experimental result shows that the proposed method not only runs faster but provides accurate result.

关键词： Motion estimation

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Information technology literacy for non-engineers

Information technology literacy for non-engineers

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2008 ASEE Annual Conference and Exposition

作者： Suchan, William Schwartz, Susan Sobiesk, Edward United States Military Academy Information Technology Core Program Department of Electrical Engineering and Computer Science United States Military Academy Information Technology Core Program Department of Electrical Engineering and Computer Science United States Military Academy Course IT305-Theory and Practice of Military IT Systems Department of Electrical Engineering and Computer Science United States Military Academy

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Visual equivalence: An object-based approach to image quality

Visual equivalence: An object-based approach to image qualit...

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16th Color Imaging Conference: Color science and Engineering Systems, Technologies, and Applications

作者： Ferwerda, James A. Ramanarayanan, Ganesh Walter, Bruce Bala, Kavita Munsell Color Science Laboratory Center for Imaging Science Rochester Institute of Technology Rochester NY United States Department of Computer Science Cornell University Ithaca NY United States Program of Computer Graphics Cornell University Ithaca NY United States

ISBN: (纸本)9780892082810

In this paper we introduce a new approach to characterizing image quality: visual equivalence, Images are visually equivalent if they convey the same information about object appearance even if they are visibly different. In a series of psychophysical experiments we explore how object geometry, material, and illumination interact to produce images that are visually equivalent, and we identify how two kinds of transformations on illumination fields (blurring and warping) influence observers' judgments of equivalence. We use the results of the experiments to derive metrics that can serve as visual equivalence predictors (VEPs) and we generalize these metrics so they can be applied to novel objects and scenes. Finally we validate the predictors in a confirmatory study, and show that they reliably predict observer's judgments of equivalence. Visual equivalence is a significant new approach to measuring image quality that goes beyond existing visible difference metrics by leveraging the fact that some kinds of image differences do not matter to human observers. By taking advantage of higher order aspects of visual object coding, visual equivalence metrics should enable the development of powerful new classes of image capture, compression, rendering, and display algorithms.

关键词： Image quality

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