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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Hearing loss prevalence and years lived with disability, 1990-2019: Findings from the Global Burden of Disease Study 2019

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The Lancet 2021年第10278期397卷 996-1009页

作者： Haile, Lydia M. Kamenov, Kaloyan Briant, Paul Svitil Orji, Aislyn U. Steinmetz, Jaimie D. Abdoli, Amir Abdollahi, Mohammad Abu-Gharbieh, Eman Afshin, Ashkan Ahmed, Haroon Rashid, Tarik Ahmed Akalu, Yonas Alahdab, Fares Alanezi, Fahad Mashhour Alanzi, Turki M. Al Hamad, Hanadi Ali, Liaqat Alipour, Vahid Al-Raddadi, Rajaa M. Amu, Hubert Arabloo, Jalal Arab-Zozani, Morteza Arulappan, Judie Ashbaugh, Charlie Atnafu, Desta Debalkie Babar, Zaheer-Ud-Din Baig, Atif Amin Banik, Palash Chandra Bärnighausen, Till Winfried Barrow, Amadou Bender, Rose G. Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bibi, Sadia Bijani, Ali Burkart, Katrin Cederroth, Christopher R. Charan, Jaykaran Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Dagnew, Amare Belachew Dagnew, Baye Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi Desalew, Assefa Dhamnetiya, Deepak Dhimal, Mandira Lamichhane Dhimal, Meghnath Doyle, Kerrie E. Duncan, Bruce B. Ekholuenetale, Michael Filip, Irina Fischer, Florian Franklin, Richard Charles Gaidhane, Abhay Motiramji Gaidhane, Shilpa Gallus, Silvano Ghamari, Farhad Ghashghaee, Ahmad Ghozali, Ghozali Gilani, Syed Amir Glǎvan, Ionela-Roxana Golechha, Mahaveer Goulart, Barbara Niegia Garcia Gupta, Veer Bala Gupta, Vivek Kumar Hamidi, Samer Hammond, Billy Randall Hay, Simon I. Hayat, Khezar Heidari, Golnaz Hoffman, Howard J. Hopf, Kathleen Pillsbury Hosseinzadeh, Mehdi Househ, Mowafa Hussain, Rabia Hwang, Bing-Fang Iavicoli, Ivo Ibitoye, Segun Emmanuel Ilesanmi, Olayinka Stephen Irvani, Seyed Sina Naghibi Islam, Sheikh Mohammed Shariful Iwagami, Masao Jacob, Louis Jayapal, Sathish Kumar Jha, Ravi Prakash Jonas, Jost B. Kalhor, Rohollah Al-Salihi, Nawzad Kameran Kandel, Himal Kasa, Ayele Semachew Kayode, Gbenga A. Khalilov, Rovshan Khan, Ejaz Ahmad Khatib, Mahalaqua Nazli Kosen, Soewarta Koyanagi, Ai Kumar, G. Anil Landires, Ivan Lasrado, Savita Lim, Stephen S. Liu, Xuefeng Lobo, Stany W. Lugo, Alessandra Makki, Alaa Mendoza, Walter Mersha, Amanual Getnet Mihretie, Kebadnew Mulatu Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Noncommunicable Diseases World Health Organization (WHO) Geneva Switzerland Department of Parasitology and Mycology Jahrom University of Medical Sciences Jahrom Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran University of Medical Sciences Tehran Iran School of Pharmacy Tehran University of Medical Sciences Tehran Iran Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Department of Biosciences COMSATS Institute of Information Technology Islamabad Pakistan Department of Computer Science and Engineering University of Kurdistan Hewler Erbil Iraq Department of Medical Physiology University of Gondar Gondar Ethiopia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia Health Information Management and Technology Department Dammam Saudi Arabia Geriatric and Long Term Care Department Hamad Medical Corporation Doha Qatar Rumailah Hospital Hamad Medical Corporation Doha Qatar Department of Biological Sciences National University of Medical Sciences (NUMS) Rawalpindi Pakistan Health Management and Economics Research Center Tehran Iran Department of Community Medicine King Abdulaziz University Jeddah Saudi Arabia Department of Population and Behavioural Sciences University of Health and Allied Sciences Ho Ghana Social Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran Department of Maternal and Child Health Sultan Qaboos University Muscat Oman Department of Health System and Health Economics Bahir Dar University Bahir Dar Ethiopia Department of Pharmacy University of Huddersfield Huddersfield United Kingdom Unit of Biochemistry Universiti

Background: Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability. Methods: We did systematic reviews of population-representative surveys on hearing loss prevalence from 1990 to 2019. We fitted nested meta-regression models for severity-specific prevalence, accounting for hearing aid coverage, cause, and the presence of tinnitus. We also forecasted the prevalence of hearing loss until 2050. Findings: An estimated 1·57 billion (95% uncertainty interval 1·51–1·64) people globally had hearing loss in 2019, accounting for one in five people (20·3% [19·5–21·1]). Of these, 403·3 million (357·3–449·5) people had hearing loss that was moderate or higher in severity after adjusting for hearing aid use, and 430·4 million (381·7–479·6) without adjustment. The largest number of people with moderate-to-complete hearing loss resided in the Western Pacific region (127·1 million people [112·3–142·6]). Of all people with a hearing impairment, 62·1% (60·2–63·9) were older than 50 years. The Healthcare Access and Quality (HAQ) Index explained 65·8% of the variation in national age-standardised rates of years lived with disability, because countries with a low HAQ Index had higher rates of years lived with disability. By 2050, a projected 2·45 billion (2·35–2·56) people will have hearing loss, a 56·1% (47·3–65·2) increase from 2019, despite stable age-standardised prevalence. Interpretation: As populations age, the number of people with hearing loss will increase. Interventions such as childhood screening, hearing aids, effective management of otitis media and meningitis, and cochlear implants have the potential to ameliorate this burden. Because the burden of moderate-to-complete hearing loss is concentrated in countries with low health-ca

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First Constraints on the Epoch of Reionization Using the Non-Gaussianity of the Kinematic Sunyaev-Zel’dovich Effect from the South Pole Telescope and Herschel-SPIRE Observations

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Physical Review Letters 2024年第12期133卷 121004页

作者： S. Raghunathan P. A. R. Ade A. J. Anderson B. Ansarinejad M. Archipley J. E. Austermann L. Balkenhol J. A. Beall K. Benabed A. N. Bender B. A. Benson F. Bianchini L. E. Bleem J. Bock F. R. Bouchet L. Bryant E. Camphuis J. E. Carlstrom T. W. Cecil C. L. Chang P. Chaubal H. C. Chiang P. M. Chichura T.-L. Chou R. Citron A. Coerver T. M. Crawford A. T. Crites A. Cukierman C. Daley K. R. Dibert M. A. Dobbs A. Doussot D. Dutcher W. Everett C. Feng K. R. Ferguson K. Fichman A. Foster S. Galli J. Gallicchio A. E. Gambrel R. W. Gardner F. Ge E. M. George N. Goeckner-Wald R. Gualtieri F. Guidi S. Guns N. Gupta T. de Haan N. W. Halverson E. Hivon G. P. Holder W. L. Holzapfel J. C. Hood J. D. Hrubes A. Hryciuk N. Huang J. Hubmayr K. D. Irwin F. Kéruzoré A. R. Khalife L. Knox M. Korman K. Kornoelje C.-L. Kuo A. T. Lee K. Levy D. Li A. E. Lowitz C. Lu A. Maniyar E. S. Martsen J. J. McMahon F. Menanteau M. Millea J. Montgomery C. Corbett Moran Y. Nakato T. Natoli J. P. Nibarger G. I. Noble V. Novosad Y. Omori S. Padin Z. Pan P. Paschos S. Patil K. A. Phadke K. Prabhu C. Pryke W. Quan M. Rahimi A. Rahlin C. L. Reichardt M. Rouble J. E. Ruhl B. R. Saliwanchik K. K. Schaffer E. Schiappucci C. Sievers G. Smecher J. A. Sobrin A. A. Stark J. Stephen A. Suzuki C. Tandoi K. L. Thompson B. Thorne C. Trendafilova C. Tucker C. Umilta T. Veach J. D. Vieira M. P. Viero Y. Wan G. Wang N. Whitehorn W. L. K. Wu V. Yefremenko M. R. Young J. A. Zebrowski M. Zemcov Center for AstroPhysical Surveys School of Physics and Astronomy Cardiff University Cardiff CF24 3YB United Kingdom Fermi National Accelerator Laboratory MS209 P.O. Box 500 Batavia Illinois 60510 USA Kavli Institute for Cosmological Physics University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Department of Astronomy and Astrophysics University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA School of Physics University of Melbourne Parkville Victoria 3010 Australia Department of Astronomy University of Illinois Urbana-Champaign 1002 West Green Street Urbana Illinois 61801 USA NIST Quantum Devices Group 325 Broadway Mailcode 817.03 Boulder Colorado 80305 USA Department of Physics University of Colorado Boulder Colorado 80309 USA Institut d’Astrophysique de Paris UMR 7095 CNRS and Sorbonne Université 98 bis boulevard Arago 75014 Paris France High-Energy Physics Division Argonne National Laboratory 9700 South Cass Avenue Lemont Illinois 60439 USA Kavli Institute for Particle Astrophysics and Cosmology Stanford University 452 Lomita Mall Stanford California 94305 USA Department of Physics Stanford University 382 Via Pueblo Mall Stanford California 94305 USA SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park California 94025 USA California Institute of Technology Pasadena California 91125 USA Jet Propulsion Laboratory California Institute of Technology Pasadena California 91109 USA Enrico Fermi Institute University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Department of Physics University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Department of Physics and McGill Space Institute McGill University 3600 Rue University Montreal Quebec H3A 2T8 Canada School of Mathematics Statistics and Computer Science University of KwaZulu-Natal Durban South Africa University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA Department of Physics

We report results from an analysis aimed at detecting the trispectrum of the kinematic Sunyaev-Zel’dovich (kSZ) effect by combining data from the South Pole Telescope (SPT) and Herschel-SPIRE experiments over a 100 deg2 field. The SPT observations combine data from the previous and current surveys, namely SPTpol and SPT-3G, to achieve depths of 4.5, 3, and 16 μK−arcmin in bands centered at 95, 150, and 220 GHz. For SPIRE, we include data from the 600 and 857 GHz bands. We reconstruct the velocity-induced large-scale correlation of the small-scale kSZ signal with a quadratic estimator that uses two cosmic microwave background (CMB) temperature maps, constructed by optimally combining data from all the frequency bands. We reject the null hypothesis of a zero trispectrum at 10.3σ level. However, the measured trispectrum contains contributions from both the kSZ and other undesired components, such as CMB lensing and astrophysical foregrounds, with kSZ being sub-dominant. We use the agora simulations to estimate the expected signal from CMB lensing and astrophysical foregrounds. After accounting for the contributions from CMB lensing and foreground signals, we do not detect an excess kSZ-only trispectrum and use this nondetection to set constraints on reionization. By applying a prior based on observations of the Gunn-Peterson trough, we obtain an upper limit on the duration of reionization of Δzre,50<4.5 (95% confidence level). We find these constraints are fairly robust to foregrounds assumptions. This trispectrum measurement is independent of, but consistent with, Planck’s optical depth measurement. This result is the first constraint on the epoch of reionization using the non-Gaussian nature of the kSZ signal.

关键词： Cosmic microwave background Evolution of the Universe Formation & evolution of stars & galaxies

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The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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Nature Communications 2022年第1期13卷 1-14页

作者： Reiner, Robert C. Welgan, Catherine A. Troeger, Christopher E. Baumann, Mathew M. Weiss, Daniel J. Deshpande, Aniruddha Blacker, Brigette F. Miller-Petrie, Molly K. Earl, Lucas Bhatt, Samir Abolhassani, Hassan Abosetugn, Akine Eshete Abu-Gharbieh, Eman Adekanmbi, Victor Adetokunboh, Olatunji O. Aghaali, Mohammad Aji, Budi Alahdab, Fares Al-Aly, Ziyad Alhassan, Robert Kaba Ali, Saqib Alizade, Hesam Aljunid, Syed Mohamed Almasi-Hashiani, Amir Al-Mekhlafi, Hesham M. Altirkawi, Khalid A. Alvis-Guzman, Nelson Amare, Azmeraw T. Amini, Saeed Amugsi, Dickson A. Ancuceanu, Robert Andrei, Catalina Liliana Ansari, Fereshteh Anvari, Davood Appiah, Seth Christopher Yaw Arabloo, Jalal Aremu, Olatunde Atout, Maha Moh’d Wahbi Ausloos, Marcel Ausloos, Floriane Ayanore, Martin Amogre Aynalem, Yared Asmare Azene, Zelalem Nigussie Badawi, Alaa Baig, Atif Amin Banach, Maciej Bedi, Neeraj Bhagavathula, Akshaya Srikanth Bhandari, Dinesh Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bijani, Ali Birhanu, Tesega Tesega Mengistu Bitew, Zebenay Workneh Boloor, Archith Brady, Oliver J. Butt, Zahid A. Car, Josip Carvalho, Felix Casey, Daniel C. Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Coelho, Camila H. Cook, Aubrey J. Damiani, Giovanni Daoud, Farah Gela, Jiregna Darega Darwish, Amira Hamed Daryani, Ahmad Das, Jai K. Davis Weaver, Nicole Deribe, Kebede Desalew, Assefa Dharmaratne, Samath Dhamminda Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Dorostkar, Fariba Dubljanin, Eleonora Duko, Bereket Dwyer-Lindgren, Laura Effiong, Andem El Sayed Zaki, Maysaa El Tantawi, Maha Enany, Shymaa Fattahi, Nazir Feigin, Valery L. Fernandes, Eduarda Ferrara, Pietro Fischer, Florian Foigt, Nataliya A. Folayan, Morenike Oluwatoyin Foroutan, Masoud Frostad, Joseph Jon Fukumoto, Takeshi Gaidhane, Abhay Motiramji Gebrekrstos, Hailemikael Gebrekidan G. K. Gebremeskel, Leake Gebreslassie, Assefa Ayalew Gething, Peter W. Gezae, Kebede Embaye Ghadiri, Keyghobad Ghashghaee, Ahmad Golechha, Mahaveer Gubar Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Malaria Atlas Project University of Oxford Oxford United Kingdom Imperial College London London United Kingdom Department of Laboratory Medicine Karolinska University Hospital Huddinge Sweden Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Debre Berhan University Debre Berhan Ethiopia Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Population Health Sciences King’s College London London United Kingdom Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Stellenbosch South Africa Department of Global Health Stellenbosch University Cape Town South Africa Department of Epidemiology and Biostatistics Qom University of Medical Sciences Qom Iran Faculty of Medicine and Public Health Jenderal Soedirman University Purwokerto Indonesia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T. Milliken Department of Internal Medicine Washington University in St. Louis St. Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Institute of Health Research University of Health and Allied Sciences Ho Ghana Department of Information Systems College of Economics and Political Science Sultan Qaboos University Muscat Oman Infectious and Tropical Disease Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Health Policy and Management Kuwait University Safat Kuwait International Centre for Casemix and Clinical Coding National University of Malaysia Bandar Tun Razak Malaysia Department of Epidemiology Arak University of Medical Sciences Arak Iran Medical Research Center

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).

关键词： Biogeography Epidemiology Infectious diseases Malaria

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Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas program

arXiv

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arXiv 2019年

作者： Snyder, Michael P. Lin, Shin Posgai, Amanda Atkinson, Mark Regev, Aviv Rood, Jennifer Rozenblatt-Rosen, Orit Gaffney, Leslie Hupalowska, Anna Satija, Rahul Gehlenborg, Nils Shendure, Jay Laskin, Julia Harbury, Pehr Nystrom, Nicholas A. Bar-Joseph, Ziv Zhang, Kun Börner, Katy Lin, Yiing Conroy, Richard Procaccini, Dena Roy, Ananda L. Pillai, Ajay Brown, Marishka Galis, Zorina S. Cai, Long Shendure, Jay Trapnell, Cole Lin, Shin Jackson, Dana Snyder, Michael P. Nolan, Garry Greenleaf, William James Lin, Yiing Plevritis, Sylvia Ahadi, Sara Lee, Hayan Nevins, Stephanie Esplin, Ed Horning, Aaron Bahmani, Amir Zhang, Kun Sun, Xin Jain, Sanjay Hagood, James Kharchenko, Peter Atkinson, Mark Bodenmiller, Bernd Brusko, Todd Clare-Salzler, Michael Nick, Harry Otto, Kevin Posgai, Amanda Wasserfall, Clive Maffioletti, Sergio Caprioli, Richard M. Spraggins, Jeffrey M. Gutierrez, Danielle Patterson, Nathan Heath Neumann, Elizabeth K. Harris, Raymond deCaestecker, Mark de Plas, Raf Van Lau, Ken Cai, Long Yuan, Guo-Cheng Zhu, Qian Dries, Ruben Yin, Peng Saka, Sinem K. Kishi, Jocelyn Y. Wang, Yu Goldaracena, Isabel Laskin, Julia Ye, DongHye Burnum-Johnson, Kristin E. Piehowski, Paul D. Ansong, Charles Zhu, Ying Harbury, Pehr Desai, Tushar Mulye, Jay Chou, Peter Nagendran, Monica Bar-Joseph, Ziv Teichmann, Sarah A. Paten, Benedict Murphy, Robert F. Ma, Jian Kiselev, Vladimir Yu Kingsford, Carl Ricarte, Allyson Ruffalo, Matthew Gehlenborg, Nils Kharchenko, Peter Vella, Margaret McCallum, Chuck Börner, Katy Cross, Leonard E. Friedman, Samuel H. Heiland, Randy Herr, Bruce Macklin, Paul Quardokus, Ellen M. Record, Lisel Sluka, James P. Weber, Griffin M. Nystrom, Nicholas A. Silverstein, Jonathan C. Blood, Philip D. Ropelewski, Alexander J. Shirey, William E. Mabee, Paula Lenhardt, W. Christopher Robasky, Kimberly Michailidis, Stavros Satija, Rahul Marioni, John Regev, Aviv Butler, Andrew Stuart, Tim Fisher, Eyal Ghazanfar, Shila Rood, Jennifer Gaffney, Leslie Ersalan, Gokcen Biancalani, Tommaso Conroy, Richard Procaccini, Dena Roy, Anan School of Medicine Stanford University 300 Pasteur Drive United States Department of Genetics Stanford School of Medicine StanfordCA94305 United States Department of Medicine University of Washington SeattleWA98195 United States Department of Pathology University of Florida Diabetes Institute GainesvilleFL32610 United States Klarman Cell Observatory Broad Institute of MIT and Harvard CambridgeMA02142 United States Howard Hughes Medical Institute Koch Institute of Integrative Cancer Research Department of Biology Massachusetts Institute of Technology CambridgeMA02140 United States New York Genome Center New York CityNY10013 United States New York University New YorkNY10012 United States Department of Biomedical Informatics Harvard Medical School BostonMA02115 United States Department of Genome Sciences University of Washington SeattleWA98105 United States Department of Chemistry Purdue University West LafayetteIN47907 United States Department of Biochemistry Stanford University School of Medicine StanfordCA94305 United States Pittsburgh Supercomputing Center Carnegie Mellon University PittsburghPA15213 United States Department of Computational Biology School of Computer Science Carnegie Mellon University PittsburghPA15213 United States Department of Bioengineering University of California San Diego La JollaCA92093 United States Department of Intelligent Systems Engineering School of Informatics Computing and Engineering Indiana University BloomingtonIN47408 United States Department of Surgery Washington University School of Medicine St LouisMO63110 United States Division of Program Coordination Planning and Strategic Initiatives National Institutes of Health BethesdaMD20892 United States National Human Genome Research Institute National Institutes of Health BethesdaMD20892 United States National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Caltech-UW TMC Departmen

Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible 3D molecular and cellular atlas of the human body, in health and various disease settings. Copyright © 2019, The Authors. All rights reserved.

关键词： Mapping

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Author Correction: The interrelation of sleep and mental and physical health is anchored in grey-matter neuroanatomy and under genetic control

Communications biology

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Communications biology 2020年第1期3卷 290页

作者： Masoud Tahmasian Fateme Samea Habibolah Khazaie Mojtaba Zarei Shahrzad Kharabian Masouleh Felix Hoffstaedter Julia Camilleri Peter Kochunov B T Thomas Yeo Simon Bodo Eickhoff Sofie Louise Valk Institute of Medical Science and Technology Shahid Beheshti University Tehran Iran. Sleep Disorders Research Center Kermanshah University of Medical Sciences Kermanshah Iran. Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour) Research Centre Jülich 52425 Jülich Germany. Institute of Systems Neuroscience Heinrich Heine University Düsseldorf 40225 Düsseldorf Germany. Maryland Psychiatric Research Center University of Maryland School of Medicine Baltimore MD 21201 USA. Department of Electrical and Computer Engineering Clinical Imaging Research Centre N.1 Institute for Health and Memory Networks Program National University of Singapore Singapore 119077 Singapore. Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown MA 02114 USA. Centre for Sleep and Cognition National University of Singapore Singapore 119077 Singapore. NUS Graduate School for Integrative Sciences and Engineering National University of Singapore Singapore 119077 Singapore. Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour) Research Centre Jülich 52425 Jülich Germany. svalk@fz-juelich.de. Institute of Systems Neuroscience Heinrich Heine University Düsseldorf 40225 Düsseldorf Germany. svalk@fz-juelich.de.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: Determination of RNA structural diversity and its role in HIV-1 RNA splicing

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Nature 2020年第7837期588卷 E16页

作者： Phillip J Tomezsko Vincent D A Corbin Paromita Gupta Harish Swaminathan Margalit Glasgow Sitara Persad Matthew D Edwards Lachlan Mcintosh Anthony T Papenfuss Ann Emery Ronald Swanstrom Trinity Zang Tammy C T Lan Paul Bieniasz Daniel R Kuritzkes Athe Tsibris Silvi Rouskin Whitehead Institute for Biomedical Research Cambridge MA USA. Program in Virology Harvard Medical School Boston MA USA. Brigham and Women's Hospital Boston MA USA. Bioinformatics Division Walter and Eliza Hall Institute Parkville Victoria Australia. Department of Medical Biology The University of Melbourne Melbourne Victoria Australia. Massachusetts Institute of Technology Cambridge MA USA. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge MA USA. Peter MacCallum Cancer Centre Melbourne Victoria Australia. Department of Mathematics and Statistics University of Melbourne Melbourne Victoria Australia. Sir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Victoria Australia. Curriculum in Genetics and Molecular Biology University of North Carolina at Chapel Hill Chapel Hill NC USA. Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC USA. Department of Microbiology and Immunology University of North Carolina at Chapel Hill Chapel Hill NC USA. Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Chapel Hill NC USA. Laboratory of Retrovirology The Rockefeller University New York NY USA. Howard Hughes Medical Institute The Rockefeller University New York NY USA. Department of Medicine Harvard Medical School Boston MA USA. Whitehead Institute for Biomedical Research Cambridge MA USA. srouskin@wi.mit.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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DeepZipper: A Novel Deep Learning Architecture for Lensed Supernovae Identification

arXiv

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arXiv 2021年

作者： Morgan, Robert Nord, B. Bechtol, K. González, S.J. Buckley-Geer, E. Möller, A. Park, J.W. Kim, A.G. Birrer, S. Aguena, M. Annis, J. Bocquet, S. Brooks, D. Rosell, A. Carnero Kind, M. Carrasco Carretero, J. Cawthon, R. da Costa, L.N. Davis, T.M. De Vicente, J. Doel, P. Ferrero, I. Friedel, D. Frieman, J. García-Bellido, J. Gatti, M. Gaztanaga, E. Giannini, G. Gruen, D. Gruendl, R.A. Gutierrez, G. Hollowood, D.L. Honscheid, K. James, D.J. Kuehn, K. Kuropatkin, N. Maia, M.A.G. Miquel, R. Palmese, A. Paz-Chinchón, F. Pereira, M.E.S. Pieres, A. Plazas Malagón, A.A. Reil, K. Roodman, A. Sanchez, E. Smith, M. Suchyta, E. Swanson, M.E.C. Tarle, G. To, C. Physics Department University of Wisconsin-Madison 1150 University Avenue MadisonWI53706 United States Fermi National Accelerator Laboratory P. O. Box 500 BataviaIL60510 United States Legacy Survey of Space and Time Corporation Data Science Fellowship Program United States Department of Astronomy and Astrophysics University of Chicago ChicagoIL60637 United States Kavli Institute for Cosmological Physics University of Chicago ChicagoIL60637 United States Legacy Survey of Space and Time 933 North Cherry Avenue TucsonAZ85721 United States Centre for Astrophysics & Supercomputing Swinburne University of Technology VIC3122 Australia Kavli Institute for Particle Astrophysics and Cosmology Department of Physics Stanford University StanfordCA94305 United States SLAC National Accelerator Laboratory Menlo ParkCA94025 United States Lawrence Berkeley National Laboratory 1 Cyclotron Road BerkeleyCA94720 United States Laboratório Interinstitucional de e-Astronomia - LIneA Rua Gal. José Cristino 77 RJ Rio de Janeiro20921-400 Brazil Faculty of Physics Ludwig-Maximilians-Universität Scheinerstr. 1 Munich81679 Germany Department of Physics & Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom Center for Astrophysical Surveys National Center for Supercomputing Applications 1205 West Clark St. UrbanaIL61801 United States Department of Astronomy University of Illinois at Urbana-Champaign 1002 W. Green Street UrbanaIL61801 United States The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Physics Department William Jewell College LibertyMO64068 United States Observatório Nacional Rua Gal. José Cristino 77 RJ Rio de Janeiro20921-400 Brazil School of Mathematics and Physics University of Queensland BrisbaneQLD4072 Australia Madrid Spain Institute of Theoretical Astrophysics University of Oslo P.O. Box 1029 Blindern OsloNO-0315 Norway Instituto de Fisica Teorica UAM/CSIC

Large-scale astronomical surveys have the potential to capture data on large numbers of strongly gravitationally lensed supernovae (LSNe). To facilitate timely analysis and spectroscopic follow-up before the supernova fades, an LSN needs to be identified soon after it begins. To quickly identify LSNe in optical survey datasets, we designed ZipperNet, a multi-branch deep neural network that combines convolutional layers (traditionally used for images) with long short-term memory (LSTM) layers (traditionally used for time series). We tested ZipperNet on the task of classifying objects from four categories – no lens, galaxy-galaxy lens, lensed type Ia supernova, lensed core-collapse supernova – within high-fidelity simulations of three cosmic survey data sets – the Dark Energy Survey (DES), Rubin Observatory’s Legacy Survey of Space and Time (LSST), and a Dark Energy Spectroscopic Instrument (DESI) imaging survey. Among our results, we find that for the LSST-like dataset, ZipperNet classifies LSNe with a receiver operating characteristic area under the curve of 0.97, predicts the spectroscopic type of the lensed supernovae with 79% accuracy, and demonstrates similarly high performance for LSNe 1-2 epochs after first detection. We anticipate that a model like ZipperNet, which simultaneously incorporates spatial and temporal information, can play a significant role in the rapid identification of lensed transient systems in cosmic survey experiments. Copyright © 2021, The Authors. All rights reserved.

关键词： Supernovae

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A bright millisecond-duration radio burst from a Galactic magnetar

arXiv

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arXiv 2020年

作者： Andersen, B.C. Bandura, K.M. Bhardwaj, M. Bij, A. Boyce, M.M. Boyle, P.J. Brar, C. Cassanelli, T. Chawla, P. Chen, T. Cliche, J.-F. Cook, A. Cubranic, D. Curtin, A.P. Denman, N.T. Dobbs, M. Dong, F.Q. Fandino, M. Fonseca, E. Gaensler, B.M. Giri, U. Good, D.C. Halpern, M. Hill, A.S. Hinshaw, G.F. Höfer, C. Josephy, A. Kania, J.W. Kaspi, V.M. Landecker, T.L. Leung, C. Li, D.Z. Lin, H.-H. Masui, K.W. McKinven, R. Mena-Parra, J. Merryfield, M. Meyers, B.W. Michilli, D. Milutinovic, N. Mirhosseini, A. Münchmeyer, M. Naidu, A. Newburgh, L.B. Ng, C. Patel, C. Pen, U.-L. Pinsonneault-Marotte, T. Pleunis, Z. Quine, B.M. Rafiei-Ravandi, M. Rahman, M. Ransom, S.M. Renard, A. Sanghavi, P. Scholz, P. Shaw, J.R. Shin, K. Siegel, S.R. Singh, S. Smegal, R.J. Smith, K.M. Stairs, I.H. Tan, C.M. Tendulkar, S.P. Tretyakov, I. Vanderlinde, K. Wang, H. Wulf, D. Zwaniga, A.V. Department of Physics McGill University 3600 rue University MontréalQCH3A 2T8 Canada McGill Space Institute McGill University 3550 rue University MontréalQCH3A 2A7 Canada CSEE West Virginia University MorgantownWV26505 United States Center for Gravitational Waves and Cosmology West Virginia University MorgantownWV26505 United States Canadian Institute for Theoretical Astrophysics 60 St. George Street TorontoONM5S 3H8 Canada Department of Physics and Astronomy University of Manitoba Allen Building WinnipegMBR3T 2N2 Canada Dunlap Institute for Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada David A. Dunlap Department of Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada MIT Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road VancouverBCV6T 1Z1 Canada Central Development Laboratory National Radio Astronomy Observatory 1180 Boxwood Estate Road CharlottesvilleVA22903 United States Perimeter Institute for Theoretical Physics 31 Caroline Street North WaterlooONN2L 2Y5 Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada Department of Computer Science Math Physics and Statistics University of British Columbia 3187 University Way KelownaBCV1V 1V7 Canada National Research Council Canada Herzberg Research Centre for Astronomy and Astrophysics Dominion Radio Astrophysical Observatory PO Box 248 PentictonBCV2A 6J9 Canada Department of Physics and Astronomy West Virginia Univeristy MorgantownWV26506 United States Department of Physics Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Department of Physics University of Toronto 60 St. George Street TorontoONM5S 1A7 Canada Max-Planck-Inst

Magnetars are highly magnetized young neutron stars that occasionally produce enormous bursts and flares of X-rays and gamma-rays1. Of the approximately thirty magnetars currently known in our Galaxy and Magellanic Clouds, five have exhibited transient radio pulsations2, 3. Fast radio bursts (FRBs) are millisecond-duration bursts of radio waves arriving from cosmological distances4. Some have been seen to repeat5–7. A leading model for repeating FRBs is that they are extragalactic magnetars, powered by their intense magnetic fields8–10. However, a challenge to this model has been that FRBs must have radio luminosities many orders of magnitude larger than those seen from known Galactic magnetars. Here we report the detection of an extremely intense radio burst from the Galactic magnetar SGR 1935+2154 using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) FRB project. The fluence of this two-component bright radio burst and the estimated distance to SGR 1935+2154 together imply a 400–800 MHz burst energy of - 3 × 1034 erg, which is three orders of magnitude brighter than those of any radio-emitting magnetar detected thus far. Such a burst coming from a nearby galaxy would be indistinguishable from a typical FRB. This event thus bridges a large fraction of the radio energy gap between the population of Galactic magnetars and FRBs, strongly supporting the notion that magnetars are the origin of at least some FRBs. Copyright © 2020, The Authors. All rights reserved.

关键词： Galaxies

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BHEL Smart Wall Blowing System: New Product Development in Manufacturing Industry

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Vikalpa 2021年第4期45卷 240 - 249页

作者： Abhishek Kumar R. Dhanuskodi R. Kaliappan K. Nandakumar Abhishek Kumar teaches design philosophies at Anant National University Ahmedabad. He earned his Ph.D in Management from Pondicherry University. He is an Economics graduate from Calcutta University and MBA from BIM Trichy. He has published more than 20 articles in reputed international journals has authored two books written articles and columns for newspapers and is quoted on issues related to leadership and marketing by various media platforms. His research work comprises construction of brand personality scale for media aesthetics and phenomenological design. His recent publications are on philosophy of a photograph hermeneutic reality of product and on philosophy of intimate spaces. R. Dhanuskodi has nearly 40 years of R&D experience at BHEL India in technical areas applicable for thermal power plants. He is a life member of The Institution of Engineers (India) and The Combustion Institute. He has won two BHEL’s Excel awards under the best author category for technical papers. He has visited France Netherlands and Germany under Indo-Europe Clean Coal Development Program. He has guided 42 UG PG and PhD project works. He holds 11 patents 40 copyrights and 2 design registrations. He has presented papers in 20 conferences and published in 10 national and international journals. R. Kaliappan completed his bachelors in electrical and electronics engineering and Masters in Computer Science. He has 36 years of research experience in different fields of power generation and power plant subsystems such as heat transfer studies on boiler circulation efficiency improvements of boiler subsystems product improvements/ enhancements and setting up test facilities for research studies. He has published a number of technical papers on MHD power generation and heat transfer studies in various national and international journals. He has more than 25 patents and copyrights on products development related to power boilers. He has won BHEL’S gold medal for product development for Smart Wall Blowing system. K. Nandakumar

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